| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Mechanisms of NF-κB p65 and strategies for therapeutic manipulation
PMID: 30464573
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 7.3
The transcription factor NF-kappaB is a critical regulator of immune and inflammatory responses. In mammals, the NF-kappaB/Rel family comprises five …
Biphasic Ccl20 regulation by Toll-like receptor 9 through the activation of ERK…
PMID: 27590109
Year: 2017
Relationship Type:
Mechanism Investigation
Score: 7.3
Inflammatory bowel disease (IBD) affects millions of people worldwide. Although the etiology of this disease is uncertain, accumulating evidence ind…
[Effect of Tripterygium wilfordii polycoride upon inflammation and TLR4/MyD88 s…
PMID: 27266354
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 7.3
OBJECTIVE: To observe the effect of Tripterygium wilfordii polycoride (TWP) on ulcerative colitis (UC), and its intervention effect on toll-like rece…
The multiple roles of guanylate cyclase C, a heat stable enterotoxin receptor
PMID: 24304979
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 7.3
PURPOSE OF REVIEW: Guanylate cyclase C (GC-C) is a transmembrane receptor that is expressed primarily on intestinal epithelial cells. Activation of t…
Inosine, AMP, and Vidarabine: Network Pharmacology and LC-MS Reveal Key Bioacti…
PMID: 40564909
Year: 2025
Relationship Type:
Target Validation
Score: 6.8
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with unmet therapeutic needs. This study investigates the therapeutic potential of Pe…
Repurposing of clinical-stage FLT3 inhibitor HYML-122 as a potent RIPK2 inhibit…
PMID: 40403506
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
Nucleotide-binding oligomerization domain-containing proteins 1 and 2 (NOD 1/2) are important cytoplasmic pattern recognition receptors that initiate…
Epigenetic mechanism of iPSC-MSC-EVs in colonic epithelial cell pyroptosis in u…
PMID: 40315630
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
Ulcerative colitis (UC) is a chronic inflammatory bowel disease in the colon and rectum. Mesenchymal stem cell-derived extracellular vesicles (MSCs-E…
Function and therapeutic potential of Amuc_1100, an outer membrane protein of A…
PMID: 40157674
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
The gut microbiota-derived protein Amuc_1100, a key outer membrane component of Akkermansia muciniphila, has emerged as a groundbreaking therapeutic …
Lack of IFN-γ response of human uterine myometrium-derived MSCs significantly i…
PMID: 40154933
Year: 2025
Relationship Type:
Target Validation
Score: 6.8
The clinical efficacy of mesenchymal stem cell (MSC) therapy for inflammatory bowel disease (IBD) is inconsistent and often fails to match promising …
Qingre Huayu Jianpi prescription alleviates the inflammatory transformation of …
PMID: 40043824
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
ETHNOPHARMACOLOGICAL RELEVANCE: Inflammation-to-cancer transformation is critical for the progression of ulcerative colitis to colitis-associated col…
AhR Activation Transcriptionally Induces Anti-Microbial Peptide Alpha-Defensin …
PMID: 39894796
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
Alpha-defensin 1 is a small antimicrobial peptide that acts as the first line of defense against pathogens. It is induced following microbial cues an…
Huanglian Ganjiang Decoction alleviates DSS-induced colitis through suppressing…
PMID: 39788168
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
ETHNOPHARMACOLOGICAL RELEVANCE: Huanglian Ganjiang decoction (HGD), which is composed of Chinese medicines with cold, warm, and astringent properties…
Macrophage-Derived Exosomes Promoted the Development and Stemness of Inflammato…
PMID: 39425913
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: Inflammatory bowel disease (IBD) is closely associated with the development of colorectal cancer (CRC) due to the chronic inflammatory re…
The Therapeutic Target of IBD and the Mechanism of Dipyridamole in Treating IBD…
PMID: 38803168
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND AND AIMS: Inflammatory Bowel Disease (IBD) is a refractory disease with repeated attacks, and there is no accurate treatment target at pre…
Gut microbial metabolite deoxycholic acid facilitates Th17 differentiation thro…
PMID: 37789469
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: High-fat diet (HFD) is closely associated with the increased prevalence of inflammatory bowel disease (IBD). Excessive gut microbial meta…
Cepharanthine Exerts Antioxidant and Anti-Inflammatory Effects in Lipopolysacch…
PMID: 37630322
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
Cepharanthine (CEP), a biscoclaurine alkaloid extracted from Stephania cepharantha Hayata, has been widely used for the treatment of various acute an…
A network medicine-based approach to explore the relationship between depressio…
PMID: 37492068
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: Depression is widespread global problem that not only severely impacts individuals' physical and mental health but also imposes a heavy d…
Transcriptomic analysis reveals the regulatory mechanism underlying the indirub…
PMID: 37439220
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
CONTEXT: Aryl hydrocarbon receptor (AhR) agonists are potential therapeutic agents for ulcerative colitis (UC). Indirubin (IDR), which is a natural A…
Discovery of a novel RIPK2 inhibitor for the treatment of inflammatory bowel di…
PMID: 37315817
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
Nucleotide-binding oligomerization domain-containing protein 1 and 2 (NOD 1/2) are important cytosolic pattern recognition receptors that initiate ho…
Exploring the molecular mechanism of comorbidity of autism spectrum disorder an…
PMID: 37291580
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: Autism spectrum disorder (ASD) is a neurodevelopmental disorder that is difficult to diagnose. Inflammatory bowel disease (IBD) is a comm…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||