Research Article Details
| Article ID: | A17425 |
| PMID: | 27788715 |
| Source: | Zhonghua Gan Zang Bing Za Zhi |
| Title: | [Autophagy and nonalcoholic fatty liver disease]. |
| Abstract: | Autophagy is a lysosomal degradation pathway that functions to promote cell survival and maintain homeostasis by removing damaged organelles, unfolded proteins, and intracellular pathogens to lysosomes for degradation. Nonalcoholic fatty liver disease (NAFLD) is a clinicopathological syndrome whose hepatic histological features are similar to alcoholic liver disease (ALD), yet without excessive alcohol intake. Recent studies have revealed the close relationship of autophagy with development, progression, and outcome of NAFLD. Autophagy is capable of modulating lipid metabolism, improving insulin resistance, reducing oxidative stress, alleviating hepatocyte damage, etc., through multiple pathways. To induce hepatocyte autophagy pharmaceutically may be a novel therapeutic strategy for NAFLD. This review focuses on the mechanisms as well as the therapeutic targets of autophagy in NAFLD. |
| DOI: | 10.3760/cma.j.issn.1007-3418.2016.08.016 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S01 | Improve insulin resistance | insulin sensitizer; insulin resistance; glucose tolerance | Biguanide: increases 5-AMP activated protein kinase signaling; SGLT-2 inhibitor; Thiazalidinedione: selective PPAR-γ agonists; GLP-1 agonist | Metformin; Empagliflozin; Canagliflozin; Rosiglitazone; Pioglitazone; Liraglutide | Details |
| S02 | Enhance lipid metabolism | triglyceride-lowering; lipid tolerance; lipid metabolism | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor; Decreases intestinal cholesterol absorption; FXR agonist; ACC inhibitor; FAS inhibitor; DGAT2 inhibitor; SCD-1 inhibitor | Atorvastatin; Ezetimibe; Obeticholic Acid; GS-9674; GS-0976; TVB-2640; IONIS-DGAT2rx; Aramchol; | Details |
| S04 | Anti-oxidative stress | oxidative stress | α-tocopherol: antioxidant | Vitamin E | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |