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T-cell co-stimulatory molecules are upregulated on intestinal macrophages from inflammatory bowel disease mucosa
Publication Year: 1999 Source: Eur J Gastroenterol Hepatol PMID: 10524639 DOI: 10.1097/00042737-199910000-00006
A complex set of interactions between the human genes encoding innate protective functions and immune defenses and the environment of the intestinal mucosa with its microbiota is currently considered key to the pathogenesis of the chronic inflammatory bowel diseases (IBD). Probiotics offer a method to potentially alter the intestinal microbiome …
Interleukin-6 and soluble interleukin-6 receptor in the colonic mucosa of inflammatory bowel disease
Publication Year: 1999 Source: J Gastroenterol Hepatol PMID: 10530495 DOI: 10.1046/j.1440-1746.1999.01989.x
BACKGROUND: Several serologic tests, including anti-outer membrane porin C antibody (Omp C), are used for screening and as marker of disease course in inflammatory bowel diseases (IBD). Our aim was to investigate possible differences in Omp C level in patients with active and inactive IBD compared to controls. METHODS: All …
Mycophenolate mofetil in IBD patients
Publication Year: 1999 Source: Lancet PMID: 10533889 DOI: 10.1016/S0140-6736(05)76240-1
Not found
The intestinal mucus layer from patients with inflammatory bowel disease harbors high numbers of bacteria compared with controls
Publication Year: 1999 Source: Gastroenterology PMID: 10535871 DOI: 10.1016/s0016-5085(99)70393-8
The diagnosis, prognosis, and assessment of disease activity of inflammatory bowel disease (IBD) require investigating clinical, radiological, and histological criteria, as well as serum inflammatory markers. However, a range of fecal inflammatory markers now appears to have the potential to greatly assist in these processes. Calprotectin, a prominent neutrophil protein, …
In vitro activated CD4+ T cells from interferon-gamma (IFN-gamma)-deficient mice induce intestinal inflammation in immunodeficient hosts
Publication Year: 1999 Source: Clin Exp Immunol PMID: 10540183 DOI: 10.1046/j.1365-2249.1999.01058.x
Mice rendered deficient in the production of interleukin 10 (IL-10-/-) develop a chronic inflammatory bowel disease (IBD) that predominates in the colon and shares histopathological features with human IBD. Our aim was to identify which cell type(s) can mediate colitis in IL-10-/- mice. We detected an influx of immunoglobulin-positive cells …
Dysplasia in inflammatory bowel diseases: definition and clinical impact
Publication Year: 1999 Source: Can J Gastroenterol PMID: 10545655 DOI: 10.1155/1999/124190
Cytokines play a central role in the modulation of the intestinal immune system. They are produced by lymphocytes (especially T cells of the Th1 and Th2 phenotypes), monocytes, intestinal macrophages, granulocytes, epithelial cells, endothelial cells, and fibroblasts. They have proinflammatory functions [interleukin-1 (IL-1), tumor necrosis factor (TNF), IL-6, IL-8, IL-12] …
A note on the power provided by sibships of sizes 2, 3, and 4 in genetic covariance modeling of a codominant QTL
Publication Year: 1999 Source: Behav Genet PMID: 10547922 DOI: 10.1023/a:1021687817609
Indices of bone mass were measured in 23 volunteers weekly over 14-16 weeks using dual-energy x-ray absorptiometry (DEXA) and special-purpose computed tomography (gamma-CT). In vitro, the precision for both systems was excellent (coefficient of variation less than 0.5%). Over 4 months, the precision in vivo (average CV for all subjects) …
p27 expression in inflammatory bowel disease-associated neoplasia. Further evidence of a unique molecular pathogenesis
Publication Year: 1999 Source: Am J Pathol PMID: 10550307 DOI: 10.1016/S0002-9440(10)65466-1
Not found
Interleukin-10 (IL-10) genotypes in inflammatory bowel disease
Publication Year: 1999 Source: Tissue Antigens PMID: 10551422 DOI: 10.1034/j.1399-0039.1999.540408.x
BACKGROUND: Laparoscopic bowel surgery was evaluated in 44 consecutive patients who underwent surgery for inflammatory bowel disease (IBD). We studied feasibility, results, and final outcome. METHODS: At two academic institutes, 44 laparoscopically assisted colectomies and laparoscopic ileostomies or colostomies were attempted. All patients had histologically proven IBD and no prior …
New strategies in the management of inflammatory bowel disease
Publication Year: 1999 Source: Acta Clin Belg PMID: 10555385 DOI: 10.1080/17843286.1999.11754245
Receptors for interleukin-6 (IL-6) occur in body fluids in soluble form, as well. This is an approx. 50 kDa protein with the ability to bind IL-6. The soluble IL-6 receptor (sIL-6R)/IL-6 complex can attach to membrane anchored gp130, a molecule associated with the signal transduction induced by IL-6 and by …
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