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Structure-activity relationship studies on 1-[2-(4-Phenylphenoxy)ethyl]pyrrolidine (SC-22716), a potent inhibitor of leukotriene A(4) (LTA(4)) hydrolase
Publication Year: 2000 Source: J Med Chem PMID: 10691697 DOI: 10.1021/jm990496z
A groundswell of therapeutic modalities is presently sweeping through the field of inflammatory bowel disease (IBD), revolutionising the treatment and management of these disorders. At the forefront of newer agents are biological therapies, also referred to as 'biologics'. These include infliximab (cA2), CDP 571, rhIL-10, ICAM-1 antisense oligonucleotide (ISIS 2302) …
Use of community resources before inflammatory bowel disease surgery is associated with postsurgical quality of life
Publication Year: 2000 Source: Can J Gastroenterol PMID: 10694281 DOI: 10.1155/2000/512142
Nuclear factor kappB (NFkappaB) is a transcription factor that controls several genes important for immunity and inflammation. The aim of this study was to assess if activation of NFkappaB plays a role in the pathogenesis of inflammatory bowel disease (IBD), and whether steroid treatment affects NFkappaB activation. Activation of NFkappaB …
Cytokine mRNA expression in mucosal biopsies from German shepherd dogs with small intestinal enteropathies
Publication Year: 2000 Source: Dig Dis Sci PMID: 10695606 DOI: 10.1023/a:1005436721798
BACKGROUND: Mycophenolate mofetil (MMF) is a new immunosuppressant with pharmacodynamic properties comparable to azathioprine. Recent reports found MMF to be effective in inflammatory bowel disease (IBD). METHODS: An open-label prospective and uncontrolled multicentre 6 month trial of MMF in combination with steroids was conducted in 24 chronic active IBD patients. …
Concerns of patients with inflammatory bowel disease: a review of emerging themes
Publication Year: 2000 Source: Dig Dis Sci PMID: 10695609 DOI: 10.1023/a:1005492806777
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Role of psychological stress on IBD onset
Publication Year: 2000 Source: Dig Dis Sci PMID: 10695610 DOI: 10.1023/a:1005444923615
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Subclinical gut inflammation in spondyloarthropathy patients is associated with upregulation of the E-cadherin/catenin complex
Publication Year: 2000 Source: Ann Rheum Dis PMID: 10700430 DOI: 10.1136/ard.59.3.211
OBJECTIVE: The incidence of inflammatory bowel disease (IBD) varies among and within countries, but several studies have indicated that genetic factors may play an important role in the etiology of IBD. A Danish regional study has observed an almost 10-fold increased risk for ulcerative colitis (UC) and Crohn's disease (CD) …
Well-adjusted children: an alternate view of children with inflammatory bowel disease and functional gastrointestinal complaints
Publication Year: 2000 Source: Inflamm Bowel Dis PMID: 10701143 DOI: 10.1097/00054725-200002000-00001
Related individuals are identical by descent (IBD) at a genetic locus if they share the same DNA material from a common ancestor. Continuous gamete IBD data consist of the lengths of (in order) IBD and non-IBD regions along the genomes for gametes segregating from two related individuals and can be …
Viruses and inflammatory bowel disease: is there evidence for a causal association?
Publication Year: 2000 Source: Inflamm Bowel Dis PMID: 10701147 DOI: 10.1097/00054725-200002000-00005
BACKGROUND: While traditional nonsteroidal antiinflammatory drugs (t-NSAIDs) are relatively contraindicated in patients with inflammatory bowel disease (IBD) for fear of disease aggravation, controlled clinical trials showed that cyclo-oxygenase-2 inhibitors have fewer gastrointestinal side effects than the t-NSAIDs. Etoricoxib is a new antiinflammatory inhibitor that has high Cox-2 selectivity. OBJECTIVES: To …
IBD highlights from the 1999 American College of Gastroenterology meeting: infliximab and 6-MP
Publication Year: 2000 Source: Inflamm Bowel Dis PMID: 10701151 DOI: 10.1097/00054725-200002000-00011
Erratum in J Immunol. 2004 Jul 1;173(1):695. Null mutation of the Galphai2 trimeric G protein results in a discrete and profound mucosal disorder, including inflammatory bowel disease (IBD), attenuation of IL-10 expression, and immune function polarized to Th1 activity. Genetic and adoptive transfer experiments have established a role for B …
PSC in UC: is it or is it not a risk factor for the development of neoplasia?
Publication Year: 2000 Source: Inflamm Bowel Dis PMID: 10701152 DOI: 10.1097/00054725-200002000-00012
Comment on Gut. 2010 Feb;59(2):186-96.
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