| Target ID: | Tar6 |
|---|---|
| ID: | T72835 |
| Target Name: | E-selectin (SELE) |
| Target Type: | Protein |
| CID: | 71600085 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T72835 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug151 | Uproleselan | Chemical drug | DB14829 | -- | -- | Under clinical trials | Details |
RM, a novel resveratrol derivative, attenuates inflammatory responses induced b…
PMID: 31835082
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 6.3
Although the novel resveratrol derivative RM has therapeutic potential for the treatment of inflammatory bowel disease, little is currently known reg…
Pharmacological inhibitory profile of TAK-828F, a potent and selective orally a…
PMID: 29369782
Year: 2018
Relationship Type:
Therapeutic Applications
Score: 6.3
Retinoic acid-related orphan receptor gammat (RORgammat) is a key master regulator of the differentiation and activation of IL-17 producing CD4(+) Th…
Amelioration of autoimmunity with an inhibitor selectively targeting all active…
PMID: 29034459
Year: 2018
Relationship Type:
Mechanism Investigation
Score: 6.3
BACKGROUND AND PURPOSE: Multicatalytic endopeptidase complex-like-1 (beta2i), low molecular mass polypeptide (LMP) 2 (beta1i) and LMP7 (beta5i) are t…
BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiat…
PMID: 28265070
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 6.3
T-helper 17 (Th17) cells have important functions in adaptor immunity and have also been implicated in inflammatory disorders. The bromodomain and ex…
Selective immunoproteasome inhibitors with non-peptide scaffolds identified fro…
PMID: 24913713
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 6.3
As a major component of the crucial nonlysosomal protein degradation pathway in the cells, the proteasome has been implicated in many diseases such a…
Interleukin-6: from basic biology to selective blockade of pro-inflammatory act…
PMID: 24325804
Year: 2014
Relationship Type:
Mechanism Investigation
Score: 6.3
Cytokines receptors exist in membrane bound and soluble form. A soluble form of the human IL-6R is generated by limited proteolysis and alternative s…
Novel immunomodulatory properties of cirsilineol through selective inhibition o…
PMID: 19698701
Year: 2010
Relationship Type:
Mechanism Investigation
Score: 6.3
Regulation of signal transducer and activator of transcription (STAT) 1 signaling is being explored as a new approach to the treatment of inflammator…
Functional targeting of ILC2s and ILC3s reveals selective roles in intestinal f…
PMID: 40434419
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
Innate lymphoid cells (ILCs) are long-lived, tissue-resident cell analogs to T helper subsets that lack antigen-specific receptors. Understanding the…
Somatostatin and Mannooligosaccharide Modified Selenium Nanoparticles with Dual…
PMID: 40214514
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel disease (IBD) is a prevalent condition worldwide, characterized by complex etiologies, limited efficacy of clinical drug treatment…
A Novel Selenium-Based Nanozyme (GSH-Se) Ameliorates Colitis in Mice by Modulat…
PMID: 40076493
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.8
Combination of selenium (Se) and glutathione peroxidase (GPx) can reduce the dose of Se used while concurrently exploiting their antioxidative perfor…
Oral creatine-modified selenium-based hyaluronic acid nanogel mediated mitochon…
PMID: 39609811
Year: 2024
Relationship Type:
Mechanism Investigation
Score: 5.8
The damnification of mitochondrion is often considered to be an important culprit of inflammatory bowel disease (IBD), however, there are fewer repor…
Selective Uptake Into Inflamed Human Intestinal Tissue and Immune Cell Targetin…
PMID: 38109123
Year: 2024
Relationship Type:
Therapeutic Applications
Score: 5.8
Inflammatory bowel disease (IBD) has become a globally prevalent chronic disease with no causal therapeutic options. Targeted drug delivery systems w…
Design, synthesis and anticancer activity of N-aryl indolylsulfoximines: Identi…
PMID: 37659217
Year: 2023
Relationship Type:
Target Validation
Score: 5.8
A facile and efficient approach utilizing copper-mediated cross-coupling reaction of N-boc-3-indolylsulfoximines with aryl iodides was developed to s…
Discovery of a Bromodomain and Extra Terminal Domain (BET) Inhibitor with the S…
PMID: 37478496
Year: 2023
Relationship Type:
Therapeutic Applications
Score: 5.8
Selective inhibitors targeting the first bromodomain (BD1) or the second bromodomain (BD2) of the bromodomain and extra terminal domain (BET) protein…
Infliximab vs adalimumab: Points to consider when selecting anti-tumor necrosis…
PMID: 37274072
Year: 2023
Relationship Type:
Mechanism Investigation
Score: 5.8
Biologic agents with various mechanisms against Crohn's disease (CD) have been released and are widely used in clinical practice. However, two anti-t…
Unfermented β-fructan Fibers Fuel Inflammation in Select Inflammatory Bowel Dis…
PMID: 36183751
Year: 2023
Relationship Type:
Target Validation
Score: 5.8
BACKGROUND & AIMS: Inflammatory bowel diseases (IBD) are affected by dietary factors, including nondigestible carbohydrates (fibers), which are ferme…
Design of Diselenide-Bridged Hyaluronic Acid Nano-antioxidant for Efficient ROS…
PMID: 35861614
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Overproduction of reactive oxygen species (ROS), a key characteristic of inflammatory bowel disease (IBD), is responsible for dysregulation of signal…
Discovery of Potent and Selective Receptor-Interacting Serine/Threonine Protein…
PMID: 35709396
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.8
Receptor-interacting serine/threonine protein kinase 2 (RIPK2) has been demonstrated to be a promising target for treating inflammatory diseases. Her…
Selective tyrosine kinase 2 inhibitors in inflammatory bowel disease
PMID: 35277286
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
Recent significant advances have been made in the treatment of chronic inflammatory diseases with initiation of the era of biologics. However, an unm…
Supplementary selenium in the form of selenylation α-D-1,6-glucan ameliorates d…
PMID: 34896151
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
In many mammalian species, including pigs, heat stress (HS) detrimentally leads to epithelium damage and increases intestinal permeability. However,…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio13441 | CHEMBL5315060 | Small molecule | ENFLICOXIB | 405.35 | C16H12F5N3O2S | NEUTRAL | Details |
| bio13442 | CHEMBL2107214 | Small molecule | IOMEPROL | 777.09 | C17H22I3N3O8 | NEUTRAL | Details |
| bio13443 | CHEMBL1257 | Small molecule | ENFLURANE | 184.49 | C3H2ClF5O | NEUTRAL | Details |
| bio13444 | CHEMBL5315109 | Unknown | BOVINE CONCENTRATED LACTOSERUM CONTAINING SPECIFIC IMMUNOGLOBULINS G AGAINST E. COLI F5 (K99) ADHESIN | -- | -- | -- | Details |
| bio13445 | CHEMBL2105897 | Small molecule | BARIUM SULFATE | 233.39 | BaO4S | -- | Details |
| bio13446 | CHEMBL1678 | Small molecule | DONEPEZIL HYDROCHLORIDE | 415.96 | C24H30ClNO3 | BASE | Details |
| bio13447 | CHEMBL2103856 | Small molecule | ATOPAXAR | 527.64 | C29H38FN3O5 | NEUTRAL | Details |
| bio13448 | CHEMBL1160819 | Small molecule | AMMONIA SOLUTION, STRONG | 17.03 | H3N | BASE | Details |
| bio13449 | CHEMBL3185229 | Small molecule | MAGNESIUM CHLORIDE | 203.3 | H12Cl2MgO6 | -- | Details |
| bio13450 | CHEMBL1200930 | Small molecule | RABEPRAZOLE SODIUM | 381.43 | C18H20N3NaO3S | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||