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Genomics and inflammatory bowel disease
Publication Year: 2000 Source: Curr Opin Gastroenterol PMID: 17031092 DOI: 10.1097/00001574-200007000-00002
Colorectal cancer (CRC) develops from a dysplastic precursor lesion, regardless of whether it arises sporadically, in the setting of high-risk hereditary conditions, or in the context of chronic inflammation like inflammatory bowel disease (IBD). This review focuses on the molecular alterations associated with CRC pathogenesis in IBD. Although none of …
Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci
Publication Year: 2000 Source: Am J Hum Genet PMID: 10777714 DOI: 10.1086/302913
11 African and two German IBDV strains isolated in the mid '80s from field outbreaks in vaccinated and unvaccinated chicken flocks displayed features of very virulent (vv) IBDV strains. The sequence data of the VP2 variable region and phylogenetic analysis confirm that these strains can be grouped within vv IBDV …
Assessment of the prevalence of infection with Helicobacter pylori in patients with inflammatory bowel disease
Publication Year: 2000 Source: Eur J Gastroenterol Hepatol PMID: 10783998 DOI: 10.1097/00042737-200012040-00012
In healthy individuals measures of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme activity predict the change in bone formation markers in response to therapeutic glucocorticoids. It is unclear whether these measures remain predictive in inflammatory disease. We therefore examined whether 11β-HSD1 activity predicts changes in bone markers and bone mineral density …
Transforming growth factor-beta and hepatocyte growth factor plasma levels in patients with inflammatory bowel disease
Publication Year: 2000 Source: Eur J Gastroenterol Hepatol PMID: 10783999 DOI: 10.1097/00042737-200012040-00013
Comment in Gastroenterology. 1990 Jul;99(1):286-7. Genetic factors have been implicated in the etiology of inflammatory bowel disease (IBD) because of the increased occurrence of IBD in relatives. To further characterize the familial aggregation of IBD, we obtained family histories by interview on 188 IBD patients, including 154 Ashkenazi Jews (82%), …
The incidence of childhood inflammatory bowel disease in Wales
Publication Year: 2000 Source: Eur J Pediatr PMID: 10789930 DOI: 10.1007/s004310050066
OBJECTIVE: The impact of inflammatory bowel disease (IBD) on disability remains poorly understood. The World Health Organization's integrative model of human functioning and disability in the International Classification of Functioning, Disability and Health (ICF) makes disability assessment possible. The ICF is a hierarchical coding system with four levels of details …
Fine mapping of quantitative trait loci using linkage disequilibria with closely linked marker loci
Publication Year: 2000 Source: Genetics PMID: 10790414 DOI: 10.1093/genetics/155.1.421
In chronic inflammatory bowel disease, self-destructive, exaggerated inflammation seems to occur in the absence of a well defined pathogen. However, epidemiological data strongly suggests that development of disease does not depend on endogenous factors alone. In this review, we summarize how a possible role for microbial factors can be reconciled …
Increased production of matrix metalloproteinase-3 and tissue inhibitor of metalloproteinase-1 by inflamed mucosa in inflammatory bowel disease
Publication Year: 2000 Source: Clin Exp Immunol PMID: 10792371 DOI: 10.1046/j.1365-2249.2000.01227.x
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[Incidence of inflammatory bowel disease in children in Brittany (1994-1997). Breton association of study and research on digestive system diseases (Abermad)]
Publication Year: 2000 Source: Arch Pediatr PMID: 10793924 DOI: 10.1016/s0929-693x(00)88832-6
Chronic inflammatory bowel disease (IBD) presents as two major clinical forms, Crohn's disease (CD) and ulcerative colitis (UC). Genetic epidemiological studies and animal models suggest that inherited factors play significant roles in the susceptibility to both forms of IBD. From four genome-wide scans, putative susceptibility loci on chromosome 16 (IBD1 …
Neutrophil apoptosis is delayed in patients with inflammatory bowel disease
Publication Year: 2000 Source: Shock PMID: 10807010 DOI: 10.1097/00024382-200005000-00003
BACKGROUND: Several studies have shown an inverse relationship between appendicectomy and subsequent development of inflammatory bowel disease (IBD), although these findings remain contentious. This study aims to further elucidate the role appendicitis/appendicectomy has in the development of IBD. METHOD: All patients undergoing appendicectomy at Hereford County Hospital between 1986 and …
Food induced stimulation of the antisecretory factor can improve symptoms in human inflammatory bowel disease: a study of a concept
Publication Year: 2000 Source: Gut PMID: 10807895 DOI: 10.1136/gut.46.6.824
The intestinal epithelium plays an important role in the recognition of pathogenic organisms and in the recruitment of inflammatory cells to the mucosa. Epithelial chemokine production may constitute a key target in future therapies for inflammatory bowel disease (IBD). Chemokines are divided into two subfamilies, the C-C family and C-X-C …
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