Research Article Details

Article ID: A44521
PMID: 28377639
Source: Nat Rev Gastroenterol Hepatol
Title: NASH: Novel therapeutic strategies targeting ASK1 in NASH.
Abstract:
DOI: 10.1038/nrgastro.2017.42

Strategy ID Therapy Strategy Synonyms Therapy Targets Therapy Drugs
S13 Anti-apoptosis hepatocyte apoptosis; hepatic autophagy; apoptosis Pan-caspase inhibitor Emricasan Details

Target ID Target Name GENE Action Class UniProtKB ID Entry Name
T10 Caspase-1 CASP1 inhibitor Enzyme P29466 CASP1_HUMAN Details
T20 Fatty acid synthase FASN inhibitor Enzyme P49327 FAS_HUMAN Details
T13 Apoptosis Signal-regulating Kinase 1 ASK1 inhibitor Enzyme Q99683 M3K5_HUMAN Details

Diseases ID DO ID Disease Name Definition Class

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress