| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Disrupting Myelin-Specific Th17 Cell Gut Homing Confers Protection in an Adopti…
PMID: 31597098
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Multiple sclerosis (MS) is a common autoimmune disease of the CNS. Although an association between MS and inflammatory bowel diseases is observed, th…
Lymphomatoid Papulosis Type B in a Patient with Crohn's Disease Treated with TN…
PMID: 31542070
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
Dear Editor, Lymphomatoid papulosis (LP) is a chronic, recurrent, usually self-limited papulonecrotic or papulonodular skin disease, which belongs to…
Monitoring of Adalimumab Concentrations at Home in Patients with Inflammatory B…
PMID: 31464823
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Adalimumab (ADL) is a subcutaneously administered anti-tumor necrosis factor (TNF) agent used in the treatment of patients with inflammat…
Weak Agonistic LPS Restores Intestinal Immune Homeostasis
PMID: 31416777
Year: 2019
Relationship Type:
Correlation Studies
Score: 5.3
Generated by gram-negative bacteria, lipopolysaccharides (LPSs) are one of the most abundant and potent immunomodulatory substances present in the in…
Tuberculosis, onychomycosis and immune deficiency in complicated Crohn's disease
PMID: 31383674
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
The immune system is composed of innate humoral defence and adaptive immunity. One of the key mechanisms of the innate humoral defence is through com…
Induction of the metal transporter ZIP8 by interferon gamma in intestinal epith…
PMID: 31151823
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Transition metals are required for intestinal homeostasis and provide essential nutrients for the resident microbiota. Abnormalities in metal homeost…
Cytomegalovirus infection in a T-cell lymphoma patient presenting with multiple…
PMID: 30993166
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
Background and study aims Gastrointestinal ulcers are responsible for a wide spectrum of diseases. Infection, drug-induced enteritis, malignancy, va…
Intestinal development and homeostasis require activation and apoptosis of diet…
PMID: 30939122
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
The impact of food antigens on intestinal homeostasis and immune function is poorly understood. Here, we explored the impact of dietary antigens on t…
Nitric Oxide Is Involved in Activation of Toll-Like Receptor 4 Signaling throug…
PMID: 30504685
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 5.3
Ulcerative colitis is characterized by colonic mucosal bleeding and ulceration, often with repeated active and remission stages. One factor in ulcera…
Human Gut Symbiont Roseburia hominis Promotes and Regulates Innate Immunity
PMID: 29018440
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVE: Roseburia hominis is a flagellated gut anaerobic bacterium belonging to the Lachnospiraceae family within the Firmicutes phylum. A signifi…
A Two-Component System Regulates Bacteroides fragilis Toxin to Maintain Intesti…
PMID: 28943327
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.3
Intestinal microbes are recognized for their role in human disease. Enterotoxigenic Bacteroides fragilis (ETBF) has been implicated in inflammatory b…
Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic …
PMID: 28710114
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Endogenous circadian clocks regulate 24-h rhythms of physiology and behavior. Circadian rhythm disruption (CRD) is suggested as a risk factor for inf…
Molecular mechanisms by which casein glycomacropeptide maintains internal homeo…
PMID: 28700735
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
OBJECTIVES: The aim of this study was to elucidate the molecular mechanisms by which food-derived casein glycomacropeptide (CGMP) maintains internal …
From sensing to shaping microbiota: insights into the role of NOD2 in intestina…
PMID: 28450278
Year: 2017
Relationship Type:
Correlation Studies
Score: 5.3
The Pregnane and Xenobiotic Receptor (PXR; NR1I2) is a ligand-modulated transcription factor that belongs to the nuclear receptor superfamily. It is…
Tauroursodeoxycholic acid protects bile acid homeostasis under inflammatory con…
PMID: 28165466
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
Bile acids regulate the expression of intestinal bile acid transporters and are natural ligands for nuclear receptors controlling inflammation. Accum…
γδ T Cells Coexpressing Gut Homing α4β7 and αE Integrins Define a Novel Subset …
PMID: 27927968
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 5.3
gammadelta T lymphocytes, dominant T cell subsets in the intestine, mediate both regulatory and pathogenic roles, yet the mechanisms underlying such …
Standardization of the homogeneous mobility shift assay protocol for evaluation…
PMID: 27664854
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: The availability of a quantitative method to measure anti-infliximab (IFX) antibodies (ATI) would facilitate the implementation of therap…
Identification of a human intestinal myeloid cell subset that regulates gut hom…
PMID: 27421871
Year: 2016
Relationship Type:
Target Validation
Score: 5.3
Inappropriate activation of T helper (Th) cells, such as Th1 and Th17 cells, is implicated in the pathogenesis of chronic inflammatory disorders incl…
Colonic macrophage polarization in homeostasis, inflammation, and cancer
PMID: 27229123
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
Our review focuses on the colonic macrophage, a monocyte-derived, tissue-resident macrophage, and the role it plays in health and disease, specifical…
[Association of lymphoma and granulomatosis: A case series]
PMID: 26611429
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.3
PURPOSE: The sarcoidosis-lymphoma syndrome is a recognised entity. However, the presence of granulomas in patients with a haematological disease shou…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||