| Target ID: | Tar21 |
|---|---|
| ID: | T53684 |
| Target Name: | Inflammation pathogenesis (IP) |
| Target Type: | Protein |
| CID: | -- |
| URL: | https://db.idrblab.net/ttd/data/target/details/T53684 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| No data available | |||||||
Impact of 5-HT₃ receptor antagonists on peripheral and central diseases
PMID: 22390946
Year: 2012
Relationship Type:
Therapeutic Applications
Score: 5.3
In this article we discuss the novel pharmacological aspects of 5-HT(3) receptor antagonists. Commonly used to counteract chemotherapy-induced emesis…
Involvement of the mannose receptor and p38 mitogen-activated protein kinase si…
PMID: 22290149
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.3
The microdomain of the integral membrane protein (MIMP) has been shown to adhere to mucin and to antagonize the adhesion of enteropathogenic Escheric…
Matriptase protects against experimental colitis and promotes intestinal barrie…
PMID: 22081509
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: Probiotic bacteria can be used for the prevention and treatment of human inflammatory diseases including inflammatory bowel diseases (IB…
Selective upregulation of microRNA expression in peripheral blood leukocytes in…
PMID: 22043014
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
IL-10(-/-) mice, an animal model of Th1-mediated inflammatory bowel disease, were screened for the expression of 600 microRNAs (miRNAs) using colonic…
From gut microflora imbalance to mycobacteria infection: is there a relationshi…
PMID: 21988043
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.3
The gut of a healthy adult harbours a myriad of different microbial species. It is estimated that approximately 10 14 are present in total bacterial …
Small-molecule protein and lipid kinase inhibitors in inflammation and specific…
PMID: 21960213
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.3
The inflammatory response requires complex and coordinated cooperation of different signaling pathways and cell types. Therefore, more than 40 differ…
Relationship between human intestinal dendritic cells, gut microbiota, and dise…
PMID: 21910165
Year: 2011
Relationship Type:
Clinical Research
Score: 5.3
BACKGROUND: Altered intestinal dendritic cell (DC) function underlies dysregulated T-cell responses to bacteria in Crohn's disease (CD) but it is unc…
The antioxidant potential of alprazolam on the redox status of peripheral blood…
PMID: 21851827
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.3
AIMS: Stress can cause adverse reactions in the body that induce a wide range of biochemical and behavioral changes. Oxidative damage is an establish…
Aspirin-triggered lipoxin enhances macrophage phagocytosis of bacteria while in…
PMID: 21659618
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
The macrophage plays a major role in the induction and resolution phases of inflammation; however, how lipid mediator-derived signals may modulate ma…
Triptolide protects mice from ischemia/reperfusion injury by inhibition of IL-1…
PMID: 21621648
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
Ischemia and reperfusion have been identified as a complex cascade of inflammatory mediators that are involved in the pathogenesis of hepatic injury.…
Peripheral blood based discrimination of ulcerative colitis and Crohn's disease…
PMID: 21508504
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
Target cell overexpression of the integrase binding domain (IBD) of LEDGF/p75 (LEDGF) inhibits HIV-1 replication. The mechanism and protein structur…
Role of nitric oxide-synthase and cyclooxygenase/lipooxygenase systems in devel…
PMID: 21451211
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
Development of ulcerative colitis was accompanied by the activation of iNOS/COX-2/5-LOX and increased contents of nitric oxide (NO), prostaglandin E(…
Non-coated multiparticulate matrix systems for colon targeting
PMID: 21417601
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: Colon specific drug delivery can significantly improve the efficacy of local treatments of inflammatory bowel diseases. Film coatings con…
Depression's multiple comorbidities explained by (neuro)inflammatory and oxidat…
PMID: 21407167
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
There is now evidence that depression, as characterized by melancholic symptoms, anxiety, and fatigue and somatic (F&S) symptoms, is the clinical exp…
C1q/TNF-related protein-3 (CTRP-3) is secreted by visceral adipose tissue and e…
PMID: 21351204
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND: The adipokine CTRP-3 (C1q/TNF-related protein-3) belongs to the C1q/TNF-related protein family which antagonizes the effects of lipopolys…
Macrophages and liposomes in inflammatory disease: friends or foes?
PMID: 21238559
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.3
Liposome-encapsulated corticosteroids have shown to exert strong beneficial effects in inflammatory diseases, such as arthritis and cancer. To extend…
Microparticles mediate enzyme transfer from platelets to mast cells: a new path…
PMID: 20801099
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 5.3
The inflammation-resolving lipid mediator lipoxin A4 (LXA4), which is derived from arachidonic acid in the context of inflammation, can be generated …
Up-regulation of signal transducer and activator of transcription-3 is associat…
PMID: 20709283
Year: 2010
Relationship Type:
Therapeutic Applications
Score: 5.3
OBJECTIVE: The signal transducers and activators of transcription (STAT) family of proteins are intracellular signal transduction molecules involved …
Diverse targets of the transcription factor STAT3 contribute to T cell pathogen…
PMID: 20493732
Year: 2010
Relationship Type:
Correlation Studies
Score: 5.3
STAT3, an essential transcription factor with pleiotropic functions, plays critical roles in the pathogenesis of autoimmunity. Despite recent data li…
Sera from patients with Crohn's disease break bacterial lipopolysaccharide tole…
PMID: 20351135
Year: 2010
Relationship Type:
Clinical Research
Score: 5.3
Myeloid differentiation (MD)-2 is linked to the cell surface as a Toll-like receptor (TLR) 4-bound protein though may also function as a soluble rece…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio4154 | CHEMBL456341 | Small molecule | LENABASUM | 400.56 | C25H36O4 | ACID | Details |
| bio4155 | CHEMBL2108152 | Oligonucleotide | AFOVIRSEN SODIUM | -- | -- | -- | Details |
| bio4156 | CHEMBL5095268 | Unknown | BMS-986184 | -- | -- | -- | Details |
| bio4157 | CHEMBL2104745 | Small molecule | PAGOCLONE | 407.9 | C23H22ClN3O2 | NEUTRAL | Details |
| bio4158 | CHEMBL538867 | Small molecule | PATIDEGIB | 504.78 | C29H48N2O3S | BASE | Details |
| bio4159 | CHEMBL3084748 | Small molecule | TROSPIUM CHLORIDE | 427.97 | C25H30ClNO3 | NEUTRAL | Details |
| bio4160 | CHEMBL25 | Small molecule | ASPIRIN | 180.16 | C9H8O4 | ACID | Details |
| bio4161 | CHEMBL4650310 | Small molecule | IP-2018 | 271.32 | C16H17NO3 | BASE | Details |
| bio4162 | CHEMBL1256994 | Small molecule | CITICOLINE SODIUM | 510.31 | C14H25N4NaO11P2 | ACID | Details |
| bio4163 | CHEMBL1231700 | Small molecule | CITICOLINE | 488.33 | C14H26N4O11P2 | ACID | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||