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The application of organoids in colorectal diseases
Publication Year: 2024 Source: Front Pharmacol PMID: 38983913
No Abstract
Fecal calprotectin and endoscopic scores: The cornerstones in clinical practice for evaluating mucosal healing in inflammatory bowel disease
Publication Year: 2024 Source: World J Gastroenterol PMID: 38983953 DOI: 10.3748/wjg.v30.i24.3022
Managing inflammatory bowel disease (IBD) is becoming increasingly complex and personalized, considering the advent of new advanced therapies with distinct mechanisms of action. Achieving mucosal healing (MH) is a pivotal therapeutic goal in IBD management and can prevent IBD progression and reduce flares, hospitalization, surgery, intestinal damage, and colorectal cancer. …
Harnessing autophagy: A potential breakthrough in digestive disease treatment
Publication Year: 2024 Source: World J Gastroenterol PMID: 38983959
No Abstract
Global patterns in the epidemiology, cancer risk, and surgical implications of inflammatory bowel disease
Publication Year: 2024 Source: Gastroenterol Rep (Oxf) PMID: 38984068 DOI: 10.1093/gastro/goae053
Inflammatory bowel disease (IBD), mainly including ulcerative colitis and Crohn's disease, imposes a huge medical and economic burden worldwide. Recently, the diagnosis, treatment, and surveillance of IBD have advanced rapidly, which has changed the epidemiology, cancer risk, and surgery risk of IBD. Here, we reviewed the recent literature on the …
Multicentre study and systematic review: Allopurinol exposure during pregnancy
Publication Year: 2024 Source: Aliment Pharmacol Ther PMID: 38984819 DOI: 10.1111/apt.18126
BACKGROUND: Data about the safety of allopurinol in pregnant women are sparsely reported. AIMS: To investigate the risk of adverse pregnancy outcome and congenital abnormalities after in utero exposure to allopurinol in inflammatory bowel disease (IBD) pregnancies and in general. METHODS: We collected safety data of patients with IBD who …
Dmxl1 Is an Essential Mammalian Gene that Is Required for V-ATPase Assembly and Function In Vivo
Publication Year: 2024 Source: Function (Oxf) PMID: 38984989
No Abstract
Efficacy and safety of infliximab and adalimumab in inflammatory bowel disease patients
Publication Year: 2024 Source: Inflammopharmacology PMID: 38985232 DOI: 10.1007/s10787-024-01508-w
INTRODUCTION: Inflammatory bowel disease (IBD), consists of two primary types: Ulcerative Colitis (UC) and Crohn's Disease (CD). Infliximab (IFX) and Adalimumab (ADA) are frequently utilized in the management of moderate to severe cases of IBD. AIM: This study aimed to assess the efficacy and safety of IFX and ADA in …
Disease-Tailored Brief Intervention for Alcohol Use Among Youths With Chronic Medical Conditions: A Secondary Analysis of a Randomized Clinical Trial
Publication Year: 2024 Source: JAMA Netw Open PMID: 38985475
No Abstract
Multiscale Bowel Sound Event Spotting in Highly Imbalanced Wearable Monitoring Data: Algorithm Development and Validation Study
Publication Year: 2024 Source: JMIR AI PMID: 38985504 DOI: 10.2196/51118
BACKGROUND: Abdominal auscultation (i.e., listening to bowel sounds (BSs)) can be used to analyze digestion. An automated retrieval of BS would be beneficial to assess gastrointestinal disorders noninvasively. OBJECTIVE: This study aims to develop a multiscale spotting model to detect BSs in continuous audio data from a wearable monitoring system. …
[Ancient DNA speaks]
Publication Year: 2024 Source: Med Sci (Paris) PMID: 38986104 DOI: 10.1051/medsci/2024070
Many human DNA sequences have been obtained from ancient remains dating back from several millennia. However, these have low coverage and may contain many errors; this has limited their usefulness for many analyses, in particular the search for Identical By Descent (IBD) segments that is very powerful for detection of …
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