Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A49485 | 35740238 | Biomedicines | Association of Metabolomic Change and Treatment Response in Patients with Non-Alcoholic Fatty Liver Disease. | 2022 | Details |
| A49502 | 35734974 | J Cell Mol Med | A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease. | 2022 | Details |
| A49531 | 35723408 | Curr Issues Mol Biol | Validation of a Quantification Method for Curcumin Derivatives and Their Hepatoprotective Effects on Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A49532 | 35723304 | Curr Issues Mol Biol | Tremella fuciformis Crude Polysaccharides Attenuates Steatosis and Suppresses Inflammation in Diet-Induced NAFLD Mice. | 2022 | Details |
| A49541 | 35721143 | Front Pharmacol | Medicinal Formula Huazhi-Rougan Attenuates Non-Alcoholic Steatohepatitis Through Enhancing Fecal Bile Acid Excretion in Mice. | 2022 | Details |
| A49614 | 35691078 | Phytomedicine | The improvement of nonalcoholic steatohepatitis by Poria cocos polysaccharides associated with gut microbiota and NF-κB/CCL3/CCR1 axis. | 2022 | Details |
| A49643 | 35682720 | Int J Mol Sci | Maternal Pyrroloquinoline Quinone Supplementation Improves Offspring Liver Bioactive Lipid Profiles throughout the Lifespan and Protects against the Development of Adult NAFLD. | 2022 | Details |
| A49736 | 35654350 | J Ethnopharmacol | Danhe granule ameliorates nonalcoholic steatohepatitis and fibrosis in rats by inhibiting ceramide de novo synthesis related to CerS6 and CerK. | 2022 | Details |
| A49751 | 35647758 | J Clin Endocrinol Metab | Normal HDL cholesterol efflux and anti-inflammatory capacities in type 2 diabetes despite lipidomic abnormalities. | 2022 | Details |
| A49812 | 35629938 | Metabolites | Individuals with Metabolic Syndrome Show Altered Fecal Lipidomic Profiles with No Signs of Intestinal Inflammation or Increased Intestinal Permeability. | 2022 | Details |
| A49938 | 35588334 | Cell Mol Life Sci | Macrophages evoke autophagy of hepatic stellate cells to promote liver fibrosis in NAFLD mice via the PGE2/EP4 pathway. | 2022 | Details |
| A49944 | 35586049 | Front Pharmacol | Artemether Ameliorates Non-Alcoholic Steatohepatitis by Repressing Lipogenesis, Inflammation, and Fibrosis in Mice. | 2022 | Details |
| A49957 | 35583194 | J Mater Chem B | Ratiometric imaging of butyrylcholinesterase activity in mice with nonalcoholic fatty liver using an AIE-based fluorescent probe. | 2022 | Details |
| A49976 | 35576742 | Phytomedicine | Multiple anti-non-alcoholic steatohepatitis (NASH) efficacies of isopropylidenyl anemosapogenin via farnesoid X receptor activation and TFEB-mediated autophagy. | 2022 | Details |
| A49996 | 35568098 | J Nutr Biochem | Indole supplementation ameliorates MCD-induced NASH in mice. | 2022 | Details |
| A50040 | 35550529 | Biomed Pharmacother | The anti-inflammatory effect of Pien Tze Huang in non-alcoholic fatty liver disease. | 2022 | Details |
| A50044 | 35547757 | Theranostics | AGK regulates the progression to NASH by affecting mitochondria complex I function. | 2022 | Details |
| A50078 | 35535064 | J Clin Exp Hepatol | Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs. | 2021 | Details |
| A50088 | 35531719 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Tibetan medicine Ershiwuwei Songshi Pills in regulating intestinal flora and improving non-alcoholic steatohepatitis]. | 2022 | Details |
| A50118 | 35514751 | Front Med (Lausanne) | SPP1 and CXCL9 Promote Non-alcoholic Steatohepatitis Progression Based on Bioinformatics Analysis and Experimental Studies. | 2022 | Details |
| A50124 | 35511653 | Minerva Gastroenterol (Torino) | Treatment with phosphatidylcholine of patients with non-alcoholic fatty liver disease: a prospective pilot study. | 2022 | Details |
| A50135 | 35507845 | Anim Biosci | Severe choline deficiency induces alternative splicing aberrance in optimized duck primary hepatocyte cultures. | 2022 | Details |
| A50190 | 35484644 | Clin Mol Hepatol | Discovery of dipeptidyl peptidase-4 inhibitor specific biomarker in NAFLD mouse models using modified basket trial. | 2022 | Details |
| A50212 | 35472433 | J Nutr Biochem | Chlorogenic acid alleviated liver fibrosis in methionine and choline deficient diet-induced nonalcoholic steatohepatitis in mice and its mechanism. | 2022 | Details |
| A50217 | 35469167 | JHEP Rep | Lipid alterations in chronic liver disease and liver cancer. | 2022 | Details |
| A50244 | 35460694 | J Biol Chem | MicroRNA-200c coordinates HNF1 homeobox B and apolipoprotein O functions to modulate lipid homeostasis in alcoholic fatty liver disease. | 2022 | Details |
| A50257 | 35452693 | J Hepatol | Lack of VMP1 impairs hepatic lipoprotein secretion and promotes non-alcoholic steatohepatitis. | 2022 | Details |
| A50263 | 35450049 | Front Pharmacol | Rifaximin Ameliorates Non-alcoholic Steatohepatitis in Mice Through Regulating gut Microbiome-Related Bile Acids. | 2022 | Details |
| A50266 | 35449483 | Mol Cell Biochem | Hepatocyte expressed chemerin-156 does not protect from experimental non-alcoholic steatohepatitis. | 2022 | Details |
| A50302 | 35438166 | Clin Sci (Lond) | Annexin A1 treatment prevents the evolution to fibrosis of experimental nonalcoholic steatohepatitis. | 2022 | Details |
| A50303 | 35438091 | Food Funct | Changes in the serum metabolomic profiles of subjects with NAFLD in response to n-3 PUFAs and phytosterol ester: a double-blind randomized controlled trial. | 2022 | Details |
| A50320 | 35434600 | Food Chem X | Kombucha - An ancient fermented beverage with desired bioactivities: A narrowed review. | 2022 | Details |
| A50321 | 35434590 | JHEP Rep | Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease. | 2022 | Details |
| A50372 | 35413401 | Biochim Biophys Acta Mol Basis Dis | The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression. | 2022 | Details |
| A50378 | 35411667 | Hepatol Commun | Variants in mitochondrial amidoxime reducing component 1 and hydroxysteroid 17-beta dehydrogenase 13 reduce severity of nonalcoholic fatty liver disease in children and suppress fibrotic pathways through distinct mechanisms. | 2022 | Details |
| A50392 | 35406736 | Cells | Multi-Omics Approach Reveals Dysregulation of Protein Phosphorylation Correlated with Lipid Metabolism in Mouse Non-Alcoholic Fatty Liver. | 2022 | Details |
| A50440 | 35391786 | J Lipids | Age- and Diet-Dependent Changes in Hepatic Lipidomic Profiles of Phospholipids in Male Mice: Age Acceleration in Cyp2b-Null Mice. | 2022 | Details |
| A50464 | 35380992 | J Clin Invest | Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis. | 2022 | Details |
| A50483 | 35368766 | Evid Based Complement Alternat Med | An Open-Label Exploratory Clinical Trial Evaluating the Effects of GLS (Coptidis Rhizoma-Evodiae Fructus 2 : 1) on Fibroblast Growth Factor 21 in Patients with Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A50506 | 35359878 | Front Pharmacol | Regression of Liver Steatosis Following Phosphatidylcholine Administration: A Review of Molecular and Metabolic Pathways Involved. | 2022 | Details |
| A50591 | 35331317 | Diabetol Metab Syndr | NAFLD in normal weight individuals. | 2022 | Details |
| A50681 | 35304272 | J Ethnopharmacol | Antrodia cinnamomea and its compound dehydroeburicoic acid attenuate nonalcoholic fatty liver disease by upregulating ALDH2 activity. | 2022 | Details |
| A50698 | 35296223 | Nutr Neurosci | RNA-sequencing revealed apple pomace ameliorates expression of genes in the hypothalamus associated with neurodegeneration in female rats fed a Western diet during adolescence to adulthood. | 2022 | Details |
| A50700 | 35295576 | Front Physiol | Polyene Phosphatidylcholine Ameliorates High Fat Diet-Induced Non-alcoholic Fatty Liver Disease via Remodeling Metabolism and Inflammation. | 2022 | Details |
| A50719 | 35288065 | Dig Liver Dis | Ubiquitin-specific peptidase 10 ameliorates hepatic steatosis in nonalcoholic steatohepatitis model by restoring autophagic activity. | 2022 | Details |
| A50747 | 35279807 | Indian J Gastroenterol | Effect of combined farnesoid X receptor agonist and angiotensin II type 1 receptor blocker on ongoing hepatic fibrosis. | 2022 | Details |
| A50753 | 35277075 | Nutrients | Simvastatin Improves Microcirculatory Function in Nonalcoholic Fatty Liver Disease and Downregulates Oxidative and ALE-RAGE Stress. | 2022 | Details |
| A50769 | 35273160 | Nat Commun | Deep proteomic profiling unveils arylsulfatase A as a non-alcoholic steatohepatitis inducible hepatokine and regulator of glycemic control. | 2022 | Details |
| A50787 | 35266816 | mBio | Interleukin-17 Weakens the NAFLD/NASH Process by Facilitating Intestinal Barrier Restoration Depending on the Gut Microbiota. | 2022 | Details |
| A51100 | 35766964 | J Med Food | Persimmon Water Extract Suppresses Hepatic Lipotoxicity by Regulating Lipid Metabolites. | 2022 | Details |
| A51134 | 35559233 | Front Pharmacol | Revealing the Mechanism of Huazhi Rougan Granule in the Treatment of Nonalcoholic Fatty Liver Through Intestinal Flora Based on 16S rRNA, Metagenomic Sequencing and Network Pharmacology. | 2022 | Details |
| A51139 | 35516840 | J Toxicol Pathol | CD44 expression in the bile duct epithelium is related to hepatic fibrosis in nonalcoholic steatohepatitis rats induced by a choline-deficient, methionine-lowered, L-amino acid diet. | 2021 | Details |
| A51171 | 35364359 | Nutr Res | Lower plasma glutathione, choline, and betaine concentrations are associated with fatty liver in postmenopausal women. | 2022 | Details |
| A51250 | 35318125 | Biochim Biophys Acta Mol Basis Dis | Kupffer cells are protective in alcoholic steatosis. | 2022 | Details |
| A51252 | 35274962 | J Proteome Res | Metabolic Signature of Ethanol-Induced Hepatotoxicity in HepaRG Cells by Liquid Chromatography-Mass Spectrometry-Based Untargeted Metabolomics. | 2022 | Details |
| A51293 | 1054827 | Proc Natl Acad Sci U S A | Sequential production of fatty liver, hepatitis, and cirrhosis in sub-human primates fed ethanol with adequate diets. | 1975 | Details |
| A51306 | 35735253 | Hepatol Commun | Combinations of an acetyl CoA carboxylase inhibitor with hepatic lipid modulating agents do not augment antifibrotic efficacy in preclinical models of NASH and fibrosis. | 2022 | Details |
| A51309 | 35711841 | J Cancer | Research progress in the role and mechanism of LPCAT3 in metabolic related diseases and cancer. | 2022 | Details |
| A51314 | 35696549 | J Cell Physiol | Dynein light chain LC8 alleviates nonalcoholic steatohepatitis by inhibiting NF-κB signaling and reducing oxidative stress. | 2022 | Details |
| A51325 | 35617134 | Autophagy | VMP1 regulates hepatic lipoprotein secretion and NASH independent of autophagy. | 2022 | Details |
| A51334 | 35535112 | J Clin Exp Hepatol | Spectrum of Neuroimaging Abnormalities in Brain in Patients of Acute-on-Chronic Liver Failure. | 2021 | Details |
| A51348 | 35419738 | Inflammation | Melatonin Attenuates Inflammation, Oxidative Stress, and DNA Damage in Mice with Nonalcoholic Steatohepatitis Induced by a Methionine- and Choline-Deficient Diet. | 2022 | Details |
| A51349 | 35400820 | J Clin Biochem Nutr | Effect of tocotrienol on the primary progression of nonalcoholic steatohepatitis in a mouse model. | 2021 | Details |
| A51352 | 35397697 | Dig Dis Sci | Astaxanthin Attenuates Nonalcoholic Steatohepatitis with Downregulation of Osteoprotegerin in Ovariectomized Mice Fed Choline-Deficient High-Fat Diet. | 2022 | Details |
| A51360 | 35294987 | Cancer Sci | Histone H1.2 promotes hepatocarcinogenesis by regulating signal transducer and activator of transcription 3 signaling. | 2022 | Details |
| A51390 | 35548714 | RSC Adv | SKLB023 as an iNOS inhibitor alleviated liver fibrosis by inhibiting the TGF-beta/Smad signaling pathway. | 2018 | Details |
| A51398 | 35814685 | Front Microbiol | Saccharomyces Boulardii Ameliorates Non-alcoholic Steatohepatitis in Mice Induced by a Methionine-Choline-Deficient Diet Through Gut-Liver Axis. | 2022 | Details |
| A51402 | 35787976 | Cell Mol Gastroenterol Hepatol | Hydroxynonenal causes hepatocyte death by disrupting lysosomal integrity in non-alcoholic steatohepatitis. | 2022 | Details |
| A51406 | 35761808 | Exp Ther Med | Tanshinone IIA regulates the TGF-β1/Smad signaling pathway to ameliorate non-alcoholic steatohepatitis-related fibrosis. | 2022 | Details |
| A51409 | 35749827 | Phytomedicine | Kinsenoside alleviates inflammation and fibrosis in experimental NASH mice by suppressing the NF-κB/NLRP3 signaling pathway. | 2022 | Details |
| A51428 | 35514019 | Dig Liver Dis | Rifaximin and lubiprostone mitigate liver fibrosis development by repairing gut barrier function in diet-induced rat steatohepatitis. | 2022 | Details |
| A51451 | 35310936 | iScience | Prevention and regression of megamitochondria and steatosis by blocking mitochondrial fusion in the liver. | 2022 | Details |
| A51452 | 35292349 | J Hepatol | Role of XBP1 in regulating the progression of non-alcoholic steatohepatitis. | 2022 | Details |
| A51453 | 35285180 | FEBS J | HPS protects the liver against steatosis, cell death, inflammation, and fibrosis in mice with steatohepatitis. | 2022 | Details |
| A51477 | 30627433 | J Nutr Sci | Hot water extract of turmeric (Curcuma longa) prevents non-alcoholic steatohepatitis in mice by inhibiting hepatic oxidative stress and inflammation. | 2018 | Details |
| A51571 | 35042855 | Nutr Diabetes | Metabolic biomarkers related to cardiac dysfunction in metabolic-dysfunction-associated fatty liver disease: a cross-sectional analysis. | 2022 | Details |
| A51670 | 35070008 | World J Hepatol | Gut dysbiosis and systemic inflammation promote cardiomyocyte abnormalities in an experimental model of steatohepatitis. | 2021 | Details |
| A51686 | 34920733 | Cardiovasc Diabetol | Pharmacometabolomic profiles in type 2 diabetic subjects treated with liraglutide or glimepiride. | 2021 | Details |
| A51723 | 34596865 | Hepatol Int | Effect of microbiota metabolites on the progression of chronic hepatitis B virus infection. | 2021 | Details |
| A51755 | 34345813 | JHEP Rep | Cell fate analysis of zone 3 hepatocytes in liver injury and tumorigenesis. | 2021 | Details |
| A51766 | 34274572 | Poult Sci | Untargeted and targeted metabolomics profiling reveals the underlying pathogenesis and abnormal arachidonic acid metabolism in laying hens with fatty liver hemorrhagic syndrome. | 2021 | Details |
| A51788 | 34067313 | Biology (Basel) | Beneficial Effects of Betaine: A Comprehensive Review. | 2021 | Details |
| A51804 | 33987742 | Int J Legal Med | Application of Q-TOF-MS based metabonomics techniques to analyze the plasma metabolic profile changes on rats following death due to acute intoxication of phorate. | 2021 | Details |
| A51815 | 33946522 | Metabolites | Characterization of the Plasma Lipidome in Dairy Cattle Transitioning from Gestation to Lactation: Identifying Novel Biomarkers of Metabolic Impairment. | 2021 | Details |
| A51819 | 33940322 | Int Immunopharmacol | Untargeted lipidomics analysis of Mori Fructus polysaccharide on acute alcoholic liver injury in mice using ultra performance liquid chromatography-quadrupole-orbitrap-high resolution mass spectrometry. | 2021 | Details |
| A51823 | 33923230 | Nutrients | High Choline Intake during Pregnancy Reduces Characteristics of the Metabolic Syndrome in Male Wistar Rat Offspring Fed a High Fat But Not a Normal Fat Post-Weaning Diet. | 2021 | Details |
| A51919 | 33244184 | Commun Biol | Cerebellar and hepatic alterations in ACBD5-deficient mice are associated with unexpected, distinct alterations in cellular lipid homeostasis. | 2020 | Details |
| A51962 | 32864127 | J Anim Sci Biotechnol | Role of nutraceuticals during the transition period of dairy cows: a review. | 2020 | Details |
| A52012 | 32303571 | Dis Model Mech | A comprehensive study of phospholipid fatty acid rearrangements in metabolic syndrome: correlations with organ dysfunction. | 2020 | Details |
| A52051 | 31888144 | Int J Mol Sci | Altered Metabolic Profile and Adipocyte Insulin Resistance Mark Severe Liver Fibrosis in Patients with Chronic Liver Disease. | 2019 | Details |
| A52087 | 31467335 | Sci Rep | Arterio-venous metabolomics exploration reveals major changes across liver and intestine in the obese Yucatan minipig. | 2019 | Details |
| A52199 | 30200659 | Nutrients | Changes in Plasma Acylcarnitine and Lysophosphatidylcholine Levels Following a High-Fructose Diet: A Targeted Metabolomics Study in Healthy Women. | 2018 | Details |
| A52238 | 29852870 | Curr Alzheimer Res | Acetylcholinesterase Inhibitor Donepezil Effects on Plasma β-Hydroxybutyrate Levels in the Treatment of Alzheimer's Disease. | 2018 | Details |
| A52251 | 29684438 | Exp Neurol | The cytoskeleton in 'couch potato-ism': Insights from a murine model of impaired actin dynamics. | 2018 | Details |
| A52416 | 29889418 | Eksp Klin Gastroenterol | METABOLIC DYSBIOSIS OF THE GUT MICROBIOTA AND ITS BIOMARKERS. | 2016 | Details |
| A52444 | 27086014 | Anal Bioanal Chem | Development and application of a comprehensive lipidomic analysis to investigate Tripterygium wilfordii-induced liver injury. | 2016 | Details |
| A52466 | 26742069 | Nutrients | Peroxisome Proliferator-Activated Receptor Activation is Associated with Altered Plasma One-Carbon Metabolites and B-Vitamin Status in Rats. | 2016 | Details |
| A52487 | 26446667 | BMC Vet Res | Blood plasma lipidome profile of dairy cows during the transition period. | 2015 | Details |
| A52616 | 24834723 | Ukr Biochem J | [The effect of N-stearoylethanolamine on liver phospholipid composition of rats with insulin resistance caused by alimentary obesity]. | 2014 | Details |
| A52619 | 24756314 | Metab Brain Dis | Myeloid-specific deletion of SIRT1 increases hepatic steatosis and hypothalamic inflammation in mice fed a high-fat diet. | 2014 | Details |