| Target ID: | Tar6 |
|---|---|
| ID: | T72835 |
| Target Name: | E-selectin (SELE) |
| Target Type: | Protein |
| CID: | 71600085 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T72835 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug151 | Uproleselan | Chemical drug | DB14829 | -- | -- | Under clinical trials | Details |
The Selective 5-HT1A Agonist SR57746A Protects Intestinal Epithelial Cells and …
PMID: 34417821
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Neurotrophic growth factors can stabilize the intestinal barrier by preventing the apoptosis of enteric glial cells (EGCs) and enterocyte…
The rationale for selenium supplementation in inflammatory bowel disease: A mec…
PMID: 33578241
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: The differences between adults and children in inflammatory bowel disease (IBD) phenotype, severity, complications, co-morbidities, and …
Development of Gut-Selective Pan-Janus Kinase Inhibitor TD-1473 for Ulcerative …
PMID: 32161949
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND AND AIMS: Oral systemic pan-Janus kinase [JAK] inhibition is effective for ulcerative colitis [UC] but is limited by toxicities. We descri…
A JAK1 Selective Kinase Inhibitor and Tofacitinib Affect Macrophage Activation …
PMID: 30668755
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Janus kinases (JAKs) mediate cytokine signaling involved in inflammatory bowel disease. The pan-JAK inhibitor tofacitinib has shown effic…
First insight into structure-activity relationships of selective meprin β inhib…
PMID: 28408220
Year: 2017
Relationship Type:
Therapeutic Applications
Score: 5.8
The astacin proteases meprin alpha and beta are emerging drug targets for treatment of disorders such as kidney failure, fibrosis or inflammatory bow…
Effect of Narrow Spectrum Versus Selective Kinase Inhibitors on the Intestinal …
PMID: 27104822
Year: 2016
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND: Kinases are key mediators of inflammation, highlighting the potential of kinase inhibitors as treatments for inflammatory disorders. Sele…
Population Structure of a Widespread Species under Balancing Selection: The Cas…
PMID: 26793231
Year: 2016
Relationship Type:
Mechanism Investigation
Score: 5.8
Human ADAMs (a disintegrin and metalloproteinases) have been established as an attractive therapeutic target of inflammatory disorders such as infla…
Tricyclic covalent inhibitors selectively target Jak3 through an active site th…
PMID: 25552479
Year: 2015
Relationship Type:
Mechanism Investigation
Score: 5.8
The action of Janus kinases (JAKs) is required for multiple cytokine signaling pathways, and as such, JAK inhibitors hold promise for treatment of au…
Drug delivery by polymeric micelles: an in vitro and in vivo study to deliver l…
PMID: 23219878
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.8
Colitis is the term used for chronic inflammatory bowel diseases at substantially increased risk of developing a form of colorectal cancer (CRC) know…
Anti-inflammatory effect and selectivity profile of AS1940477, a novel and pote…
PMID: 23183108
Year: 2013
Relationship Type:
Mechanism Investigation
Score: 5.8
Given the key role p38 mitogen-activated protein kinase (MAPK) plays in inflammatory responses through the production of cytokines and inflammatory m…
P-selectin glycoprotein ligand-1 is needed for sequential recruitment of T-help…
PMID: 22009715
Year: 2012
Relationship Type:
Mechanism Investigation
Score: 5.8
BACKGROUND: Activated effector T cells contribute to tissue injury observed in inflammatory bowel disease. T cells are recruited to effector sites af…
Geographic variation in advertisement calls in a tree frog species: gene flow a…
PMID: 21858061
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.8
Appendicitis followed by appendectomy (AA) at a young age protects against inflammatory bowel disease (IBD). Using a novel murine appendicitis model…
Discovery and characterization of 2-aminobenzimidazole derivatives as selective…
PMID: 21802003
Year: 2011
Relationship Type:
Mechanism Investigation
Score: 5.8
NLR family proteins play important roles in innate immune response. NOD1 (NLRC1) activates various signaling pathways including NF-kappaB in response…
A humanized monoclonal antibody targeting the β7 integrin selectively blocks in…
PMID: 21232034
Year: 2011
Relationship Type:
Therapeutic Applications
Score: 5.8
BACKGROUND AND PURPOSE: rhuMAb Beta7 is a humanized anti-human beta7 monoclonal antibody currently in phase I in inflammatory bowel disease. rhuMAb B…
Modulation of macrophage inflammatory function through selective inhibition of …
PMID: 35986286
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.5
BACKGROUND: SP140 is a bromodomain-containing protein expressed predominantly in immune cells. Genetic polymorphisms and epigenetic modifications in …
Identification of neutrophil extracellular trap-related biomarkers in ulcerativ…
PMID: 40620701
Year: 2025
Relationship Type:
Target Validation
Score: 5.3
BACKGROUND: The incidence of ulcerative colitis (UC) is rapidly increasing worldwide, but existing therapeutics are limited. Neutrophil extracellular…
Highly multiplexed molecular inversion probe panel in Plasmodium falciparum tar…
PMID: 40574802
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
INTRODUCTION: The use of next-generation sequencing technologies (NGS) to study parasite populations and their response and evolution to intervention…
Converting indoprofen to moderate selective COX-2 inhibitors: Design, synthesis…
PMID: 40393356
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
Moderate COX-2 inhibitors with favorable safety profiles might benefit the treatment of ulcerative colitis. Herein, biochemical differences between C…
Highly multiplex molecular inversion probe panel in Plasmodium falciparum targe…
PMID: 40162260
Year: 2025
Relationship Type:
Mechanism Investigation
Score: 5.3
INTRODUCTION: The use of next-generation sequencing technologies (NGS) to study parasite populations and their response and evolution to intervention…
Biaryl Phosphates and Phosphonates as Selective Inhibitors of the Transcription…
PMID: 40067743
Year: 2025
Relationship Type:
Therapeutic Applications
Score: 5.3
The transcription factor STAT4 has been implicated in the pathogenesis of autoimmune diseases, including inflammatory bowel disease, multiple scleros…
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio13441 | CHEMBL5315060 | Small molecule | ENFLICOXIB | 405.35 | C16H12F5N3O2S | NEUTRAL | Details |
| bio13442 | CHEMBL2107214 | Small molecule | IOMEPROL | 777.09 | C17H22I3N3O8 | NEUTRAL | Details |
| bio13443 | CHEMBL1257 | Small molecule | ENFLURANE | 184.49 | C3H2ClF5O | NEUTRAL | Details |
| bio13444 | CHEMBL5315109 | Unknown | BOVINE CONCENTRATED LACTOSERUM CONTAINING SPECIFIC IMMUNOGLOBULINS G AGAINST E. COLI F5 (K99) ADHESIN | -- | -- | -- | Details |
| bio13445 | CHEMBL2105897 | Small molecule | BARIUM SULFATE | 233.39 | BaO4S | -- | Details |
| bio13446 | CHEMBL1678 | Small molecule | DONEPEZIL HYDROCHLORIDE | 415.96 | C24H30ClNO3 | BASE | Details |
| bio13447 | CHEMBL2103856 | Small molecule | ATOPAXAR | 527.64 | C29H38FN3O5 | NEUTRAL | Details |
| bio13448 | CHEMBL1160819 | Small molecule | AMMONIA SOLUTION, STRONG | 17.03 | H3N | BASE | Details |
| bio13449 | CHEMBL3185229 | Small molecule | MAGNESIUM CHLORIDE | 203.3 | H12Cl2MgO6 | -- | Details |
| bio13450 | CHEMBL1200930 | Small molecule | RABEPRAZOLE SODIUM | 381.43 | C18H20N3NaO3S | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||