Research Article Details
| Article ID: | A43589 |
| PMID: | 31341440 |
| Source: | Integr Med (Encinitas) |
| Title: | Barrie Tan, PhD: Using Tocotrienols to Address Lifestyle and Metabolic Disease. |
| Abstract: | Vitamin E has two subgroups, tocopherols and tocotrienols. In this interview, Dr Tan describes current sources and compositions of tocotrienols. The discussion also explores the anti-inflammatory properties observed with tocotrienol application in cardiovascular and metabolic disease, cancer, radiation exposure, and bone ailments; the nutrient's potential in management of nonalcoholic fatty liver disease; and addresses recent studies highlighting tocotrienol's role as the 21st century vitamin E. Tocotrienols from plant sources were first developed and brought to the market by Dr Tan, inventor of numerous processes for tocotrienol extraction from plants. These discoveries include tocotrienols from palm (1992), then rice (1998), and finally annatto (2002). |
| DOI: |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S05 | Anti-inflammatory | inflammatory | Bile acid; TNF-a inhibitor; Dual PPAR-α and -δ agonists; Toll-Like Receptor; (TLR)-4 antagonist; Caspase inhibitor; ASK-1 inhibitor | Ursodeoxycholic Acid; Pentoxifylline; Elafibranor; JKB-121; Emricasan; Selonsertib; | Details |
| Diseases ID | DO ID | Disease Name | Definition | Class |
|---|
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D328 | Serine | Chemical drug | DB00133 | SRR | Improve insulin resistance | Under clinical trials | Details |
| D579 | Emfilermin | Miscellany | -- | adipocytes | Enhance lipid metabolism | Under investigation | Details |
| D371 | Tocotrienol | Chemical drug | DB12647 | HMG-CoA inhibitor | Enhance lipid metabolism | Under clinical trials | Details |
| D388 | Vitamin E | Supplement | DB00163 | NR1I2; ALOX5; DGKA | Anti-inflammatory | Under clinical trials | Details |