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Effect of argatroban on trinitrobenzene sulfonic acid-induced colitis
Publication Year: 2000 Source: J Gastroenterol Hepatol PMID: 11022836 DOI: 10.1046/j.1440-1746.2000.02279.x
OBJECTIVE: CD40-CD40 ligand (CD40L) interaction is essential for the T-lymphocyte-dependent immune response. This interaction may be operational in the pathogenesis of inflammatory bowel diseases (IBD). The present study examined the expression of CD40 in peripheral blood mononuclear cells (PBMNCs) and tissue specimens, and CD40-stimulated interleukin (IL)-12 release from PBMNCs in …
Colonic expression and synthesis of interleukin 13 and interleukin 15 in inflammatory bowel disease
Publication Year: 2000 Source: Cytokine PMID: 11023669 DOI: 10.1006/cyto.2000.0744
BACKGROUND: Recent studies have suggested that heparin is effective for treatment of inflammatory bowel disease (IBD) and its various effects (in addition to the anticoagulant effect). We evaluated the effects of argatroban as an antithrombin drug on trinitrobenzene sulfonic acid (TNB)-induced colitis, an established model of IBD. METHODS: Rats were …
Advances in inflammatory bowel disease
Publication Year: 2000 Source: Med Clin North Am PMID: 11026920 DOI: 10.1016/s0025-7125(05)70278-9
The need for a basic epidemiological study, according to international standards, of the prevalence of IBD in Slovakia was increased by the dissolution of Czechoslovakia. This paper presents the results of CD prevalence to 30 April 1994 in Slovakia. To evaluate the statistical data of the prevalence of the disease …
Mediators of stress effects in inflammatory bowel disease: not the usual suspects
Publication Year: 2000 Source: J Psychosom Res PMID: 11033376 DOI: 10.1016/s0022-3999(00)00098-2
Oxygen radicals particularly superoxide and hydroxyl radicals are very reactive species believed to be involved in cell and tissue damage in a variety of diseases including inflammatory bowel disease (IBD). Today there are four major arguments for such a role in IBD: Infiltration of the inflamed intestinal mucosa with myeloperoxidase …
Ongoing innovations in biomechanics and materials for the new millennium
Publication Year: 2000 Source: Angle Orthod PMID: 11036996 DOI: 10.1043/0003-3219(2000)070<0366:OIIBAM>2.0.CO;2
Positional cloning has been applied successfully to many Mendelian disorders. Because of the public health significance, there is strong interest in mapping susceptibility genes for common disorders, such as asthma and allergy, that have a genetic component. Genome-wide screening has been very useful in detecting regions of the genome likely …
Inferring the impact of linguistic boundaries on population differentiation: application to the Afro-Asiatic-Indo-European case
Publication Year: 2000 Source: Eur J Hum Genet PMID: 11039574 DOI: 10.1038/sj.ejhg.5200519
BACKGROUND: The failure of standard treatments for inflammatory bowel disease (IBD) has led to the use of immuno-modulatory therapy. Most reports of the use of cyclosporin are from single specialist centres. AIM: To survey the use of cyclosporin in IBD in Bristol's three teaching hospitals. PATIENTS AND METHODS: Over a …
Genetic factors determine extent of bone loss in inflammatory bowel disease
Publication Year: 2000 Source: Gastroenterology PMID: 11040178 DOI: 10.1053/gast.2000.18158
OBJECTIVE: Most complications of 6-mercaptopurine (6MP) used in the treatment of inflammatory bowel disease (IBD) occur early, whereas neoplasms occur late in the course. Concern persists that the risk is increased when 6MP is used. We report our experience with malignant tumors developing over 27 yr of treating IBD patients …
IL-10 secretion and sensitivity in normal human intestine and inflammatory bowel disease
Publication Year: 2000 Source: J Clin Immunol PMID: 11051278 DOI: 10.1023/a:1006672114184
Inflammation of the intestine causes pain and altered motility, at least in part through effects on the enteric nervous system. While these changes may be reversed with healing, permanent damage may contribute to inflammatory bowel disease (IBD) and post-enteritis irritable bowel syndrome. Since little information exists, we induced colitis in …
Homocysteine in inflammatory bowel disease: a risk factor for thromboembolic complications?
Publication Year: 2000 Source: Am J Gastroenterol PMID: 11051355 DOI: 10.1111/j.1572-0241.2000.03193.x
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Optimization of technetium-99m-HMPAO leukocyte scintigraphy in evaluation of active inflammatory bowel disease
Publication Year: 2000 Source: Dig Dis Sci PMID: 11052327 DOI: 10.1023/a:1005513723968
Identifying the normal concerns of people with ulcerative colitis and Crohn's disease (CD) facilitates a comprehensive approach to their medical care. Clinically, it can be easily appreciated that the concerns of men and women with inflammatory bowel disease (IBD) may differ and that this may have a substantial impact on …
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