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Analysis of the cellular basis of keratinocyte growth factor overexpression in inflammatory bowel disease
Publication Year: 1999 Source: Gut PMID: 10562583 DOI: 10.1136/gut.45.6.848
BACKGROUND: An increased tendency for thromboembolism is a well known problem of inflammatory bowel disease (IBD). Microvascular thrombosis has also been claimed as a pathogenic factor in IBD. Recently a point mutation in the gene coding factor V (FV Leiden) has been identified in various thromboembolic diseases, but the role …
An investigation of the association of the factor V Leiden mutation and inflammatory bowel disease
Publication Year: 1999 Source: Eur J Gastroenterol Hepatol PMID: 10563542 DOI: 10.1097/00042737-199911000-00018
The genes for the interferon-gamma receptor 1 and the natural resistance-associated macrophage protein 1 (NRAMP1) control the immune response to intracellular microbial pathogens. Such pathogens, in particular Mycobacterium paratuberculosis, have been implicated in the pathogenesis of Crohn's disease. We studied markers in the genes for NRAMP1 and two mutations in …
Polymorphisms in tumour necrosis factor and adhesion molecule genes in patients with inflammatory bowel disease: associations with HLA-DR and -DQ alleles and subclinical markers
Publication Year: 1999 Source: Scand J Gastroenterol PMID: 10563674 DOI: 10.1080/003655299750025147
Not found
Promising new agents for the treatment of inflammatory bowel disorders
Publication Year: 1999 Source: Drugs R D PMID: 10566035 DOI: 10.2165/00126839-199901030-00011
The incidence and prevalence of IBD increase in our Western populations. Standard therapy with glucocorticosteroids and 5-ASA formulations allow control in only about half of the patients with substantial toxicity for the former drug. Since it became apparent that both UC and Crohn's disease are disorders mediated through abnormalities in …
Risk of ulcerative colitis and Crohn's disease among offspring of patients with chronic inflammatory bowel disease
Publication Year: 1999 Source: Am J Gastroenterol PMID: 10566721 DOI: 10.1111/j.1572-0241.1999.01526.x
BACKGROUND: Neutrophils are thought to play a role in the pathogenesis of inflammatory bowel diseases (IBD) such as ulcerative colitis and Crohn's disease, since prominent neutrophil infiltration has been observed in the inflamed colonic mucosa of patients with IBD. However, the role of neutrophils in the pathogenesis of IBD and …
Malignant neoplasms subsequent to treatment of inflammatory bowel disease with 6-mercaptopurine
Publication Year: 1999 Source: Am J Gastroenterol PMID: 10566724 DOI: 10.1111/j.1572-0241.1999.01530.x
Not found
Identification of a novel mycobacterial histone H1 homologue (HupB) as an antigenic target of pANCA monoclonal antibody and serum immunoglobulin A from patients with Crohn's disease
Publication Year: 1999 Source: Infect Immun PMID: 10569769 DOI: 10.1128/IAI.67.12.6510-6517.1999
The pathogenetic role of activated alpha beta and gamma delta T cells in inflammatory bowel disease (IBD) is not well defined. To elucidate this, interleukin-2 receptor (IL-2R) alpha and IL-2R beta single chain expression and coexpression by peripheral blood TCR alpha beta + cells and TCR gamma delta + cells …
Current management of pediatric inflammatory bowel disease
Publication Year: 1999 Source: Semin Pediatr Surg PMID: 10573433 DOI: 10.1016/s1055-8586(99)70030-2
A pluridisciplinary approach that integrates medical therapy with surgery and other aspects of patient care, such as nutritional and psychosocial support, is essential to the management of patients with inflammatory bowel disease (IBD). Despite new medical therapies, such as 5-amino-salicylic acid compounds, steroids, and immunomodulators, the treatment of patients with …
Identification of multiple candidate genes for IBD susceptibility using high-density transcript mapping in the IBD2 locus on chromosome 12q
Publication Year: 1999 Source: Gastroenterology PMID: 10576977 DOI: 10.1016/s0016-5085(99)70376-8
Not found
Linkage of inflammatory bowel disease to human chromosome 6p
Publication Year: 1999 Source: Am J Hum Genet PMID: 10577918 DOI: 10.1086/302677
Comment in Inflamm Bowel Dis. 2012 Mar;18(3):597. BACKGROUND: The use of complementary and alternative medicine in inflammatory bowel disease (IBD) has been extensively studied. However, the use of probiotics and prebiotics is poorly documented, despite evidence of efficacy of particular probiotic strains in specific forms of IBD. METHODS: A case-control …
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