Research Article Details

Article ID: A43731
PMID: 31006135
Source: Hepatology
Title: Incretin-Based Therapies for the Management of Nonalcoholic Fatty Liver Disease in Patients With Type 2 Diabetes.
Abstract:
DOI: 10.1002/hep.30670

Strategy ID Therapy Strategy Synonyms Therapy Targets Therapy Drugs

Target ID Target Name GENE Action Class UniProtKB ID Entry Name

Diseases ID DO ID Disease Name Definition Class
I05 9352 Type 2 diabetes mellitus A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus Details

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D225 Metformin Chemical drug DB00331 PRKAB1 inducer activator; ETEDH inhibitor; GPD1 inhibitor Improve insulin resistance Under clinical trials Details
D207 Liraglutide Biological drug DB06655 GLP1R activator; GLP1R agonist; GCG receptor antagonist activity Improve insulin resistance Under clinical trials Details
D338 Sitagliptin Chemical drug DB01261 DPP4 inhibitor Antidiabetic drug Under clinical trials Details
D182 Insulin Biological drug DB00030 INSR agonist; CPE modulator&product of -- Under clinical trials Details
D183 Insulin Glargine Biological drug DB00047 INSR agonist Antidiabetic drug Under clinical trials Details
D157 Glucophage Chemical drug DB00331 -- -- Under clinical trials Details