Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A23070 | 24066058 | PLoS One | Aldose reductase is involved in the development of murine diet-induced nonalcoholic steatohepatitis. | 2013 | Details |
| A23085 | 24053454 | BMC Gastroenterol | The role of ursodeoxycholic acid in non-alcoholic steatohepatitis: a systematic review. | 2013 | Details |
| A23088 | 24048683 | Dig Dis Sci | Characterization of hepatocellular carcinoma related genes and metabolites in human nonalcoholic fatty liver disease. | 2013 | Details |
| A23150 | 24002947 | Hepatology | Role of adipose triglyceride lipase (PNPLA2) in protection from hepatic inflammation in mouse models of steatohepatitis and endotoxemia. | 2014 | Details |
| A23161 | 23996518 | Horm Metab Res | Olive oil attenuates the cholesterol-induced development of nonalcoholic steatohepatitis despite increased insulin resistance in a rodent model. | 2013 | Details |
| A23276 | 23906870 | Exp Mol Pathol | Chemerin is highly expressed in hepatocytes and is induced in non-alcoholic steatohepatitis liver. | 2013 | Details |
| A23305 | 23880135 | Curr Opin Microbiol | Colonic bacterial metabolites and human health. | 2013 | Details |
| A23310 | 23875703 | Clin Sci (Lond) | Involvement of the HIF-1α and Wnt/β-catenin pathways in the protective effects of losartan on fatty liver graft with ischaemia/reperfusion injury. | 2014 | Details |
| A23349 | 23850676 | Biochem Biophys Res Commun | Propranolol, a β-adrenoceptor antagonist, worsens liver injury in a model of non-alcoholic steatohepatitis. | 2013 | Details |
| A23360 | 23843692 | Drug Des Devel Ther | S-nitroso-N-acetylcysteine attenuates liver fibrosis in experimental nonalcoholic steatohepatitis. | 2013 | Details |
| A23365 | 23842720 | Clin Rev Allergy Immunol | Autoimmune features in metabolic liver disease: a single-center experience and review of the literature. | 2013 | Details |
| A23390 | 23824212 | Diabetologia | Prediction of non-alcoholic fatty-liver disease and liver fat content by serum molecular lipids. | 2013 | Details |
| A23495 | 23727306 | J Hepatol | Dendritic cells in liver injury and fibrosis: shortcomings and promises. | 2013 | Details |
| A23503 | 26201793 | Hepatol Int | Amelioration of hepatic inflammation in a mouse model of NASH using a dithiocarbamate derivative. | 2013 | Details |
| A23531 | 23703665 | Hepatology | Advanced glycation endproducts induce fibrogenic activity in nonalcoholic steatohepatitis by modulating TNF-α-converting enzyme activity in mice. | 2013 | Details |
| A23532 | 23703580 | Hepatology | Hepatoprotective effects of the dual peroxisome proliferator-activated receptor alpha/delta agonist, GFT505, in rodent models of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. | 2013 | Details |
| A23538 | 23701387 | Hepatol Res | Osteopontin: Versatile modulator of liver diseases. | 2013 | Details |
| A23542 | 23696823 | PLoS One | Butyrate-producing probiotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis. | 2013 | Details |
| A23557 | 23682724 | Liver Int | Transgenic expression of human neutrophil peptide-1 enhances hepatic fibrosis in mice fed a choline-deficient, L-amino acid-defined diet. | 2013 | Details |
| A23566 | 23669283 | J Hepatol | NKT-cell subsets: promoters and protectors in inflammatory liver disease. | 2013 | Details |
| A23648 | 23598120 | Talanta | Validated liquid chromatography-tandem mass spectrometry method for determination of totally nine probe metabolites of cytochrome P450 enzymes and UDP-glucuronosyltransferases. | 2012 | Details |
| A23659 | 23592516 | Mol Pharmacol | Nrf2 activators attenuate the progression of nonalcoholic steatohepatitis-related fibrosis in a dietary rat model. | 2013 | Details |
| A23683 | 23567080 | J Hepatol | Lysophosphatidylcholine acyltransferase 1 altered phospholipid composition and regulated hepatoma progression. | 2013 | Details |
| A23702 | 23554890 | PLoS One | Oral probiotic microcapsule formulation ameliorates non-alcoholic fatty liver disease in Bio F1B Golden Syrian hamsters. | 2013 | Details |
| A23722 | 23537027 | Appl Physiol Nutr Metab | Nonalcoholic fatty liver disease is associated with lower hepatic and erythrocyte ratios of phosphatidylcholine to phosphatidylethanolamine. | 2012 | Details |
| A23745 | 23514731 | Diabetes Care | Circulating lysophosphatidylcholines are markers of a metabolically benign nonalcoholic fatty liver. | 2013 | Details |
| A23757 | 23508103 | Mol Cell Biol | Activation of the aryl hydrocarbon receptor sensitizes mice to nonalcoholic steatohepatitis by deactivating mitochondrial sirtuin deacetylase Sirt3. | 2013 | Details |
| A23766 | 23503837 | J Gastroenterol | Oral choline tolerance test as a novel noninvasive method for predicting nonalcoholic steatohepatitis. | 2013 | Details |
| A23799 | 23472083 | PLoS One | Hepatic methionine homeostasis is conserved in C57BL/6N mice on high-fat diet despite major changes in hepatic one-carbon metabolism. | 2013 | Details |
| A23800 | 23467489 | Lab Anim | Gender and strain-specific differences in the development of steatosis in rats. | 2013 | Details |
| A23815 | 23452163 | Clin Microbiol Infect | Gut microbiota and non-alcoholic fatty liver disease: new insights. | 2013 | Details |
| A23817 | 23451176 | PLoS One | Differential intrahepatic phospholipid zonation in simple steatosis and nonalcoholic steatohepatitis. | 2013 | Details |
| A23831 | 23441159 | PLoS One | PKCδ as a regulator for TGFβ1-induced α-SMA production in a murine nonalcoholic steatohepatitis model. | 2013 | Details |
| A23833 | 23439872 | FASEB J | Strain-dependent dysregulation of one-carbon metabolism in male mice is associated with choline- and folate-deficient diet-induced liver injury. | 2013 | Details |
| A23853 | 23426790 | Int J Mol Med | Anti-inflammatory effects of total alkaloids from Rubus alceifolius Poir [corrected]. on non-alcoholic fatty liver disease through regulation of the NF-κB pathway. | 2013 | Details |
| A23939 | 23370355 | Biol Pharm Bull | A novel inhibitor of stearoyl-CoA desaturase-1 attenuates hepatic lipid accumulation, liver injury and inflammation in model of nonalcoholic steatohepatitis. | 2013 | Details |
| A23976 | 23331460 | Basic Clin Pharmacol Toxicol | Quercetin decreases liver damage in mice with non-alcoholic steatohepatitis. | 2013 | Details |
| A24006 | 23305254 | Int J Exp Pathol | An improved mouse model that rapidly develops fibrosis in non-alcoholic steatohepatitis. | 2013 | Details |
| A24007 | 23305008 | Klin Lab Diagn | [The unity of pathogenesis of insulin resistance syndrome and non-alcoholic fatty disease of liver. The metabolic disorder of fatty acids and triglycerides]. | 2012 | Details |
| A24014 | 23301938 | J Gastroenterol Hepatol | Cross talk between toll-like receptor-4 signaling and angiotensin-II in liver fibrosis development in the rat model of non-alcoholic steatohepatitis. | 2013 | Details |
| A24019 | 23299577 | Hepatology | Role of vascular endothelial growth factor in the pathophysiology of nonalcoholic steatohepatitis in two rodent models. | 2013 | Details |
| A24080 | 23256442 | J Med Food | Dandelion leaf extract protects against liver injury induced by methionine- and choline-deficient diet in mice. | 2012 | Details |
| A24210 | 23118937 | PLoS One | Perinatal exposure to a high-fat diet is associated with reduced hepatic sympathetic innervation in one-year old male Japanese macaques. | 2012 | Details |
| A24217 | 23112047 | J Biol Chem | Role of Pin1 protein in the pathogenesis of nonalcoholic steatohepatitis in a rodent model. | 2012 | Details |
| A24265 | 23066023 | J Biol Chem | Kuppfer cells trigger nonalcoholic steatohepatitis development in diet-induced mouse model through tumor necrosis factor-α production. | 2012 | Details |
| A24278 | 23044079 | Dig Liver Dis | The pro-inflammatory action of tumour necrosis factor-α in non-alcoholic steatohepatitis is independent of the NSMAF gene product. | 2012 | Details |
| A24289 | 23036186 | Dig Liver Dis | A new approach to facilitate diagnosis of nonalcoholic fatty liver disease through a galactose single point method in rats with fatty liver. | 2012 | Details |
| A24298 | 23028442 | PLoS One | Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis. | 2012 | Details |
| A24337 | 22987396 | Hepatology | Toll-like receptor 2 and palmitic acid cooperatively contribute to the development of nonalcoholic steatohepatitis through inflammasome activation in mice. | 2013 | Details |
| A24358 | 22970906 | Clin Sci (Lond) | NF-κB1 deficiency stimulates the progression of non-alcoholic steatohepatitis (NASH) in mice by promoting NKT-cell-mediated responses. | 2013 | Details |
| A24420 | 22915297 | J Nutr | Quercetin treatment ameliorates inflammation and fibrosis in mice with nonalcoholic steatohepatitis. | 2012 | Details |
| A24423 | 22913202 | Eur Rev Med Pharmacol Sci | Glycine alleviates liver injury induced by deficiency in methionine and or choline in rats. | 2012 | Details |
| A24441 | 22890552 | Lab Invest | Increased intrahepatic resistance in severe steatosis: endothelial dysfunction, vasoconstrictor overproduction and altered microvascular architecture. | 2012 | Details |
| A24444 | 22886508 | J Gastroenterol | Angiotensin II type 1 receptor antagonist prevents hepatic carcinoma in rats with nonalcoholic steatohepatitis. | 2012 | Details |
| A24448 | 22883218 | Dig Liver Dis | Effects of bile duct ligation and cholic acid treatment on fatty liver in two rat models of non-alcoholic fatty liver disease. | 2012 | Details |
| A24462 | 22872676 | FASEB J | Interstrain differences in the severity of liver injury induced by a choline- and folate-deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism. | 2012 | Details |
| A24533 | 22796156 | J Hepatol | Translocator protein (18 kDa), a potential molecular imaging biomarker for non-invasively distinguishing non-alcoholic fatty liver disease. | 2012 | Details |
| A24534 | 22796155 | J Hepatol | Phenotyping the effect of diet on non-alcoholic fatty liver disease. | 2012 | Details |
| A24541 | 22780848 | Hepatol Res | Plasma free choline is a novel non-invasive biomarker for early-stage non-alcoholic steatohepatitis: A multi-center validation study. | 2012 | Details |
| A24577 | 22734967 | Clin Sci (Lond) | Kupffer cell depletion attenuates leptin-mediated methoxamine-stimulated portal perfusion pressure and thromboxane A2 release in a rodent model of NASH-cirrhosis. | 2012 | Details |
| A24597 | 22710359 | Int J Mol Med | Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: analysis of isolated hepatic stellate cells. | 2012 | Details |
| A24600 | 22706738 | Turk J Gastroenterol | Effects of probiotics on methionine choline deficient diet-induced steatohepatitis in rats. | 2012 | Details |
| A24606 | 22699396 | Drug Metab Dispos | Altered arsenic disposition in experimental nonalcoholic fatty liver disease. | 2012 | Details |
| A24651 | 22648174 | Genes Nutr | Dietary supplementation with methyl donors reduces fatty liver and modifies the fatty acid synthase DNA methylation profile in rats fed an obesogenic diet. | 2012 | Details |
| A24664 | 22641095 | J Hepatol | p53/p66Shc-mediated signaling contributes to the progression of non-alcoholic steatohepatitis in humans and mice. | 2012 | Details |
| A24665 | 22641094 | J Hepatol | A hedgehog survival pathway in 'undead' lipotoxic hepatocytes. | 2012 | Details |
| A24668 | 22633099 | Transl Res | Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis. | 2012 | Details |
| A24692 | 22593713 | ScientificWorldJournal | Deficiency in galectin-3 promotes hepatic injury in CDAA diet-induced nonalcoholic fatty liver disease. | 2012 | Details |
| A24721 | 22561871 | Toxicol Appl Pharmacol | Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet. | 2012 | Details |
| A24741 | 22545719 | Clin Sci (Lond) | Lack of CC chemokine ligand 2 differentially affects inflammation and fibrosis according to the genetic background in a murine model of steatohepatitis. | 2012 | Details |
| A24752 | 22536512 | Int J Hepatol | Paraoxonase activity and expression is modulated by therapeutics in experimental rat nonalcoholic Fatty liver disease. | 2012 | Details |
| A24779 | 22505328 | Hepatology | Hydrogen-rich water prevents progression of nonalcoholic steatohepatitis and accompanying hepatocarcinogenesis in mice. | 2012 | Details |
| A24808 | 22469640 | J Clin Gastroenterol | The role of nutrients in the development, progression, and treatment of nonalcoholic fatty liver disease. | 2012 | Details |
| A24830 | 22455888 | Zhonghua Bing Li Xue Za Zhi | [Mechanism of hepatocyte apoptosis in rats with liver fibrosis induced by lipogenic methionine-choline-deficient diet]. | 2012 | Details |
| A24839 | 22439844 | Clin Sci (Lond) | Adenosine A(2a) receptor stimulation prevents hepatocyte lipotoxicity and non-alcoholic steatohepatitis (NASH) in rats. | 2012 | Details |
| A24857 | 22427237 | Gut | NKT-associated hedgehog and osteopontin drive fibrogenesis in non-alcoholic fatty liver disease. | 2012 | Details |
| A24903 | 22375551 | J Biomed Sci | Amelioration of diet-induced nonalcoholic steatohepatitis in rats by Mn-salen complexes via reduction of oxidative stress. | 2012 | Details |
| A24913 | 22367065 | Dig Dis Sci | Innate immune reactivity of the ileum-liver axis in nonalcoholic steatohepatitis. | 2012 | Details |
| A24916 | 22364002 | Eksp Klin Gastroenterol | [Study of clinical efficiency of essential phospholipids and silymarin combination in nonalcoholic and alcoholic steatohepatitis]. | 2011 | Details |
| A24933 | 22343419 | Free Radic Biol Med | Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. | 2012 | Details |
| A24939 | 22338037 | Am J Clin Nutr | Choline intake in a large cohort of patients with nonalcoholic fatty liver disease. | 2012 | Details |
| A24940 | 22334337 | Hepatology | Specific immunization strategies against oxidized low-density lipoprotein: a novel way to reduce nonalcoholic steatohepatitis in mice. | 2012 | Details |
| A24953 | 22319522 | Exp Diabetes Res | Pentoxifylline attenuates methionine- and choline-deficient-diet-induced steatohepatitis by suppressing TNF-α expression and endoplasmic reticulum stress. | 2012 | Details |
| A24968 | 22297845 | Nature | Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. | 2012 | Details |
| A24975 | 22290395 | Hepatology | Disruption of phospholipid and bile acid homeostasis in mice with nonalcoholic steatohepatitis. | 2012 | Details |
| A25070 | 22197629 | Dig Liver Dis | Silibinin improves hepatic and myocardial injury in mice with nonalcoholic steatohepatitis. | 2011 | Details |
| A25082 | 22183953 | Hepatology | Hepatic endothelin-1 and endocannabinoids-dependent effects of hyperleptinemia in nonalcoholic steatohepatitis-cirrhotic rats. | 2012 | Details |
| A25083 | 22183915 | Hepatology | Ursodeoxycholyl lysophosphatidylethanolamide improves steatosis and inflammation in murine models of nonalcoholic fatty liver disease. | 2012 | Details |
| A25084 | 22183894 | Mol Med | Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. | 2012 | Details |
| A25122 | 22154902 | Life Sci | Alpha-lipoic acid attenuates methionine choline deficient diet-induced steatohepatitis in C57BL/6 mice. | 2011 | Details |
| A25128 | 22152378 | Zhonghua Gan Zang Bing Za Zhi | [The role of Fas mutation on non-alcoholic steatohepatitis in mice]. | 2011 | Details |
| A25142 | 22142284 | Clin Sci (Lond) | Bias in macrophage activation pattern influences non-alcoholic steatohepatitis (NASH) in mice. | 2012 | Details |
| A25150 | 22134222 | Curr Opin Gastroenterol | Choline metabolism provides novel insights into nonalcoholic fatty liver disease and its progression. | 2012 | Details |
| A25162 | 22121808 | Zhongguo Zhong Yao Za Zhi | [Effect of total alkaloids of Rubus alceaefolius on oxidative stress in rats with non-alcoholic fatty liver disease]. | 2011 | Details |
| A25168 | 22118966 | Mol Cell Endocrinol | Adiponectin upregulates hepatocyte CMKLR1 which is reduced in human fatty liver. | 2011 | Details |
| A25173 | 22112382 | Drug Metab Dispos | Molecular mechanism of altered ezetimibe disposition in nonalcoholic steatohepatitis. | 2011 | Details |
| A25174 | 22112193 | Metab Syndr Relat Disord | Association of serum lipoprotein-associated phospholipase A2 level with nonalcoholic fatty liver disease. | 2011 | Details |
| A25176 | 22111040 | Diabetes Metab J | Dietary oleate has beneficial effects on every step of non-alcoholic Fatty liver disease progression in a methionine- and choline-deficient diet-fed animal model. | 2011 | Details |
| A25184 | 22108588 | Exp Cell Res | A methionine-choline-deficient diet elicits NASH in the immunodeficient mouse featuring a model for hepatic cell transplantation. | 2011 | Details |
| A25204 | 22095799 | Hepatology | Hepatic ratio of phosphatidylcholine to phosphatidylethanolamine predicts survival after partial hepatectomy in mice. | 2012 | Details |