Research Article Details
| Article ID: | A06654 |
| PMID: | 32791802 |
| Source: | Zhonghua Gan Zang Bing Za Zhi |
| Title: | [Research progress of non-alcoholic fatty liver disease in postmenopausal women]. |
| Abstract: | Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disease with a risk of developing non-alcoholic hepatitis, cirrhosis and liver cancer. Postmenopausal women have an increased risk of developing metabolic diseases including NAFLD under the influence of various factors such as aging, endocrine and metabolic changes. This article summarizes the latest research of NAFLD in postmenopausal women to elaborate and analyze the epidemiological characteristics, correlation between NAFLD and postmenopause, possible pathogenesis as well as feasible prevention and treatment methods. |
| DOI: | 10.3760/cma.j.cn501113-20200525-00270 |
| Strategy ID | Therapy Strategy | Synonyms | Therapy Targets | Therapy Drugs | |
|---|---|---|---|---|---|
| S01 | Improve insulin resistance | insulin sensitizer; insulin resistance; glucose tolerance | Biguanide: increases 5-AMP activated protein kinase signaling; SGLT-2 inhibitor; Thiazalidinedione: selective PPAR-γ agonists; GLP-1 agonist | Metformin; Empagliflozin; Canagliflozin; Rosiglitazone; Pioglitazone; Liraglutide | Details |
| Target ID | Target Name | GENE | Action | Class | UniProtKB ID | Entry Name |
|---|
| Diseases ID | DO ID | Disease Name | Definition | Class | |
|---|---|---|---|---|---|
| I05 | 9352 | Type 2 diabetes mellitus | A diabetes that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both. A diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. http://en.wikipedia.org/wiki/Diabetes, http://en.wikipedia.org/wiki/Diabetes_mellitus_type_2 | disease of metabolism/inherited metabolic disorder/ carbohydrate metabolic disorder/glucose metabolism disease/diabetes/ diabetes mellitus | Details |