Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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lipogenesis1889 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A15963 | 28636830 | Appl Physiol Nutr Metab | Attenuation of hepatic steatosis by purple sweet potato colour is associated with blocking Src/ERK/C/EBPβ signalling in high-fat-diet-treated mice. | 2017 | Details |
| A15975 | 28630692 | J Nutr Sci | Liver fat: a relevant target for dietary intervention? Summary of a Unilever workshop. | 2017 | Details |
| A16023 | 28605664 | J Nutr Biochem | Soy compared with milk protein in a Western diet changes fecal microbiota and decreases hepatic steatosis in obese OLETF rats. | 2017 | Details |
| A16027 | 28602867 | J Ethnopharmacol | Effect of Gangjihwan on hepatic steatosis and inflammation in high fat diet-fed mice. | 2017 | Details |
| A16073 | 28585211 | Adv Exp Med Biol | Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16079 | 28580850 | Orv Hetil | [Advances in the pathogenesis of non alcoholic fatty liver disease]. | 2017 | Details |
| A16081 | 28579536 | Gastroenterology | Effects of Dietary Fructose Restriction on Liver Fat, De Novo Lipogenesis, and Insulin Kinetics in Children With Obesity. | 2017 | Details |
| A16083 | 28578672 | Lipids Health Dis | Sake lees extract improves hepatic lipid accumulation in high fat diet-fed mice. | 2017 | Details |
| A16086 | 28577569 | Lipids Health Dis | Overexpression of apolipoprotein A-I alleviates endoplasmic reticulum stress in hepatocytes. | 2017 | Details |
| A16087 | 28577437 | Int Immunopharmacol | Rutin exhibits hepatoprotective effects in a mouse model of non-alcoholic fatty liver disease by reducing hepatic lipid levels and mitigating lipid-induced oxidative injuries. | 2017 | Details |
| A16104 | 28570612 | PLoS One | Caveolin1 protects against diet induced hepatic lipid accumulation in mice. | 2017 | Details |
| A16129 | 28549240 | J Nutr Biochem | Dietary salecan reverts partially the metabolic gene expressions and NMR-based metabolomic profiles from high-fat-diet-induced obese rats. | 2017 | Details |
| A16186 | 28511733 | Nutr Res Rev | Similarities and interactions between the ageing process and high chronic intake of added sugars. | 2017 | Details |
| A16204 | 28507343 | Sci Rep | Non-alcoholic fatty liver disease, vascular inflammation and insulin resistance are exacerbated by TRAIL deletion in mice. | 2017 | Details |
| A16239 | 28490610 | Diabetes | Mechanisms of Insulin Resistance in Primary and Secondary Nonalcoholic Fatty Liver. | 2017 | Details |
| A16253 | 28483554 | Biochim Biophys Acta Mol Cell Biol Lipids | Downregulation of miR-192 causes hepatic steatosis and lipid accumulation by inducing SREBF1: Novel mechanism for bisphenol A-triggered non-alcoholic fatty liver disease. | 2017 | Details |
| A16290 | 28470676 | Hepatology | Acetyl-coenzyme A carboxylase inhibition reduces de novo lipogenesis in overweight male subjects: A randomized, double-blind, crossover study. | 2017 | Details |
| A16293 | 28469795 | Am J Transl Res | MicroRNA-199a-3p attenuates hepatic lipogenesis by targeting Sp1. | 2017 | Details |
| A16325 | 28458350 | Biol Pharm Bull | Therapeutic Effect of Gypenosides on Nonalcoholic Steatohepatitis via Regulating Hepatic Lipogenesis and Fatty Acid Oxidation. | 2017 | Details |
| A16361 | 28437865 | Hepatology | A novel role of astrocyte elevated gene-1 (AEG-1) in regulating nonalcoholic steatohepatitis (NASH). | 2017 | Details |
| A16369 | 28434046 | Amino Acids | Oral arginine supplementation protects female mice from the onset of non-alcoholic steatohepatitis. | 2017 | Details |
| A16377 | 28428362 | J Endocrinol | Hepatic lipid accumulation: cause and consequence of dysregulated glucoregulatory hormones. | 2017 | Details |
| A16403 | 28415887 | Free Radic Res | Amelioration of late-onset hepatic steatosis in IDH2-deficient mice. | 2017 | Details |
| A16407 | 28414056 | Eur J Pharmacol | Protective effects of glycyrrhizic acid against non-alcoholic fatty liver disease in mice. | 2017 | Details |
| A16450 | 28381526 | Gut | miRNA-132 induces hepatic steatosis and hyperlipidaemia by synergistic multitarget suppression. | 2017 | Details |
| A16472 | 28368295 | Nutrients | Homocysteine Induces Hepatic Steatosis Involving ER Stress Response in High Methionine Diet-Fed Mice. | 2017 | Details |
| A16487 | 28359088 | Endocrinology | Sex Hormone-Binding Globulin Reduction in Metabolic Disorders May Play a Role in NAFLD Development. | 2017 | Details |
| A16496 | 28355557 | Cell Rep | Liver-Specific Activation of AMPK Prevents Steatosis on a High-Fructose Diet. | 2017 | Details |
| A16515 | 28346237 | Curr Opin Gastroenterol | Current and future pharmacologic treatment of nonalcoholic steatohepatitis. | 2017 | Details |
| A16539 | 28325853 | Diabetes | Deletion of Macrophage Mineralocorticoid Receptor Protects Hepatic Steatosis and Insulin Resistance Through ERα/HGF/Met Pathway. | 2017 | Details |
| A16575 | 28298542 | J Nutr | Lipid Emulsion Added to a Liquid High-Carbohydrate Diet and Voluntary Running Exercise Reduce Lipogenesis and Ameliorate Early-Stage Hepatic Steatosis in Mice. | 2017 | Details |
| A16593 | 28294174 | Eur J Clin Nutr | Docosahexaenoic acid enrichment in NAFLD is associated with improvements in hepatic metabolism and hepatic insulin sensitivity: a pilot study. | 2017 | Details |
| A16622 | 28278289 | PLoS One | Toyocamycin attenuates free fatty acid-induced hepatic steatosis and apoptosis in cultured hepatocytes and ameliorates nonalcoholic fatty liver disease in mice. | 2017 | Details |
| A16633 | 28273805 | Nutrients | Fructose and NAFLD: The Multifaceted Aspects of  Fructose Metabolism. | 2017 | Details |
| A16690 | 28241825 | BMC Med | Non-alcoholic fatty liver disease. | 2017 | Details |
| A16691 | 28241817 | BMC Endocr Disord | Berberine improves glucogenesis and lipid metabolism in nonalcoholic fatty liver disease. | 2017 | Details |
| A16696 | 28239368 | Front Endocrinol (Lausanne) | Connection of Nicotine to Diet-Induced Obesity and Non-Alcoholic Fatty Liver Disease: Cellular and Mechanistic Insights. | 2017 | Details |
| A16697 | 30263537 | Food Sci Biotechnol | Inhibitory effect of esculetin on free-fatty-acid-induced lipid accumulation in human HepG2 cells through activation of AMP-activated protein kinase. | 2017 | Details |
| A16700 | 28235613 | J Hepatol | Impaired hepatic lipid synthesis from polyunsaturated fatty acids in TM6SF2 E167K variant carriers with NAFLD. | 2017 | Details |
| A16717 | 28225186 | Aliment Pharmacol Ther | Randomised clinical trial: the efficacy and safety of oltipraz, a liver X receptor alpha-inhibitory dithiolethione in patients with non-alcoholic fatty liver disease. | 2017 | Details |
| A16723 | 28223420 | Sci Signal | New connections: New targets for fighting hepatic steatosis. | 2017 | Details |
| A16745 | 28212548 | Oncotarget | Branched-chain amino acids prevent hepatic fibrosis and development of hepatocellular carcinoma in a non-alcoholic steatohepatitis mouse model. | 2017 | Details |
| A16751 | 28210913 | Int Urol Nephrol | Dietary and commercialized fructose: Sweet or sour? | 2017 | Details |
| A16754 | 28207798 | PLoS One | Altered hepatic lipid metabolism in mice lacking both the melanocortin type 4 receptor and low density lipoprotein receptor. | 2017 | Details |
| A16756 | 28205519 | Nat Commun | Mitochondrial ATP transporter depletion protects mice against liver steatosis and insulin resistance. | 2017 | Details |
| A16766 | 28194019 | Cell Mol Immunol | IL-25 stimulates M2 macrophage polarization and thereby promotes mitochondrial respiratory capacity and lipolysis in adipose tissues against obesity. | 2017 | Details |
| A16772 | 28189916 | J Nutr Biochem | Chronic administration of saturated fats and fructose differently affect SREBP activity resulting in different modulation of Nrf2 and Nlrp3 inflammasome pathways in mice liver. | 2017 | Details |
| A16776 | 28184213 | Front Endocrinol (Lausanne) | Loss of Hepatic CEACAM1: A Unifying Mechanism Linking Insulin Resistance to Obesity and Non-Alcoholic Fatty Liver Disease. | 2017 | Details |
| A16803 | 28164196 | Food Funct | Preventive effect of Silibinin in combination with Pu-erh tea extract on non-alcoholic fatty liver disease in ob/ob mice. | 2017 | Details |
| A16805 | 28163011 | Obes Res Clin Pract | Aerobic endurance training improves nonalcoholic fatty liver disease (NAFLD) features via miR-33 dependent autophagy induction in high fat diet fed mice. | 2017 | Details |
| A16825 | 28146130 | Nutrients | Effects of Natural Products on Fructose-Induced Nonalcoholic Fatty Liver Disease (NAFLD). | 2017 | Details |
| A16831 | 28142119 | Biomed Pharmacother | Ginkgolide A ameliorates non-alcoholic fatty liver diseases on high fat diet mice. | 2017 | Details |
| A16833 | 28139281 | Clin Nutr | Non-alcoholic fatty liver disease and its treatment with n-3 polyunsaturated fatty acids. | 2017 | Details |
| A16861 | 28123944 | Mol Metab | Celastrol ameliorates liver metabolic damage caused by a high-fat diet through Sirt1. | 2016 | Details |
| A16863 | 28123933 | Mol Metab | A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. | 2016 | Details |
| A16868 | 28119530 | Int J Obes (Lond) | Decreased lipid metabolism but increased FA biosynthesis are coupled with changes in liver microRNAs in obese subjects with NAFLD. | 2017 | Details |
| A16870 | 28116873 | Endocrinol Metab (Seoul) | The SCAP/SREBP Pathway: A Mediator of Hepatic Steatosis. | 2017 | Details |
| A16916 | 28094767 | J Clin Invest | Impaired SUMOylation of nuclear receptor LRH-1 promotes nonalcoholic fatty liver disease. | 2017 | Details |
| A16917 | 28092906 | Med Princ Pract | Association between Nicotinamide Phosphoribosyltransferase and de novo Lipogenesis in Nonalcoholic Fatty Liver Disease. | 2017 | Details |
| A16949 | 28077733 | J Nutr | Identification of Potential Plasma Biomarkers for Nonalcoholic Fatty Liver Disease by Integrating Transcriptomics and Proteomics in Laying Hens. | 2017 | Details |
| A16981 | 28064013 | J Nutr Biochem | Changes in liver proteins of rats fed standard and high-fat and sucrose diets induced by fish omega-3 PUFAs and their combination with grape polyphenols according to quantitative proteomics. | 2016 | Details |
| A17032 | 29911800 | Yao Xue Xue Bao | [Protective effect and underlying mechanism of cordycepin on non-alcoholic fatty liver in ob/ob mice]. | 2017 | Details |
| A17038 | 28036028 | Nutrients | Application of an In Vivo Hepatic Triacylglycerol Production Method in the Setting of a High-Fat Diet in Mice. | 2016 | Details |
| A17054 | 28025996 | Int J Mol Med | Rosuvastatin as a potential preventive drug for the development of hepatocellular carcinoma associated with non-alcoholic fatty liver disease in mice. | 2016 | Details |
| A17055 | 28025059 | J Hepatol | MicroRNA-206 prevents hepatosteatosis and hyperglycemia by facilitating insulin signaling and impairing lipogenesis. | 2016 | Details |
| A17070 | 28008992 | Sci Rep | Acylated and desacyl ghrelin are associated with hepatic lipogenesis, β-oxidation and autophagy: role in NAFLD amelioration after sleeve gastrectomy in obese rats. | 2016 | Details |
| A17110 | 27986627 | Eur J Pharmacol | A novel and selective melanin-concentrating hormone receptor 1 antagonist ameliorates obesity and hepatic steatosis in diet-induced obese rodent models. | 2016 | Details |
| A17120 | 27981809 | Mol Nutr Food Res | Chicoric acid attenuate a nonalcoholic steatohepatitis by inhibiting key regulators of lipid metabolism, fibrosis, oxidation, and inflammation in mice with methionine and choline deficiency. | 2017 | Details |
| A17158 | 27941940 | Nutr Diabetes | Kefir peptides prevent high-fructose corn syrup-induced non-alcoholic fatty liver disease in a murine model by modulation of inflammation and the JAK2 signaling pathway. | 2016 | Details |
| A17220 | 27906700 | Curr Opin Clin Nutr Metab Care | Update on lipid species and paediatric nonalcoholic fatty liver disease. | 2017 | Details |
| A17225 | 27903831 | J Nutr | Dietary Mung Bean Protein Reduces Hepatic Steatosis, Fibrosis, and Inflammation in Male Mice with Diet-Induced, Nonalcoholic Fatty Liver Disease. | 2016 | Details |
| A17271 | 27874078 | Sci Rep | Glutamate dehydrogenase activator BCH stimulating reductive amination prevents high fat/high fructose diet-induced steatohepatitis and hyperglycemia in C57BL/6J mice. | 2016 | Details |
| A17276 | 27869139 | Sci Rep | The transcription cofactor CRTC1 protects from aberrant hepatic lipid accumulation. | 2016 | Details |
| A17278 | 27866836 | Cell Metab | Physiological Suppression of Lipotoxic Liver Damage by Complementary Actions of HDAC3 and SCAP/SREBP. | 2016 | Details |
| A17279 | 27866076 | J Nutr Biochem | Antioxidant properties of tea blunt ROS-dependent lipogenesis: beneficial effect on hepatic steatosis in a high fat-high sucrose diet NAFLD obese rat model. | 2016 | Details |
| A17286 | 27862769 | Cancer Sci | NS5ABP37 inhibits liver cancer by impeding lipogenesis and cholesterogenesis. | 2017 | Details |
| A17316 | 27852305 | Lipids Health Dis | Schisandra polysaccharide inhibits hepatic lipid accumulation by downregulating expression of SREBPs in NAFLD mice. | 2016 | Details |
| A17323 | 27845424 | Sci Rep | MicroRNA-124 promotes hepatic triglyceride accumulation through targeting tribbles homolog 3. | 2016 | Details |
| A17324 | 27845265 | J Ethnopharmacol | The effects of herbal composition Gambigyeongsinhwan (4) on hepatic steatosis and inflammation in Otsuka Long-Evans Tokushima fatty rats and HepG2 cells. | 2016 | Details |
| A17326 | 27843095 | EBioMedicine | Branched Chain Amino Acids Cause Liver Injury in Obese/Diabetic Mice by Promoting Adipocyte Lipolysis and Inhibiting Hepatic Autophagy. | 2016 | Details |
| A17346 | 27832630 | Cell Physiol Biochem | Decreased MiR-155 Level in the Peripheral Blood of Non-Alcoholic Fatty Liver Disease Patients may Serve as a Biomarker and may Influence LXR Activity. | 2016 | Details |
| A17352 | 27828718 | J Med Food | 5,7-Dimethoxyflavone Attenuates Obesity by Inhibiting Adipogenesis in 3T3-L1 Adipocytes and High-Fat Diet-Induced Obese C57BL/6J Mice. | 2016 | Details |
| A17406 | 27801862 | Nutrients | Liver Fatty Acid Composition and Inflammation in Mice Fed with High-Carbohydrate Diet or High-Fat Diet. | 2016 | Details |
| A17411 | 27796685 | Mol Cell Biochem | Genes involved in the establishment of hepatic steatosis in Muscovy, Pekin and mule ducks. | 2016 | Details |
| A17445 | 27653239 | Hepatol Res | Rosuvastatin limits the activation of hepatic stellate cells in diet-induced obese mice. | 2016 | Details |
| A17471 | 27773935 | Acta Pharmacol Sin | Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation. | 2016 | Details |
| A17481 | 27490779 | Biomed Pharmacother | Swertiamarin ameliorates oleic acid induced lipid accumulation and oxidative stress by attenuating gluconeogenesis and lipogenesis in hepatic steatosis. | 2016 | Details |
| A17488 | 27768909 | J Nutr Biochem | High-fructose corn syrup-55 consumption alters hepatic lipid metabolism and promotes triglyceride accumulation. | 2016 | Details |
| A17491 | 27765690 | Gastroenterology | Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes. | 2016 | Details |
| A17492 | 27765368 | Phytomedicine | The chloroform extract of Cyclocarya paliurus attenuates high-fat diet induced non-alcoholic hepatic steatosis in Sprague Dawley rats. | 2016 | Details |
| A17512 | 27762456 | Phytother Res | Hovenia Dulcis Extract Reduces Lipid Accumulation in Oleic Acid-Induced Steatosis of Hep G2 Cells via Activation of AMPK and PPARα/CPT-1 Pathway and in Acute Hyperlipidemia Mouse Model. | 2016 | Details |
| A17533 | 27565538 | Antioxid Redox Signal | Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice. | 2016 | Details |
| A17587 | 27732328 | J Clin Endocrinol Metab | Effect of Liraglutide Therapy on Liver Fat Content in Patients With Inadequately Controlled Type 2 Diabetes: The Lira-NAFLD Study. | 2017 | Details |
| A17627 | 27708333 | Nat Commun | Differential hepatic distribution of insulin receptor substrates causes selective insulin resistance in diabetes and obesity. | 2016 | Details |
| A17631 | 27701891 | Expert Opin Drug Discov | Recent advances in targeting the fatty acid biosynthetic pathway using fatty acid synthase inhibitors. | 2016 | Details |
| A17635 | 27697525 | Biochem Biophys Res Commun | Long-term fructose consumption prolongs hepatic stearoyl-CoA desaturase 1 activity independent of upstream regulation in rats. | 2016 | Details |
| A17637 | 27697366 | C R Biol | High carbohydrate diet induces nonalcoholic steato-hepatitis (NASH) in a desert gerbil. | 2016 | Details |
| A17641 | 27693527 | Life Sci | Effect of HFD/STZ on expression of genes involved in lipid, cholesterol and glucose metabolism in rats. | 2016 | Details |
| A17647 | 27689765 | Hepatol Res | Increased lipogenesis in spite of upregulated hepatic 5'AMP-activated protein kinase in human non-alcoholic fatty liver. | 2016 | Details |
| A17662 | 27680310 | Biochem Biophys Res Commun | Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease. | 2016 | Details |