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Upadacitinib for ulcerative colitis and pyoderma gangrenosum in a patient with schizophrenia on long-term risperidone: A case report
Publication Year: 2025 Source: World J Gastroenterol PMID: 40495949
BACKGROUND: Pyoderma gangrenosum (PG) is one of the most severe extra-intestinal manifestations of ulcerative colitis (UC). The treatment of refractory UC combined with PG is challenging, particularly for patients with schizophrenia (SCZ) with a long-term history of risperidone use, and there have been no successfully treated patients reported in the …
Case Report: Azathioprine-induced Sweet's syndrome with associated myocardial infarction
Publication Year: 2025 Source: Front Med (Lausanne) PMID: 40495975 DOI: 10.3389/fmed.2025.1548941
Sweet's syndrome (SS) is an acute febrile neutrophilic dermatosis characterized by a rash with tender erythematous plaques or nodules, fevers and leukocytosis. Drug-induced SS is a subtype of SS which is associated with a growing number of medications including azathioprine (AZA). Cardiovascular complications secondary to SS are rare but have …
Current and forecasted 10-year prevalence and incidence of inflammatory bowel disease in Hong Kong, Japan, and the United States
Publication Year: 2025 Source: World J Gastroenterol PMID: 40496360 DOI: 10.3748/wjg.v31.i18.105472
BACKGROUND: The rising incidence of inflammatory bowel disease (IBD) globally has increased disease burden and economic impact. Gaps remain in understanding the IBD burden between Asian and Western populations. AIM: To estimate the current and following 10-year prevalence and incidence of IBD in Hong Kong, Japan, and the United States. …
Idiopathic myointimal hyperplasia of the mesenteric veins affecting the small intestine alone: A case report and review of literature
Publication Year: 2025 Source: World J Gastroenterol PMID: 40496361
BACKGROUND: Idiopathic myointimal hyperplasia of the mesenteric veins (IMHMV) is a rare disease characterized by narrowing of the lumen caused by mesenteric vein intimal hyperplasia, resulting in chronic intestinal ischemia. Although the colorectum is the primary site affected by this condition, involvement of the small intestine is even more rare. …
Role of serological biomarkers in evaluating and predicting endoscopic activity in inflammatory bowel disease
Publication Year: 2025 Source: World J Gastroenterol PMID: 40496365
BACKGROUND: Diagnosis of inflammatory bowel disease and assessment of disease activity are fundamentally reliant on endoscopy. Nonetheless, it is costly and invasive, highlighting the necessity for more accessible and non-invasive biomarkers to assist in the diagnosis and evaluation of inflammatory bowel disease. AIM: To examine the correlation of biomarkers with …
Teprotumumab in the management of thyroid eye disease mechanistic insights and adverse reactions: a comprehensive review
Publication Year: 2025 Source: Front Endocrinol (Lausanne) PMID: 40496563 DOI: 10.3389/fendo.2025.1480195
Teprotumumab has shown significant efficacy in treating Thyroid Eye Disease (TED), but its adverse effects require careful management. Key reactions include hearing impairment, hyperglycemia, and potential exacerbation of pre-existing inflammatory bowel disease (IBD). Hearing impairment, likely due to inhibition of the insulin-like growth factor 1 receptor (IGF-1R), manifests as more …
Alleviating ulcerative colitis via rectal administration: Enhancing the therapeutic effects of silk sericin-proanthocyanidins nanoparticles with a Poloxamer thermosensitive in situ gel
Publication Year: 2025 Source: Int J Pharm X PMID: 40496657
Ulcerative colitis, a type of inflammatory bowel disease, primarily impacts the colon's mucous membrane, leading to distressing symptoms. Both healthcare and socioeconomic aspects are significantly impacted by this condition. In this study, we stabilized proanthocyanidins (PAC) with silk sericin (SS) to create SS/PAC nanoparticles. These nanoparticles were then loaded into …
Plasmon-activated water enhances gut-barrier function and alleviates inflammation in a mouse model of ulcerative colitis
Publication Year: 2025 Source: Exp Ther Med PMID: 40496763
Ulcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease characterized by disruption of the intestinal epithelial barrier and alterations in mucosal gene expression associated with intestinal integrity. Given the risks associated with UC, novel therapies capable of restoring intestinal barrier function and inhibiting inflammation are needed. Plasmon-activated water (PAW) …
Comparative study on the pathogenesis of Crohn's disease and ulcerative colitis
Publication Year: 2025 Source: World J Gastroenterol PMID: 40497094 DOI: 10.3748/wjg.v31.i19.106406
Inflammatory bowel disease (IBD) is an incurable disease of the digestive system; however, the therapeutic methods for IBD remain limited. The pathogenesis of IBD was systematically discussed and compared in this paper, primarily comprising Crohn's disease and ulcerative colitis. This paper focused on six common aspects: (1) Dysregulated immune responses; …
Intestinal ultrasound measurement of bowel wall thickness can be used as a sole marker for defining anti-TNF maintenance therapy failure in Crohn's disease
Publication Year: 2025 Source: Therap Adv Gastroenterol PMID: 40497241
INTRODUCTION: Bowel wall thickness (BWT) measurements in intestinal ultrasound (IUS) are recognized indicators of inflammatory activity in Crohn's disease (CD). However, the added value of other ultrasonographic parameters for monitoring and predicting treatment failure during anti-tumor necrosis factors' (TNF) maintenance therapy is still not absolutely defined. OBJECTIVES: To determine whether …
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