Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A25209 | 22093454 | Liver Int | Prevention of free fatty acid-induced hepatic lipotoxicity by carnitine via reversal of mitochondrial dysfunction. | 2011 | Details |
| A25220 | 22083307 | Mol Cells | Time-dependent changes in lipid metabolism in mice with methionine choline deficiency-induced fatty liver disease. | 2011 | Details |
| A25225 | 22081873 | Comp Hepatol | The effect of cocoa supplementation on hepatic steatosis, reactive oxygen species and LFABP in a rat model of NASH. | 2011 | Details |
| A25231 | 22072850 | World J Gastroenterol | Decreased accumulation of ultrasound contrast in the liver of nonalcoholic steatohepatitis rat model. | 2011 | Details |
| A25275 | 22015962 | J Hepatol | A lipid to treat non-alcoholic fatty liver disease - the dawn of 'lipo-rehabilitation'? | 2011 | Details |
| A25342 | 21946918 | Mol Med Rep | Nifedipine prevents hepatic fibrosis in a non-alcoholic steatohepatitis model induced by an L-methionine-and choline-deficient diet. | 2011 | Details |
| A25410 | 21881966 | Metab Brain Dis | Non-alcoholic fatty liver induces insulin resistance and metabolic disorders with development of brain damage and dysfunction. | 2011 | Details |
| A25429 | 21857953 | PLoS One | Increased diacylglycerols characterize hepatic lipid changes in progression of human nonalcoholic fatty liver disease; comparison to a murine model. | 2011 | Details |
| A25441 | 21837751 | Hepatology | Methionine adenosyltransferase 1A gene deletion disrupts hepatic very low-density lipoprotein assembly in mice. | 2011 | Details |
| A25456 | 21813474 | Gut | Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury. | 2011 | Details |
| A25488 | 21773586 | Food Funct | The impact of choline availability on muscle lipid metabolism. | 2010 | Details |
| A25519 | 21748768 | Hepatology | Dysregulation of the unfolded protein response in db/db mice with diet-induced steatohepatitis. | 2011 | Details |
| A25522 | 21745592 | Biochim Biophys Acta | Phosphatidylcholine protects against steatosis in mice but not non-alcoholic steatohepatitis. | 2011 | Details |
| A25542 | 21733354 | Chang Gung Med J | Disrupted hepatic adiponectin signaling impairs liver regeneration of steatotic rats. | 2011 | Details |
| A25668 | 21563774 | J Proteome Res | A proton nuclear magnetic resonance metabonomics approach for biomarker discovery in nonalcoholic fatty liver disease. | 2011 | Details |
| A25692 | 21537547 | Arq Gastroenterol | Methionine- and choline-deficient diet induces hepatic changes characteristic of non-alcoholic steatohepatitis. | 2011 | Details |
| A25739 | 21492876 | J Surg Res | The effect of hepatic ischemia reperfusion injury in a murine model of nonalcoholic steatohepatitis. | 2011 | Details |
| A25745 | 21488066 | Hepatology | Fatty acid and endotoxin activate inflammasomes in mouse hepatocytes that release danger signals to stimulate immune cells. | 2011 | Details |
| A25779 | 21464822 | Lab Invest | Fatty liver is associated with impaired activity of PPARγ-coactivator 1α (PGC1α) and mitochondrial biogenesis in mice. | 2011 | Details |
| A25799 | 21448953 | J Magn Reson Imaging | Effect of disease progression on liver apparent diffusion coefficient values in a murine model of NASH at 11.7 Tesla MRI. | 2011 | Details |
| A25800 | 21446920 | Clin Sci (Lond) | Methionine and protein metabolism in non-alcoholic steatohepatitis: evidence for lower rate of transmethylation of methionine. | 2011 | Details |
| A25822 | 21426695 | Zhonghua Er Ke Za Zhi | [Metformin prevents non-alcoholic fatty liver disease in rats: role of phospholipase A2/lysophosphatidylcholine lipoapoptosis pathway in hepatocytes]. | 2011 | Details |
| A25872 | 21372165 | Am J Physiol Gastrointest Liver Physiol | Combination treatment of angiotensin II type I receptor blocker and new oral iron chelator attenuates progression of nonalcoholic steatohepatitis in rats. | 2011 | Details |
| A25881 | 21356259 | J Hepatol | Insulin resistance and liver microcirculation in a rat model of early NAFLD. | 2011 | Details |
| A25961 | 21261727 | J Gastroenterol Hepatol | Reversal of hepatic steatosis by omega-3 fatty acids measured non-invasively by (1) H-magnetic resonance spectroscopy in a rat model. | 2011 | Details |
| A25973 | 21250982 | Eur J Clin Invest | Altered distribution of caveolin-1 in early liver steatosis. | 2011 | Details |
| A25985 | 21237679 | Acad Radiol | The Possibility of differentiation between nonalcoholic steatohepatitis and fatty liver in rabbits on Gd-EOB-DTPA-enhanced open-type MRI scans. | 2011 | Details |
| A25988 | 21233280 | Am J Physiol Gastrointest Liver Physiol | Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice. | 2011 | Details |
| A25991 | 21228496 | J Nutr Sci Vitaminol (Tokyo) | Serum cytokeratin 18 M30 antigen level and its correlation with nutritional parameters in middle-aged Japanese males with nonalcoholic fatty liver disease (NAFLD). | 2010 | Details |
| A26027 | 21190824 | J Nutr Biochem | A mouse model for nonalcoholic steatohepatitis. | 2010 | Details |
| A26028 | 21190397 | Ups J Med Sci | A preliminary investigation on the possible association between diminished copper availability and non-alcoholic fatty liver disease in epileptic patients treated with valproic acid. | 2010 | Details |
| A26031 | 21184788 | J Hepatol | Impact of artificial sunlight therapy on the progress of non-alcoholic fatty liver disease in rats. | 2010 | Details |
| A26042 | 21173431 | Carcinogenesis | Constitutive active/androstane receptor promotes hepatocarcinogenesis in a mouse model of non-alcoholic steatohepatitis. | 2010 | Details |
| A26084 | 21129376 | Gastroenterology | Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. | 2010 | Details |
| A26131 | 21045794 | Nat Rev Gastroenterol Hepatol | The role of the gut microbiota in nonalcoholic fatty liver disease. | 2010 | Details |
| A26162 | 20971848 | J Biol Chem | PKC{delta} is activated in a dietary model of steatohepatitis and regulates endoplasmic reticulum stress and cell death. | 2010 | Details |
| A26166 | 20967826 | Hepatology | Osteopontin is induced by hedgehog pathway activation and promotes fibrosis progression in nonalcoholic steatohepatitis. | 2010 | Details |
| A26182 | 20943080 | Zhonghua Gan Zang Bing Za Zhi | [The role of heme oxygenase-1 in non-alcoholic steatohepatitis]. | 2010 | Details |
| A26238 | 20848203 | Dig Dis Sci | Eicosapentaenoic acid attenuates progression of hepatic fibrosis with inhibition of reactive oxygen species production in rats fed methionine- and choline-deficient diet. | 2010 | Details |
| A26309 | 20664958 | Int J Mol Med | Selective aldosterone blocker ameliorates the progression of non-alcoholic steatohepatitis in rats. | 2010 | Details |
| A26317 | 20656836 | Radiology | Nonalcoholic fatty liver disease: detection of elevated nicotinamide adenine dinucleotide phosphate with in vivo 3.0-T 31P MR spectroscopy with proton decoupling. | 2010 | Details |
| A26323 | 20651599 | Eur J Gastroenterol Hepatol | Treatment with omega-3 fatty acids but not exendin-4 improves hepatic steatosis. | 2010 | Details |
| A26355 | 20602678 | Liver Int | Cannabinoid receptor 1 and 2 agonists increase lipid accumulation in hepatocytes. | 2010 | Details |
| A26382 | 20557969 | J Hepatol | Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. | 2010 | Details |
| A26388 | 20548286 | Lab Invest | Attenuated progression of diet-induced steatohepatitis in glutathione-deficient mice. | 2010 | Details |
| A26402 | 20512988 | Hepatology | Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. | 2010 | Details |
| A26403 | 20509914 | BMC Gastroenterol | Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis. | 2010 | Details |
| A26421 | 20487204 | J Pharm Pharmacol | Effects of Eriobotrya japonica seed extract on oxidative stress in rats with non-alcoholic steatohepatitis. | 2010 | Details |
| A26426 | 20473736 | Chin J Integr Med | Effect of Xuezhikang Capsule on serum tumor necrosis factor-alpha and interleukin-6 in patients with nonalcoholic fatty liver disease and hyperlipidemia. | 2010 | Details |
| A26430 | 20471811 | Exp Toxicol Pathol | Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis. | 2010 | Details |
| A26439 | 20460919 | Dig Dis | Animal models of non-alcoholic steatohepatitis: of mice and man. | 2010 | Details |
| A26472 | 20423748 | Metabolism | Plasma metabolomic profile in nonalcoholic fatty liver disease. | 2010 | Details |
| A26492 | 20398952 | Arch Gerontol Geriatr | Hepatic steatosis: an experimental model for quantification. | 2010 | Details |
| A26547 | 20227260 | Nutr Metab Cardiovasc Dis | Endothelial dysfunction and non-alcoholic liver steatosis in hypertensive patients. | 2010 | Details |
| A26559 | 20206399 | J Hepatol | Impaired liver regeneration of steatotic rats after portal vein ligation: a particular emphasis on (99m)Tc-DISIDA scintigraphy and adiponectin signaling. | 2010 | Details |
| A26566 | 20196952 | Zhonghua Gan Zang Bing Za Zhi | [Involvement of endoplasmic reticulum stress in development of fatty liver fibrosis induced by methionine-choline-deficient diet in rats]. | 2010 | Details |
| A26596 | 20131032 | Chin J Integr Med | Treatment of non-alcoholic fatty liver disease by Qianggan Capsule. | 2010 | Details |
| A26660 | 20032580 | J Atheroscler Thromb | Expression of perilipin and adipophilin in nonalcoholic fatty liver disease; relevance to oxidative injury and hepatocyte ballooning. | 2009 | Details |
| A26698 | 19937697 | Hepatology | The plasma lipidomic signature of nonalcoholic steatohepatitis. | 2009 | Details |
| A26699 | 19936233 | PLoS One | IL-6 deficiency attenuates murine diet-induced non-alcoholic steatohepatitis. | 2009 | Details |
| A26710 | 19919948 | Gut | Super paramagnetic iron oxide MRI shows defective Kupffer cell uptake function in non-alcoholic fatty liver disease. | 2009 | Details |
| A26713 | 19914374 | Free Radic Biol Med | Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis. | 2009 | Details |
| A26824 | 19710104 | Innate Immun | Interleukin-6 is associated with liver lipid homeostasis but not with cell death in experimental hepatic steatosis. | 2009 | Details |
| A26839 | 19676126 | Hepatology | Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. | 2009 | Details |
| A26890 | 19577569 | Gastroenterology | Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. | 2009 | Details |
| A26896 | 19571473 | J Toxicol Sci | Children's toxicology from bench to bed--Liver Injury (2): Mechanism of antioxidant therapy for nonalcoholic fatty liver disease. | 2009 | Details |
| A26964 | 19450891 | J Hepatol | Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet. | 2009 | Details |
| A26967 | 19446916 | J Hepatol | Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model. | 2009 | Details |
| A26992 | 19387108 | J Alzheimers Dis | Hepatic ceramide may mediate brain insulin resistance and neurodegeneration in type 2 diabetes and non-alcoholic steatohepatitis. | 2009 | Details |
| A26993 | 19386026 | Liver Int | Telmisartan attenuates progression of steatohepatitis in mice: role of hepatic macrophage infiltration and effects on adipose tissue. | 2009 | Details |
| A27012 | 19358839 | Eur J Pharmacol | Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats. | 2009 | Details |
| A27049 | 19269347 | Biochim Biophys Acta | In vivo assessment of hepatic triglycerides in murine non-alcoholic fatty liver disease using magnetic resonance spectroscopy. | 2009 | Details |
| A27067 | 19226377 | J Gastroenterol Hepatol | Apoptosis in experimental NASH is associated with p53 activation and TRAIL receptor expression. | 2008 | Details |
| A27126 | 19119140 | J Biol Chem | Hepatic lipid partitioning and liver damage in nonalcoholic fatty liver disease: role of stearoyl-CoA desaturase. | 2009 | Details |
| A27137 | 19115316 | Hepatology | VSL#3 probiotic treatment attenuates fibrosis without changes in steatohepatitis in a diet-induced nonalcoholic steatohepatitis model in mice. | 2009 | Details |
| A27175 | 19034968 | World J Gastroenterol | Innate immune reactivity of the liver in rats fed a choline-deficient L-amino-acid-defined diet. | 2008 | Details |
| A27237 | 18929425 | J Hepatol | A rodent model of NASH with cirrhosis, oval cell proliferation and hepatocellular carcinoma. | 2008 | Details |
| A27256 | 18823438 | J Gastroenterol Hepatol | Marked elevation of serum mitochondrion-derived markers in mild models of non-alcoholic steatohepatitis in rats. | 2008 | Details |
| A27261 | 18819037 | Scand J Gastroenterol | Utility of quantitative 99mTc-phytate scintigraphy to diagnose early-stage non-alcoholic steatohepatitis. | 2009 | Details |
| A27278 | 18765303 | Mitochondrion | Differential alterations in mitochondrial function induced by a choline-deficient diet: understanding fatty liver disease progression. | 2008 | Details |
| A27285 | 18752564 | J Gastroenterol Hepatol | Animal models of NASH: getting both pathology and metabolic context right. | 2008 | Details |
| A27301 | 18694396 | Clin Sci (Lond) | Phenotyping murine models of non-alcoholic fatty liver disease through metabolic profiling of intact liver tissue. | 2009 | Details |
| A27348 | 18596193 | Gut | Effectiveness of antiplatelet drugs against experimental non-alcoholic fatty liver disease. | 2008 | Details |
| A27384 | 18501344 | Eur J Pharmacol | Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects. | 2008 | Details |
| A27390 | 18488193 | Arch Toxicol | Drug metabolizing enzyme induction pathways in experimental non-alcoholic steatohepatitis. | 2008 | Details |
| A27416 | 18422963 | J Gastroenterol Hepatol | Polaprezinc attenuates liver fibrosis in a mouse model of non-alcoholic steatohepatitis. | 2008 | Details |
| A27421 | 18417155 | Life Sci | The establishment of a novel non-alcoholic steatohepatitis model accompanied with obesity and insulin resistance in mice. | 2008 | Details |
| A27472 | 18324772 | J Agric Food Chem | Dietary phosphatidylinositol prevents the development of nonalcoholic fatty liver disease in Zucker (fa/fa) rats. | 2008 | Details |
| A27481 | 18308829 | Gut | Uncoupling protein-2 (UCP2) induces mitochondrial proton leak and increases susceptibility of non-alcoholic steatohepatitis (NASH) liver to ischaemia-reperfusion injury. | 2008 | Details |
| A27486 | 18299981 | Dig Dis Sci | The transition from fatty liver to NASH associates with SAMe depletion in db/db mice fed a methionine choline-deficient diet. | 2008 | Details |
| A27560 | 18066656 | Inflammation | The treatment with antibody of TNF-alpha reduces the inflammation, necrosis and fibrosis in the non-alcoholic steatohepatitis induced by methionine- and choline-deficient diet. | 2007 | Details |
| A27586 | 17986629 | Am J Physiol Endocrinol Metab | Mitochondrial adaptations to steatohepatitis induced by a methionine- and choline-deficient diet. | 2007 | Details |
| A27620 | 17900521 | Biochim Biophys Acta | Mitochondrial dysfunction in rat with nonalcoholic fatty liver Involvement of complex I, reactive oxygen species and cardiolipin. | 2007 | Details |
| A27634 | 17868334 | J Gastroenterol Hepatol | Interstrain differences in susceptibility to non-alcoholic steatohepatitis. | 2007 | Details |
| A27635 | 17868330 | J Gastroenterol Hepatol | Activation of peroxisome proliferator-activated receptor alpha by dietary fish oil attenuates steatosis, but does not prevent experimental steatohepatitis because of hepatic lipoperoxide accumulation. | 2007 | Details |
| A27649 | 17764530 | J Gastroenterol Hepatol | Reduction of fibrosis in a rat model of non-alcoholic steatohepatitis cirrhosis by human HGF gene transfection using electroporation. | 2007 | Details |
| A27660 | 17567476 | J Gastroenterol Hepatol | Role of adipocytokines in hepatic fibrogenesis. | 2007 | Details |
| A27694 | 17654743 | Hepatology | A lipidomic analysis of nonalcoholic fatty liver disease. | 2007 | Details |
| A27699 | 17640958 | Drug Metab Dispos | Efflux transporter expression and acetaminophen metabolite excretion are altered in rodent models of nonalcoholic fatty liver disease. | 2007 | Details |
| A27750 | 17524368 | Biochem Pharmacol | Modulation of hepatic microsomal triglyceride transfer protein (MTP) induced by S-nitroso-N-acetylcysteine in ob/ob mice. | 2007 | Details |