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Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in ulcerative colitis
Publication Year: 1999 Source: Gastroenterology PMID: 10500062 DOI: 10.1016/s0016-5085(99)70338-0
Mice rendered deficient in interleukin-10 (IL-10) by gene targeting (IL-10(-/-) mice) develop chronic enterocolitis resembling human inflammatory bowel disease (IBD) when maintained in conventional animal facilities. However, they display a minimal and delayed intestinal inflammatory response when reared under specific-pathogen-free (SPF) conditions, suggesting the involvement of a microbial component in …
Involvement of neutrophils and free radicals in the potentiating effects of passive cigarette smoking on inflammatory bowel disease in rats
Publication Year: 1999 Source: Gastroenterology PMID: 10500071 DOI: 10.1016/s0016-5085(99)70347-1
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Arthritis and the gut
Publication Year: 1999 Source: Eur J Gastroenterol Hepatol PMID: 10503836 DOI: 10.1097/00042737-199909000-00008
Endoscopy has assumed a preeminent role in the diagnostic approach to IBD. It is more sensitive than radiography in detecting early, subtle changes of IBD, both through endoscopic appearance and histologic sampling of mucosa. Endoscopy also appears to be a safe technique in patients presenting with severe forms of colitis …
Extraintestinal manifestations of ulcerative colitis following restorative proctocolectomy
Publication Year: 1999 Source: Eur J Gastroenterol Hepatol PMID: 10503837 DOI: 10.1097/00042737-199909000-00009
Comment in Gut. 1999 Jun;44(6):774-5. BACKGROUND: T cell responses to normal intestinal bacteria or their products may be important in the immunopathogenesis of chronic enterocolitis. AIMS: To investigate the T cell specificity and cross reactivity towards intestinal bacteria. PATIENTS/METHODS: T cell clones were isolated with phytohaemagglutinin from peripheral blood and …
Nitric oxide end products in patients hospitalized for diarrhoea
Publication Year: 1999 Source: Eur J Gastroenterol Hepatol PMID: 10503839 DOI: 10.1097/00042737-199909000-00011
BACKGROUND & AIMS: Secretion of chemokines by epithelial cells may represent a crucial event in the pathogenesis of inflammatory bowel disease (IBD). Expression of the chemokine epithelial neutrophil-activating peptide 78 (ENA-78) was monitored in patients with IBD and normal controls. METHODS: In situ hybridizations were performed on 41 tissue specimens …
Diagnosis and management of inflammatory bowel disease
Publication Year: 1999 Source: J Am Acad Nurse Pract PMID: 10504919 DOI: 10.1111/j.1745-7599.1999.tb00536.x
BACKGROUND: The evaluation of psychologic states is very useful in the management of inflammatory bowel disease (IBD) patients, particularly when related to disease activity (DA). Our aim was to prospectively evaluate the relationship between psychologic distress and DA. METHODS: DA and psychologic distress were evaluated in 104 IBD outpatients by …
Damage to the enteric nervous system in experimental colitis
Publication Year: 1999 Source: Am J Pathol PMID: 10514387 DOI: 10.1016/S0002-9440(10)65207-8
The effects of crude thymus extract on the immune response and protection against challenge with virulent infectious bursal disease virus (IBDV) were studied in one-day-old chick. Oral administration of thymus extract (1 ml/kg) markedly and significantly increased the total protein, albumin, globulin, Tri-iodothyronine (T3), Thyroxine (T4) and the body weight …
Facilitating adjustment to inflammatory bowel disease: a model of psychosocial intervention in non-psychiatric patients
Publication Year: 1999 Source: Psychother Psychosom PMID: 10516528 DOI: 10.1159/000012339
A case of inflammatory bowel disease (IBD) presenting in pregnancy is described. Despite previous reports of severe fulminating disease in this type of patient, this woman did well with an uncomplicated course; she responded to standard medical therapy and there were no fetal complications. IBD should not be a contraindication …
Alexithymia and functional gastrointestinal disorders. A comparison with inflammatory bowel disease
Publication Year: 1999 Source: Psychother Psychosom PMID: 10516531 DOI: 10.1159/000012342
BACKGROUND: Endoscopic retrograde cholangiopancreatography was introduced in the early 1970s, making a more reliable diagnosis of primary sclerosing cholangitis (PSC) possible. Since then decreased survival and increased risk of cholangiocarcinoma have been reported. However, no population-based studies have quantified these outcomes. METHODS: A population-based cohort of 125 patients with a …
Rectal dialysate and fecal concentrations of neutrophil gelatinase-associated lipocalin, interleukin-8, and tumor necrosis factor-alpha in ulcerative colitis
Publication Year: 1999 Source: Am J Gastroenterol PMID: 10520846 DOI: 10.1111/j.1572-0241.1999.01439.x
BACKGROUND: Platelet-activating factor (PAF), a potent proinflammatory phospholipid mediator, has been implicated in inducing intestinal inflammation in diseases such as inflammatory bowel disease (IBD) and necrotizing enterocolitis (NEC). However, its mechanisms of inducing inflammatory responses are not fully understood. Therefore, studies were designed to explore the mechanisms of PAF-induced inflammatory …
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