Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A21264 | 25450203 | J Hepatol | Molecular mechanism of PPARα action and its impact on lipid metabolism, inflammation and fibrosis in non-alcoholic fatty liver disease. | 2014 | Details |
| A21309 | 25415189 | PLoS One | Transcriptome analysis on the inflammatory cell infiltration of nonalcoholic steatohepatitis in bama minipigs induced by a long-term high-fat, high-sucrose diet. | 2014 | Details |
| A21311 | 25413954 | J Inherit Metab Dis | The clinical spectrum of inherited diseases involved in the synthesis and remodeling of complex lipids. A tentative overview. | 2014 | Details |
| A21373 | 25367327 | Food Funct | Effects of Callistephus chinensis flower polyphones on improving metabolic disorders in high-fat diet-induced mice. | 2014 | Details |
| A21394 | 25352365 | J Gastroenterol Hepatol | Estimation of normal values of serum transaminases based on liver histology in healthy Asian Indians. | 2015 | Details |
| A21419 | 25333350 | Mol Med Rep | Inhibition of aldose reductase ameliorates diet-induced nonalcoholic steatohepatitis in mice via modulating the phosphorylation of hepatic peroxisome proliferator-activated receptor α. | 2014 | Details |
| A21444 | 25312970 | J Mol Endocrinol | Aberrant miR199a-5p/caveolin1/PPARα axis in hepatic steatosis. | 2014 | Details |
| A21446 | 25312517 | Liver Transpl | Mitochondrial dysfunction in steatotic rat livers occurs because a defect in complex i makes the liver susceptible to prolonged cold ischemia. | 2015 | Details |
| A21512 | 25265201 | Nanotoxicology | Intratracheal exposure to multi-walled carbon nanotubes induces a nonalcoholic steatohepatitis-like phenotype in C57BL/6J mice. | 2014 | Details |
| A21518 | 25259621 | Scand J Gastroenterol | A comparison of FibroMeter™ NAFLD Score, NAFLD fibrosis score, and transient elastography as noninvasive diagnostic tools for hepatic fibrosis in patients with biopsy-proven non-alcoholic fatty liver disease. | 2014 | Details |
| A21520 | 25256692 | J Magn Reson Imaging | Associations between histologic features of nonalcoholic fatty liver disease (NAFLD) and quantitative diffusion-weighted MRI measurements in adults. | 2014 | Details |
| A21527 | 25252298 | Anatol J Cardiol | Non alcoholic steatohepatitis is associated with subclinical impairment in left ventricular function measured by speckle tracking echocardiography. | 2014 | Details |
| A21538 | 25244504 | Atherosclerosis | Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2. | 2014 | Details |
| A21541 | 25242225 | Cell Metab | Thiazolidinediones and the promise of insulin sensitization in type 2 diabetes. | 2014 | Details |
| A21545 | 25241023 | Eur J Nutr | The effect of tomato juice supplementation on biomarkers and gene expression related to lipid metabolism in rats with induced hepatic steatosis. | 2014 | Details |
| A21550 | 25238605 | J Gastroenterol Hepatol | Modest alcohol consumption reduces the incidence of fatty liver in men: a population-based large-scale cohort study. | 2015 | Details |
| A21556 | 25232450 | World J Hepatol | Role of adipokines and peroxisome proliferator-activated receptors in nonalcoholic fatty liver disease. | 2014 | Details |
| A21562 | 25225495 | Front Immunol | Extracellular vesicle profiling and their use as potential disease specific biomarker. | 2014 | Details |
| A21571 | 25219574 | Liver Int | Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis. | 2014 | Details |
| A21585 | 25206279 | World J Gastroenterol | Osthol attenuates hepatic steatosis via decreased triglyceride synthesis not by insulin resistance. | 2014 | Details |
| A21586 | 25205520 | Biochim Biophys Acta | Creatine reduces hepatic TG accumulation in hepatocytes by stimulating fatty acid oxidation. | 2014 | Details |
| A21599 | 25195547 | J Hepatol | Effects of n-3 fish oil on metabolic and histological parameters in NASH: a double-blind, randomized, placebo-controlled trial. | 2014 | Details |
| A21635 | 25164277 | Expert Opin Investig Drugs | GFT505 for the treatment of nonalcoholic steatohepatitis and type 2 diabetes. | 2014 | Details |
| A21643 | 25157160 | Proc Natl Acad Sci U S A | Ghrelin promotes hepatic lipogenesis by activation of mTOR-PPARγ signaling pathway. | 2014 | Details |
| A21665 | 25138963 | Endocrine | Adipogenic changes of hepatocytes in a high-fat diet-induced fatty liver mice model and non-alcoholic fatty liver disease patients. | 2014 | Details |
| A21673 | 25130427 | Hepatology | Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting. | 2014 | Details |
| A21679 | 25126158 | Int J Clin Exp Med | Signal transductions and nonalcoholic fatty liver: a mini-review. | 2014 | Details |
| A21682 | 25123088 | Toxicology | Genotoxic, epigenetic, and transcriptomic effects of tamoxifen in mouse liver. | 2014 | Details |
| A21715 | 25099546 | Am J Clin Nutr | Fructose, high-fructose corn syrup, sucrose, and nonalcoholic fatty liver disease or indexes of liver health: a systematic review and meta-analysis. | 2014 | Details |
| A21730 | 25086331 | Magn Reson Imaging | Changes in diffusion tensor imaging (DTI) eigenvalues of skeletal muscle due to hybrid exercise training. | 2014 | Details |
| A21732 | 25083925 | Prog Lipid Res | Recent advances in pharmacotherapy for hypertriglyceridemia. | 2014 | Details |
| A21754 | 25071314 | World J Gastroenterol | Could metabolic syndrome lead to hepatocarcinoma via non-alcoholic fatty liver disease? | 2014 | Details |
| A21758 | 25066281 | Liver Int | Blockade of interleukin 6 signalling ameliorates systemic insulin resistance through upregulation of glucose uptake in skeletal muscle and improves hepatic steatosis in high-fat diet fed mice. | 2014 | Details |
| A21765 | 25061561 | Mol Metab | Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels. | 2014 | Details |
| A21801 | 25035342 | Arterioscler Thromb Vasc Biol | Links between ectopic fat and vascular disease in humans. | 2014 | Details |
| A21833 | 25016220 | J Hepatol | Thyrotropin increases hepatic triglyceride content through upregulation of SREBP-1c activity. | 2014 | Details |
| A21850 | 25003023 | FEBS Open Bio | Senescence marker protein-30/superoxide dismutase 1 double knockout mice exhibit increased oxidative stress and hepatic steatosis. | 2014 | Details |
| A21857 | 24995693 | Hepatology | The transrepressive activity of peroxisome proliferator-activated receptor alpha is necessary and sufficient to prevent liver fibrosis in mice. | 2014 | Details |
| A21860 | 24993341 | Int Immunopharmacol | Involvement of hepatic peroxisome proliferator-activated receptor α/γ in the therapeutic effect of osthole on high-fat and high-sucrose-induced steatohepatitis in rats. | 2014 | Details |
| A21870 | 24989077 | J Gastroenterol Hepatol | Childhood adiposity trajectories and risk of nonalcoholic fatty liver disease in adolescents. | 2015 | Details |
| A21876 | 24986741 | J Transl Med | Progression of diet induced nonalcoholic steatohepatitis is accompanied by increased expression of Kruppel-like-factor 10 in mice. | 2014 | Details |
| A21877 | 24985011 | Nutrition | Resveratrol attenuates hepatic steatosis in high-fat fed mice by decreasing lipogenesis and inflammation. | 2013 | Details |
| A21891 | 24976401 | Biochem Biophys Res Commun | NHE1 deficiency in liver: implications for non-alcoholic fatty liver disease. | 2014 | Details |
| A21959 | 24932972 | Br J Nutr | Long-term intake of soyabean phytosterols lowers serum TAG and NEFA concentrations, increases bile acid synthesis and protects against fatty liver development in dyslipidaemic hamsters. | 2014 | Details |
| A21963 | 24927728 | J Lipid Res | Hsp90 modulates PPARγ activity in a mouse model of nonalcoholic fatty liver disease. | 2014 | Details |
| A21966 | 24927063 | Mol Med Rep | Radix Hedysari polysaccharide suppresses lipid metabolism dysfunction in a rat model of non‑alcoholic fatty liver disease via adenosine monophosphate‑activated protein kinase pathway activation. | 2014 | Details |
| A21968 | 24926685 | PLoS One | Peroxisome proliferator-activated receptor α activation induces hepatic steatosis, suggesting an adverse effect. | 2014 | Details |
| A21972 | 24923363 | Hepatol Res | Hepatocellular carcinoma based on cryptogenic liver disease: The most common non-viral hepatocellular carcinoma in patients aged over 80 years. | 2014 | Details |
| A21991 | 24905748 | Nutrients | Sasa borealis stem extract attenuates hepatic steatosis in high-fat diet-induced obese rats. | 2014 | Details |
| A21994 | 24904182 | Angiology | Association between nonalcoholic fatty liver disease and carotid artery inflammation evaluated by 18F-fluorodeoxyglucose positron emission tomography. | 2014 | Details |
| A22032 | 24864249 | Biomed Res Int | Endocannabinoid receptors gene expression in morbidly obese women with nonalcoholic fatty liver disease. | 2014 | Details |
| A22049 | 24850609 | Georgian Med News | [Effect of gene polymorphism of PPARgamma2 regulatory proteins on the metabolic syndrome in children with nonalcoholic fatty liver disease and obesity]. | 2014 | Details |
| A22096 | 24824123 | Zhonghua Gan Zang Bing Za Zhi | [Relationship of non-alcoholic steatohepatitis with arterial endothelial function and atherosclerosis]. | 2014 | Details |
| A22113 | 24812009 | Toxicol Sci | Human receptor activation by aroclor 1260, a polychlorinated biphenyl mixture. | 2014 | Details |
| A22131 | 24797163 | Sci Rep | Lipid modulatory activities of Cichorium glandulosum Boiss et Huet are mediated by multiple components within hepatocytes. | 2014 | Details |
| A22146 | 24789994 | Am J Physiol Regul Integr Comp Physiol | Oxidative stress and altered lipid homeostasis in the programming of offspring fatty liver by maternal obesity. | 2014 | Details |
| A22151 | 24786095 | Int J Mol Sci | Molecular mechanisms and new treatment strategies for non-alcoholic steatohepatitis (NASH). | 2014 | Details |
| A22168 | 24772164 | PPAR Res | Modes-of-Action Related to Repeated Dose Toxicity: Tissue-Specific Biological Roles of PPAR γ Ligand-Dependent Dysregulation in Nonalcoholic Fatty Liver Disease. | 2014 | Details |
| A22191 | 24758097 | Invest Clin | [Hepatic steatosis, visceral fat and metabolic alterations in apparently healthy overweight/obese individuals]. | 2014 | Details |
| A22197 | 24753460 | Nephrol Dial Transplant | Obesity and renal disease: not all fat is created equal and not all obesity is harmful to the kidneys. | 2014 | Details |
| A22233 | 24735863 | J Ethnopharmacol | Hugan Qingzhi medication ameliorates hepatic steatosis by activating AMPK and PPARα pathways in L02 cells and HepG2 cells. | 2014 | Details |
| A22268 | 24704474 | Biochem Pharmacol | Chrysin attenuates inflammation by regulating M1/M2 status via activating PPARγ. | 2014 | Details |
| A22270 | 24702805 | Chin J Nat Med | Effect of Trifolium pratense extract on methionine-choline-deficient diet-induced steatohepatitis in C57BL/6 mice. | 2014 | Details |
| A22275 | 24697566 | Genet Test Mol Biomarkers | Meta-analysis of associations between the peroxisome proliferator-activated receptor-γ Pro12Ala polymorphism and susceptibility to nonalcoholic fatty liver disease, rheumatoid arthritis, and psoriatic arthritis. | 2014 | Details |
| A22301 | 24680992 | J Ethnopharmacol | In vitro effects of active components of Polygonum Multiflorum Radix on enzymes involved in the lipid metabolism. | 2014 | Details |
| A22316 | 24669786 | Diabetol Metab Syndr | Liver fat accumulation is associated with reduced hepatic insulin extraction and beta cell dysfunction in healthy older individuals. | 2014 | Details |
| A22359 | 24638096 | PLoS One | Evaluation of dietary effects on hepatic lipids in high fat and placebo diet fed rats by in vivo MRS and LC-MS techniques. | 2014 | Details |
| A22368 | 24634829 | Mol Metab | Tissue-selective estrogen complexes with bazedoxifene prevent metabolic dysfunction in female mice. | 2014 | Details |
| A22457 | 24553694 | J Nutr | β-Carotene-9',10'-oxygenase status modulates the impact of dietary tomato and lycopene on hepatic nuclear receptor-, stress-, and metabolism-related gene expression in mice. | 2014 | Details |
| A22471 | 24534255 | Toxicol Appl Pharmacol | PPAR agonists reduce steatosis in oleic acid-overloaded HepaRG cells. | 2014 | Details |
| A22489 | 24520264 | Exp Ther Med | Comparison between the efficacies of curcumin and puerarin in C57BL/6 mice with steatohepatitis induced by a methionine- and choline-deficient diet. | 2013 | Details |
| A22495 | 24517411 | Metab Syndr Relat Disord | Comparative effects of the renin-angiotensin system blockers on nonalcoholic fatty liver disease and insulin resistance in C57BL/6 mice. | 2014 | Details |
| A22529 | 24489777 | PLoS One | Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. | 2014 | Details |
| A22537 | 24481563 | J Physiol Biochem | Effects of binge ethanol on lipid homeostasis and oxidative stress in a rat model of nonalcoholic fatty liver disease. | 2014 | Details |
| A22544 | 24475795 | Radiology | Nonalcoholic Fatty Liver Disease: Intravoxel Incoherent Motion Diffusion-weighted MR Imaging-An Experimental Study in a Rabbit Model. | 2013 | Details |
| A22553 | 24466347 | PLoS One | Inhibitory effects of Japanese herbal medicines sho-saiko-to and juzen-taiho-to on nonalcoholic steatohepatitis in mice. | 2014 | Details |
| A22561 | 24463129 | Nan Fang Yi Ke Da Xue Xue Bao | [Effects of farnesoid X receptor agonist on adiponectin and its receptors]. | 2014 | Details |
| A22570 | 24456734 | J Nutr Biochem | Betaine attenuates hepatic steatosis by reducing methylation of the MTTP promoter and elevating genomic methylation in mice fed a high-fat diet. | 2013 | Details |
| A22571 | 24456353 | J Med Food | Cooked rice inhibits hepatic fat accumulation by regulating lipid metabolism-related gene expression in mice fed a high-fat diet. | 2014 | Details |
| A22581 | 24445216 | J Hepatol | Mindin/Spondin 2 inhibits hepatic steatosis, insulin resistance, and obesity via interaction with peroxisome proliferator-activated receptor α in mice. | 2014 | Details |
| A22598 | 24428677 | Expert Opin Pharmacother | New peroxisome proliferator-activated receptor agonists: potential treatments for atherogenic dyslipidemia and non-alcoholic fatty liver disease. | 2014 | Details |
| A22615 | 24411941 | Cell Metab | Regulation of steatohepatitis and PPARγ signaling by distinct AP-1 dimers. | 2014 | Details |
| A22630 | 24396693 | Endocrinol Metab (Seoul) | Association of serum adipocyte-specific Fatty Acid binding protein with Fatty liver index as a predictive indicator of nonalcoholic Fatty liver disease. | 2013 | Details |
| A22631 | 24396649 | Endocrinol Metab (Seoul) | Tumor Necrosis Factor-α as a Predictor for the Development of Nonalcoholic Fatty Liver Disease: A 4-Year Follow-Up Study. | 2013 | Details |
| A22662 | 24377452 | Nutrition | Central obesity and altered peripheral adipose tissue gene expression characterize the NAFLD patient with insulin resistance: Role of nutrition and insulin challenge. | 2014 | Details |
| A22664 | 24376752 | PLoS One | COH-SR4 reduces body weight, improves glycemic control and prevents hepatic steatosis in high fat diet-induced obese mice. | 2013 | Details |
| A22676 | 27508182 | J Hepatocell Carcinoma | Emerging role of the peroxisome proliferator-activated receptor-gamma in hepatocellular carcinoma. | 2014 | Details |
| A22692 | 25859286 | Clin Epigenetics | Leucine alters hepatic glucose/lipid homeostasis via the myostatin-AMP-activated protein kinase pathway - potential implications for nonalcoholic fatty liver disease. | 2014 | Details |
| A22703 | 25744638 | Nihon Rinsho Meneki Gakkai Kaishi | [Cellular senescence and chronic inflammation]. | 2014 | Details |
| A22735 | 24348633 | Hepat Mon | Normal limit for serum alanine aminotransferase level and distribution of metabolic factors in old population of kalaleh, iran. | 2013 | Details |
| A22746 | 24335764 | Int J Obes (Lond) | Kefir improves fatty liver syndrome by inhibiting the lipogenesis pathway in leptin-deficient ob/ob knockout mice. | 2013 | Details |
| A22757 | 24327268 | Hepatology | Hepatocyte-specific Ptpn6 deletion promotes hepatic lipid accretion, but reduces NAFLD in diet-induced obesity: potential role of PPARγ. | 2014 | Details |
| A22762 | 24324835 | PLoS One | Nutrigenomics of high fat diet induced obesity in mice suggests relationships between susceptibility to fatty liver disease and the proteasome. | 2013 | Details |
| A22778 | 24314869 | J Nutr Biochem | Effects of a Lactobacillus paracasei B21060 based synbiotic on steatosis, insulin signaling and toll-like receptor expression in rats fed a high-fat diet. | 2013 | Details |
| A22783 | 24307947 | J Lipids | Grape seed proanthocyanidin rescues rats from steatosis: a comparative and combination study with metformin. | 2013 | Details |
| A22802 | 24292949 | Genes Nutr | Dietary supplementation with soy isoflavones or replacement with soy proteins prevents hepatic lipid droplet accumulation and alters expression of genes involved in lipid metabolism in rats. | 2013 | Details |
| A22832 | 24275555 | Biochim Biophys Acta | Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring. | 2013 | Details |
| A22833 | 24275089 | Food Chem Toxicol | Monascin and ankaflavin act as natural AMPK activators with PPARα agonist activity to down-regulate nonalcoholic steatohepatitis in high-fat diet-fed C57BL/6 mice. | 2013 | Details |
| A22834 | 24275070 | Toxicol Appl Pharmacol | Prenatal ethanol exposure programs an increased susceptibility of non-alcoholic fatty liver disease in female adult offspring rats. | 2013 | Details |
| A22846 | 24274866 | Clin Liver Dis | The role of medications for the management of patients with NAFLD. | 2013 | Details |