Research Article Details
| Article ID: | A23861 |
| PMID: | 23424924 |
| Source: | Rev Prat |
| Title: | [Epidemiology and natural history of nonalcoholic fatty liver disease]. |
| Abstract: | Nonalcoholic fatty liver disease (NAFLD) encompasses a spectrum of diseases that ranges from simple steatosis to steatohepatitis (NASH), two entities with strikingly different outcomes. NAFLD is becoming one of the leading causes of chronic liver disease worldwide, but the real prevalence of the disease is still underestimated. NAFLD is strongly linked to insulin resistance and should be suspected in all patients with overweight, obesity, diabetes or other features of metabolic syndrome seeking medical care inside or outside Hepatology clinics. NASH is a slowly progressive fibrotic disease. Patients with NASH may develop cirrhosis, endstage liver disease and hepatocellular carcinoma. The overall and liver-related mortality are increased in patients with NASH compared to general population. |
| DOI: |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S01 | Improve insulin resistance | insulin sensitizer; insulin resistance; glucose tolerance | Biguanide: increases 5-AMP activated protein kinase signaling; SGLT-2 inhibitor; Thiazalidinedione: selective PPAR-γ agonists; GLP-1 agonist | Metformin; Empagliflozin; Canagliflozin; Rosiglitazone; Pioglitazone; Liraglutide | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |