Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Lipid metabolism4743 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A10329 | 31387169 | Biomed Pharmacother | Mitochondrial dysfunction in high-fat diet-induced nonalcoholic fatty liver disease: The alleviating effect and its mechanism of Polygonatum kingianum. | 2019 | Details |
| A10337 | 31384535 | Acta Pharm Sin B | Silibinin ameliorates hepatic lipid accumulation and oxidative stress in mice with non-alcoholic steatohepatitis by regulating CFLAR-JNK pathway. | 2019 | Details |
| A10359 | 31375359 | Mol Ther | A Mitochondrial VDAC1-Based Peptide Greatly Suppresses Steatosis and NASH-Associated Pathologies in a Mouse Model. | 2019 | Details |
| A10370 | 31371265 | Nutr Metab Cardiovasc Dis | Non-invasive assessment of hepatic lipid subspecies matched with non-alcoholic fatty liver disease phenotype. | 2019 | Details |
| A10373 | 31367159 | World J Gastroenterol | Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota. | 2019 | Details |
| A10378 | 31366243 | FASEB J | Long-term exercise prevents hepatic steatosis: a novel role of FABP1 in regulation of autophagy-lysosomal machinery. | 2019 | Details |
| A10379 | 31364723 | Int J Mol Med | Green tea polyphenols attenuate hepatic steatosis, and reduce insulin resistance and inflammation in high-fat diet-induced rats. | 2019 | Details |
| A10384 | 31361524 | FASEB J | Maslinic acid protects against obesity-induced nonalcoholic fatty liver disease in mice through regulation of the Sirt1/AMPK signaling pathway. | 2019 | Details |
| A10386 | 31360108 | Int J Biol Sci | Treatment implications of natural compounds targeting lipid metabolism in nonalcoholic fatty liver disease, obesity and cancer. | 2019 | Details |
| A10391 | 31358770 | Nat Commun | ER-residential Nogo-B accelerates NAFLD-associated HCC mediated by metabolic reprogramming of oxLDL lipophagy. | 2019 | Details |
| A10392 | 31357780 | Zhonghua Gan Zang Bing Za Zhi | [A new attempt with lipoprotein lipase agonists in the treatment of nonalcoholic steatohepatitis]. | 2019 | Details |
| A10394 | 31357643 | Int J Mol Sci | Association between Lysosomal Dysfunction and Obesity-Related Pathology: A Key Knowledge to Prevent Metabolic Syndrome. | 2019 | Details |
| A10397 | 31355570 | Zhongguo Zhong Yao Za Zhi | [Psoralen and isopsoralen improve lipid metabolism disorder via inhibition of NF-κB activation in LO2 cells]. | 2019 | Details |
| A10407 | 31349604 | Nutrients | Gut Microbiota-Derived Components and Metabolites in the Progression of Non-Alcoholic Fatty Liver Disease (NAFLD). | 2019 | Details |
| A10425 | 31341532 | Oxid Med Cell Longev | Dietary Glycotoxins Impair Hepatic Lipidemic Profile in Diet-Induced Obese Rats Causing Hepatic Oxidative Stress and Insulin Resistance. | 2019 | Details |
| A10427 | 31341422 | Mediators Inflamm | Role of Bile Acids in Dysbiosis and Treatment of Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A10432 | 31338065 | Front Endocrinol (Lausanne) | Resveratrol Reduces Glucolipid Metabolic Dysfunction and Learning and Memory Impairment in a NAFLD Rat Model: Involvement in Regulating the Imbalance of Nesfatin-1 Abundance and Copine 6 Expression. | 2019 | Details |
| A10453 | 31330977 | Antioxidants (Basel) | Nutritional Importance of Carotenoids and Their Effect on Liver Health: A Review. | 2019 | Details |
| A10456 | 31330134 | Metabolism | AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease. | 2019 | Details |
| A10463 | 31325892 | J Nutr Biochem | Apigenin ameliorates HFD-induced NAFLD through regulation of the XO/NLRP3 pathways. | 2019 | Details |
| A10471 | 31323923 | Toxins (Basel) | Sub-Chronic Microcystin-LR Liver Toxicity in Preexisting Diet-Induced Nonalcoholic Steatohepatitis in Rats. | 2019 | Details |
| A10498 | 31311123 | Nutrients | Western Diet-Induced Metabolic Alterations Affect Circulating Markers of Liver Function before the Development of Steatosis. | 2019 | Details |
| A10506 | 31309533 | FEBS Lett | Chronic exposure to Pb2+ perturbs ChREBP transactivation and coerces hepatic dyslipidemia. | 2019 | Details |
| A10523 | 31301418 | Life Sci | (5R)-5-hydroxytriptolide ameliorates liver lipid accumulation by suppressing lipid synthesis and promoting lipid oxidation in mice. | 2019 | Details |
| A10529 | 31300518 | Gut | miRNAs and NAFLD: from pathophysiology to therapy. | 2019 | Details |
| A10532 | 31299271 | Toxicol Appl Pharmacol | IFN-α-2b treatment protects against diet-induced obesity and alleviates non-alcoholic fatty liver disease in mice. | 2019 | Details |
| A10536 | 31297627 | Dig Dis Sci | A Cholecystokinin Receptor Antagonist Halts Nonalcoholic Steatohepatitis and Prevents Hepatocellular Carcinoma. | 2019 | Details |
| A10547 | 31293337 | World J Gastroenterol | Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease. | 2019 | Details |
| A10565 | 31288993 | Mol Metab | GDF10 blocks hepatic PPARγ activation to protect against diet-induced liver injury. | 2019 | Details |
| A10571 | 31284538 | Molecules | The Modulatory Action of Vitamin D on the Renin-Angiotensin System and the Determination of Hepatic Insulin Resistance. | 2019 | Details |
| A10591 | 31278754 | J Physiol | Liver sympathetic denervation reverses obesity-induced hepatic steatosis. | 2019 | Details |
| A10592 | 31278418 | Eur J Nutr | Açaí (Euterpe oleracea Martius) supplementation in the diet during gestation and lactation attenuates liver steatosis in dams and protects offspring. | 2019 | Details |
| A10619 | 31269758 | Mar Drugs | Chitosan Oligosaccharide Ameliorates Nonalcoholic Fatty Liver Disease (NAFLD) in Diet-Induced Obese Mice. | 2019 | Details |
| A10621 | 31267355 | J Nat Med | Consumption of lycopene-rich tomatoes improved glucose homeostasis in rats via an increase in leptin levels. | 2019 | Details |
| A10623 | 31266893 | Proc Natl Acad Sci U S A | p110γ deficiency protects against pancreatic carcinogenesis yet predisposes to diet-induced hepatotoxicity. | 2019 | Details |
| A10648 | 31255630 | Dig Liver Dis | Contribution of a genetic risk score to clinical prediction of hepatic steatosis in obese children and adolescents. | 2019 | Details |
| A10669 | 31244392 | Biosci Biotechnol Biochem | Extracts of bilberry (Vaccinium myrtillus L.) fruits improve liver steatosis and injury in mice by preventing lipid accumulation and cell death. | 2019 | Details |
| A10673 | 31242974 | Biochem Biophys Res Commun | Cordycepin alleviates hepatic lipid accumulation by inducing protective autophagy via PKA/mTOR pathway. | 2019 | Details |
| A10686 | 31236687 | Handb Exp Pharmacol | Potential of Intestine-Selective FXR Modulation for Treatment of Metabolic Disease. | 2019 | Details |
| A10687 | 31236111 | Int J Endocrinol | Liraglutide Attenuates Nonalcoholic Fatty Liver Disease through Adjusting Lipid Metabolism via SHP1/AMPK Signaling Pathway. | 2019 | Details |
| A10698 | 31233523 | PLoS One | Apical sodium-dependent bile acid transporter inhibition with volixibat improves metabolic aspects and components of non-alcoholic steatohepatitis in Ldlr-/-.Leiden mice. | 2019 | Details |
| A10699 | 31233505 | PLoS One | Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats. | 2019 | Details |
| A10707 | 31227825 | Hum Mol Genet | Recent advances in novel therapies for lipid disorders. | 2019 | Details |
| A10711 | 31226595 | J Hazard Mater | Chronic exposure to tetrabromodiphenyl ether (BDE-47) aggravates hepatic steatosis and liver fibrosis in diet-induced obese mice. | 2019 | Details |
| A10712 | 31226399 | Free Radic Biol Med | Berberine attenuates nonalcoholic hepatic steatosis through the AMPK-SREBP-1c-SCD1 pathway. | 2019 | Details |
| A10717 | 31225483 | Cell Stress | Foie gras and liver regeneration: a fat dilemma. | 2018 | Details |
| A10734 | 31216433 | J Ethnopharmacol | Exploring the protective effect of ShengMai-Yin and Ganmaidazao decoction combination against type 2 diabetes mellitus with nonalcoholic fatty liver disease by network pharmacology and validation in KKAy mice. | 2019 | Details |
| A10737 | 31215394 | Mol Med | FBXW7 suppresses HMGB1-mediated innate immune signaling to attenuate hepatic inflammation and insulin resistance in a mouse model of nonalcoholic fatty liver disease. | 2019 | Details |
| A10738 | 31215262 | Expert Rev Gastroenterol Hepatol | Olive oil antioxidants and non-alcoholic fatty liver disease. | 2019 | Details |
| A10739 | 31214287 | Nutr Res Pract | Free fatty acid-induced histone acetyltransferase activity accelerates lipid accumulation in HepG2 cells. | 2019 | Details |
| A10748 | 31212314 | J Nutr | Dietary β-Cryptoxanthin Inhibits High-Refined Carbohydrate Diet-Induced Fatty Liver via Differential Protective Mechanisms Depending on Carotenoid Cleavage Enzymes in Male Mice. | 2019 | Details |
| A10757 | 31208043 | Nutrients | Dietary Fiber in Bilberry Ameliorates Pre-Obesity Events in Rats by Regulating Lipid Depot, Cecal Short-Chain Fatty Acid Formation and Microbiota Composition. | 2019 | Details |
| A10767 | 31203627 | J Agric Food Chem | Polyphenol-Rich Loquat Fruit Extract Prevents Fructose-Induced Nonalcoholic Fatty Liver Disease by Modulating Glycometabolism, Lipometabolism, Oxidative Stress, Inflammation, Intestinal Barrier, and Gut Microbiota in Mice. | 2019 | Details |
| A10769 | 31202833 | Metabolism | Effects of dapagliflozin and/or insulin glargine on beta cell mass and hepatic steatosis in db/db mice. | 2019 | Details |
| A10770 | 31202118 | J Nutr Biochem | Cyp2b-null male mice are susceptible to diet-induced obesity and perturbations in lipid homeostasis. | 2019 | Details |
| A10780 | 31197036 | J Biol Chem | Enhanced acetylation of ATP-citrate lyase promotes the progression of nonalcoholic fatty liver disease. | 2019 | Details |
| A10782 | 31195981 | Mol Med | miR-122 promotes hepatic lipogenesis via inhibiting the LKB1/AMPK pathway by targeting Sirt1 in non-alcoholic fatty liver disease. | 2019 | Details |
| A10792 | 31191323 | Front Pharmacol | Role of Myeloid-Epithelial-Reproductive Tyrosine Kinase and Macrophage Polarization in the Progression of Atherosclerotic Lesions Associated With Nonalcoholic Fatty Liver Disease. | 2019 | Details |
| A10804 | 31182918 | Int J Biol Sci | A Comprehensive Study of High Cholesterol Diet-Induced Larval Zebrafish Model: A Short-Time In Vivo Screening Method for Non-Alcoholic Fatty Liver Disease Drugs. | 2019 | Details |
| A10812 | 31177593 | Traffic | Metabolic regulation through the endosomal system. | 2019 | Details |
| A10819 | 31173696 | Appl Physiol Nutr Metab | Resveratrol protects against nonalcoholic fatty liver disease by improving lipid metabolism and redox homeostasis via the PPARα pathway. | 2019 | Details |
| A10820 | 31173506 | FASEB J | Protein kinase MST3 modulates lipid homeostasis in hepatocytes and correlates with nonalcoholic steatohepatitis in humans. | 2019 | Details |
| A10822 | 31173200 | Mol Med Rep | Diallyl disulfide attenuates non‑alcoholic steatohepatitis by suppressing key regulators of lipid metabolism, lipid peroxidation and inflammation in mice. | 2019 | Details |
| A10823 | 31173180 | Int J Mol Med | Excess fructose and fatty acids trigger a model of non‑alcoholic fatty liver disease progression in vitro: Protective effect of the flavonoid silybin. | 2019 | Details |
| A10860 | 31152791 | Free Radic Biol Med | Lipidomic biomarkers and mechanisms of lipotoxicity in non-alcoholic fatty liver disease. | 2019 | Details |
| A10865 | 31151002 | J Mech Behav Biomed Mater | Biomechanics of cultured hepatic cells during different steatogenic hits. | 2019 | Details |
| A10876 | 31144451 | J Cell Mol Med | Alisol A attenuates high-fat-diet-induced obesity and metabolic disorders via the AMPK/ACC/SREBP-1c pathway. | 2019 | Details |
| A10888 | 31139087 | Front Physiol | Circadian Clock Genes in the Metabolism of Non-alcoholic Fatty Liver Disease. | 2019 | Details |
| A10892 | 31137047 | Planta Med | Z-ligustilide and n-Butylidenephthalide Isolated from the Aerial Parts of Angelica tenuissima Inhibit Lipid Accumulation In Vitro and In Vivo. | 2019 | Details |
| A10894 | 31136662 | Am J Clin Nutr | Yogurt improves insulin resistance and liver fat in obese women with nonalcoholic fatty liver disease and metabolic syndrome: a randomized controlled trial. | 2019 | Details |
| A10900 | 31134334 | J Gastroenterol | Nonalcoholic fatty liver disease is associated with lower hepatitis B viral load and antiviral response in pediatric population. | 2019 | Details |
| A10908 | 31130652 | Metabolites | Non-Alcoholic Fatty Liver Disease, and the Underlying Altered Fatty Acid Metabolism, Reveals Brain Hypoperfusion and Contributes to the Cognitive Decline in APP/PS1 Mice. | 2019 | Details |
| A10928 | 31117231 | Nutrients | Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation. | 2019 | Details |
| A10930 | 31115630 | Appl Microbiol Biotechnol | Lactobacillus plantarum NA136 improves the non-alcoholic fatty liver disease by modulating the AMPK/Nrf2 pathway. | 2019 | Details |
| A10943 | 31111657 | Obes Rev | The effects of oleoylethanolamide, an endogenous PPAR-α agonist, on risk factors for NAFLD: A systematic review. | 2019 | Details |
| A10952 | 31105592 | Front Physiol | Tangshen Formula Alleviates Hepatic Steatosis by Inducing Autophagy Through the AMPK/SIRT1 Pathway. | 2019 | Details |
| A10960 | 31101783 | Georgian Med News | RESULTS OF CORRECTION OF THE HEPATIC STEATOSIS ON THE BACKGROUND OF HYPERTENSION AND OVERWEIGHT WITH HELP OF ESSENTIAL PHOSPHOLIPID COMPLEX. | 2019 | Details |
| A10969 | 31098621 | Endocr Rev | The Liver as an Endocrine Organ-Linking NAFLD and Insulin Resistance. | 2019 | Details |
| A10972 | 31097771 | Sci Rep | The Differential Expression of Cide Family Members is Associated with Nafld Progression from Steatosis to Steatohepatitis. | 2019 | Details |
| A10976 | 31094472 | Ter Arkh | Biochemical and molecular-genetic indicators of inflammation and apoptosis in liver cirrhosis as an outcome of the progression of non-alcoholic steatohepatitis. | 2019 | Details |
| A10983 | 31092797 | J Oleo Sci | Hepatoprotective Effect of Seed Coat ofEuryale ferox Extract in Non-alcoholic Fatty Liver Disease Induced by High-fat Diet in Mice by Increasing IRs-1 and Inhibiting CYP2E1. | 2019 | Details |
| A10986 | 31090267 | J Zhejiang Univ Sci B | Bile-ology: from bench to bedside. | 2019 | Details |
| A10988 | 31089602 | Food Funct | A sulfated polysaccharide from Gracilaria Lemaneiformis regulates cholesterol and bile acid metabolism in high-fat diet mice. | 2019 | Details |
| A10995 | 31087530 | Physiol Rep | Whole-body vibration for patients with nonalcoholic fatty liver disease: a 6-month prospective study. | 2019 | Details |
| A10997 | 31086120 | Int J Mol Sci | Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis. | 2019 | Details |
| A11006 | 31083505 | Cells | Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet. | 2019 | Details |
| A11010 | 31082799 | J Endocrinol | Impact of exenatide on mitochondrial lipid metabolism in mice with nonalcoholic steatohepatitis. | 2019 | Details |
| A11031 | 31076985 | Dig Dis Sci | Vitamin E Ameliorates Lipid Metabolism in Mice with Nonalcoholic Fatty Liver Disease via Nrf2/CES1 Signaling Pathway. | 2019 | Details |
| A11044 | 31070764 | J Nutr | Triplet Male Lambs Are More Susceptible than Twins to Dietary Soybean Oil-Induced Fatty Liver. | 2019 | Details |
| A11046 | 31070259 | Hepatology | Unexpected Rapid Increase in the Burden of NAFLD in China From 2008 to 2018: A Systematic Review and Meta-Analysis. | 2019 | Details |
| A11047 | 31069793 | J Cell Physiol | S100A16, a novel lipogenesis promoting factor in livers of mice and hepatocytes in vitro. | 2019 | Details |
| A11050 | 31067824 | J Clin Med | Lysosomal Acid Lipase as a Molecular Target of the Very Low Carbohydrate Ketogenic Diet in Morbidly Obese Patients: The Potential Effects on Liver Steatosis and Cardiovascular Risk Factors. | 2019 | Details |
| A11053 | 31064820 | Biosci Rep | LncRNA-H19 promotes hepatic lipogenesis by directly regulating miR-130a/PPARγ axis in non-alcoholic fatty liver disease. | 2019 | Details |
| A11059 | 31063640 | Hepatology | Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast-Food Diet Model. | 2019 | Details |
| A11074 | 31057294 | World J Gastroenterol | Repurposing drugs to target nonalcoholic steatohepatitis. | 2019 | Details |
| A11078 | 31055201 | Environ Int | Low-dose PCB126 compromises circadian rhythms associated with disordered glucose and lipid metabolism in mice. | 2019 | Details |
| A11087 | 31048208 | J Nutr Biochem | Metabolic dysfunction following weight regain compared to initial weight gain in a high-fat diet-induced obese mouse model. | 2019 | Details |
| A11105 | 31040374 | Sci Rep | Metformin attenuates the onset of non-alcoholic fatty liver disease and affects intestinal microbiota and barrier in small intestine. | 2019 | Details |
| A11130 | 31029756 | J Ethnopharmacol | Antisteatotic and antioxidant activities of Thymbra spicata L. extracts in hepatic and endothelial cells as in vitro models of non-alcoholic fatty liver disease. | 2019 | Details |
| A11154 | 31020720 | Exp Physiol | Combined treatment of dipeptidyl peptidase-4 inhibitor and exercise training improves lipid profile in KK/Ta mice. | 2019 | Details |