| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
The Wu-Shi-Cha formula protects against ulcerative colitis by orchestrating imm…
PMID: 36572328
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.3
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) has become a healthy burden worldwide due to its insidious onset and repetitive relapse, with…
Pharmacological inhibition of toll-like receptor 4 with TLR4-IN-C34 modulates t…
PMID: 36152840
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Toll-like receptor 4, a highly conserved protein of innate immunity, is responsible for the regulation and maintenance of homeostasis. It has been im…
Total flavonoids of Sophora flavescens and kurarinone ameliorated ulcerative co…
PMID: 35863614
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis (UC) is relevant to dysregulation of inflammation and immune processes. Sophora flavescens Aiton i…
CD30L is involved in the regulation of the inflammatory response through induci…
PMID: 35834956
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
The pathogenesis of inflammatory bowel diseases (IBD) is complex, and dysregulated immune responses play a pivotal role in its occurrence and develop…
Gut homeostasis, injury, and healing: New therapeutic targets
PMID: 35633906
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 6.3
The integrity of the gastrointestinal mucosa plays a crucial role in gut homeostasis, which depends upon the balance between mucosal injury by destru…
m(6)A mRNA modification maintains colonic epithelial cell homeostasis via NF-κB…
PMID: 35333576
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.3
Colonic mucosal barrier dysfunction is one of the major causes of inflammatory bowel disease (IBD). However, the mechanisms underlying mucosal barrie…
Curcumin Regulated the Homeostasis of Memory T Cell and Ameliorated Dextran Sul…
PMID: 33597887
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
Immune memory is protective against reinvasion by pathogens in the homeostatic state, while immune memory disorders can cause autoimmune disease, inc…
A Novel PAK1-Notch1 Axis Regulates Crypt Homeostasis in Intestinal Inflammation
PMID: 33189893
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND & AIMS: p21-activated kinase-1 (PAK1) belongs to a family of serine-threonine kinases and contributes to cellular pathways such as nuclear…
The JAK1/3 inhibitor tofacitinib suppresses T cell homing and activation in chr…
PMID: 32808031
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND & AIMS: The molecular mechanism of action of the Janus kinase (JAK) inhibitor tofacitinib is poorly understood. METHODS: Here, we analysed…
Gegen Qinlian decoction maintains colonic mucosal homeostasis in acute/chronic …
PMID: 32065953
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND: Gegen Qinlian decoction (GQ) is a well-known traditional Chinese medicine that has been clinically proven to be effective in treating ulc…
Contributions of Myosin Light Chain Kinase to Regulation of Epithelial Paracell…
PMID: 32028590
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
Intestinal barrier function is required for the maintenance of mucosal homeostasis. Barrier dysfunction is thought to promote progression of both int…
Libertellenone M, a diterpene derived from an endophytic fungus Phomopsis sp. S…
PMID: 31927507
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 6.3
NLRP3 inflammasome may serve as a potential target for the development of novel therapeutics for inflammatory bowel diseases. In this study, we found…
Tipping the balance: inhibitory checkpoints in intestinal homeostasis
PMID: 30498201
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 6.3
The small intestinal and colonic lamina propria are populated with forkhead box P3 (FOXP3)(+)CD4(+) regulatory T cells (Tregs) and interleukin-10-pro…
Canonical Wnt Signaling in CD11c(+) APCs Regulates Microbiota-Induced Inflammat…
PMID: 29602775
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.3
Aberrant Wnt/beta-catenin signaling occurs in several inflammatory diseases, including inflammatory bowel disease and inflammatory bowel disease-asso…
Fortunellin-Induced Modulation of Phosphatase and Tensin Homolog by MicroRNA-37…
PMID: 29472916
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.3
TL1A is an attractive therapeutic target for the treatment of mucosal inflammation associated with inflammatory bowel disease (IBD) and asthma. Blo…
C/EBP homologous protein-induced loss of intestinal epithelial stemness contrib…
PMID: 28926118
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.3
Impaired intestinal barrier function promotes the progression of various liver diseases, including cholestatic liver diseases. The close association …
Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithel…
PMID: 27940058
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 6.3
The importance of cyclooxygenase and lipoxygenase pathways and the consequent eicosanoid synthesis in the physiology and pathophysiology of the intes…
The role for protein tyrosine phosphatase non-receptor type 22 in regulating in…
PMID: 27403297
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 6.3
Inflammatory bowel disease represents a chronic intestinal inflammation. Recent knowledge suggests a crucial role for genetic, immunological and bact…
The AMPK enzyme-complex: from the regulation of cellular energy homeostasis to …
PMID: 26414111
Year: 2016
Relationship Type:
Target Validation
Score: 6.3
INTRODUCTION: Adenosine monophosphate-activated protein kinase (AMPK), known as an enzymatic complex that regulates the energetic metabolism, is emer…
Innate lymphoid cells in homeostasis, infection, chronic inflammation and tumor…
PMID: 24100718
Year: 2013
Relationship Type:
Therapeutic Applications
Score: 6.3
PURPOSE OF REVIEW: To highlight the functions of a recently discovered group of immune cells known as innate lymphoid cells (ILCs) during homeostasis…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||