Research Article Details
| Article ID: | A19184 |
| PMID: | 29188949 |
| Source: | Duodecim |
| Title: | Fatty liver - so what? |
| Abstract: | Approximately one third of the Finnish adult population are affected with overweight-related non-alcoholic fatty liver disease (NAFLD). NAFLD can appear as a simple fat accumulation in the liver of the liver, but in some individuals the condition may advance to non-alcoholic steatohepatitis (NASH) and even to liver cirrhosis. In many cases, NAFLD is detected as an incidental finding. In differential diagnosis, the most common alternatives are alcohol use, drugs and viral hepatites. For a patient with NAFLD, the risk factors of cardiovascular diseases should be investigated and the possibility of having NASH and liver fibrosis assessed. Targeted therapy for NASH is not yet available. |
| DOI: |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S03 | Anti-fibrosis | fibrosis | Angiotensin Receptor Blocker (ARB); CCR2/CCR5 antagonist; Thyroid receptor β agonist; PEGylated human FGF21 analogue; Monoclonal antibody to lysyl oxidase-like 2 (LOXL2); Galectin-3 inhibitor; FGF19 variant | Losartan; Cenicriviroc; VK-2809; MGL-3196; Pegbelfermin; Simtuzumab; GR-MD-02; NGM282 | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |