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Site-specific changes in transforming growth factor-alpha and -beta1 expression in colonic mucosa of adolescents with inflammatory bowel disease
Publication Year: 1999 Source: Scand J Gastroenterol PMID: 10440609 DOI: 10.1080/003655299750026056
Comment in Gastroenterology. 1998 Nov;115(5):1286-9. BACKGROUND & AIMS: Inflammatory bowel disease (IBD) is a complex disorder of unknown etiology. Epidemiological investigations suggest a genetic basis for IBD. Recent genetic studies have identified several IBD linkages. The significance of these linkages will be determined by studies in large patient collections. The …
Commonalities in the time trends of Crohn's disease and ulcerative colitis
Publication Year: 1999 Source: Am J Gastroenterol PMID: 10445545 DOI: 10.1111/j.1572-0241.1999.01290.x
BACKGROUND & AIMS: Children with inflammatory bowel disease (IBD) are at risk for osteoporosis because of undernutrition, delayed puberty, and prolonged corticosteroid use. The aim of this study was to compare bone mineral density (BMD) in children with IBD with that in normal children and to assess the effects of …
Acute lower gastrointestinal bleeding in Crohn's disease: characteristics of a unique series of 34 patients. Belgian IBD Research Group
Publication Year: 1999 Source: Am J Gastroenterol PMID: 10445546 DOI: 10.1111/j.1572-0241.1999.01291.x
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Low prevalence of the APC I1307K sequence in Jewish and non-Jewish patients with inflammatory bowel disease
Publication Year: 1999 Source: Oncogene PMID: 10445854 DOI: 10.1038/sj.onc.1202638
Inflammatory bowel disease (IBD) is a multifactorial disorder which is characterized by massive damage of the epithelium and the underlying mesenchyme of the intestine. Due to the potent effect of connective tissue growth factor (CTGF) on fibroblast proliferation and connective tissue deposition we speculated about a possible role of this …
Increased prevalence of methylenetetrahydrofolate reductase C677T variant in patients with inflammatory bowel disease, and its clinical implications
Publication Year: 1999 Source: Gut PMID: 10446107 DOI: 10.1136/gut.45.3.389
Reactive thrombocytosis is a typical feature in inflammatory bowel disease (IBD). The question arose as to whether the normal negative feedback regulation of the concentration of thrombopoietin (TPO) in blood was altered in IBD patients. We measured serum immunoreactive TPO in 30 patients with active IBD, 29 patients with inactive …
HLA-DR and -DQ phenotypes in inflammatory bowel disease: a meta-analysis
Publication Year: 1999 Source: Gut PMID: 10446108 DOI: 10.1136/gut.45.3.395
The ability of inflammatory bowel disease (IBD) patients to tolerate dairy products and the guidance they receive from physicians and nutritionists on this subject are important considerations in the management of their IBD. Although most affected persons are able to consume a glass of milk daily without discomfort, additional consideration …
A novel therapy for colitis utilizing PPAR-gamma ligands to inhibit the epithelial inflammatory response
Publication Year: 1999 Source: J Clin Invest PMID: 10449430 DOI: 10.1172/JCI7145
Comment in J Pediatr Gastroenterol Nutr. 1997 Mar;24(3):361-2. BACKGROUND: In patients with inflammatory bowel disease (IBD), accelerated bone loss and osteopenia have been found. Potential etiologies of these bone abnormalities have included malnutrition, poor calcium intake or absorption, and the use of corticosteroids. Recent studies have suggested that circulating pro-inflammatory …
Laparoscopically assisted bowel surgery for inflammatory bowel disease. The combined experiences of two academic centers
Publication Year: 1999 Source: Surg Endosc PMID: 10449844 DOI: 10.1007/s004649901125
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Presenting symptoms and diagnostic lag in children with inflammatory bowel disease
Publication Year: 1999 Source: Inflamm Bowel Dis PMID: 10453370 DOI: 10.1097/00054725-199908000-00002
Hypersensitivity reactions to 6-mercaptopurine (6-MP) or azathioprine occur during the treatment of inflammatory bowel disease (IBD), raising significant diagnostic and therapeutic challenges. Charts of 591 patient with IBD treated with 6-MP in a single center were retrospectively reviewed. All allergic reactions were recorded along with results of rechallenge, desensitization, and …
Metabolic bone disease in adults with inflammatory bowel disease
Publication Year: 1999 Source: Inflamm Bowel Dis PMID: 10453377 DOI: 10.1097/00054725-199908000-00009
Multipoint linkage analysis is commonly used to evaluate linkage of a disease to multiple markers in a small region. Multipoint analysis is particularly powerful when the IBD relations of family members at the trait locus are ambiguous. The increased power arises because, unlike single-marker analyses, multipoint analysis uses haplotype information …
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