| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Quercetin serves as the major component of Xiang-lian Pill to ameliorate ulcera…
PMID: 37142141
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
ETHNOPHARMACOLOGICAL RELEVANCE: The traditional Chinese herbal formula, Xiang-lian Pill (XLP), is commonly prescribed for ulcerative colitis (UC) pat…
Lipid metabolism in Th17 cell function
PMID: 37037407
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
Among the subset of T helper cells, Th17 cells are known to play a crucial role in the pathogenesis of various autoimmune disorders, such as psoriasi…
Browning of Mesenteric White Adipose Tissue in Crohn's Disease: A New Pathologi…
PMID: 36932969
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKROUND: Hypertrophic mesenteric adipose tissue [htMAT] is a distinctive hallmark of Crohn's disease [CD], and it affects enteritis via inflammator…
The Efficacy and Mechanism of Qinghua Jianpi Recipe in Inhibiting Canceration o…
PMID: 36844438
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
OBJECTIVE: This study is aimed at exploring the effect of Qinghua Jianpi Recipe on preventing colon polyp recurrence and inhibiting the progress of "…
Distinct transcriptional signatures in purified circulating immune cells drive …
PMID: 36746519
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
OBJECTIVE: To infer potential mechanisms driving disease subtypes among patients with inflammatory bowel disease (IBD), we profiled the transcriptome…
Progress in the relationship between P2X7R and colorectal cancer
PMID: 36417079
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 6.8
Purinergic ligand-gated ion channel 7 receptor (P2X7R) is a nonselective cation channel of the purinergic receptor family. P2X7R is activated by aden…
The transcription factor Cdx2 regulates inflammasome activity through expressio…
PMID: 35985421
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.8
The intestine-specific transcription factor Cdx2 is essential for intestinal homeostasis and has been implicated in the pathogenesis of disorders inc…
Neutrophil Infiltration Characterized by Upregulation of S100A8, S100A9, S100A1…
PMID: 35795659
Year: 2022
Relationship Type:
Target Validation
Score: 6.8
BACKGROUND: Crohn's disease (CD) and peripheral arterial disease (PAD) are closely related. The pathophysiological mechanisms underlying the coexiste…
Aberrant Mesenteric Adipose Extracellular Matrix Remodelling is Involved in Adi…
PMID: 35708752
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND AND AIMS: Hypertrophic mesenteric adipose tissue [htMAT] is involved in the disease progression of Crohn's disease [CD] through expressing…
Trifolirhizin regulates the balance of Th17/Treg cells and inflammation in the …
PMID: 35575951
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.8
Ulcerative colitis (UC) is a chronic and recurrent autoimmune disease, characterized by recurrence and remission of mucosal inflammation. Although th…
RIP3 knockdown inhibits necroptosis of human intestinal epithelial cells via TL…
PMID: 35346043
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.8
BACKGROUND: Ulcerative colitis (UC) is a common inflammatory bowel disease, during which cell necroptosis plays key roles in driving inflammation ini…
Prodrug-Based Targeting Approach for Inflammatory Bowel Diseases Therapy: Mecha…
PMID: 35269813
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.8
Therapeutics with activity specifically at the inflamed sites throughout the gastrointestinal tract (GIT) would be a major advance in our therapeutic…
Electroacupuncture Attenuated Anxiety and Depression-Like Behavior via Inhibiti…
PMID: 35087621
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 6.8
This study was designed to explore the potential mechanisms of electroacupuncture (EA) in treating inflammatory bowel disease- (IBD-) related anxiety…
A randomised, placebo-controlled study of RIPK1 inhibitor GSK2982772 in patient…
PMID: 34389633
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.8
OBJECTIVE: Tumour necrosis factor signalling via the receptor-interacting protein kinase 1 (RIPK1) pathway regulates colonic inflammation suggesting …
Extracellular vesicles of Fusobacterium nucleatum compromise intestinal barrier…
PMID: 33769187
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.8
Microbial factors that mediate microbes-host interaction in ulcerative colitis (UC), a chronic disease seriously affecting human health, are not full…
Enema based therapy using liposomal formulation of low molecular weight heparin…
PMID: 33579485
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.8
Ulcerative colitis (UC) is an idiopathic bowel disease involving chronic inflammation and ulcers in colon and implicates severe epithelial damage wit…
Quantitative relationship between infliximab exposure and inhibition of C-react…
PMID: 33184852
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 6.8
Inflammatory bowel disease (IBD) is an important chronic condition associated with the infection affecting the gastrointestinal tract (G.I.) in dogs…
Identification of Differential Intestinal Mucosa Transcriptomic Biomarkers for …
PMID: 33144895
Year: 2020
Relationship Type:
Target Validation
Score: 6.8
BACKGROUND: Ulcerative colitis (UC) is a complicated disease caused by the interaction between genetic and environmental factors that affect mucosal …
Inhibition of RIPK3 Pathway Attenuates Intestinal Inflammation and Cell Death o…
PMID: 32395368
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.8
Receptor-interacting serine/threonine-protein kinase (RIPK) 3 is a member of the TNF receptor-I signaling complex and mediates necroptosis, an inflam…
Tilapia head glycolipids reduce inflammation by regulating the gut microbiota i…
PMID: 32219260
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.8
Proton-sensing ovarian cancer G-protein coupled receptor (OGR1) plays an important role in pH homeostasis. Acidosis occurs at sites of intestinal i…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||