Research Article Details

Article ID: A44689
PMID: 27734248
Source: Dig Dis Sci
Title: FXR Agonists: From Bench to Bedside, a Guide for Clinicians.
Abstract:
DOI: 10.1007/s10620-016-4334-8

Strategy ID Therapy Strategy Synonyms Therapy Targets Therapy Drugs

Target ID Target Name GENE Action Class UniProtKB ID Entry Name
T17 Farnesoid X-activated receptor NR1H4 agonist Nuclear hormone receptor Q96RI1 NR1H4_HUMAN Details
T07 Bile acid receptor NR1H4 agonist Nuclear hormone receptor Q96RI1 NR1H4_HUMAN Details

Diseases ID DO ID Disease Name Definition Class
I12 10763 Hypertension An artery disease characterized by chronic elevated blood pressure in the arteries. https://en.wikipedia.org/wiki/Hypertension, https://www.ncbi.nlm.nih.gov/pubmed/24352797 disease of anatomical entity/ cardiovascular system disease/vascular disease/ artery disease Details

Drug ID Drug Name Type DrugBank ID Targets Category Latest Progress
D381 Ursodeoxycholic acid Chemical drug DB01586 AKR1C2 inducer Anti-inflammatory Under clinical trials Details