Research Article Details
| Article ID: | A47591 |
| PMID: | 6219359 |
| Source: | Presse Med |
| Title: | [Influence of chronic alcoholism on plasma 25-hydroxycholecalciferol levels]. |
| Abstract: | In order to evaluate the influence of chronic alcoholism on vitamin D metabolism, plasma 25-hydroxycholecalciferol (25-OHD) concentrations were measured during winter-time in alcoholic patients with cirrhosis (n = 9) or steatosis (n = 5) and in nonalcoholic patients with cirrhosis (n = 8) or without liver disease (n = 10). Low levels of 25-OHD were found in 91% of the whole population studied. After oral administration of vitamin D 2600000 units, the increase in 25-OHD observed was less pronounced in patients with cirrhosis, but was similar in alcoholic and non-alcoholic patients. The study indicates that chronic alcoholism is not responsible for the 25-OHD deficiency. |
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| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs |
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| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
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| Diseases ID | DO ID | Disease Name | Definition | Class |
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| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D387 | Vitamin D | Supplement | DB11094 | -- | Vitamin source drug | Under clinical trials | Details |
| D328 | Serine | Chemical drug | DB00133 | SRR | Improve insulin resistance | Under clinical trials | Details |
| D248 | Obeticholic Acid | Chemical drug | DB05990 | NR1H4 activator; NR1H4 agonist; FXR agonist | Enhance lipid metabolism | Approval rejected | Details |
| D094 | Cysteamine | Chemical drug | DB00847 | GSS stimulant | Renal drug | Under clinical trials | Details |
| D126 | Ergocalciferol | Supplement | DB00153 | VDR agonist; VDR modulator | Calcium regulator; Vitamin source drug | Under clinical trials | Details |
| D095 | Cysteamine bitartrate | Chemical drug | DB00847 | -- | -- | Under clinical trials | Details |