| Target ID: | Tar17 |
|---|---|
| ID: | T48470 |
| Target Name: | Hormone unspecific (HOM) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T48470 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Border patrol: regulation of immunity, inflammation and tissue homeostasis at b…
PMID: 21502992
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 6.3
The maintenance of barrier function at exposed surfaces of the mammalian body is essential for limiting exposure to environmental stimuli, preventing…
Advances in Understanding Intestinal Homeostasis: Lessons from Inflammatory Bow…
PMID: 40649913
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Inflammatory bowel diseases (IBDs) are chronic inflammatory conditions of the gastrointestinal tract that are multifactorial in nature. The pathophys…
SLAMF7 regulates goblet cell mucus production and negatively impacts gut homeos…
PMID: 40646691
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Crosstalk between the intestinal mucosal barrier and the gut microbiota contributes to maintaining intestinal homeostasis. Accumulating evidence sugg…
5'-tiRNA-Lys maintains intestinal epithelial homeostasis by EWSR1-dependent sup…
PMID: 40542577
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
The intestinal epithelium relies on autophagy to maintain barrier integrity and homeostasis, and dysregulation of this process has been implicated in…
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal f…
PMID: 40434419
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
Innate lymphoid cells (ILCs) are long-lived, tissue-resident cell analogs to T helper subsets that lack antigen-specific receptors. Understanding the…
Probiotic Membrane-Modified Nanocomposite Alleviates Inflammation and Microbiot…
PMID: 40184333
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel disease (IBD) is a complex chronic intestinal disorder in which excessive oxidative stress, dysregulated immune response, and micr…
Enteric GABAergic neuron-derived γ-aminobutyric acid initiates expression of Ig…
PMID: 40033120
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Neuronal signals have emerged as critical factors that regulate group 3 innate lymphoid cell (ILC3) response and tissue homeostasis, but the molecula…
Gasdermin B modulates intestinal epithelial homeostasis via regulating hyperact…
PMID: 39831701
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Impaired intestinal epithelial barrier has been considered to be associated with an increasing variety of gastrointestinal diseases, espe…
A stromal inflammasome Ras safeguard against Myc-driven lymphomagenesis
PMID: 39747433
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
The inflammasome plays multifaceted roles in cancer, but less is known about its function during premalignancy upon initial cell transformation. We r…
Aloe-emodin alleviates inflammatory bowel disease in mice by modulating intesti…
PMID: 39157379
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
INTRODUCTION: Inflammatory bowel disease (IBD) is a global health concern. Aloe-emodin (AE) has diverse pharmacological benefits, including anti-infl…
Interactions between toll-like receptors signaling pathway and gut microbiota i…
PMID: 39073297
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Toll-like receptors (TLRs) are a family of fundamental pattern recognition receptors in the innate immune system, constituting the first …
Gut microbiota metabolite indole-3-acetic acid maintains intestinal epithelial …
PMID: 39068517
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
The global incidence and prevalence of inflammatory bowel disease (IBD) are gradually increasing. A high-fat diet (HFD) is known to disrupt intestina…
Alzheimer's disease-related presenilins are key to intestinal epithelial cell f…
PMID: 38684238
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
OBJECTIVE: Mutations in presenilin genes are the major cause of Alzheimer's disease. However, little is known about their expression and function in …
Macrophage Tim-3 maintains intestinal homeostasis in DSS-induced colitis by sup…
PMID: 38330550
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
T-cell immunoglobulin domain and mucin domain-3 (Tim-3) is a versatile immunomodulator that protects against intestinal inflammation. Necroptosis is …
Blocking GPR15 Counteracts Integrin-dependent T Cell Gut Homing in Vivo
PMID: 38243565
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND AND AIMS: The G protein coupled receptor GPR15 is expressed on and functionally important for T cells homing to the large intestine. Howev…
Lnc-ing RNA to intestinal homeostasis and inflammation
PMID: 38220553
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
Long noncoding RNAs (lncRNAs) play important roles in numerous biological processes, including the immune system. Initial research in this area focus…
Nuclear localization of STING1 competes with canonical signaling to activate AH…
PMID: 38016467
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Extensive studies demonstrate the importance of the STING1 (also known as STING) protein as a signaling hub that coordinates immune and autophagic re…
Shaoyao decoction alleviates TNBS-induced ulcerative colitis by decreasing infl…
PMID: 38001450
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Ulcerative colitis (UC) is a persistent and non-specific inflammatory condition that mainly affects the bowels and has challenging treatm…
The signaling pathway of hypoxia inducible factor in regulating gut homeostasis
PMID: 37965556
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Hypoxia represent a condition in which an adequate amount of oxygen supply is missing in the body, and it could be caused by a variety of diseases, i…
Pro-inflammatory cytokine expression and the STAT1/3 pathway in canine chronic …
PMID: 37906531
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
The accumulation of intraepithelial lymphocytes (IELs) is a histopathological feature of canine chronic enteropathy (CE), and IELs are considered the…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio44521 | CHEMBL4297525 | Small molecule | RELAMORELIN | 790.99 | C43H50N8O5S | BASE | Details |
| bio44522 | CHEMBL1201620 | Protein | SOMATREM | -- | -- | -- | Details |
| bio44523 | CHEMBL4650335 | Protein | NENDRATAREOTIDE UZATANSINE | 1786.58 | C83H109ClN14O20S4 | -- | Details |
| bio44524 | CHEMBL58547 | Protein | IPAMORELIN | 711.87 | C38H49N9O5 | BASE | Details |
| bio44525 | CHEMBL2357192 | Protein | DESLORELIN ACETATE | 1342.53 | C66H87N17O14 | -- | Details |
| bio44526 | CHEMBL1200516 | Protein | GONADORELIN HYDROCHLORIDE | 1218.77 | C55H76ClN17O13 | -- | Details |
| bio44527 | CHEMBL4540843 | Protein | PANCREATIC POLYPEPTIDE | 4181.78 | C185H287N53O54S2 | -- | Details |
| bio44528 | CHEMBL113313 | Small molecule | CAPROMORELIN | 505.62 | C28H35N5O4 | NEUTRAL | Details |
| bio44529 | CHEMBL1680 | Protein | OCTREOTIDE | 1019.26 | C49H66N10O10S2 | -- | Details |
| bio44530 | CHEMBL1201515 | Protein | PEGVISOMANT | -- | -- | -- | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||