Research Article Details
| Article ID: | A28905 |
| PMID: | 34844875 |
| Source: | Trends Mol Med |
| Title: | Targeting ACC for NASH resolution. |
| Abstract: | A recent paper published in Nature Medicine by Calle et al. reported anti-nonalcoholic steatohepatitis (NASH) efficiencies by acetyl-CoA carboxylase (ACC) 1/2 inhibitors alone or by co-administration with a ACC1/2 inhibitor and a diacylglycerol acyltransferase 2 (DGAT2) inhibitor. Whereas the monotherapy achieved remarkable reductions in liver steatosis but induced hyperlipidemia, DGAT2 inhibitor co-administration mitigated the increase in serum triglycerides (TGs). |
| DOI: | 10.1016/j.molmed.2021.11.002 |
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