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1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease
Publication Year: 2000 Source: J Nutr PMID: 11053501 DOI: 10.1093/jn/130.11.2648
OBJECTIVES: To quantify the coexistence of inflammatory bowel disease (IBD) and multiple sclerosis (MS) and to characterize the diseases when they coexist. PATIENTS AND METHODS: In this retrospective study of medical records spanning 1950 through 1995, the diagnoses of Crohn disease (CD), ulcerative colitis (UC), and MS were based on …
Bone mineral density in patients with recently diagnosed inflammatory bowel disease
Publication Year: 2000 Source: Gastroenterology PMID: 11054377 DOI: 10.1053/gast.2000.19280
Not found
Suppression of NF-kappaB activity by sulfasalazine is mediated by direct inhibition of IkappaB kinases alpha and beta
Publication Year: 2000 Source: Gastroenterology PMID: 11054378 DOI: 10.1053/gast.2000.19458
The reason why 10% to 20% of all patients with primary sclerosing cholangitis (PSC) develop cholangiocarcinoma (CC) remains unknown. The aim of this study was to compare the clinical and biochemical presentation in PSC patients with and without hepatobiliary malignancy and to look for risk factors for developing hepatobiliary carcinoma …
Isolation and characterization of an antigenically distinct 68-kd protein from nonviral intracytoplasmic inclusions in Boa constrictors chronically infected with the inclusion body disease virus (IBDV: Retroviridae)
Publication Year: 2000 Source: Vet Pathol PMID: 11055868 DOI: 10.1354/vp.37-5-449
Inflammatory bowel disease (IBD) comprises the two disorders ulcerative colitis (UC) and Crohn's disease (CD). Although the etiology is still unclear, initiation and aggravation of the inflammatory processes seem to be due to a massive local mucosal immune response. An increased number of greatly activated macrophages seems to contribute to …
Interferon-gamma sensitizes colonic epithelial cell lines to physiological and therapeutic inducers of colonocyte apoptosis
Publication Year: 2000 Source: J Cell Physiol PMID: 11056003 DOI: 10.1002/1097-4652(200012)185:3<331::AID-JCP3>3.0.CO;2-V
Interleukin-10 (IL-10) deficiency in gene knockout mice causes chronic enterocolitis. We hypothesized that inflammation in human inflammatory bowel disease might result from innate alterations in the IL-10 pathway. Serum, supernatants, and mRNA of peripheral blood mononuclear cells (PBMC) and lamina propria mononuclear cells (LPMC) derived from inflamed (LPMC-i) and noninflamed …
Distribution of genome shared identical by descent by two individuals in grandparent-type relationship
Publication Year: 2000 Source: Genetics PMID: 11063711 DOI: 10.1093/genetics/156.3.1403
Parametric-linkage analysis applied to large pedigrees with many affected individuals has helped in the identification of highly penetrant genes; but, for diseases lacking a clear Mendelian inheritance pattern or caused by several genes of low to moderate penetrance, a more robust strategy is nonparametric analysis applied to small sets of …
Deficient iNOS in inflammatory bowel disease intestinal microvascular endothelial cells results in increased leukocyte adhesion
Publication Year: 2000 Source: Free Radic Biol Med PMID: 11063913 DOI: 10.1016/s0891-5849(00)00391-9
Not found
Alteration of V beta usage and cytokine production of CD4+ TCR beta beta homodimer T cells by elimination of Bacteroides vulgatus prevents colitis in TCR alpha-chain-deficient mice
Publication Year: 2000 Source: J Immunol PMID: 11067950 DOI: 10.4049/jimmunol.165.10.5891
Comment in Gastroenterology. 2008 Dec;135(6):2149-50. BACKGROUND: The constellation of human inflammatory bowel disease (IBD) includes ulcerative colitis and Crohn's disease, which both display a wide spectrum in the severity of pathology. One theory is that multiple genetic hits to the host immune system may contribute to the susceptibility and severity …
Human immunodeficiency virus type 1 infection is associated with significant mucosal inflammation characterized by increased expression of CCR5, CXCR4, and beta-chemokines
Publication Year: 2000 Source: J Infect Dis PMID: 11069233 DOI: 10.1086/317625
Histiocytic ulcerative colitis (HUC) is an inflammatory bowel disease (IBD) that occurs predominantly in dogs of the boxer breed. The lesions are characterized by mucosal ulceration and mixed inflammatory cell infiltrate that includes the presence of periodic acid-Schiff (PAS)-positive macrophages. However, the phenotype of the inflammatory cells has not been …
Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency
Publication Year: 2000 Source: Digestion PMID: 11070407 DOI: 10.1159/000007822
Flora-bearing mice with targeted disruption of T cell receptor (TCR)-alpha or -beta genes spontaneously develop intestinal inflammation with features similar to ulcerative colitis in humans. TCR-alpha-deficient mice maintained germfree or colonized with a limited number of intestinal bacteria failed to develop inflammatory bowel disease (IBD)-like lesions. Evidently, inflammation in these …
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