Investigational Drug Details
| Drug ID: | D284 |
| Drug Name: | Probiotic |
| Synonyms: | -- |
| Type: | Supplement |
| DrugBank ID: | -- |
| DrugBank Description: | -- |
| PubChem ID: | -- |
| CasNo: | 1830109-69-7 |
| Repositioning for NAFLD: | No |
| SMILES: | -- |
| InChiKey: | -- |
| Molecular Weight: | -- |
| DrugBank Targets: | -- |
| DrugBank MoA: | -- |
| DrugBank Pharmacology: | -- |
| DrugBank Indication: | -- |
| Targets: | -- |
| Therapeutic Category: | -- |
| Clinical Trial Progress: | Phase 1&2 on-going (NCT04175392) |
| Latest Progress: | Under clinical trials |
| Trial ID | Source ID | Phases | Status | Study Results | Start Date | Last Update Posted | |
|---|---|---|---|---|---|---|---|
| L0089 | NCT03511365 | Phase 1/Phase 2 | Terminated | No Results Available | May 15, 2018 | January 7, 2020 | Details |
| L0117 | NCT04175392 | Phase 1/Phase 2 | Recruiting | No Results Available | January 12, 2021 | November 24, 2021 | Details |
| L0177 | NCT00068094 | Phase 1/Phase 2 | Terminated | No Results Available | July 2005 | August 18, 2006 | Details |
| L0357 | NCT00099723 | Phase 1 | Terminated | No Results Available | October 2004 | February 11, 2010 | Details |
| L0372 | IRCT20220104053626N1 | Phase 1/Phase 2 | Not Recruiting | No Results Available | 11/01/2022 | 7 February 2022 | Details |
| L0521 | IRCT2017102537007N1 | Not applicable | Not Recruiting | No Results Available | 12/11/2017 | 22 February 2018 | Details |
| L0609 | IRCT2013100414882N1 | Not applicable | Not Recruiting | No Results Available | 02/06/2015 | 22 February 2018 | Details |
| L0617 | IRCT201410052394N13 | Phase 2 | Not Recruiting | No Results Available | 14/12/2014 | 22 February 2018 | Details |
| L0635 | IRCT201301223140N6 | Phase 2 | Not Recruiting | No Results Available | 16/01/2014 | 22 February 2018 | Details |
| L0643 | IRCT2012122911920N1 | Not applicable | Not Recruiting | No Results Available | 19/05/2013 | 22 February 2018 | Details |
| L0648 | IRCT201210313664N8 | Phase 2 | Not Recruiting | No Results Available | 28/11/2012 | 22 February 2018 | Details |
| L0653 | IRCT201204049376N1 | Not applicable | Not Recruiting | No Results Available | 05/07/2012 | 22 February 2018 | Details |
| L0684 | NCT00870012 | Not applicable | Not recruiting | No Results Available | 25/03/2009 | 19 February 2015 | Details |
| L0732 | NCT04074889 | Not applicable | Recruiting | No Results Available | 29/08/2019 | 12 December 2020 | Details |
| L0757 | NCT03528707 | Not applicable | Not recruiting | No Results Available | 01/05/2018 | 12 December 2020 | Details |
| L0776 | SLCTR/2018/042 | Phase 0 | Recruiting | No Results Available | 31/12/2018 | 7 February 2022 | Details |
| L0788 | NCT03614039 | Not applicable | Not recruiting | No Results Available | 29/07/2018 | 12 December 2020 | Details |
| L0798 | NCT03467282 | Not applicable | Not recruiting | No Results Available | 09/03/2018 | 12 December 2020 | Details |
| L0802 | CTRI/2017/12/010997 | Phase 1 | Not Recruiting | No Results Available | 27/12/2017 | 24 November 2021 | Details |
| L0815 | IRCT2017080135408N1 | Not applicable | Not Recruiting | No Results Available | 12/08/2017 | 22 February 2018 | Details |
| L0844 | SLCTR/2016/021 | Phase 4 | Recruiting | No Results Available | 27/07/2016 | 7 February 2022 | Details |
| L0847 | NCT02764047 | Not applicable | Recruiting | No Results Available | 27/04/2016 | 16 December 2017 | Details |
| L0882 | IRCT2014010715879N3 | Not applicable | Not Recruiting | No Results Available | 08/02/2015 | 22 February 2018 | Details |
| L0907 | IRCT2013122811763N15 | Not applicable | Not Recruiting | No Results Available | 02/01/2014 | 22 February 2018 | Details |
| L0918 | NCT01922830 | Not applicable | Not recruiting | No Results Available | 12/08/2013 | 12 December 2020 | Details |
| L0933 | ISRCTN05474560 | Not applicable | Not Recruiting | No Results Available | 09/08/2012 | 17 October 2016 | Details |
| L0973 | NCT00808990 | Phase 1 | Not recruiting | No Results Available | 15/12/2008 | 18 April 2016 | Details |
| L0974 | CTRI/2008/091/000074 | Phase 2/Phase 3 | Not Recruiting | No Results Available | 09/06/2008 | 24 November 2021 | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Strategy ID | Strategy | Synonyms | Related Targets | Related Drugs |
|---|
| Article ID | PMID | Source | Title | |
|---|---|---|---|---|
| A00010 | 35255811 | BMC Gastroenterol | The effect of daily consumption of probiotic yogurt on liver enzymes, steatosis and fibrosis in patients with nonalcoholic fatty liver disease (NAFLD): study protocol for a randomized clinical trial. | Details |
| A00094 | 35222044 | Front Pharmacol | Antibiotic Disruption of the Gut Microbiota Enhances the Murine Hepatic Dysfunction Associated With a High-Salt Diet. | Details |
| A00113 | 35216439 | Int J Mol Sci | Heat-Inactivated Akkermansia muciniphila Improves Gut Permeability but Does Not Prevent Development of Non-Alcoholic Steatohepatitis in Diet-Induced Obese Ldlr-/-.Leiden Mice. | Details |
| A00181 | 35195774 | Arch Microbiol | A review on the effect of gut microbiota on metabolic diseases. | Details |
| A00229 | 35174500 | J Sci Food Agric | Identification of a novel probiotic and its protective effects on NAFLD via modulating gut microbial community. | Details |
| A00521 | 35053962 | Foods | Limosilactobacillus fermentum MG4295 Improves Hyperglycemia in High-Fat Diet-Induced Mice. | Details |
| A00526 | 35053205 | Biomolecules | Understanding the Role of the Gut Microbiome and Microbial Metabolites in Non-Alcoholic Fatty Liver Disease: Current Evidence and Perspectives. | Details |
| A00533 | 35052765 | Biomedicines | Bifidobacterium bifidum Shows More Diversified Ways of Relieving Non-Alcoholic Fatty Liver Compared with Bifidobacterium adolescentis. | Details |
| A00706 | 34994824 | Naunyn Schmiedebergs Arch Pharmacol | The crucial role of oxidative stress in non-alcoholic fatty liver disease-induced male reproductive toxicity: the ameliorative effects of Iranian indigenous probiotics. | Details |
| A00758 | 34978141 | Obes Rev | Human microbiome and metabolic health: An overview of systematic reviews. | Details |
| A00794 | 34965016 | Clin Transl Med | Lactobacillus lactis and Pediococcus pentosaceus-driven reprogramming of gut microbiome and metabolome ameliorates the progression of non-alcoholic fatty liver disease. | Details |
| A00808 | 34959747 | Nutrients | High-Fructose, High-Fat Diet Alters Muscle Composition and Fuel Utilization in a Juvenile Iberian Pig Model of Non-Alcoholic Fatty Liver Disease. | Details |
| A00822 | 34957088 | Front Cell Dev Biol | Molecular Immune Mechanism of Intestinal Microbiota and Their Metabolites in the Occurrence and Development of Liver Cancer. | Details |
| A00851 | 34948020 | Int J Mol Sci | The New Therapeutic Approaches in the Treatment of Non-Alcoholic Fatty Liver Disease. | Details |
| A00854 | 34945677 | Foods | Lactobacillus plantarum MA2 Ameliorates Methionine and Choline-Deficient Diet Induced Non-Alcoholic Fatty Liver Disease in Rats by Improving the Intestinal Microecology and Mucosal Barrier. | Details |
| A00956 | 34919684 | J Nutr | A Specifically Tailored Multistrain Probiotic and Micronutrient Mixture Affects Nonalcoholic Fatty Liver Disease-Related Markers in Patients with Obesity after Mini Gastric Bypass Surgery. | Details |
| A01074 | 34877910 | Expert Rev Gastroenterol Hepatol | Effects of probiotics on nonalcoholic fatty liver disease: a systematic review and meta-analysis. | Details |
| A01191 | 34835410 | Microorganisms | Polyclonal Aptamers for Specific Fluorescence Labeling and Quantification of the Health Relevant Human Gut Bacterium Parabacteroides distasonis. | Details |
| A01352 | 34778099 | Front Cell Infect Microbiol | Gut Microbiota, Glucose, Lipid, and Water-Electrolyte Metabolism in Children With Nonalcoholic Fatty Liver Disease. | Details |
| A01357 | 34776827 | Food Nutr Res | Weissella cibaria MG5285 and Lactobacillus reuteri MG5149 attenuated fat accumulation in adipose and hepatic steatosis in high-fat diet-induced C57BL/6J obese mice. | Details |