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Retrospective case series analysis of patients with inflammatory bowel disease on azathioprine. A district general hospital experience
Publication Year: 2000 Source: Digestion PMID: 11070408 DOI: 10.1159/000007823
A disease similar to ulcerative colitis in humans has been identified in cotton-top tamarins (CTTs) in captivity. The clinical signs include weight loss, diarrhea, and rectal bleeding with the pathological features and biochemical abnormalities of ulcerative colitis. Approximately 25 to 40% of these animals develop colon cancer after 2 to …
Expression of platelet P-selectin and detection of soluble P-selectin, NPY and RANTES in patients with inflammatory bowel disease
Publication Year: 2000 Source: Inflamm Res PMID: 11071121 DOI: 10.1007/s000110050618
Twenty percent of inflammatory bowel disease (IBD) patients present in the pediatric years, with recent reports suggesting a rising incidence in the pediatric age group. This highlights the need for both pediatric and adult gastroenterologists to better understand issues related to the process of transition from pediatric to adult care. …
Gene therapy of chronic inflammatory disease
Publication Year: 2000 Source: Adv Drug Deliv Rev PMID: 11072115 DOI: 10.1016/s0169-409x(00)00095-8
OBJECTIVE: To determine whether the presence of polymorphisms associated with reduced or absent activity of thiopurine methyltransferase (TPMT), an enzyme involved in azathioprine metabolism, can predict side-effects, particularly myelosuppression, in patients taking this drug. METHODS: The TPMT genotype was determined in 120 patients with systemic lupus erythematosus (SLE) together with …
Inhibition of inducible nitric oxide synthase in the human intestinal epithelial cell line, DLD-1, by the inducers of heme oxygenase 1, bismuth salts, heme, and nitric oxide donors
Publication Year: 2000 Source: Gut PMID: 11076874 DOI: 10.1136/gut.47.6.771
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Genetic analyses of chromosome 12 loci in Crohn's disease
Publication Year: 2000 Source: Gut PMID: 11076876 DOI: 10.1136/gut.47.6.787
Erratum in Ann Rheum Dis 2000 May;59(5):400. OBJECTIVE: Previously an upregulation of E-cadherin and its associated molecules alpha-catenin, beta-catenin and plakoglobin has been demonstrated in clinically overt inflammatory bowel disease (IBD). The aim of this study was to investigate the expression of the E-cadherin/catenin complex in subclinically inflamed bowel mucosa …
Update on inflammatory bowel disease genetics
Publication Year: 2000 Source: Curr Gastroenterol Rep PMID: 11079043 DOI: 10.1007/s11894-000-0004-1
Inflammatory bowel disease (IBD) is a relatively rare condition of childhood, although the wide range of presenting complaints, scope of complications, and choices of therapy for this condition make it particularly difficult to treat in children. Novel approaches to the management of Crohn's disease and ulcerative colitis have gained recent …
Neoplastic and other complications of inflammatory bowel disease
Publication Year: 2000 Source: Curr Gastroenterol Rep PMID: 11079046 DOI: 10.1007/s11894-000-0007-y
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Laparoscopic-assisted vs open colectomy for severe acute colitis in patients with inflammatory bowel disease (IBD): a retrospective study in 42 patients
Publication Year: 2000 Source: Surg Endosc PMID: 11080402 DOI: 10.1007/s004640000262
A review of reported cases of inflammatory bowel diseases (IBDs) of horses for which no etiology was identified included cases of granulomatous enteritis (GE), multisystemic eosinophilic epitheliotropic disease (MEED), lymphocytic-plasmacytic enterocolitis (LPE), and idiopathic eosinophilic enterocolitis (EC). The terms EC and MEED were both used to describe a disease in …
Crohn's disease complicated by relapsed extranodal Hodgkin's lymphoma: prolonged complete remission after unmanipulated PBPC autotransplant
Publication Year: 2000 Source: Bone Marrow Transplant PMID: 11081397 DOI: 10.1038/sj.bmt.1702621
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Differential alteration in intestinal epithelial cell expression of toll-like receptor 3 (TLR3) and TLR4 in inflammatory bowel disease
Publication Year: 2000 Source: Infect Immun PMID: 11083826 DOI: 10.1128/IAI.68.12.7010-7017.2000
BACKGROUND: NKX2-3 is associated with inflammatory bowel disease (IBD). NKX2-3 is expressed in microvascular endothelial cells and the muscularis mucosa of the gastrointestinal tract. Human intestinal microvascular endothelial cells (HIMECs) are actively involved in the pathogenesis of IBD and IBD-associated microvascular dysfunction. To understand the cellular function of NKX2-3 and …
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