Research Article Details
| Article ID: | A28428 |
| PMID: | 15017657 |
| Source: | Clin Gastroenterol Hepatol |
| Title: | Effect of pioglitazone on biochemical indices of non-alcoholic fatty liver disease in upper body obesity. |
| Abstract: | BACKGROUND & AIMS: The aim of our study is to report our observations on the change in liver function tests of volunteers receiving pioglitazone as part of a study of its effects on fatty acid metabolism. Treatment with other thiazolidinediones has been reported to ameliorate non-alcoholic fatty liver disease (NAFLD) in obese and diabetic humans, but whether pioglitazone has similar effects has not been reported. METHODS: Five of 20 upper body obese volunteers (10 men, 10 premenopausal women) had abnormal baseline liver enzymes (3 had ultrasonographic evidence of hepatic steatosis). All volunteers were treated with 30 mg pioglitazone per day for 18 +/- 0.4 weeks. Body composition, blood lipids, and insulin sensitivity (intravenous glucose tolerance test) were assessed at baseline and after pioglitazone treatment. RESULTS: During pioglitazone treatment, the liver enzyme abnormalities uniformly improved in subjects with evidence of NAFLD, primarily during the first 2 months. Some parameters of insulin sensitivity improved when measured after 18 weeks of pioglitazone treatment. Liver function tests remained normal in the 15 volunteers without evidence of NAFLD. CONCLUSIONS: Liver function studies improved in obese volunteers with NAFLD during pioglitazone treatment. Although the nature of our observations does not prove a cause and effect relationship between pioglitazone treatment and improvement in liver enzymes, the time course and magnitude of improvement we observed may facilitate future research into thiazolidinedione treatment of NAFLD. |
| DOI: | 10.1053/s1542-3565(03)00198-8 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S01 | Improve insulin resistance | insulin sensitizer; insulin resistance; glucose tolerance | Biguanide: increases 5-AMP activated protein kinase signaling; SGLT-2 inhibitor; Thiazalidinedione: selective PPAR-γ agonists; GLP-1 agonist | Metformin; Empagliflozin; Canagliflozin; Rosiglitazone; Pioglitazone; Liraglutide | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I14 | 9970 | Obesity | An overnutrition that is characterized by excess body fat, traditionally defined as an elevated ratio of weight to height (specifically 30 kilograms per meter squared), has_material_basis_in a multifactorial etiology related to excess nutrition intake, decreased caloric utilization, and genetic susceptibility, and possibly medications and certain disorders of metabolism, endocrine function, and mental illness. https://en.wikipedia.org/wiki/Obesity | disease of metabolism/acquired metabolic disease/ nutrition disease/overnutrition | Details |
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D545 | Pig placenta extract | Biological extract | -- | -- | -- | Under clinical trials | Details |
| D199 | L-alanine | Chemical drug | DB00160 | KYNU | -- | Failed in clinical trials | Details |
| D328 | Serine | Chemical drug | DB00133 | SRR | Improve insulin resistance | Under clinical trials | Details |
| D366 | Thiazolidinediones | Chemical drug | DB11898 | -- | -- | Under clinical trials | Details |
| D275 | Pioglitazone | Chemical drug | DB01132 | PPARG agonist | Improve insulin resistance | Advanced in clinical trials | Details |
| D182 | Insulin | Biological drug | DB00030 | INSR agonist; CPE modulator&product of | -- | Under clinical trials | Details |
| D316 | S-adenosyl-L-methionine | Chemical drug | DB00118 | GNMT cofactor | Antiviral | Under clinical trials | Details |
| D094 | Cysteamine | Chemical drug | DB00847 | GSS stimulant | Renal drug | Under clinical trials | Details |
| D095 | Cysteamine bitartrate | Chemical drug | DB00847 | -- | -- | Under clinical trials | Details |