Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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apoptosis1710 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A47339 | 15885730 | Toxicol Appl Pharmacol | Role of osteopontin in hepatic neutrophil infiltration during alcoholic steatohepatitis. | 2005 | Details |
| A47342 | 15603541 | Toxicol Pathol | Hepatocyte proliferation is the possible mechanism for the transient decrease in liver injury during steatosis stage of alcoholic liver disease. | 2005 | Details |
| A47345 | 15368449 | Hepatology | Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury. | 2004 | Details |
| A47483 | 2295475 | Hepatology | The natural history of nonalcoholic steatohepatitis: a follow-up study of forty-two patients for up to 21 years. | 1990 | Details |
| A47609 | 35156314 | Obesity (Silver Spring) | Suppression of RIP1 activity via S415 dephosphorylation ameliorates obesity-related hepatic insulin resistance. | 2022 | Details |
| A47624 | 34816633 | Hepatol Commun | Pcsk9 Deletion Promotes Murine Nonalcoholic Steatohepatitis and Hepatic Carcinogenesis: Role of Cholesterol. | 2021 | Details |
| A47726 | 32892258 | Hepatol Int | Interleukin-22 in alcoholic hepatitis and beyond. | 2020 | Details |
| A47764 | 32289582 | Eur J Med Chem | Discovery of a 2-pyridinyl urea-containing compound YD57 as a potent inhibitor of apoptosis signal-regulating kinase 1 (ASK1). | 2020 | Details |
| A47784 | 31974614 | Mol Med Rep | Protein kinase C promotes choline transporter‑like protein 1 function via improved cell surface expression in immortalized human hepatic cells. | 2019 | Details |
| A47830 | 31213776 | Drug Des Devel Ther | Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways. | 2019 | Details |
| A47831 | 31201023 | Transfus Clin Biol | The emerging roles of eryptosis in liver diseases. | 2019 | Details |
| A47874 | 30357770 | Semin Liver Dis | Role of TGR5 (GPBAR1) in Liver Disease. | 2018 | Details |
| A47886 | 30063802 | Hepatology | Emricasan (IDN-6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension. | 2018 | Details |
| A47901 | 29687726 | Antioxid Redox Signal | The Association of Peroxiredoxin 4 with the Initiation and Progression of Hepatocellular Carcinoma. | 2018 | Details |
| A47903 | 29619419 | Hepatol Commun | Tumor necrosis factor-α-mediated hepatocyte apoptosis stimulates fibrosis in the steatotic liver in mice. | 2018 | Details |
| A47908 | 29500886 | Cell Biol Int | Biological effects of trans fatty acids and their possible roles in the lipid rafts in apoptosis regulation. | 2018 | Details |
| A47909 | 29486473 | Cell Physiol Biochem | ShenFu Preparation Protects AML12 Cells Against Palmitic Acid-Induced Injury Through Inhibition of Both JNK/Nox4 and JNK/NFκB Pathways. | 2018 | Details |
| A47923 | 29191940 | Am J Physiol Gastrointest Liver Physiol | Loss of cellular FLICE-inhibitory protein promotes acute cholestatic liver injury and inflammation from bile duct ligation. | 2017 | Details |
| A47930 | 28985205 | Nat Med | Corrigendum: Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates. | 2017 | Details |
| A47976 | 27618480 | Clin Res Hepatol Gastroenterol | Stress-induced cellular responses and cell death mechanisms during inflammatory cholangiopathies. | 2016 | Details |
| A47999 | 26872435 | J Microbiol Immunol Infect | Serum pentraxin-3 and tumor necrosis factor-like weak inducer of apoptosis (TWEAK) predict severity of infections in acute decompensated cirrhotic patients. | 2016 | Details |
| A48000 | 26853542 | Hepatology | Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver. | 2016 | Details |
| A48009 | 26686910 | Reprod Toxicol | Anti-inflammatory potential of β-cryptoxanthin against LPS-induced inflammation in mouse Sertoli cells. | 2015 | Details |
| A48013 | 26557935 | Prz Gastroenterol | Cytokeratins in gastroenterology. Systematic review. | 2015 | Details |
| A48092 | 24204981 | PLoS One | Aliskiren attenuates steatohepatitis and increases turnover of hepatic fat in mice fed with a methionine and choline deficient diet. | 2013 | Details |
| A48115 | 22922425 | Gastroenterology | NF-κB essential modifier is required for hepatocyte proliferation and the oval cell reaction after partial hepatectomy in mice. | 2012 | Details |
| A48124 | 22521608 | Toxicol Appl Pharmacol | Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells. | 2012 | Details |
| A48130 | 22239000 | Pol Merkur Lekarski | [Cytokeratin 18 as an indicator of the activity of liver disease]. | 2011 | Details |
| A48133 | 22102395 | Korean J Hepatol | Apoptosis and diagnosis of nonalcoholic steatohepatitis. | 2011 | Details |
| A48136 | 21941003 | J Biol Chem | Death receptor 5 signaling promotes hepatocyte lipoapoptosis. | 2011 | Details |
| A48162 | 20945987 | Biomark Med | Apoptosis in nonalcoholic steatohepatitis with normal aminotransferase values: zooming in on cytokeratin 18 fragments. | 2010 | Details |
| A48178 | 20651240 | Am J Pathol | Acidic sphingomyelinase controls hepatic stellate cell activation and in vivo liver fibrogenesis. | 2010 | Details |
| A48188 | 20223120 | Zhonghua Yi Xue Za Zhi | [Mechanism of hepatocyte regeneration inhibition in rats with liver fibrosis induced by lipogenic methionine-choline- deficient diet]. | 2009 | Details |
| A48210 | 19593820 | Hepatology | An apoptosis biomarker for prediction of nonalcoholic steatohepatitis. | 2009 | Details |
| A48220 | 19407360 | Dis Markers | Could high levels of tissue polypeptide specific antigen, a marker of apoptosis detected in nonalcoholic steatohepatitis, improve after weight loss? | 2009 | Details |
| A48249 | 18715620 | Hum Pathol | Apoptosis markers in liver biopsy of nonalcoholic steatohepatitis in pediatric patients. | 2008 | Details |
| A48263 | 18161050 | Hepatology | Etiology-dependent molecular mechanisms in human hepatocarcinogenesis. | 2008 | Details |
| A48267 | 18032466 | Am J Physiol Regul Integr Comp Physiol | Attenuation of acute and chronic liver injury in rats by iron-deficient diet. | 2007 | Details |
| A48278 | 17626006 | J Biol Chem | Transcriptional regulation of Bim by FoxO3A mediates hepatocyte lipoapoptosis. | 2007 | Details |
| A48299 | 17023945 | Curr Opin Gastroenterol | Pathology of the liver. | 1999 | Details |
| A48333 | 16265071 | Nat Clin Pract Gastroenterol Hepatol | Mechanisms of disease: Mechanisms of hepatic fibrosis and therapeutic implications. | 2004 | Details |
| A48348 | 15738389 | Proc Natl Acad Sci U S A | Liver-specific inactivation of the Nrf1 gene in adult mouse leads to nonalcoholic steatohepatitis and hepatic neoplasia. | 2005 | Details |
| A48357 | 15368448 | Hepatology | Norepinephrine regulates hepatic innate immune system in leptin-deficient mice with nonalcoholic steatohepatitis. | 2004 | Details |
| A48407 | 12122863 | Clin Liver Dis | Alcoholic and nonalcoholic steatohepatitis. | 2002 | Details |
| A48423 | 11557505 | Am J Physiol Gastrointest Liver Physiol | Nonalcoholic steatosis and steatohepatitis. I. Molecular mechanism for polyunsaturated fatty acid regulation of gene transcription. | 2001 | Details |
| A48452 | 10094957 | Hepatology | Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. | 1999 | Details |
| A48526 | 34774873 | Life Sci | GPR40 agonist inhibits NLRP3 inflammasome activation via modulation of nuclear factor-κB and sarco/endoplasmic reticulum Ca2+-ATPase. | 2021 | Details |
| A48583 | 33624852 | J Food Biochem | Red yeast rice prevents chronic alcohol-induced liver disease by attenuating oxidative stress and inflammatory response in mice. | 2021 | Details |
| A48596 | 33390846 | Int J Biol Sci | miR-340: A multifunctional role in human malignant diseases. | 2021 | Details |
| A48605 | 33201177 | Brief Bioinform | Tracing the footsteps of autophagy in computational biology. | 2021 | Details |
| A48701 | 31171906 | Int J Med Sci | MALAT1 as a Diagnostic and Therapeutic Target in Diabetes-Related Complications: A Promising Long-Noncoding RNA. | 2019 | Details |
| A48718 | 30748014 | Alcohol Clin Exp Res | The Chemical Chaperone 4-Phenylbutyric Acid Prevents Alcohol-Induced Liver Injury in Obese KK-Ay Mice. | 2019 | Details |
| A48725 | 30602573 | Clin Sci (Lond) | Elafibranor interrupts adipose dysfunction-mediated gut and liver injury in mice with alcoholic steatohepatitis. | 2019 | Details |
| A48738 | 30267745 | Toxicol Appl Pharmacol | Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases. | 2018 | Details |
| A48756 | 29597210 | Pharmacology | Euodia daniellii Hemsl. (Bee-Bee Tree) Oil Attenuates Palmitate-Induced Lipid Accumulation and Apoptosis in Hepatocytes. | 2018 | Details |
| A48777 | 29108122 | Hepatology | Pyroptosis by caspase11/4-gasdermin-D pathway in alcoholic hepatitis in mice and patients. | 2018 | Details |
| A48814 | 27734263 | Med Oncol | Statin attenuates cell proliferative ability via TAZ (WWTR1) in hepatocellular carcinoma. | 2016 | Details |
| A48841 | 26808690 | PLoS One | Hepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice. | 2016 | Details |
| A48848 | 26701066 | Toxicol Appl Pharmacol | Genetically obese (ob/ob) mice are resistant to the lethal effects of thioacetamide hepatotoxicity. | 2015 | Details |
| A48851 | 26651978 | Curr Drug Metab | Indole-3-Carbinol (I3C) and its Major Derivatives: Their Pharmacokinetics and Important Roles in Hepatic Protection. | 2016 | Details |
| A48857 | 26448681 | Mediators Inflamm | C57BL/6 and A/J Mice Have Different Inflammatory Response and Liver Lipid Profile in Experimental Alcoholic Liver Disease. | 2015 | Details |
| A48888 | 25531568 | Lab Invest | TRAIL-producing NK cells contribute to liver injury and related fibrogenesis in the context of GNMT deficiency. | 2014 | Details |
| A48895 | 25356026 | World J Gastroenterol | Non-invasive diagnosis of alcoholic liver disease. | 2014 | Details |
| A48912 | 24769730 | Cell Death Differ | Degradation of Keap1 activates BH3-only proteins Bim and PUMA during hepatocyte lipoapoptosis. | 2014 | Details |
| A48916 | 24592262 | Front Immunol | TWEAK and LTβ Signaling during Chronic Liver Disease. | 2014 | Details |
| A48921 | 24400890 | J Cell Mol Med | The functional role of microRNAs in alcoholic liver injury. | 2014 | Details |
| A48943 | 23663886 | Zhonghua Gan Zang Bing Za Zhi | [Activation of Fas/FasL and its downstream signaling pathway promotes development of alcoholic steatohepatitis and liver fibrosis in mice]. | 2013 | Details |
| A48946 | 23560159 | Gut Liver | Lipoic Acid prevents the changes of intracellular lipid partitioning by free Fatty Acid. | 2013 | Details |
| A48958 | 23184344 | Eur J Nutr | Inhibition of DNA-dependent protein kinase reduced palmitate and oleate-induced lipid accumulation in HepG2 cells. | 2012 | Details |
| A48963 | 23057725 | Hepatol Res | Fatty liver Shionogi-ob/ob mouse: A new candidate for a non-alcoholic steatohepatitis model. | 2012 | Details |
| A48964 | 23027617 | Carcinogenesis | Preventive effects of branched-chain amino acid supplementation on the spontaneous development of hepatic preneoplastic lesions in C57BL/KsJ-db/db obese mice. | 2012 | Details |
| A48966 | 22959770 | Biochem Biophys Res Commun | Expression and function of the atypical cadherin FAT1 in chronic liver disease. | 2012 | Details |
| A48974 | 22637703 | Gut | Transcriptome analysis identifies TNF superfamily receptors as potential therapeutic targets in alcoholic hepatitis. | 2012 | Details |
| A48977 | 22489261 | World J Hepatol | Human immunodeficiency virus infection and the liver. | 2012 | Details |
| A49001 | 21763667 | J Hepatol | Caspase-cleaved keratin 18 as a biomarker for non-alcoholic steatohepatitis (NASH) - the need for correct terminology. | 2011 | Details |
| A49009 | 21466434 | Curr Pharm Biotechnol | Silymarin in the prevention and treatment of liver diseases and primary liver cancer. | 2012 | Details |
| A49016 | 21256123 | Chem Biol Interact | Murine hepatic aldehyde dehydrogenase 1a1 is a major contributor to oxidation of aldehydes formed by lipid peroxidation. | 2011 | Details |
| A49025 | 20979658 | Lipids Health Dis | Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice. | 2010 | Details |
| A49038 | 20460903 | Dig Dis | Apoptosis in immune-mediated liver diseases. | 2010 | Details |
| A49044 | 20192918 | Cell Biol Int | Recent advances in understanding the roles of transglutaminase 2 in alcoholic steatohepatitis. | 2010 | Details |
| A49045 | 20186755 | Proteomics | Prohibitin deficiency blocks proliferation and induces apoptosis in human hepatoma cells: molecular mechanisms and functional implications. | 2010 | Details |
| A49051 | 19957376 | Hepatology | Epigenetic regulation of hepatic endoplasmic reticulum stress pathways in the ethanol-fed cystathionine beta synthase-deficient mouse. | 2010 | Details |
| A49061 | 19638343 | J Biol Chem | JNK1-dependent PUMA expression contributes to hepatocyte lipoapoptosis. | 2009 | Details |
| A49072 | 19247452 | PLoS One | HIV induces TRAIL sensitivity in hepatocytes. | 2009 | Details |
| A49075 | 18947977 | Nutrition | Nutritional lipid-induced oxidative stress leads to mitochondrial dysfunction followed by necrotic death in FaO hepatocytes. | 2008 | Details |
| A49076 | 18925608 | Hepatology | Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism. | 2008 | Details |
| A49087 | 18443813 | Histochem Cell Biol | Intermediate filament cytoskeleton of the liver in health and disease. | 2008 | Details |
| A49105 | 17510198 | Am J Physiol Gastrointest Liver Physiol | Undernutrition enhances alcohol-induced hepatocyte proliferation in the liver of rats fed via total enteral nutrition. | 2007 | Details |
| A49119 | 16958675 | J Gastroenterol Hepatol | Methionine adenosyltransferase and S-adenosylmethionine in alcoholic liver disease. | 2006 | Details |
| A49169 | 15641470 | Gac Med Mex | [Obesity and steatohepatitis. Histologic aspects]. | 2005 | Details |
| A49175 | 15489566 | Eur J Gastroenterol Hepatol | Mitochondrial injury in steatohepatitis. | 2004 | Details |
| A49244 | 35811662 | Dis Markers | Advance of Serum Biomarkers and Combined Diagnostic Panels in Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A49250 | 35810800 | Clin Chim Acta | Alpha-1 antitrypsin: a novel biomarker and potential therapeutic approach for metabolic diseases. | 2022 | Details |
| A49268 | 35806300 | Int J Mol Sci | Different Metabolism and Toxicity of TRANS Fatty Acids, Elaidate and Vaccenate Compared to Cis-Oleate in HepG2 Cells. | 2022 | Details |
| A49276 | 35804007 | Sci Rep | IκBζ regulates the development of nonalcoholic fatty liver disease through the attenuation of hepatic steatosis in mice. | 2022 | Details |
| A49330 | 35786619 | Turk J Gastroenterol | Therapeutic Effect of Crocin on the NASH Model by Targeting the Fas Receptor Signaling Pathway. | 2022 | Details |
| A49366 | 35777449 | Biochem Pharmacol | Ceramide de novo synthesis in non-alcoholic fatty liver disease: Pathogenic mechanisms and therapeutic perspectives. | 2022 | Details |
| A49368 | 35774609 | Front Pharmacol | Exploring Ganweikang Tablet as a Candidate Drug for NAFLD Through Network Pharmacology Analysis and Experimental Validation. | 2022 | Details |
| A49396 | 35765026 | J Transl Med | Rhubarb free anthraquinones improved mice nonalcoholic fatty liver disease by inhibiting NLRP3 inflammasome. | 2022 | Details |
| A49431 | 35750235 | Metabolism | Higd1a facilitates exercise-mediated alleviation of fatty liver in diet-induced obese mice. | 2022 | Details |