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Carbonylation and disassembly of the F-actin cytoskeleton in oxidant induced barrier dysfunction and its prevention by epidermal growth factor and transforming growth factor alpha in a human colonic cell line
Publication Year: 2000 Source: Gut PMID: 10807896 DOI: 10.1136/gut.46.6.830
One-day-old chickens were divided into two groups and reared under similar conditions. One group was fed a diet supplemented with 1000ppm ascorbic acid and the other group was fed an identical diet, but not supplemented with ascorbic acid. Both groups were vaccinated against infectious bursal disease (IBD) at 7 days …
Mycophenolate mofetil versus azathioprine in patients with chronic active ulcerative colitis: a 12-month pilot study
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10811328 DOI: 10.1111/j.1572-0241.2000.02010.x
Monocytic cells have been shown to produce endothelin, a potent vasoconstrictor molecule with immune modulating properties. The signalling mechanisms involved in this response are presently unclear. Monocytes are also believed to play an important role in inflammatory bowel disease (IBD). The objective of this study was to characterize the role …
Are 99mTc leukocyte scintigraphy and SBFT studies useful in children suspected of having inflammatory bowel disease?
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10811329 DOI: 10.1111/j.1572-0241.2000.02011.x
A dysregulated secretion of contra-inflammatory cytokines such as interleukin-10 (IL-10) could play a role in the pathogenesis of inflammatory bowel disease (IBD). We have investigated the expression of IL-10 in gut tissues from patients with Crohn's disease (CD), ulcerative colitis (UC) and controls by mRNA in situ hybridization and immunohistochemistry. …
Mucosal cytokine production in radiation-induced proctosigmoiditis compared with inflammatory bowel disease
Publication Year: 2000 Source: Am J Gastroenterol PMID: 10811331 DOI: 10.1111/j.1572-0241.2000.02013.x
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Linkage and linkage disequilibrium in chromosome band 1p36 in American Chaldeans with inflammatory bowel disease
Publication Year: 2000 Source: Hum Mol Genet PMID: 10814724 DOI: 10.1093/hmg/9.9.1425
Although peripheral blood eosinophilia is strongly associated with the risk of developing asthma, genetic determinants of eosinophilia have not been extensively studied. We used sib-pair analysis to assess linkage of circulating eosinophils (as a percent of total white blood cells [WBC]) to nine markers located in chromosome 5q31-33. The study …
Anticipation in inflammatory bowel disease: a phenomenon caused by an accumulation of confounders
Publication Year: 2000 Source: Am J Med Genet PMID: 10817651 DOI: 10.1002/(sici)1096-8628(20000529)92:3<178::aid-ajmg4>3.0.co;2-p
BACKGROUND: Two separate nationwide, retrospective epidemiological studies of inflammatory bowel disease (IBD) in Iceland over a combined 40-year period, 1950-1989, have shown a continually rising incidence. The main objective of this study was to investigate the incidence of IBD prospectively for the 5-year period 1990-1994 to determine whether there still …
Prevention of experimental colitis in SCID mice reconstituted with CD45RBhigh CD4+ T cells by blocking the CD40-CD154 interactions
Publication Year: 2000 Source: J Immunol PMID: 10820284 DOI: 10.4049/jimmunol.164.11.6005
pANCA is a marker antibody associated with inflammatory bowel disease (IBD), including most patients with ulcerative colitis and a subset with Crohn's disease. This study addressed the hypothesis that pANCA reacts with an antigen(s) of microbial agents potentially relevant to IBD pathogenesis. Using a pANCA monoclonal antibody, we have previously …
[Validation of the new German translation version of the "Short Inflammatory Bowel Disease Questionnaire" (SIBDQ)]
Publication Year: 2000 Source: Z Gastroenterol PMID: 10820859 DOI: 10.1055/s-2000-14868
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Sonographic measurement of thickened bowel wall segments as a quantitative parameter for activity in inflammatory bowel disease
Publication Year: 2000 Source: Z Gastroenterol PMID: 10820861 DOI: 10.1055/s-2000-14875
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Ascorbic acid supplementation improved antibody response to infectious bursal disease vaccination in chickens
Publication Year: 2000 Source: Poult Sci PMID: 10824956 DOI: 10.1093/ps/79.5.680
P-Glycoproteins are transmembrane proteins associated with acquired multidrug resistance in mammalian cells and some protozoan parasites by a process of active drug export. P-glycoproteins contain two nucleotide binding domains which couple ATP to the drug transport process. The region between the nucleotide binding domains of P-glycoproteins, termed the internucleotide binding …
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