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Frequency of use and standards of care for the use of azathioprine and 6-mercaptopurine in the treatment of inflammatory bowel disease: a systematic review of the literature and a survey of Canadian gastroenterologists
Publication Year: 2001 Source: Can J Gastroenterol PMID: 11173323 DOI: 10.1155/2001/518192
Scid mice transplanted with CD4(+) T cells from congenic donor mice develop a chronic and lethal inflammatory bowel disease (IBD) 2-3 months post-transplantation. In the present study we have investigated the response of CD4(+) T cells from scid mice with colitis against fecal extracts. Our results show that in contrast …
New insights into mechanism of inflammatory and allergic diseases in mucosal tissues
Publication Year: 2001 Source: Digestion PMID: 11173903 DOI: 10.1159/000051904
Interleukin (IL)-10(-/-) mice spontaneously develop intestinal inflammation characterized by discontinuous transmural lesions affecting the small and large intestine and by dysregulated production of proinflammatory cytokines. The uncontrolled generation of IFN-gamma-producing CD4(+) T cells (Th1 type) has been shown to play a causal role in the development of enterocolitis affecting these …
The immuno-inflammatory mechanism for tissue injury in inflammatory bowel disease and Helicobacter pylori-infected chronic active gastritis. Roles of the mucosal immune system
Publication Year: 2001 Source: Digestion PMID: 11173904 DOI: 10.1159/000051905
OBJECTIVE: To measure the intestinal permeability in patients with Behçet's syndrome (BS) and to compare the results with those obtained from healthy and diseased controls. METHOD: The study group comprised 34 patients with BS without known gastrointestinal disease. Ten patients with ankylosing spondylitis (AS), 6 with inflammatory bowel diseases (IBD), …
Increased secretion of granulocyte-macrophage colony-stimulating factor in mucosal lesions of inflammatory bowel disease
Publication Year: 2001 Source: Digestion PMID: 11173907 DOI: 10.1159/000051908
Comment in Am J Gastroenterol. 2000 Jun;95(6):1389-92. OBJECTIVE: The measles virus has been implicated as a possible etiological agent in the development of inflammatory bowel disease (IBD). Measles infection at an early age is associated with subacute sclerosing panencephalitis, a degenerative neurological condition caused by persistent measles infection of the …
Transcription factor-targeted therapies in inflammatory bowel disease
Publication Year: 2001 Source: Digestion PMID: 11173913 DOI: 10.1159/000051914
Comment in Gastroenterology. 2006 Feb;130(2 Suppl 1):S91-2.
Inflammatory bowel disease: immunodiagnostics, immunotherapeutics, and ecotherapeutics
Publication Year: 2001 Source: Gastroenterology PMID: 11179240 DOI: 10.1053/gast.2001.22122
We present here a quantitative way to assess the impact of language-family boundaries on population differentiation and to evaluate the homogeneity of the genetic processes along these boundaries. Our estimator (delta a) of the impact of the boundary is based on an isolation by distance (IBD) model and measures the …
Experimental study on lipid and bilirubin metabolism after biliary drainage for obstructive jaundice
Publication Year: 2001 Source: J Surg Res PMID: 11180996 DOI: 10.1006/jsre.2000.6057
The activity of phospholipase (PL)A2 is elevated in the intestinal epithelia of patients with inflammatory bowel disease (IBD). Recently, we reported that lysophosphatidylcholine (L-PC), the PLA2 hydrolysis product of phosphatidylcholine (PC), stimulates bacterial translocation (BT) in an enterocyte cell-culture model. These two observations stimulated us to examine the effects of …
Ulcerative colitis and Crohn's disease: distinctive gene expression profiles and novel susceptibility candidate genes
Publication Year: 2001 Source: Hum Mol Genet PMID: 11181568 DOI: 10.1093/hmg/10.5.445
The gastrointestinal mucosa is exposed to myriads of infectious and food antigens, and a unique barrier mechanism handles them on the mucosal surface, and specific immune responses to these antigens call on the mucosal immune system in the mucosal tissues to maintain homeostasis of gastrointestinal functions and structure. Abrogation of …
Further evidence that 6-MP taken by the father with IBD provides risk of congenital anomaly to the pregnancy
Publication Year: 2001 Source: Am J Gastroenterol PMID: 11197267 DOI: 10.1111/j.1572-0241.2001.03489.x
Inflammatory Bowel Diseases (IBDs) are chronic, relapsing and remitting gastrointestinal conditions with no known cure. Previous studies have linked behavioral factors, including stress and medication adherence, to relapse. PURPOSE: We sought to determine the effect of participation in a behavioral self-management program on incidence of flare within 12 months following …
Immunohistochemical analysis of measles related antigen in IBD
Publication Year: 2001 Source: Gut PMID: 11200076 DOI: 10.1136/gut.48.1.136
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