Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
Choline1715 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A32689 | 27760889 | J Biomed Res | G-Aminobutyric acid promotes methionine-choline deficient diet-induced nonalcoholic steatohepatitis. | 2016 | Details |
| A32695 | 27754931 | J Pharmacol Exp Ther | Selective Inhibition of Autotaxin Is Efficacious in Mouse Models of Liver Fibrosis. | 2016 | Details |
| A32710 | 27729955 | World J Hepatol | DNA methylation of angiotensin II receptor gene in nonalcoholic steatohepatitis-related liver fibrosis. | 2016 | Details |
| A32785 | 27477940 | Gastroenterology | Inflammation-Induced Expression and Secretion of MicroRNA 122 Leads to Reduced Blood Levels of Kidney-Derived Erythropoietin and Anemia. | 2016 | Details |
| A32811 | 27421062 | Hepatol Res | Pharmacological evaluation of pioglitazone and candesartan cilexetil in a novel mouse model of non-alcoholic steatohepatitis, modified choline-deficient, amino acid-defined diet fed low-density lipoprotein receptor knockout mice. | 2016 | Details |
| A32820 | 27357826 | Mol Cell Biochem | MCD diet-induced steatohepatitis is associated with alterations in asymmetric dimethylarginine (ADMA) and its transporters. | 2016 | Details |
| A32824 | 27347340 | Am J Transl Res | The effect of polyene phosphatidyl choline intervention on nonalcoholic steatohepatitis and related mechanism. | 2016 | Details |
| A32956 | 26992446 | Hepatol Res | Non-alcoholic steatohepatitis-associated hepatic fibrosis and hepatocellular carcinoma in a combined mouse model of genetic modification and dietary challenge. | 2016 | Details |
| A33142 | 26605278 | Hepatobiliary Surg Nutr | Accumulated myeloid-derived suppressor cells demonstrate distinct phenotypes and functions in two non-alcoholic steatohepatitis mouse models. | 2015 | Details |
| A33159 | 26579446 | Acta Pharm Sin B | Kallistatin, a new and reliable biomarker for the diagnosis of liver cirrhosis. | 2015 | Details |
| A33163 | 26576191 | Evid Based Complement Alternat Med | Berberine Reduces Neurotoxicity Related to Nonalcoholic Steatohepatitis in Rats. | 2015 | Details |
| A33443 | 25977701 | Evid Based Complement Alternat Med | Metabolomics profiling to investigate the pharmacologic mechanisms of berberine for the treatment of high-fat diet-induced nonalcoholic steatohepatitis. | 2015 | Details |
| A33490 | 25888330 | Gastroenterology | Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice. | 2015 | Details |
| A33492 | 25885479 | J Agric Food Chem | Dietary Supplementation of Genistein Alleviates Liver Inflammation and Fibrosis Mediated by a Methionine-Choline-Deficient Diet in db/db Mice. | 2015 | Details |
| A33639 | 25536170 | J Agric Food Chem | Purified anthocyanins from bilberry and black currant attenuate hepatic mitochondrial dysfunction and steatohepatitis in mice with methionine and choline deficiency. | 2015 | Details |
| A33719 | 25314080 | Cancer Cell | Metabolic activation of intrahepatic CD8+ T cells and NKT cells causes nonalcoholic steatohepatitis and liver cancer via cross-talk with hepatocytes. | 2014 | Details |
| A33774 | 25178843 | Biochim Biophys Acta | Role of white adipose lipolysis in the development of NASH induced by methionine- and choline-deficient diet. | 2014 | Details |
| A33927 | 24842243 | Diabetes Res Clin Pract | Sitagliptin attenuates methionine/choline-deficient diet-induced steatohepatitis. | 2014 | Details |
| A33951 | 24793484 | Biochimie | ApoA-I or ABCA1 expression suppresses fatty acid synthesis by reducing 27-hydroxycholesterol levels. | 2014 | Details |
| A33974 | 24750585 | Hepatol Res | Anti-M3 muscarinic acetylcholine receptor antibodies in patients with primary biliary cirrhosis. | 2014 | Details |
| A34076 | 24471744 | J Pharm Pharmacol | Bupropion effects on high-fat diet-induced steatohepatitis and endothelial dysfunction in rats: role of tumour necrosis factor-alpha. | 2014 | Details |
| A34100 | 24384915 | Drug Metab Dispos | Modeling human nonalcoholic steatohepatitis-associated changes in drug transporter expression using experimental rodent models. | 2014 | Details |
| A34109 | 27433515 | Int Sch Res Notices | Serological and Histological Examination of a Nonalcoholic Steatohepatitis Mouse Model Created via the Administration of Monosodium Glutamate. | 2014 | Details |
| A34237 | 23996730 | Hepatology | Transforming growth factor beta signaling in hepatocytes participates in steatohepatitis through regulation of cell death and lipid metabolism in mice. | 2013 | Details |
| A34247 | 23974795 | Mol Pharmacol | Ursodeoxycholyl lysophosphatidylethanolamide inhibits lipoapoptosis by shifting fatty acid pools toward monosaturated and polyunsaturated fatty acids in mouse hepatocytes. | 2013 | Details |
| A34295 | 23832448 | Hepatology | Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. | 2013 | Details |
| A34425 | 23481610 | Toxicol Appl Pharmacol | Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation. | 2013 | Details |
| A34441 | 23448275 | Hepatol Res | Direct renin inhibitor, aliskiren, attenuates the progression of non-alcoholic steatohepatitis in the rat model. | 2013 | Details |
| A34486 | 23339067 | Hepatology | Hepatocyte caspase-8 is an essential modulator of steatohepatitis in rodents. | 2013 | Details |
| A34575 | 23170052 | J Clin Biochem Nutr | Anti-oxidative and anti-inflammatory effects of spirulina on rat model of non-alcoholic steatohepatitis. | 2012 | Details |
| A34846 | 22442158 | Am J Physiol Gastrointest Liver Physiol | Hepatic recruitment of macrophages promotes nonalcoholic steatohepatitis through CCR2. | 2012 | Details |
| A34859 | 22411067 | Lab Invest | Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. | 2012 | Details |
| A34881 | 22318941 | Hepatology | Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. | 2012 | Details |
| A34884 | 22294490 | Phytother Res | Hepatoprotective effects of pycnogenol in a rat model of non-alcoholic steatohepatitis. | 2012 | Details |
| A34947 | 22176027 | Hepatol Res | Spontaneously hypertensive rats develop pronounced hepatic steatosis induced by choline-deficient diet: Evidence for hypertension as a potential enhancer in non-alcoholic steatohepatitis. | 2011 | Details |
| A34970 | 22108052 | Biochem Biophys Res Commun | Nicotine induces fibrogenic changes in human liver via nicotinic acetylcholine receptors expressed on hepatic stellate cells. | 2011 | Details |
| A35035 | 21909411 | PLoS One | Oxidation of hepatic carnitine palmitoyl transferase-I (CPT-I) impairs fatty acid beta-oxidation in rats fed a methionine-choline deficient diet. | 2011 | Details |
| A35067 | 21818687 | Hepatol Int | Hepatocyte growth factor overexpression ameliorates liver inflammation and fibrosis in a mouse model of nonalcoholic steatohepatitis. | 2011 | Details |
| A35113 | 21711424 | Hepatol Res | Ursodeoxycholic acid dose-dependently improves liver injury in rats fed a methionine- and choline-deficient diet. | 2011 | Details |
| A35212 | 21435125 | Hepatol Res | Splenectomy reduces fibrosis and preneoplastic lesions with increased triglycerides and essential fatty acids in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. | 2011 | Details |
| A35214 | 21425308 | Hepatology | Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. | 2011 | Details |
| A35227 | 21373270 | J Clin Biochem Nutr | Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model. | 2010 | Details |
| A35241 | 21321532 | Lab Invest | Blockade of IL-6 signaling exacerbates liver injury and suppresses antiapoptotic gene expression in methionine choline-deficient diet-fed db/db mice. | 2011 | Details |
| A35259 | 21276150 | Hepatol Res | Pitavastatin inhibits hepatic steatosis and fibrosis in non-alcoholic steatohepatitis model rats. | 2011 | Details |
| A35286 | 21194384 | Antioxid Redox Signal | Transcriptional profile of genes involved in oxidative stress and antioxidant defense in a dietary murine model of steatohepatitis. | 2011 | Details |
| A35316 | 21119028 | Am J Physiol Endocrinol Metab | Metabolic pathways promoting intrahepatic fatty acid accumulation in methionine and choline deficiency: implications for the pathogenesis of steatohepatitis. | 2010 | Details |
| A35325 | 21081801 | J Physiol Pharmacol | The effects of L-tryptophan and melatonin on selected biochemical parameters in patients with steatohepatitis. | 2010 | Details |
| A35338 | 21056947 | Hum Exp Toxicol | Teucrium polium reversed the MCD diet-induced liver injury in rats. | 2010 | Details |
| A35362 | 20962016 | Exp Biol Med (Maywood) | Extracellular signal-regulated kinases 1/2 suppression aggravates transforming growth factor-beta1 hepatotoxicity: a potential mechanism for liver injury in methionine-choline deficient-diet-fed mice. | 2010 | Details |
| A35407 | 20818485 | Int J Mol Med | Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan. | 2010 | Details |
| A35453 | 20625232 | J Oleo Sci | Effects of docosahexaenoic acid in an experimental rat model of nonalcoholic steatohepatitis. | 2010 | Details |
| A35483 | 20557367 | Hepatol Res | Crucial role of impaired Kupffer cell phagocytosis on the decreased Sonazoid-enhanced echogenicity in a liver of a nonalchoholic steatohepatitis rat model. | 2010 | Details |
| A35544 | 20395294 | J Biol Chem | Specific contribution of methionine and choline in nutritional nonalcoholic steatohepatitis: impact on mitochondrial S-adenosyl-L-methionine and glutathione. | 2010 | Details |
| A35552 | 20376096 | Gene Ther | PPARgamma is essential for protection against nonalcoholic steatohepatitis. | 2010 | Details |
| A35554 | 20374300 | Hepatol Res | Chymase inhibitor prevents the nonalcoholic steatohepatitis in hamsters fed a methionine- and choline-deficient diet. | 2010 | Details |
| A35557 | 20368703 | Lab Invest | Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice. | 2010 | Details |
| A35570 | 20347818 | Gastroenterology | Toll-like receptor 9 promotes steatohepatitis by induction of interleukin-1beta in mice. | 2010 | Details |
| A35643 | 20034403 | Mol Neurodegener | Nitrosamine exposure exacerbates high fat diet-mediated type 2 diabetes mellitus, non-alcoholic steatohepatitis, and neurodegeneration with cognitive impairment. | 2009 | Details |
| A35675 | 19938191 | World J Gastroenterol | Immunotherapy for nonalcoholic steatohepatitis using the multiple cytokine production modulator Y-40138. | 2009 | Details |
| A35693 | 19902025 | J Clin Biochem Nutr | A Novel Animal Model of Nonalcoholic Steatohepatitis (NASH): Hypoxemia Enhances the Development of NASH. | 2009 | Details |
| A35699 | 19884114 | Evid Based Complement Alternat Med | Antioxidant and hepatoprotective effects of silibinin in a rat model of nonalcoholic steatohepatitis. | 2011 | Details |
| A35710 | 19856102 | Dig Dis Sci | Highly purified eicosapentaenoic acid ethyl ester prevents development of steatosis and hepatic fibrosis in rats. | 2009 | Details |
| A35753 | 19764881 | Antioxid Redox Signal | Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice. | 2009 | Details |
| A35765 | 19748164 | Clin Nutr | Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. | 2009 | Details |
| A35779 | 19711427 | Hepatology | Role of microRNA-155 at early stages of hepatocarcinogenesis induced by choline-deficient and amino acid-defined diet in C57BL/6 mice. | 2009 | Details |
| A35822 | 19606393 | Scand J Gastroenterol | Antioxidants vitamin E and 1-aminobenzotriazole prevent experimental non-alcoholic steatohepatitis in mice. | 2009 | Details |
| A35856 | 19552763 | J Pineal Res | Melatonin ameliorates methionine- and choline-deficient diet-induced nonalcoholic steatohepatitis in rats. | 2009 | Details |
| A35884 | 19501927 | J Hepatol | Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis. | 2009 | Details |
| A35887 | 19496180 | Hepatology | Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent. | 2009 | Details |
| A35896 | 19473437 | Hepatol Res | Adiponectin prevents progression of steatohepatitis in mice by regulating oxidative stress and Kupffer cell phenotype polarization. | 2009 | Details |
| A35909 | 19434740 | Hepatology | Nutritional model of steatohepatitis and metabolic syndrome in the Ossabaw miniature swine. | 2009 | Details |
| A35912 | 19430612 | J Clin Biochem Nutr | Beneficial Effects of Fermented Green Tea Extract in a Rat Model of Non-alcoholic Steatohepatitis. | 2009 | Details |
| A35913 | 19424798 | Dig Dis Sci | Protective effects of the carotenoid zeaxanthin in experimental nonalcoholic steatohepatitis. | 2009 | Details |
| A35917 | 19416517 | BMC Res Notes | Losartan, an angiotensin-II type 1 receptor blocker, attenuates the liver fibrosis development of non-alcoholic steatohepatitis in the rat. | 2009 | Details |
| A35919 | 19404342 | Acta Med Okayama | Beneficial effects of Vitis coignetiae Pulliat leaves on nonalcoholic steatohepatitis in a rat model. | 2009 | Details |
| A35934 | 19387107 | J Alzheimers Dis | Mechanisms of ceramide-mediated neurodegeneration. | 2009 | Details |
| A36092 | 19026502 | Eur J Radiol | New proposal for the staging of nonalcoholic steatohepatitis: evaluation of liver fibrosis on Gd-EOB-DTPA-enhanced MRI. | 2008 | Details |
| A36112 | 18991162 | Scand J Gastroenterol | Rosiglitazone prevents nutritional fibrosis and steatohepatitis in mice. | 2009 | Details |
| A36116 | 18986378 | Alcohol Clin Exp Res | Nitric oxide plays a crucial role in the development/progression of nonalcoholic steatohepatitis in the choline-deficient, l-amino acid-defined diet-fed rat model. | 2009 | Details |
| A36150 | 18932283 | World J Gastroenterol | Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model. | 2008 | Details |
| A36182 | 18802068 | J Immunol | Novel role of IL-13 in fibrosis induced by nonalcoholic steatohepatitis and its amelioration by IL-13R-directed cytotoxin in a rat model. | 2008 | Details |
| A36192 | 18769506 | Nutr Res | The Combination of S-adenosylmethionine and Dilinoleoylphosphatidylcholine Attenuates Non-alcoholic Steatohepatitis Produced in Rats by a High-Fat Diet. | 2007 | Details |
| A36228 | 18689562 | J Am Coll Nutr | Prevention and reversion of nonalcoholic steatohepatitis in OB/OB mice by S-nitroso-N-acetylcysteine treatment. | 2008 | Details |
| A36237 | 18666257 | Hepatology | Hepatic AdipoR2 signaling plays a protective role against progression of nonalcoholic steatohepatitis in mice. | 2008 | Details |
| A36270 | 18571789 | Hepatology | Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis. | 2008 | Details |
| A36291 | 18513333 | Hepatol Res | Bezafibrate prevents hepatic stellate cell activation and fibrogenesis in a murine steatohepatitis model, and suppresses fibrogenic response induced by transforming growth factor-beta1 in a cultured stellate cell line. | 2008 | Details |
| A36302 | 18501395 | Toxicol Appl Pharmacol | Nonalcoholic steatohepatitic (NASH) mice are protected from higher hepatotoxicity of acetaminophen upon induction of PPARalpha with clofibrate. | 2008 | Details |
| A36348 | 18392239 | J Gastrointestin Liver Dis | Angiotensin II type 1 receptor antagonist improves the prognosis in rats displaying liver cirrhosis induced by a choline-deficient diet. | 2008 | Details |
| A36379 | 18339004 | Eur J Clin Invest | Alterations of hepatic ATP homeostasis and respiratory chain during development of non-alcoholic steatohepatitis in a rodent model. | 2008 | Details |
| A36429 | 18227531 | J Lipid Res | Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. | 2008 | Details |
| A36483 | 18036573 | Biochem Pharmacol | The pathogenesis of ethanol versus methionine and choline deficient diet-induced liver injury. | 2007 | Details |
| A36492 | 18000880 | Hepatology | Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. | 2008 | Details |
| A36511 | 17963695 | Biochem Biophys Res Commun | Telmisartan prevents hepatic fibrosis and enzyme-altered lesions in liver cirrhosis rat induced by a choline-deficient L-amino acid-defined diet. | 2007 | Details |
| A36514 | 17951222 | J Lipid Res | Lysophosphatidylcholine as a death effector in the lipoapoptosis of hepatocytes. | 2007 | Details |
| A36562 | 17825453 | J Hepatol | Iron preloading aggravates nutritional steatohepatitis in rats by increasing apoptotic cell death. | 2007 | Details |
| A36567 | 17729114 | Free Radic Res | Modulation of Fas-FasL related apoptosis by PBN in the early phases of choline deficient diet-mediated hepatocarcinogenesis in rats. | 2007 | Details |
| A36570 | 17721935 | J Biochem Mol Toxicol | Genes of the antioxidant response undergo upregulation in a rodent model of nonalcoholic steatohepatitis. | 2007 | Details |
| A36577 | 17710550 | Dig Dis Sci | Methionine deficiency and hepatic injury in a dietary steatohepatitis model. | 2007 | Details |
| A36583 | 17681180 | Gastroenterology | Serotonin mediates oxidative stress and mitochondrial toxicity in a murine model of nonalcoholic steatohepatitis. | 2007 | Details |
| A36634 | 17565640 | J Gastroenterol Hepatol | Effect of losartan on early liver fibrosis development in a rat model of nonalcoholic steatohepatitis. | 2007 | Details |