Research Article Details
| Article ID: | A53043 |
| PMID: | 16669279 |
| Source: | MMW Fortschr Med |
| Title: | [Secondary dyslipoproteinema in liver disease]. |
| Abstract: | By far the most common dyslipoproteinema in patients with liver disease is hypertriglyceridemia with decreased HDL cholesterol occurring in fatty liver diseases. Since these latter frequently occur in patients with a metabolic syndrome, it must be assumed that lipid metabolism disorder is associated with a pronounced atherogenic effect. This means that--in contrast to cholestatic liver disease--treatment is almost always indicated. General therapeutic measures (weight reduction, optimization of blood sugar) are to the fore. As medication, metformin, fibrates and insulin sensitizers may be considered since, apart from improving glucose metabolism and hypertriglyceridemia, they also have a direct hepatic effect. It must, however, be noted that the available study data are not yet satisfactory, so that an individual decision must be made as to whether medical treatment of a lipid metabolism disorder makes good lipidological sense and is hepatologically justified. |
| DOI: |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S01 | Improve insulin resistance | insulin sensitizer; insulin resistance; glucose tolerance | Biguanide: increases 5-AMP activated protein kinase signaling; SGLT-2 inhibitor; Thiazalidinedione: selective PPAR-γ agonists; GLP-1 agonist | Metformin; Empagliflozin; Canagliflozin; Rosiglitazone; Pioglitazone; Liraglutide | Details |
| S02 | Enhance lipid metabolism | triglyceride-lowering; lipid tolerance; lipid metabolism | 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) inhibitor; Decreases intestinal cholesterol absorption; FXR agonist; ACC inhibitor; FAS inhibitor; DGAT2 inhibitor; SCD-1 inhibitor | Atorvastatin; Ezetimibe; Obeticholic Acid; GS-9674; GS-0976; TVB-2640; IONIS-DGAT2rx; Aramchol; | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Drug ID | Drug Name | Type | DrugBank ID | Targets | Category | Latest Progress | |
|---|---|---|---|---|---|---|---|
| D225 | Metformin | Chemical drug | DB00331 | PRKAB1 inducer activator; ETEDH inhibitor; GPD1 inhibitor | Improve insulin resistance | Under clinical trials | Details |
| D182 | Insulin | Biological drug | DB00030 | INSR agonist; CPE modulator&product of | -- | Under clinical trials | Details |
| D157 | Glucophage | Chemical drug | DB00331 | -- | -- | Under clinical trials | Details |
| D094 | Cysteamine | Chemical drug | DB00847 | GSS stimulant | Renal drug | Under clinical trials | Details |
| D095 | Cysteamine bitartrate | Chemical drug | DB00847 | -- | -- | Under clinical trials | Details |