| Target ID: | Tar6 |
|---|---|
| ID: | T72835 |
| Target Name: | E-selectin (SELE) |
| Target Type: | Protein |
| CID: | 71600085 |
| URL: | https://db.idrblab.net/ttd/data/target/details/T72835 |
| Related Drugs: | -- |
Knowledge Graph
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| Drug151 | Uproleselan | Chemical drug | DB14829 | -- | -- | Under clinical trials | Details |
A biosynthetic pathway for the selective sulfonation of steroidal metabolites b…
PMID: 35982310
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Members of the human gut microbiome enzymatically process many bioactive molecules in the gastrointestinal tract. Most gut bacterial modifications ch…
Potent and selective TYK2-JH1 inhibitors highly efficacious in rodent model of …
PMID: 35842205
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
TYK2 is a member of the JAK family of kinases and a key mediator of IL-12, IL-23, and type I interferon signaling. These cytokines have been implicat…
Sodium Selenite Modulates IDO1/Kynurenine, TLR4, NF-κB and Bcl2/Bax Pathway an…
PMID: 35263537
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
BACKGROUND/AIMS: Colitis is a main presentation of inflammatory bowel disease (IBD) and yet, has no definitive cure. Currently, corticosteroids, anti…
Selective Forms of Therapy in the Treatment of Inflammatory Bowel Diseases
PMID: 35207271
Year: 2022
Relationship Type:
Mechanism Investigation
Score: 5.3
Selective interference with the functioning of the immune system consisting of the selective blockade of pro-inflammatory factors is a modern, promis…
ROS-Sensitive Polymer Micelles for Selective Degradation in Primary Human Monoc…
PMID: 35068059
Year: 2022
Relationship Type:
Clinical Research
Score: 5.3
Inflammatory bowel disease (IBD) is characterized by increased levels of reactive oxygen species (ROS) in inflamed areas of the gastrointestinal trac…
Selective Targeting of Tumour Necrosis Factor Receptor 1 Induces Stable Protect…
PMID: 34893805
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND AND AIMS: Crohn's disease is a debilitating chronic inflammatory disorder of the mammalian gastrointestinal tract. Current interventions u…
Carbonic Anhydrase IV Selective Inhibitors Counteract the Development of Coliti…
PMID: 34685520
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Persistent pain affecting patients with inflammatory bowel diseases (IBDs) is still very difficult to treat. Carbonic anhydrase (CA) represents an in…
Selective brain cooling achieves peripheral organs protection in hemorrhagic sh…
PMID: 34220319
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
Background: Although whole-body cooling has been reported to improve the ischemic/reperfusion injury in hemorrhagic shock (HS) resuscitation, it is l…
Olorinab (APD371), a peripherally acting, highly selective, full agonist of the…
PMID: 33863856
Year: 2022
Relationship Type:
Therapeutic Applications
Score: 5.3
Abdominal pain is a key symptom of inflammatory bowel disease and irritable bowel syndrome, for which there are inadequate therapeutic options. We te…
Interleukin-28A induces epithelial barrier dysfunction in CD patient-derived in…
PMID: 33595362
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
Intestinal barrier dysfunction is a pathogenic hallmark in Crohn's disease (CD). Identifying key players that regulate intestinal barrier may provide…
Discovery of 3-(4-(2-((1H-Indol-5-yl)amino)-5-fluoropyrimidin-4-yl)-1H-pyrazol-…
PMID: 33593051
Year: 2021
Relationship Type:
Mechanism Investigation
Score: 5.3
TYK2 mediates signaling of IL-23, IL-12, and Type I IFN-driven responses that are critical in immune-mediated diseases. Herein, we report the design,…
Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory a…
PMID: 33058313
Year: 2021
Relationship Type:
Therapeutic Applications
Score: 5.3
BACKGROUND: GPR18 is a recently deorphanized receptor which was reported to act with several endogenous cannabinoid ligands. Here, we aimed to descri…
Increasing the Chemical Variety of Small-Molecule-Based TLR4 Modulators: An Ove…
PMID: 32765484
Year: 2020
Relationship Type:
Target Validation
Score: 5.3
Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by Pathogen- and Damage-Associated Molecular Patterns (PAMPs …
JAK selectivity: more precision less troubles
PMID: 32520647
Year: 2020
Relationship Type:
Therapeutic Applications
Score: 5.3
Erratum in Nat Rev Gastroenterol Hepatol. 2021 Feb;18(2):143. With the increase in the number of novel drugs for inflammatory bowel disease (IB…
Efficient and Divergent Enantioselective Syntheses of DHPVs and Anti-Inflammato…
PMID: 32397326
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Despite numerous reports on the beneficial effects of catechin or epicatechin contained in tea and cacao extract on human health, a conclusive and pr…
Biogenic selenium nanoparticles synthesized by Lactobacillus casei ATCC 393 all…
PMID: 32243488
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Selenium (Se) as an essential micronutrient plays a crucial role in human health. Biogenic selenium nanoparticles (SeNPs) possess attractive biologic…
Evaluation of inflammatory bowel disease activity in children using serum trefo…
PMID: 32120375
Year: 2020
Relationship Type:
Mechanism Investigation
Score: 5.3
Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a class of severe and chronic diseases of the gastr…
Anti-TNF combination therapy in inflammatory bowel disease: de novo or selectiv…
PMID: 31602970
Year: 2019
Relationship Type:
Therapeutic Applications
Score: 5.3
Anti-TNFs still remain the backbone of advanced therapies in inflammatory bowel diseases, but their efficacy is not universal and tends to diminish o…
DNA Methylation of miR-122 Aggravates Oxidative Stress in Colitis Targeting SEL…
PMID: 31019652
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Aberrant microRNA (miRNA) expressions contribute to the development and progression of various diseases, including Crohn's disease (CD). However, the…
Ulcer-associated cell lineage expresses genes involved in regeneration and is h…
PMID: 30746716
Year: 2019
Relationship Type:
Mechanism Investigation
Score: 5.3
Protease inhibition has become a new possible approach in the inflammatory bowel disease (IBD) therapy. A serine exopeptidase, dipeptidyl peptidase …
| Candidate ID | Source ID | Source Type | Compound Type | Candidate Name | Inclusion Criteria | |
|---|---|---|---|---|---|---|
| No data available | ||||||
| Compound ID | Source ID | Source Type | Compound Name | Molecular Weight | Molecular Formula | Molecular Species | |
|---|---|---|---|---|---|---|---|
| bio13441 | CHEMBL5315060 | Small molecule | ENFLICOXIB | 405.35 | C16H12F5N3O2S | NEUTRAL | Details |
| bio13442 | CHEMBL2107214 | Small molecule | IOMEPROL | 777.09 | C17H22I3N3O8 | NEUTRAL | Details |
| bio13443 | CHEMBL1257 | Small molecule | ENFLURANE | 184.49 | C3H2ClF5O | NEUTRAL | Details |
| bio13444 | CHEMBL5315109 | Unknown | BOVINE CONCENTRATED LACTOSERUM CONTAINING SPECIFIC IMMUNOGLOBULINS G AGAINST E. COLI F5 (K99) ADHESIN | -- | -- | -- | Details |
| bio13445 | CHEMBL2105897 | Small molecule | BARIUM SULFATE | 233.39 | BaO4S | -- | Details |
| bio13446 | CHEMBL1678 | Small molecule | DONEPEZIL HYDROCHLORIDE | 415.96 | C24H30ClNO3 | BASE | Details |
| bio13447 | CHEMBL2103856 | Small molecule | ATOPAXAR | 527.64 | C29H38FN3O5 | NEUTRAL | Details |
| bio13448 | CHEMBL1160819 | Small molecule | AMMONIA SOLUTION, STRONG | 17.03 | H3N | BASE | Details |
| bio13449 | CHEMBL3185229 | Small molecule | MAGNESIUM CHLORIDE | 203.3 | H12Cl2MgO6 | -- | Details |
| bio13450 | CHEMBL1200930 | Small molecule | RABEPRAZOLE SODIUM | 381.43 | C18H20N3NaO3S | NEUTRAL | Details |
| Strategy ID | Therapy Strategy | Synonyms | Related Drugs | Mechanism | |
|---|---|---|---|---|---|
| No data available | |||||