Research Article Details
| Article ID: | A03556 |
| PMID: | 33957682 |
| Source: | Semin Liver Dis |
| Title: | New Developments in Microbiome in Alcohol-Associated and Nonalcoholic Fatty Liver Disease. |
| Abstract: | Alcohol-associated liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) are important causes of morbidity and mortality worldwide. The intestinal microbiota is involved in the development and progression of both ALD and NAFLD. Here we describe associated changes in the intestinal microbiota, and we detail randomized clinical trials in ALD and NAFLD which evaluate treatments modulating the intestinal microbiome including fecal microbiota transplantation, probiotics, prebiotics, synbiotics, and antibiotics. Finally, we discuss precision medicine approaches targeting the intestinal microbiome to ameliorate ALD and NAFLD. |
| DOI: | 10.1055/s-0040-1719174 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
|---|
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D281 | Prebiotic | Supplement | -- | -- | -- | Under clinical trials | Details |
| D587 | Fecal microbiota transplantation | Miscellany | -- | -- | -- | Under investigation | Details |
| D284 | Probiotic | Supplement | -- | -- | -- | Under clinical trials | Details |
| D357 | Synbiotic | Supplement | -- | -- | -- | Under clinical trials | Details |