Investigational Drug Details
| Drug ID: | D182 |
| Drug Name: | Insulin |
| Synonyms: | High molecular weight insulin human; Human insulin; human insulin (rDNA); Insulin (human); Insulin human; Insulin human [rDNA origin]; Insulin Human Regular; Insulin human regular (rDNA); Insulin human, rDNA origin; Insulin recombinant human; Insulin recombinant purified human; Insulin regular; Insulin, human; Neutral insulin; Regular Insulin, human; Soluble insulin |
| Type: | Biological drug |
| DrugBank ID: | DB00030 |
| DrugBank Description: | Human Insulin, also known as Regular Insulin, is a short-acting form of insulin used for the treatment of hyperglycemia caused by Type 1 and Type 2 Diabetes. Human insulin is produced by recombinant DNA technology and is identical to endogenously produced insulin. Typically prescribed for the management of diabetes mellitus, insulin is a peptide hormone produced by beta cells of the pancreas that promotes glucose metabolism. Insulin is released from the pancreas following a meal to promote the uptake of glucose from the blood into internal organs and tissues such as the liver, fat cells, and skeletal muscle. Absorption of glucose into cells allows for its transformation into glycogen or fat for storage. Insulin also inhibits hepatic glucose production, enhances protein synthesis, and inhibits lipolysis and proteolysis among many other functions. Insulin is an important treatment in the management of Type 1 Diabetes (T1D) which is caused by an autoimmune reaction that destroys the beta cells of the pancreas, resulting in the body not being able to produce or synthesize the insulin needed to manage circulating blood sugar levels. As a result, people with T1D rely primarily on exogenous forms of insulin to lower glucose levels in the blood. Insulin is also used in the treatment of Type 2 Diabetes (T2D), another form of diabetes mellitus that is a slowly progressing metabolic disorder caused by a combination of genetic and lifestyle factors that promote chronically elevated blood sugar levels. Without treatment or improvement in non-pharmacological measures such as diet and exercise to lower blood glucose, high blood sugar eventually causes cellular resistance to endogenous insulin, and in the long term, damage to pancreatic islet cells. Insulin is typically prescribed later in the course of T2D, after trying several oral medications such as , , or have been tried, when sufficient damage has been caused to pancreatic cells that the body is no longer able to produce insulin on its own. Marketed as the brand name product Humulin R or Novolin R, human insulin begins to exert its effects within 30 minutes of subcutaneous administration, while peak levels occur 3-4 hours after administration. Due to its quick onset of action, human insulin is considered "bolus insulin" as it provides high levels of insulin in a short period of time to mimic the release of endogenous insulin from the pancreas after meals. Bolus insulin is often combined with once daily, long-acting "basal insulin" such as , , and to provide low concentrations of background insulin that can keep blood sugar stable between meals or overnight. Use of basal and bolus insulin together is intended to mimic the pancreas' production of endogenous insulin, with a goal of avoiding any periods of hypoglycemia. Human insulin is also available in an inhalable form, intended to be used as a bolus meal-time insulin. Exubera was the first inhaled insulin available on the market and was developed by Inhale Therapeutics (later named Nektar Therapeutics). Unfortunately, limited uptake by physicians and patients, poor sales, bulky packaging, and concerns over the possible impact on lung cancer development resulted in Exubera products being withdrawn from the US markets . Exubera was followed by Afrezza, a monomeric inhaled insulin developed by Mannkind Corporation, which received FDA approval in 2016. While still available in the US, Afrezza has had similar concerns associated with its use, and had an FDA "black box" warning added to it to warn about use in patients with chronic lung disease. Afrezza does not currently have Health Canada or European Medicines Agency approval for marketing in Canada or the EU. Human Insulin is a 51 residue peptide hormone produced by recombinant DNA technology by inserting the human insulin gene into Escherichia coli bacteria or Saccharomyces cerevisiae. The structure is identical to native human insulin, with two amino acid chains covalently linked by disulfide bonds. Human insulin is also available in an intermediate-acting form as NPH (Neutral Protamine Hagedorn) as the marketed products Novolin N and Humulin N. NPH insulin is provided as a crystalline suspension of insulin with protamine and zinc, resulting in an onset of action in 1 to 3 hours, duration of action up to 24 hours, and peak action from 6 to 8 hours. Due to the added crystals, NPH insulin is typically cloudy when compared to other forms of insulin and has a neutral pH. Without an adequate supply of insulin to promote absorption of glucose from the bloodstream, blood sugar levels can climb to dangerously high levels and can result in symptoms such as fatigue, headache, blurred vision, and increased thirst. If left untreated, the body starts to break down fat, instead of glucose, for energy which results in a build-up of ketone acids in the blood and a syndrome called ketoacidosis, which is a life-threatening medical emergency. In the long term, elevated blood sugar levels increase the risk of heart attack, stroke, and diabetic neuropathy. |
| PubChem ID: | 16131098 |
| CasNo: | 9004-10-8 |
| Repositioning for NAFLD: | Yes |
| SMILES: | S1SC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H]2NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CN)[C@H](CC)C)C(C)C)CCC(=O)O)CCC(=O)N)CSSC2)CSSC[C@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](N)Cc2ccccc2)C(C)C)CC(=O)N)CCC(=O)N)Cc2[nH]cnc2)CC(C)C)C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N2[C@@H](CCC2)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O)[C@H](O)C)Cc2ccc(O)cc2)Cc2ccccc2)Cc2ccccc2)CCCNC(=N)N)CCC(=O)O)C1)Cc1ccc(O)cc1)C)Cc1[nH]cnc1)CO)[C@H](O)C)CO)[C@H](CC)C)CO)CC(C)C)Cc1ccc(O)cc1)CCC(=O)N)CC(C)C)CCC(=O)O)CC(=O)N)Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)N)C(=O)O |
| Structure: |
|
| InChiKey: | NOESYZHRGYRDHS-ZYCCASTOSA-N |
| Molecular Weight: | 5777.645 |
| DrugBank Targets: | Insulin receptor agonist; Insulin-like growth factor 1 receptor activator; Carboxypeptidase E modulator&product of; Protein NOV homolog downregulator; Low-density lipoprotein receptor-related protein 2 substrate; Insulin-like growth factor-binding protein |
| DrugBank MoA: | The primary activity of insulin is the regulation of glucose metabolism. Insulin promotes glucose and amino acid uptake into muscle and adipose tissues, and other tissues except brain and liver. It also has an anabolic role in stimulating glycogen, fatty acid, and protein synthesis. Insulin inhibits gluconeogenesis in the liver. Insulin binds to the insulin receptor (IR), a heterotetrameric protein consisting of two extracellular alpha units and two transmembrane beta units. The binding of insulin to the alpha subunit of IR stimulates the tyrosine kinase activity intrinsic to the beta subunit of the receptor. The bound receptor is able to autophosphorylate and phosphorylate numerous intracellular substrates such as insulin receptor substrates (IRS) proteins, Cbl, APS, Shc and Gab 1. These activated proteins, in turn, lead to the activation of downstream signaling molecules including PI3 kinase and Akt. Akt regulates the activity of glucose transporter 4 (GLUT4) and protein kinase C (PKC) which play a critical role in metabolism and catabolism. |
| DrugBank Pharmacology: | Insulin is a natural hormone produced by beta cells of the pancreas. In non-diabetic individuals, a basal level of insulin is supplemented with insulin spikes following meals. Postprandial insulin spikes are responsible for the metabolic changes that occur as the body transitions from a postabsorptive to absorptive state. Insulin promotes cellular uptake of glucose, particularly in muscle and adipose tissues, promotes energy storage via glycogenesis, opposes catabolism of energy stores, increases DNA replication and protein synthesis by stimulating amino acid uptake by liver, muscle and adipose tissue, and modifies the activity of numerous enzymes involved in glycogen synthesis and glycolysis. Insulin also promotes growth and is required for the actions of growth hormone (e.g. protein synthesis, cell division, DNA synthesis). |
| DrugBank Indication: | Human insulin is indicated to improve glycemic control in adults and pediatric patients with diabetes mellitus. |
| Targets: | INSR agonist; CPE modulator&product of |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 2 on-going (NCT04616014) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0002 | NCT03953456 | Phase 2 | Terminated | No Results Available | August 16, 2019 | August 31, 2020 | Details |
| L0004 | NCT04475276 | Phase 4 | Recruiting | No Results Available | February 23, 2021 | July 7, 2021 | Details |
| L0013 | NCT00262964 | Not applicable | Completed | Has Results | October 2004 | July 11, 2018 | Details |
| L0014 | NCT02491905 | Phase 2 | Completed | No Results Available | November 2013 | July 8, 2015 | Details |
| L0015 | NCT01963845 | Phase 2 | Completed | Has Results | January 2014 | October 20, 2016 | Details |
| L0017 | NCT05084404 | Phase 2 | Recruiting | No Results Available | October 14, 2021 | November 17, 2021 | Details |
| L0018 | NCT04330326 | Phase 2 | Unknown status | No Results Available | July 20, 2019 | April 1, 2020 | Details |
| L0019 | NCT01759628 | Phase 2 | Completed | No Results Available | April 2012 | June 13, 2013 | Details |
| L0021 | NCT01285362 | Not applicable | Completed | No Results Available | March 2013 | March 9, 2015 | Details |
| L0033 | NCT04109742 | Phase 2 | Withdrawn | No Results Available | December 9, 2019 | September 27, 2021 | Details |
| L0039 | NCT01277094 | Phase 1 | Completed | No Results Available | April 2011 | November 2, 2016 | Details |
| L0046 | NCT04640324 | Not applicable | Completed | No Results Available | January 16, 2017 | November 24, 2020 | Details |
| L0049 | NCT02147925 | Phase 4 | Completed | No Results Available | August 2014 | May 18, 2018 | Details |
| L0053 | NCT01084486 | Phase 1/Phase 2 | Completed | No Results Available | -- | March 10, 2010 | Details |
| L0055 | NCT04142749 | Phase 3 | Recruiting | No Results Available | November 15, 2019 | August 21, 2020 | Details |
| L0057 | NCT04216589 | Phase 2 | Recruiting | No Results Available | October 1, 2020 | January 31, 2022 | Details |
| L0059 | NCT03434613 | Phase 4 | Completed | No Results Available | May 14, 2018 | July 9, 2021 | Details |
| L0061 | NCT01006889 | Phase 4 | Completed | Has Results | January 2008 | September 28, 2016 | Details |
| L0063 | NCT01654549 | Phase 2 | Completed | Has Results | April 2012 | June 28, 2018 | Details |
| L0066 | NCT02649465 | Phase 4 | Completed | No Results Available | November 11, 2015 | July 2, 2021 | Details |
| L0067 | NCT03796975 | Phase 4 | Completed | No Results Available | June 28, 2018 | August 7, 2020 | Details |
| L0070 | NCT02303730 | Phase 4 | Completed | No Results Available | March 2015 | August 28, 2019 | Details |
| L0071 | NCT00736385 | Phase 4 | Terminated | Has Results | April 2009 | December 7, 2016 | Details |
| L0076 | NCT04038853 | Phase 4 | Completed | No Results Available | December 1, 2015 | July 31, 2019 | Details |
| L0077 | NCT03467217 | Phase 2 | Terminated | Has Results | October 2, 2018 | October 21, 2021 | Details |
| L0080 | NCT05067621 | Phase 3 | Not yet recruiting | No Results Available | June 2022 | February 10, 2022 | Details |
| L0081 | NCT03068065 | Phase 4 | Completed | No Results Available | May 2014 | March 1, 2017 | Details |
| L0082 | NCT02696941 | Phase 1 | Completed | No Results Available | February 2016 | May 4, 2018 | Details |
| L0092 | NCT03436420 | Phase 2 | Terminated | Has Results | March 29, 2018 | December 31, 2020 | Details |
| L0101 | NCT01289639 | Not applicable | Terminated | Has Results | October 2005 | August 17, 2017 | Details |
| L0102 | NCT01147523 | Phase 2 | Completed | No Results Available | January 2010 | January 20, 2012 | Details |
| L0103 | NCT02365233 | Phase 4 | Terminated | Has Results | May 1, 2013 | July 31, 2018 | Details |
| L0104 | NCT02265276 | Phase 3 | Unknown status | No Results Available | October 2014 | October 16, 2014 | Details |
| L0105 | NCT02927314 | Phase 2 | Completed | No Results Available | November 27, 2017 | March 17, 2020 | Details |
| L0106 | NCT03617263 | Phase 2 | Recruiting | No Results Available | December 4, 2018 | November 30, 2021 | Details |
| L0109 | NCT00252499 | Not applicable | Terminated | Has Results | October 2005 | August 20, 2014 | Details |
| L0111 | NCT02826525 | Phase 1 | Completed | No Results Available | July 18, 2016 | April 1, 2021 | Details |
| L0115 | NCT02546609 | Phase 2 | Completed | Has Results | November 19, 2015 | May 2, 2018 | Details |
| L0116 | NCT01876108 | Phase 2 | Completed | No Results Available | July 2012 | July 8, 2013 | Details |
| L0119 | NCT03969719 | Phase 2 | Completed | No Results Available | July 18, 2019 | August 5, 2021 | Details |
| L0120 | NCT00994682 | Phase 4 | Completed | Has Results | December 2008 | April 5, 2017 | Details |
| L0124 | NCT00694746 | Phase 1 | Terminated | No Results Available | June 2008 | January 29, 2016 | Details |
| L0127 | NCT03371355 | Phase 2 | Completed | Has Results | December 21, 2017 | February 1, 2021 | Details |
| L0129 | NCT01265498 | Phase 2 | Completed | Has Results | March 2011 | April 6, 2018 | Details |
| L0132 | NCT02330549 | Phase 2 | Completed | Has Results | July 17, 2015 | October 11, 2019 | Details |
| L0136 | NCT04315350 | Not applicable | Recruiting | No Results Available | December 1, 2019 | October 8, 2021 | Details |
| L0139 | NCT03639623 | Phase 2 | Recruiting | No Results Available | February 25, 2019 | January 5, 2022 | Details |
| L0147 | NCT01355575 | Phase 4 | Terminated | Has Results | May 2011 | October 28, 2020 | Details |
| L0160 | NCT01399645 | Phase 2 | Completed | No Results Available | May 2011 | August 27, 2014 | Details |
| L0163 | NCT02500147 | Phase 4 | Suspended | No Results Available | September 8, 2011 | February 5, 2020 | Details |
| L0178 | NCT04616014 | Phase 2 | Recruiting | No Results Available | March 1, 2021 | January 10, 2022 | Details |
| L0179 | NCT00681408 | Phase 2/Phase 3 | Completed | No Results Available | March 2007 | May 29, 2015 | Details |
| L0182 | NCT03421431 | Phase 2 | Completed | Has Results | April 25, 2018 | September 16, 2021 | Details |
| L0183 | NCT03008070 | Phase 2 | Completed | Has Results | February 7, 2017 | April 12, 2021 | Details |
| L0184 | NCT05254626 | Phase 4 | Not yet recruiting | No Results Available | March 2022 | February 24, 2022 | Details |
| L0185 | NCT01913470 | Phase 2 | Completed | Has Results | July 2013 | May 15, 2017 | Details |
| L0191 | NCT00596934 | Phase 2 | Completed | Has Results | February 2006 | November 24, 2017 | Details |
| L0201 | NCT03863574 | Phase 2 | Completed | No Results Available | June 12, 2019 | December 14, 2020 | Details |
| L0202 | NCT01066364 | Phase 2 | Completed | Has Results | February 2010 | July 21, 2020 | Details |
| L0207 | NCT03883607 | Phase 2 | Terminated | Has Results | June 25, 2019 | October 28, 2021 | Details |
| L0209 | NCT05039450 | Phase 2 | Recruiting | No Results Available | July 30, 2021 | February 17, 2022 | Details |
| L0220 | NCT02442687 | Phase 2 | Completed | Has Results | August 1, 2015 | January 7, 2019 | Details |
| L0223 | NCT04134091 | Phase 2 | Completed | No Results Available | August 27, 2019 | February 25, 2022 | Details |
| L0228 | NCT02970942 | Phase 2 | Completed | Has Results | November 30, 2016 | November 16, 2021 | Details |
| L0239 | NCT03551522 | Phase 2 | Terminated | No Results Available | April 30, 2018 | January 11, 2022 | Details |
| L0243 | NCT01694849 | Phase 2 | Completed | No Results Available | September 2012 | January 14, 2016 | Details |
| L0257 | NCT03723252 | Phase 3 | Recruiting | No Results Available | March 20, 2019 | June 22, 2021 | Details |
| L0258 | NCT00501592 | Phase 2 | Completed | Has Results | July 2007 | April 20, 2012 | Details |
| L0271 | NCT04342793 | Phase 2 | Recruiting | No Results Available | December 4, 2019 | January 13, 2021 | Details |
| L0282 | NCT03576755 | Phase 1/Phase 2 | Recruiting | No Results Available | January 9, 2019 | August 25, 2021 | Details |
| L0314 | NCT01934777 | Phase 3 | Completed | No Results Available | October 2013 | January 14, 2016 | Details |
| L0321 | NCT02098317 | Phase 3 | Completed | No Results Available | January 2014 | January 14, 2016 | Details |
| L0325 | NCT05011305 | Phase 2 | Recruiting | No Results Available | August 18, 2021 | August 19, 2021 | Details |
| L0329 | NCT02653300 | Phase 2 | Completed | Has Results | September 20, 2018 | September 23, 2021 | Details |
| L0351 | NCT04389775 | Phase 1 | Completed | No Results Available | March 29, 2020 | October 28, 2021 | Details |
| L0361 | NCT00323414 | Phase 2 | Completed | Has Results | April 2006 | February 23, 2018 | Details |
| L0375 | JPRN-jRCT2031210380 | Phase 2 | Recruiting | No Results Available | 20/10/2021 | 7 February 2022 | Details |
| L0388 | ChiCTR2100044996 | Not applicable | Recruiting | No Results Available | 03/04/2021 | 2 November 2021 | Details |
| L0391 | JPRN-jRCTs071200113 | Not applicable | Recruiting | No Results Available | 11/03/2021 | 10 January 2022 | Details |
| L0406 | NCT04618744 | Phase 2 | Recruiting | No Results Available | 01/11/2020 | 21 December 2021 | Details |
| L0412 | ChiCTR2000038111 | Not applicable | Not Recruiting | No Results Available | 11/09/2020 | 24 November 2020 | Details |
| L0416 | ChiCTR2000036225 | Phase 0 | Not Recruiting | No Results Available | 22/08/2020 | 7 September 2020 | Details |
| L0417 | ChiCTR2000036224 | Phase 0 | Not Recruiting | No Results Available | 22/08/2020 | 7 September 2020 | Details |
| L0418 | ChiCTR2000035899 | Phase 0 | Not Recruiting | No Results Available | 19/08/2020 | 24 August 2020 | Details |
| L0431 | NCT04321395 | Phase 2 | Not recruiting | No Results Available | 23/03/2020 | 12 April 2021 | Details |
| L0441 | ChiCTR2000029144 | Not applicable | Not Recruiting | No Results Available | 15/01/2020 | 20 January 2020 | Details |
| L0447 | IRCT20140107016123N14 | Not applicable | Recruiting | No Results Available | 04/12/2019 | 17 December 2019 | Details |
| L0449 | IRCT20191124045488N1 | Phase 2 | Recruiting | No Results Available | 29/11/2019 | 17 December 2019 | Details |
| L0459 | ISRCTN12833814 | Not applicable | Not Recruiting | No Results Available | 07/08/2019 | 14 September 2020 | Details |
| L0461 | ChiCTR1900024866 | Phase 0 | Recruiting | No Results Available | 31/07/2019 | 27 August 2019 | Details |
| L0473 | JPRN-jRCT1031180386 | Not applicable | Recruiting | No Results Available | 20/03/2019 | 17 May 2021 | Details |
| L0478 | JPRN-jRCTs031180159 | Not applicable | Not Recruiting | Has Results | 26/02/2019 | 10 January 2022 | Details |
| L0479 | EUCTR2016-002045-36-GB | Phase 2 | Not Recruiting | No Results Available | 05/02/2019 | 20 July 2020 | Details |
| L0480 | IRCT20180908040972N1 | Phase 3 | Recruiting | No Results Available | 19/01/2019 | 29 January 2019 | Details |
| L0491 | IRCT20100524004010N25 | Not applicable | Not Recruiting | No Results Available | 24/07/2018 | 25 February 2019 | Details |
| L0492 | IRCT20180412039284N2 | Not applicable | Not Recruiting | No Results Available | 19/07/2018 | 11 September 2018 | Details |
| L0493 | EUCTR2017-004365-27-GB | Phase 2 | Not Recruiting | No Results Available | 04/07/2018 | 16 December 2019 | Details |
| L0496 | EUCTR2017-004365-27-FR | Phase 2 | Not Recruiting | No Results Available | 02/07/2018 | 10 December 2019 | Details |
| L0498 | EUCTR2017-003172-32-GB | Phase 2 | Not Recruiting | No Results Available | 16/05/2018 | 9 November 2020 | Details |
| L0499 | IRCT20100524004010N24 | Not applicable | Not Recruiting | No Results Available | 14/05/2018 | 18 June 2018 | Details |
| L0500 | IRCT20180412039284N1 | Not applicable | Not Recruiting | No Results Available | 09/05/2018 | 18 June 2018 | Details |
| L0503 | IRCT20100524004010N23 | Not applicable | Not Recruiting | No Results Available | 18/04/2018 | 21 May 2018 | Details |
| L0507 | NCT03459079 | Phase 2 | Recruiting | No Results Available | 02/03/2018 | 12 April 2021 | Details |
| L0508 | IRCT20140307016876N3 | Phase 3 | Recruiting | No Results Available | 25/02/2018 | 26 March 2018 | Details |
| L0512 | IRCT20100123003140N15 | Phase 2/Phase 3 | Recruiting | No Results Available | 14/01/2018 | 22 February 2018 | Details |
| L0514 | IRCT20160920029889N1 | Phase 3 | Not Recruiting | No Results Available | 09/01/2018 | 22 February 2018 | Details |
| L0517 | JPRN-UMIN000030355 | Not applicable | Recruiting | No Results Available | 15/12/2017 | 17 May 2021 | Details |
| L0520 | IRCT2017103030489N2 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 16/11/2017 | 22 February 2018 | Details |
| L0523 | IRCT201703194010N18 | Not applicable | Not Recruiting | No Results Available | 13/10/2017 | 22 February 2018 | Details |
| L0527 | NCT03222206 | Phase 4 | Not recruiting | No Results Available | 08/07/2017 | 12 December 2020 | Details |
| L0529 | IRCT201406183664N12 | Phase 2 | Not Recruiting | No Results Available | 18/01/2015 | 22 February 2018 | Details |
| L0532 | EUCTR2009-015927-94-GB | Phase 4 | Not Recruiting | Has Results | 17/03/2010 | 25 November 2019 | Details |
| L0540 | IRCT2017053034222N1 | Phase 3 | Recruiting | No Results Available | 28/06/2017 | 26 March 2018 | Details |
| L0544 | IRCT2017012031423N1 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 22/05/2017 | 22 February 2018 | Details |
| L0548 | DRKS00005767 | Phase 3 | Not Recruiting | No Results Available | 10/05/2017 | 7 February 2022 | Details |
| L0552 | IRCT201701172709N44 | Phase 3 | Not Recruiting | No Results Available | 10/04/2017 | 13 July 2020 | Details |
| L0558 | IRCT2016102530489N1 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 06/02/2017 | 22 February 2018 | Details |
| L0559 | NCT03042767 | Phase 2 | Not recruiting | No Results Available | 02/02/2017 | 12 December 2020 | Details |
| L0562 | IRCT201610269472N11 | Phase 2 | Recruiting | No Results Available | 22/11/2016 | 22 February 2018 | Details |
| L0563 | NCT02973295 | Phase 4 | Not recruiting | No Results Available | 04/11/2016 | 12 December 2020 | Details |
| L0565 | ChiCTR-IOR-16009599 | Other | Not Recruiting | No Results Available | 25/10/2016 | 18 April 2017 | Details |
| L0566 | JPRN-UMIN000023044 | Not applicable | Not Recruiting | No Results Available | 21/10/2016 | 2 April 2019 | Details |
| L0567 | NCT02941549 | Phase 2 | Not recruiting | No Results Available | 20/10/2016 | 12 December 2020 | Details |
| L0569 | EUCTR2016-001979-70-BE | Phase 2 | Not Recruiting | No Results Available | 23/09/2016 | 2 June 2020 | Details |
| L0571 | IRCT2016061516123N8 | Not applicable | Recruiting | No Results Available | 28/08/2016 | 22 February 2018 | Details |
| L0574 | IRCT2016071915536N3 | Not applicable | Not Recruiting | No Results Available | 02/08/2016 | 22 February 2018 | Details |
| L0577 | NCT02842567 | Phase 3 | Not recruiting | No Results Available | 13/07/2016 | 12 December 2020 | Details |
| L0582 | ChiCTR-IOR-16008602 | Other | Not Recruiting | No Results Available | 06/06/2016 | 18 April 2017 | Details |
| L0583 | IRCT2016040727265N1 | Phase 3 | Not Recruiting | No Results Available | 29/05/2016 | 22 February 2018 | Details |
| L0584 | IRCT2015122425686N1 | Not applicable | Not Recruiting | No Results Available | 10/05/2016 | 22 February 2018 | Details |
| L0587 | EUCTR2015-004336-35-ES | Phase 2 | Not Recruiting | No Results Available | 18/03/2016 | 28 February 2019 | Details |
| L0588 | JPRN-UMIN000021291 | Not selected | Not Recruiting | No Results Available | 02/03/2016 | 2 April 2019 | Details |
| L0592 | EUCTR2015-005385-38-BE | Phase 3 | Not Recruiting | No Results Available | 29/01/2016 | 16 November 2020 | Details |
| L0593 | JPRN-UMIN000020544 | Not selected | Not Recruiting | No Results Available | 13/01/2016 | 21 May 2019 | Details |
| L0596 | IRCT201511143320N12 | Not applicable | Not Recruiting | No Results Available | 24/12/2015 | 22 February 2018 | Details |
| L0598 | ACTRN12615001355561 | Phase 1 | Not Recruiting | No Results Available | 14/12/2015 | 13 January 2020 | Details |
| L0601 | NCT02605616 | Phase 2 | Not recruiting | No Results Available | 18/09/2015 | 12 December 2020 | Details |
| L0617 | IRCT201410052394N13 | Phase 2 | Not Recruiting | No Results Available | 14/12/2014 | 22 February 2018 | Details |
| L0619 | NCT02290106 | Not applicable | Not recruiting | Has Results | 08/11/2014 | 12 December 2020 | Details |
| L0620 | NCT02316717 | Phase 2 | Not recruiting | Has Results | 06/11/2014 | 12 December 2020 | Details |
| L0622 | IRCT201408312709N29 | Phase 3 | Not Recruiting | No Results Available | 11/10/2014 | 22 February 2018 | Details |
| L0624 | NCT02234440 | Not applicable | Not recruiting | No Results Available | 31/08/2014 | 12 December 2020 | Details |
| L0630 | ChiCTR-TRC-14004464 | Other | Not Recruiting | No Results Available | 18/03/2014 | 18 April 2017 | Details |
| L0631 | TCTR20140303003 | Phase 3 | Not Recruiting | No Results Available | 03/03/2014 | 7 February 2022 | Details |
| L0635 | IRCT201301223140N6 | Phase 2 | Not Recruiting | No Results Available | 16/01/2014 | 22 February 2018 | Details |
| L0636 | JPRN-UMIN000000642 | Phase 4 | Not Recruiting | No Results Available | 31/12/2013 | 2 April 2019 | Details |
| L0638 | JPRN-UMIN000012351 | Not selected | Not Recruiting | No Results Available | 25/11/2013 | 2 April 2019 | Details |
| L0639 | IRCT2013071313069N2 | Phase 3 | Not Recruiting | No Results Available | 22/09/2013 | 22 February 2018 | Details |
| L0641 | EUCTR2013-002984-24-AT | Not applicable | Not Recruiting | No Results Available | 31/07/2013 | 16 February 2015 | Details |
| L0643 | IRCT2012122911920N1 | Not applicable | Not Recruiting | No Results Available | 19/05/2013 | 22 February 2018 | Details |
| L0646 | IRCT201207114010N9 | Phase 2 | Not Recruiting | No Results Available | 11/01/2013 | 22 February 2018 | Details |
| L0647 | IRCT201012084010N4 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 30/11/2012 | 22 February 2018 | Details |
| L0651 | EUCTR2012-000295-42-BE | Phase 2 | Not Recruiting | No Results Available | 16/08/2012 | 22 August 2016 | Details |
| L0654 | EUCTR2012-000975-18-DE | Not applicable | Not Recruiting | No Results Available | 03/07/2012 | 27 October 2014 | Details |
| L0655 | EUCTR2012-001975-36-IT | Not applicable | Authorised | No Results Available | 14/06/2012 | 7 January 2013 | Details |
| L0658 | EUCTR2011-003010-17-IT | Not applicable | Authorised | No Results Available | 07/03/2012 | 24 April 2012 | Details |
| L0660 | JPRN-UMIN000007260 | Not selected | Not Recruiting | No Results Available | 10/02/2012 | 2 April 2019 | Details |
| L0662 | IRCT201109197590N1 | Phase 2 | Not Recruiting | No Results Available | 23/12/2011 | 22 February 2018 | Details |
| L0664 | IRCT201105026361N1 | Phase 2 | Not Recruiting | No Results Available | 16/11/2011 | 22 February 2018 | Details |
| L0670 | JPRN-UMIN000004972 | Not selected | Not Recruiting | No Results Available | 01/02/2011 | 2 April 2019 | Details |
| L0671 | JPRN-UMIN000004512 | Not selected | Recruiting | No Results Available | 01/12/2010 | 2 April 2019 | Details |
| L0673 | EUCTR2010-021515-17-GB | Not applicable | Not Recruiting | No Results Available | 08/10/2010 | 5 November 2012 | Details |
| L0676 | ISRCTN81956288 | Not applicable | Not Recruiting | No Results Available | 19/05/2010 | 17 October 2016 | Details |
| L0677 | EUCTR2009-016761-29-GB | Phase 2 | Not Recruiting | No Results Available | 16/04/2010 | 10 December 2019 | Details |
| L0679 | EUCTR2008-002325-37-DE | Not applicable | Authorised | No Results Available | 04/08/2009 | 19 March 2012 | Details |
| L0681 | ChiCTR-TRC-09000404 | Post-market | Not Recruiting | No Results Available | 19/05/2009 | 18 April 2017 | Details |
| L0682 | ISRCTN81902209 | Not applicable | Not Recruiting | Has Results | 13/05/2009 | 13 May 2019 | Details |
| L0683 | EUCTR2008-006928-55-GB | Not applicable | Not Recruiting | No Results Available | 15/04/2009 | 19 March 2012 | Details |
| L0684 | NCT00870012 | Not applicable | Not recruiting | No Results Available | 25/03/2009 | 19 February 2015 | Details |
| L0690 | EUCTR2007-004515-56-AT | Phase 3 | Not Recruiting | No Results Available | 25/03/2008 | 26 October 2020 | Details |
| L0691 | EUCTR2007-005531-28-SE | Not applicable | Not Recruiting | No Results Available | 15/02/2008 | 10 July 2015 | Details |
| L0693 | EUCTR2007-002114-19-GB | Not applicable | Not Recruiting | No Results Available | 13/12/2007 | 19 March 2012 | Details |
| L0694 | EUCTR2007-002114-19-DE | Not applicable | Not Recruiting | No Results Available | 30/11/2007 | 7 January 2013 | Details |
| L0696 | EUCTR2007-003012-61-PT | Not applicable | Not Recruiting | No Results Available | 17/08/2007 | 19 March 2012 | Details |
| L0697 | EUCTR2007-003013-14-PT | Not applicable | Not Recruiting | No Results Available | 17/08/2007 | 11 September 2012 | Details |
| L0698 | ACTRN12606000411549 | Phase 2 | Not Recruiting | No Results Available | 20/09/2006 | 13 January 2020 | Details |
| L0700 | NCT04411862 | Phase 3 | Not recruiting | No Results Available | 10/05/2020 | 12 December 2020 | Details |
| L0703 | KCT0004923 | Not applicable | Recruiting | No Results Available | 16/04/2020 | 21 April 2020 | Details |
| L0705 | NCT04308980 | Phase 2/Phase 3 | Recruiting | No Results Available | 12/03/2020 | 16 February 2021 | Details |
| L0708 | IRCT20191009045043N1 | Phase 2/Phase 3 | Recruiting | No Results Available | 20/01/2020 | 24 February 2020 | Details |
| L0711 | IRCT20120718010333N5 | Phase 3 | Not Recruiting | No Results Available | 25/12/2019 | 26 May 2021 | Details |
| L0712 | IRCT20190819044565N2 | Phase 3 | Recruiting | No Results Available | 24/12/2019 | 13 January 2020 | Details |
| L0714 | IRCT20150205020965N5 | Phase 3 | Not Recruiting | No Results Available | 13/12/2019 | 17 August 2020 | Details |
| L0715 | IRCT20150205020965N4 | Phase 3 | Not Recruiting | No Results Available | 13/12/2019 | 6 October 2020 | Details |
| L0717 | IRCT20191015045113N1 | Phase 3 | Not Recruiting | No Results Available | 08/12/2019 | 17 December 2019 | Details |
| L0719 | IRCT20120415009472N20 | Phase 2 | Recruiting | No Results Available | 12/11/2019 | 17 December 2019 | Details |
| L0720 | IRCT20190901044662N1 | Not applicable | Not Recruiting | No Results Available | 07/11/2019 | 17 December 2019 | Details |
| L0723 | NCT04198805 | Phase 2 | Recruiting | No Results Available | 30/10/2019 | 24 January 2022 | Details |
| L0725 | SLCTR/2019/038 | Phase 2 | Not Recruiting | No Results Available | 16/10/2019 | 7 February 2022 | Details |
| L0727 | NCT04130321 | Not applicable | Not recruiting | No Results Available | 03/10/2019 | 7 September 2021 | Details |
| L0729 | NCT04117802 | Not applicable | Not recruiting | No Results Available | 30/09/2019 | 31 January 2022 | Details |
| L0733 | NCT04073407 | Not applicable | Not recruiting | No Results Available | 27/08/2019 | 12 December 2020 | Details |
| L0734 | NCT04073368 | Not applicable | Not recruiting | Has Results | 27/08/2019 | 12 July 2021 | Details |
| L0736 | IRCT20181119041701N1 | Phase 3 | Not Recruiting | No Results Available | 05/07/2019 | 26 August 2019 | Details |
| L0738 | CTRI/2019/07/020021 | Phase 1/Phase 2 | Not Recruiting | No Results Available | 04/07/2019 | 24 November 2021 | Details |
| L0740 | JPRN-jRCTs031190040 | Not applicable | Not Recruiting | Has Results | 17/06/2019 | 10 January 2022 | Details |
| L0743 | IRCT20180903040941N1 | Not applicable | Recruiting | No Results Available | 03/06/2019 | 26 August 2019 | Details |
| L0747 | ACTRN12619000701123 | Phase 3 | Not Recruiting | No Results Available | 09/05/2019 | 15 July 2019 | Details |
| L0749 | IRCT20170206032417N4 | Not applicable | Recruiting | No Results Available | 28/04/2019 | 21 May 2019 | Details |
| L0751 | NCT03925701 | Phase 3 | Recruiting | No Results Available | 22/04/2019 | 12 December 2020 | Details |
| L0752 | NCT03919929 | Phase 2/Phase 3 | Recruiting | No Results Available | 15/04/2019 | 7 June 2021 | Details |
| L0758 | CTRI/2018/03/012723 | Not applicable | Recruiting | No Results Available | 21/03/2018 | 24 November 2021 | Details |
| L0759 | NCT02178839 | Not applicable | Not recruiting | No Results Available | 18/06/2014 | 19 February 2015 | Details |
| L0764 | NCT03864783 | Not applicable | Not recruiting | No Results Available | 26/02/2019 | 16 February 2021 | Details |
| L0768 | IRCT20110530006652N2 | Phase 3 | Not Recruiting | No Results Available | 07/02/2019 | 18 May 2020 | Details |
| L0774 | IRCT20150124020765N2 | Phase 3 | Recruiting | No Results Available | 06/01/2019 | 29 January 2019 | Details |
| L0777 | IRCT20181005041238N1 | Phase 0 | Recruiting | No Results Available | 13/12/2018 | 14 January 2019 | Details |
| L0782 | NCT03738358 | Not applicable | Not recruiting | No Results Available | 08/11/2018 | 12 December 2020 | Details |
| L0783 | NCT03734510 | Not applicable | Not recruiting | No Results Available | 06/11/2018 | 12 December 2020 | Details |
| L0784 | NCT03749070 | Not applicable | Recruiting | No Results Available | 28/10/2018 | 7 February 2022 | Details |
| L0791 | NCT03627819 | Not applicable | Not recruiting | No Results Available | 18/07/2018 | 12 December 2020 | Details |
| L0792 | IRCT20170430033730N2 | Not applicable | Not Recruiting | No Results Available | 02/07/2018 | 11 September 2018 | Details |
| L0800 | NCT03439917 | Not applicable | Not recruiting | No Results Available | 14/02/2018 | 13 December 2021 | Details |
| L0804 | NCT03377153 | Not applicable | Recruiting | No Results Available | 08/12/2017 | 8 January 2018 | Details |
| L0805 | NCT03377140 | Not applicable | Recruiting | No Results Available | 08/12/2017 | 8 January 2018 | Details |
| L0811 | SLCTR/2017/033 | Not applicable | Not Recruiting | No Results Available | 28/09/2017 | 7 February 2022 | Details |
| L0821 | TCTR20170511001 | Phase 4 | Not Recruiting | Has Results | 11/05/2017 | 7 February 2022 | Details |
| L0825 | IRCT201405251485N13 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 14/03/2017 | 22 February 2018 | Details |
| L0826 | IRCT2017012232109N1 | Phase 2 | Not Recruiting | No Results Available | 12/03/2017 | 22 February 2018 | Details |
| L0829 | NCT03073343 | Not applicable | Recruiting | No Results Available | 20/02/2017 | 12 December 2020 | Details |
| L0832 | JPRN-UMIN000025866 | Not selected | Not Recruiting | No Results Available | 26/01/2017 | 2 April 2019 | Details |
| L0834 | NCT02983669 | Not applicable | Not recruiting | No Results Available | 02/12/2016 | 16 December 2017 | Details |
| L0835 | NCT03047668 | Not applicable | Recruiting | No Results Available | 21/11/2016 | 12 December 2020 | Details |
| L0836 | IRCT2015120925447N1 | Not applicable | Not Recruiting | No Results Available | 16/10/2016 | 22 February 2018 | Details |
| L0838 | NCT02930161 | Phase 2 | Not recruiting | No Results Available | 06/10/2016 | 12 December 2020 | Details |
| L0839 | IRCT2016082429508N1 | Phase 2 | Not Recruiting | No Results Available | 20/09/2016 | 22 February 2018 | Details |
| L0846 | IRCT2016042827652N1 | Phase 3 | Not Recruiting | No Results Available | 04/05/2016 | 22 February 2018 | Details |
| L0850 | IRCT2016011825957N2 | Not applicable | Not Recruiting | No Results Available | 09/02/2016 | 22 February 2018 | Details |
| L0851 | IRCT201511233664N16 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 08/02/2016 | 22 February 2018 | Details |
| L0853 | IRCT2016010411991N3 | Not applicable | Not Recruiting | No Results Available | 22/01/2016 | 22 February 2018 | Details |
| L0855 | NCT02654665 | Phase 3 | Not recruiting | No Results Available | 11/01/2016 | 12 December 2020 | Details |
| L0858 | NCT02642172 | Not applicable | Not recruiting | No Results Available | 13/12/2015 | 13 September 2021 | Details |
| L0863 | SLCTR/2015/023 | Phase 2 | Recruiting | No Results Available | 03/10/2015 | 7 February 2022 | Details |
| L0866 | SLCTR/2015/019 | Phase 2 | Not Recruiting | No Results Available | 15/09/2015 | 7 February 2022 | Details |
| L0870 | IRCT201503273320N11 | Not applicable | Not Recruiting | No Results Available | 27/07/2015 | 18 June 2018 | Details |
| L0871 | JPRN-UMIN000018361 | Not selected | Recruiting | No Results Available | 21/07/2015 | 2 April 2019 | Details |
| L0873 | IRCT201506222480N6 | Phase 3 | Not Recruiting | No Results Available | 12/07/2015 | 22 February 2018 | Details |
| L0876 | NCT02457286 | Phase 1 | Not recruiting | No Results Available | 14/05/2015 | 16 December 2017 | Details |
| L0878 | IRCT2015030721358N1 | Not applicable | Not Recruiting | No Results Available | 11/04/2015 | 22 February 2018 | Details |
| L0883 | NCT02491229 | Not applicable | Not recruiting | No Results Available | 03/02/2015 | 25 January 2016 | Details |
| L0889 | NTR4913 | Not applicable | Not Recruiting | No Results Available | -- | -- | Details |
| L0892 | IRCT2014090210826N14 | Phase 3 | Not Recruiting | No Results Available | 26/09/2014 | 14 January 2019 | Details |
| L0894 | IRCT2013102015083N1 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 01/09/2014 | 22 February 2018 | Details |
| L0897 | NCT02216552 | Phase 2/Phase 3 | Not recruiting | No Results Available | 12/08/2014 | 16 December 2017 | Details |
| L0899 | IRCT2014020516491N1 | Not applicable | Not Recruiting | No Results Available | 09/06/2014 | 22 February 2018 | Details |
| L0901 | JPRN-UMIN000013760 | Not applicable | Recruiting | No Results Available | 18/04/2014 | 2 April 2019 | Details |
| L0903 | NCT02690792 | Not applicable | Not recruiting | No Results Available | 17/03/2014 | 12 December 2020 | Details |
| L0910 | ISRCTN33414972 | Not applicable | Not Recruiting | No Results Available | 16/12/2013 | 27 February 2017 | Details |
| L0920 | IRCT201305254105N12 | Phase 2 | Not Recruiting | No Results Available | 15/06/2013 | 22 February 2018 | Details |
| L0921 | NCT01875978 | Not applicable | Not recruiting | Has Results | 03/06/2013 | 19 October 2017 | Details |
| L0925 | IRCT2012071810333N1 | Not applicable | Not Recruiting | No Results Available | 14/11/2012 | 22 February 2018 | Details |
| L0927 | ACTRN12612001135808 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 24/10/2012 | 13 January 2020 | Details |
| L0932 | KCT0000505 | Phase 4 | Not Recruiting | No Results Available | 14/08/2012 | 11 March 2019 | Details |
| L0934 | ChiCTR-TRC-12002380 | Pilot study | Not Recruiting | No Results Available | 16/07/2012 | 18 April 2017 | Details |
| L0935 | ChiCTR-TRC-12002378 | Pilot study | Not Recruiting | No Results Available | 16/07/2012 | 18 April 2017 | Details |
| L0936 | ChiCTR-TRC-12002377 | Pilot study | Not Recruiting | No Results Available | 16/07/2012 | 18 April 2017 | Details |
| L0938 | EUCTR2012-001371-37-DK | Phase 4 | Not Recruiting | No Results Available | 09/07/2012 | 10 December 2019 | Details |
| L0939 | NCT01623024 | Phase 3 | Not recruiting | No Results Available | 15/06/2012 | 19 February 2015 | Details |
| L0942 | NCT01547910 | Phase 2 | Not recruiting | No Results Available | 29/02/2012 | 19 February 2015 | Details |
| L0944 | NCT01529268 | Phase 2/Phase 3 | Not recruiting | Has Results | 18/01/2012 | 16 December 2017 | Details |
| L0946 | IRCT201111022709N20 | Not applicable | Not Recruiting | No Results Available | 26/12/2011 | 22 February 2018 | Details |
| L0948 | KCT0000193 | Phase 4 | Not Recruiting | No Results Available | 04/10/2011 | 11 March 2019 | Details |
| L0949 | NCT01446276 | Not applicable | Not recruiting | No Results Available | 03/10/2011 | 19 February 2015 | Details |
| L0950 | NCT01553500 | Phase 2 | Not recruiting | No Results Available | 03/10/2011 | 19 February 2015 | Details |
| L0955 | NTR2836 | Not applicable | Not Recruiting | No Results Available | -- | -- | Details |
| L0962 | NCT01016418 | Phase 1/Phase 2 | Not recruiting | No Results Available | 18/11/2009 | 19 February 2015 | Details |
| L0963 | EUCTR2009-015703-13-DE | Not applicable | Not Recruiting | No Results Available | 02/11/2009 | 17 December 2012 | Details |
| L0964 | NCT01002547 | Phase 4 | Not recruiting | Has Results | 23/10/2009 | 12 December 2020 | Details |
| L0970 | NCT00820651 | Phase 3 | Not recruiting | No Results Available | 09/01/2009 | 19 February 2015 | Details |
| L0971 | NCT00819338 | Phase 2 | Not recruiting | No Results Available | 08/01/2009 | 19 February 2015 | Details |
| L0972 | NCT00816465 | Phase 1 | Not recruiting | No Results Available | 31/12/2008 | 19 February 2015 | Details |
| L0974 | CTRI/2008/091/000074 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 09/06/2008 | 24 November 2021 | Details |
| L0976 | NCT00655018 | Phase 2/Phase 3 | Not recruiting | No Results Available | 03/04/2008 | 19 February 2015 | Details |
| L0977 | NCT00633282 | Phase 2 | Not recruiting | No Results Available | 03/03/2008 | 19 February 2015 | Details |
| L0978 | NCT00546455 | Phase 2 | Recruiting | No Results Available | 17/10/2007 | 19 February 2015 | Details |
| L0979 | NCT00509418 | Phase 3 | Not recruiting | No Results Available | 30/07/2007 | 19 February 2015 | Details |
| L0982 | EUCTR2006-001774-24-GB | Not applicable | Authorised | No Results Available | 18/09/2006 | 19 March 2012 | Details |
| L0984 | NCT00230113 | Phase 2 | Not recruiting | No Results Available | 29/09/2005 | 19 February 2015 | Details |
| L0985 | NCT00160407 | Phase 4 | Not recruiting | No Results Available | 08/09/2005 | 19 February 2015 | Details |
| L0987 | NCT00063232 | Phase 2 | Not recruiting | Has Results | 23/06/2003 | 19 October 2017 | Details |
| L0988 | NCT00062764 | Phase 2 | Not recruiting | Has Results | 12/06/2003 | 19 October 2017 | Details |
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00004 | 35258780 | Chin J Integr Med | Protective Roles of Shilajit in Modulating Resistin, Adiponectin, and Cytokines in Rats with Non-alcoholic Fatty Liver Disease. | Details |
| A00009 | 35256195 | Thromb Res | Impaired fibrinolysis without hypercoagulability characterises patients with non-alcoholic fatty liver disease. | Details |
| A00010 | 35255811 | BMC Gastroenterol | The effect of daily consumption of probiotic yogurt on liver enzymes, steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized clinical trial. | Details |
| A00014 | 35254877 | Arch Physiol Biochem | Resveratrol attenuates against high-fat-diet-promoted non-alcoholic fatty liver disease in rats mainly by targeting the miR-34a/SIRT1 axis. | Details |
| A00023 | 35251371 | Dis Markers | Dose-Response Associations of Metabolic Score for Insulin Resistance Index with Nonalcoholic Fatty Liver Disease among a Nonobese Chinese Population: Retrospective Evidence from a Population-Based Cohort Study. | Details |
| A00029 | 35250856 | Front Endocrinol (Lausanne) | Not Enough Fat: Mouse Models of Inherited Lipodystrophy. | Details |
| A00031 | 35250588 | Front Pharmacol | Platelets in Non-alcoholic Fatty Liver Disease. | Details |
| A00034 | 35249505 | Curr Drug Saf | Pioglitazone, Bladder Cancer and the Presumption of Innocence. | Details |
| A00037 | 35248654 | Diabetes Res Clin Pract | Metabolic determinants of NAFLD in adults with type 1 diabetes. | Details |
| A00041 | 35247611 | Mol Metab | Serum Amyloid A1 Exacerbates Hepatic Steatosis via TLR4 Mediated NF-κB Signaling Pathway. | Details |
| A00044 | 35246007 | Bioengineered | Quantitative proteomics analysis based on tandem mass tag labeling coupled with labeling coupled with liquid chromatography-tandem mass spectrometry discovers the effect of silibinin on non-alcoholic fatty liver disease in mice. | Details |
| A00054 | 35241921 | J Inflamm Res | Reduction of Hepatic Steatosis, Oxidative Stress, Inflammation, Ballooning and Insulin Resistance After Therapy with Safranal in NAFLD Animal Model: A New Approach. | Details |
| A00056 | 35240344 | Cell Mol Gastroenterol Hepatol | Activation of Liver mTORC1 Protects Against NASH via Dual Regulation of VLDL-TAG Secretion and De Novo Lipogenesis. | Details |
| A00057 | 35238939 | J Clin Endocrinol Metab | Long or Irregular Menstrual Cycles and Risk of Prevalent and Incident Nonalcoholic Fatty Liver Disease. | Details |
| A00059 | 35238641 | Proc Natl Acad Sci U S A | Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease. | Details |
| A00082 | 35227772 | Life Sci | sSTEAP4 regulates cellular homeostasis and improves high-fat-diet-caused oxidative stress in hepatocytes. | Details |
| A00085 | 35226250 | Cell Biol Toxicol | AS3MT facilitates NLRP3 inflammasome activation by m6A modification during arsenic-induced hepatic insulin resistance. | Details |
| A00089 | 35223701 | Front Pediatr | Association Between Non-invasive Diagnostic Methods of Liver Fibrosis and Type 2 Diabetes in Pediatric Patients With Non-alcoholic Fatty Liver Disease. | Details |
| A00091 | 35222903 | Ther Adv Chronic Dis | Nicotinamide supplementation in diabetic nonalcoholic fatty liver disease patients: randomized controlled trial. | Details |
| A00093 | 35222075 | Front Physiol | MicroRNA-122-5p Inhibition Improves Inflammation and Oxidative Stress Damage in Dietary-Induced Non-alcoholic Fatty Liver Disease Through Targeting FOXO3. | Details |