Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A28363 | 15471321 | Trop Gastroenterol | Prevalence of nonalcoholic fatty liver disease in coastal eastern India: a preliminary ultrasonographic survey. | 2004 | Details |
| A28382 | 15331062 | Clin Liver Dis | Nonalcoholic fatty liver disease in individuals with severe obesity. | 2004 | Details |
| A28391 | 15272263 | Adolesc Med Clin | Nonalcoholic fatty liver disease. | 2004 | Details |
| A28401 | 15209628 | J Gastroenterol Hepatol | Reduced expression of peroxisome proliferator-activated receptor-alpha may have an important role in the development of non-alcoholic fatty liver disease. | 2004 | Details |
| A28409 | 15151626 | J Gastroenterol Hepatol | Insulin resistance and C-reactive protein as independent risk factors for non-alcoholic fatty liver disease in non-obese Asian men. | 2004 | Details |
| A28430 | 15013444 | Biochem Biophys Res Commun | Pioglitazone prevents hepatic steatosis, fibrosis, and enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. | 2004 | Details |
| A28454 | 14610526 | Int J Obes Relat Metab Disord | Insulin resistance and ferritin as major determinants of nonalcoholic fatty liver disease in apparently healthy obese patients. | 2004 | Details |
| A28521 | 12198701 | Gastroenterology | The utility of radiological imaging in nonalcoholic fatty liver disease. | 2002 | Details |
| A28565 | 10902968 | Liver | The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease. | 2000 | Details |
| A28595 | 1526433 | Gastroenterol Jpn | Clinicopathologic study of alcohol-like liver disease in non-alcoholics; non-alcoholic steatohepatitis and fibrosis. | 1992 | Details |
| A28641 | 35203369 | Cells | Selective PPARα Modulator Pemafibrate and Sodium-Glucose Cotransporter 2 Inhibitor Tofogliflozin Combination Treatment Improved Histopathology in Experimental Mice Model of Non-Alcoholic Steatohepatitis. | 2022 | Details |
| A28649 | 35183812 | Ecotoxicol Environ Saf | Chronic exposure to low-dose cadmium facilitated nonalcoholic steatohepatitis in mice by suppressing fatty acid desaturation. | 2022 | Details |
| A28693 | 35121372 | Biochem Biophys Res Commun | Effects of a novel selective PPARα modulator, statin, sodium-glucose cotransporter 2 inhibitor, and combinatorial therapy on the liver and vasculature of medaka nonalcoholic steatohepatitis model. | 2022 | Details |
| A28801 | 34986326 | Cell Chem Biol | An antisense transcript transcribed from Irs2 locus contributes to the pathogenesis of hepatic steatosis in insulin resistance. | 2022 | Details |
| A28833 | 34924279 | Drug Resist Updat | Why may citrate sodium significantly increase the effectiveness of transarterial chemoembolization in hepatocellular carcinoma? | 2021 | Details |
| A28936 | 34797360 | Food Funct | Effects of Salvia hispanica L. (chia) seed on blood coagulation, endothelial dysfunction and liver fibrosis in an experimental model of Metabolic Syndrome. | 2021 | Details |
| A28945 | 34789265 | J Nanobiotechnology | Cargo proteins in extracellular vesicles: potential for novel therapeutics in non-alcoholic steatohepatitis. | 2021 | Details |
| A28983 | 34741448 | Hepatol Commun | Dissecting the Balance Between Metabolic and Oncogenic Functions of Astrocyte-Elevated Gene-1/Metadherin. | 2021 | Details |
| A29001 | 34719550 | Yakugaku Zasshi | [PPARα-Ligand Binding Modes Revealed by X-ray Crystallography]. | 2021 | Details |
| A29007 | 34712137 | Front Pharmacol | Micronized Palmitoylethanolamide Ameliorates Methionine- and Choline-Deficient Diet-Induced Nonalcoholic Steatohepatitis via Inhibiting Inflammation and Restoring Autophagy. | 2021 | Details |
| A29037 | 34668024 | Arch Toxicol | Particulate and drug-induced toxicity assessed in novel quadruple cell human primary hepatic disease models of steatosis and pre-fibrotic NASH. | 2021 | Details |
| A29063 | 34638751 | Int J Mol Sci | Anti-Obesity Effect of Polygalin C Isolated from Polygala japonica Houtt. via Suppression of the Adipogenic and Lipogenic Factors in 3T3-L1 Adipocytes. | 2021 | Details |
| A29196 | 34430785 | Hepatol Commun | Deuterium-Stabilized (R)-Pioglitazone (PXL065) Is Responsible for Pioglitazone Efficacy in NASH yet Exhibits Little to No PPARγ Activity. | 2021 | Details |
| A29205 | 34419411 | Rev Gastroenterol Mex (Engl Ed) | Reducing the heterogeneity in hepatocellular carcinoma. A cluster analysis based on clinical variables in patients treated at a quaternary care hospital. | 2021 | Details |
| A29224 | 34396545 | J Food Biochem | Nephroprotective activity of Vetiveria zizanioides (L.) Nash supplement in doxorubicin-induced nephrotoxicity model of Wistar rats. | 2021 | Details |
| A29448 | 34052659 | Biochem Biophys Res Commun | SFPQ associated with a co-activator for PPARγ, HELZ2, regulates key nuclear factors for adipocyte differentiation. | 2021 | Details |
| A29484 | 34003688 | Sci Prog | Disease burden of liver cancer attributable to specific etiologies in China from 1990 to 2019: An age-period-cohort analysis. | 2022 | Details |
| A29494 | 33987382 | Ann Transl Med | The effects of S-nitrosylation-induced PPARγ/SFRP5 pathway inhibition on the conversion of non-alcoholic fatty liver to non-alcoholic steatohepatitis. | 2021 | Details |
| A29623 | 33787460 | J Recept Signal Transduct Res | SIRT1/NFκB pathway mediates anti-inflammatory and anti-apoptotic effects of rosmarinic acid on in a mouse model of nonalcoholic steatohepatitis (NASH). | 2021 | Details |
| A29649 | 33745755 | Rev Gastroenterol Mex (Engl Ed) | Reducing the heterogeneity in hepatocellular carcinoma. A cluster analysis based on clinical variables in patients treated at a quaternary care hospital. | 2021 | Details |
| A29707 | 33640979 | Gerontologist | Results of a Randomized Trial Testing the Efficacy of Tele-Savvy, an Online Synchronous/Asynchronous Psychoeducation Program for Family Caregivers of Persons Living with Dementia. | 2022 | Details |
| A29802 | 33490669 | Heliyon | Le Carbone prevents liver damage in non-alcoholic steatohepatitis-hepatocellular carcinoma mouse model via AMPKα-SIRT1 signaling pathway activation. | 2021 | Details |
| A29858 | 33383845 | Antioxidants (Basel) | Genistein Modulated Lipid Metabolism, Hepatic PPARγ, and Adiponectin Expression in Bilateral Ovariectomized Rats with Nonalcoholic Steatohepatitis (NASH). | 2020 | Details |
| A29876 | 33354276 | Oxid Med Cell Longev | Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. | 2020 | Details |
| A29933 | 33251276 | Visc Med | Emerging Pharmacological Treatment in Nonalcoholic Steatohepatitis. | 2020 | Details |
| A30344 | 32612285 | Lab Invest | Cholestasis impairs hepatic lipid storage via AMPK and CREB signaling in hepatitis B virus surface protein transgenic mice. | 2020 | Details |
| A30441 | 32441510 | ACS Nano | Targeted Delivery of Notch Inhibitor Attenuates Obesity-Induced Glucose Intolerance and Liver Fibrosis. | 2020 | Details |
| A30482 | 32373294 | Iran J Basic Med Sci | Allantoin improves methionine-choline deficient diet-induced nonalcoholic steatohepatitis in mice through involvement in endoplasmic reticulum stress and hepatocytes apoptosis-related genes expressions. | 2019 | Details |
| A30566 | 32202059 | Pest Manag Sci | Inverse modeling of laboratory experiment to assess parameter transferability of pesticide environmental fate into outdoor experiments under paddy test systems. | 2020 | Details |
| A30599 | 32140659 | Hepatol Commun | Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK. | 2020 | Details |
| A30665 | 32025605 | Hepatol Commun | Icosabutate Exerts Beneficial Effects Upon Insulin Sensitivity, Hepatic Inflammation, Lipotoxicity, and Fibrosis in Mice. | 2019 | Details |
| A30816 | 31733122 | Oral Dis | The controversial natural history of oral herpes simplex virus type 1 infection. | 2019 | Details |
| A30860 | 31656852 | Model Earth Syst Environ | The impact of rising temperatures on water balance and phenology of European beech (Fagus sylvatica L.) stands. | 2019 | Details |
| A31047 | 31321239 | Biomed Res Int | Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice. | 2019 | Details |
| A31059 | 31294056 | Data Brief | Transcriptomics data of a human in vitro model of non-alcoholic steatohepatitis exposed to elafibranor. | 2019 | Details |
| A31100 | 31227742 | Sci Rep | Combined obeticholic acid and elafibranor treatment promotes additive liver histological improvements in a diet-induced ob/ob mouse model of biopsy-confirmed NASH. | 2019 | Details |
| A31405 | 30633968 | Eur J Pharm Sci | Lack of inhibition of CYP2C8 by saroglitazar magnesium: In vivo assessment using montelukast, rosiglitazone, pioglitazone, repaglinide and paclitaxel as victim drugs in Wistar rats. | 2019 | Details |
| A31531 | 30367397 | J Gastrointest Surg | Pioglitazone Reduces Hepatocellular Carcinoma Development in Two Rodent Models of Cirrhosis. | 2018 | Details |
| A31583 | 30248539 | Biomed Pharmacother | Effect of silibinin on CFLAR-JNK pathway in oleic acid-treated HepG2 cells. | 2018 | Details |
| A31615 | 32704804 | Transl Anim Sci | Effects of two equine digestive aid supplements on hindgut health. | 2018 | Details |
| A31979 | 29404484 | Hepatol Commun | The selective peroxisome proliferator-activated receptor-delta agonist seladelpar reverses nonalcoholic steatohepatitis pathology by abrogating lipotoxicity in diabetic obese mice. | 2017 | Details |
| A31981 | 29404476 | Hepatol Commun | The new-generation pan-peroxisome proliferator-activated receptor agonist IVA337 protects the liver from metabolic disorders and fibrosis. | 2017 | Details |
| A32082 | 29234397 | Evid Based Complement Alternat Med | Artemisia iwayomogi plus Curcuma longa Synergistically Ameliorates Nonalcoholic Steatohepatitis in HepG2 Cells. | 2017 | Details |
| A32123 | 29154799 | Toxicology | Integrative omics data analyses of repeated dose toxicity of valproic acid in vitro reveal new mechanisms of steatosis induction. | 2017 | Details |
| A32145 | 29116096 | Sci Rep | AQP3 is regulated by PPARγ and JNK in hepatic stellate cells carrying PNPLA3 I148M. | 2017 | Details |
| A32153 | 29091875 | Biomed Pharmacother | Role of endogenous hydrogen sulfide in cardiac mitochondrial preservation during ischemia reperfusion injury. | 2017 | Details |
| A32342 | 28679947 | JCI Insight | Interspecies NASH disease activity whole-genome profiling identifies a fibrogenic role of PPARα-regulated dermatopontin. | 2017 | Details |
| A32389 | 28576430 | Drug Discov Today | Gastric bypass surgery mimetic approaches. | 2017 | Details |
| A32468 | 28365916 | Dig Dis Sci | Pigment Epithelium-Derived Factor (PEDF) Prevents Hepatic Fat Storage, Inflammation, and Fibrosis in Dietary Steatohepatitis of Mice. | 2017 | Details |
| A32482 | 28331804 | IDCases | Infected ascites: Distinguishing secondary peritonitis from spontaneous bacterial peritonitis in a cirrhotic patient with classic symptoms. | 2017 | Details |
| A32517 | 28224024 | Gastroenterol Hepatol Bed Bench | Topological and functional analysis of nonalcoholic steatohepatitis through protein interaction mapping. | 2016 | Details |
| A32608 | 28003852 | Evid Based Complement Alternat Med | Shugan Xiaozhi Decoction Attenuates Nonalcoholic Steatohepatitis by Enhancing PPARα and L-FABP Expressions in High-Fat-Fed Rats. | 2016 | Details |
| A32915 | 27095224 | Arch Biochem Biophys | The rise, the fall and the renaissance of vitamin E. | 2016 | Details |
| A32923 | 27083546 | Poult Sci | Expression and methylation of microsomal triglyceride transfer protein and acetyl-CoA carboxylase are associated with fatty liver syndrome in chicken. | 2016 | Details |
| A33142 | 26605278 | Hepatobiliary Surg Nutr | Accumulated myeloid-derived suppressor cells demonstrate distinct phenotypes and functions in two non-alcoholic steatohepatitis mouse models. | 2015 | Details |
| A33269 | 26330343 | Am J Physiol Endocrinol Metab | Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions. | 2015 | Details |
| A33285 | 26301053 | World J Hepatol | Recent advances in mouse models of obesity- and nonalcoholic steatohepatitis-associated hepatocarcinogenesis. | 2015 | Details |
| A33304 | 26267753 | Sci Rep | Symmetry warrants rational cooperation by co-action in Social Dilemmas. | 2015 | Details |
| A33308 | 26259438 | Ying Yong Sheng Tai Xue Bao | [Impact of changes in land use and climate on the runoff in Liuxihe Watershed based on SWAT model]. | 2015 | Details |
| A33316 | 26246839 | Evid Based Complement Alternat Med | Genistein Attenuates Nonalcoholic Steatohepatitis and Increases Hepatic PPARγ in a Rat Model. | 2015 | Details |
| A33481 | 25911849 | Pak J Biol Sci | Correlation between total lymphocyte count, hemoglobin, hematocrit and CD4 count in HIV patients in Nigeria. | 2014 | Details |
| A33687 | 25412903 | J Viral Hepat | Oral anti-CD3 immunotherapy for HCV-nonresponders is safe, promotes regulatory T cells and decreases viral load and liver enzyme levels: results of a phase-2a placebo-controlled trial. | 2014 | Details |
| A33996 | 24674061 | Methods Enzymol | Analysis of protein-protein interactions by coimmunoprecipitation. | 2014 | Details |
| A34110 | 26709386 | Mol Cell Oncol | TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. | 2014 | Details |
| A34238 | 23995653 | Biol Pharm Bull | Peroxisome proliferator-activated receptor γ (PPARγ)-independent specific cytotoxicity against immature adipocytes induced by PPARγ antagonist T0070907. | 2013 | Details |
| A34246 | 23978712 | J Hepatol | Hepatitis C virus modulates lipid regulatory factor Angiopoietin-like 3 gene expression by repressing HNF-1α activity. | 2013 | Details |
| A34295 | 23832448 | Hepatology | Free cholesterol accumulation in hepatic stellate cells: mechanism of liver fibrosis aggravation in nonalcoholic steatohepatitis in mice. | 2013 | Details |
| A34334 | 26201790 | Hepatol Int | The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH). | 2012 | Details |
| A34345 | 23692241 | J Eval Clin Pract | Indeterminacy of definitions and criteria in mental health: case study of emotional disorders. | 2013 | Details |
| A34361 | 23640861 | Toxicol Sci | Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. | 2013 | Details |
| A34685 | 22882855 | Chin Med J (Engl) | Pioglitazone ameliorates nonalcoholic steatohepatitis by down-regulating hepatic nuclear factor-kappa B and cyclooxygenases-2 expression in rats. | 2012 | Details |
| A34790 | 22591204 | J Gastroenterol Hepatol | Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2-null mice. | 2012 | Details |
| A34881 | 22318941 | Hepatology | Stat3-mediated activation of microRNA-23a suppresses gluconeogenesis in hepatocellular carcinoma by down-regulating glucose-6-phosphatase and peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. | 2012 | Details |
| A35024 | 21931944 | Environ Monit Assess | Response of non-point source pollutant loads to climate change in the Shitoukoumen reservoir catchment. | 2011 | Details |
| A35227 | 21373270 | J Clin Biochem Nutr | Bach1 gene ablation reduces steatohepatitis in mouse MCD diet model. | 2010 | Details |
| A35407 | 20818485 | Int J Mol Med | Prevention and regression of non-alcoholic steatohepatitis (NASH) in a rat model by metabosartan, telmisartan. | 2010 | Details |
| A35422 | 20734100 | Biomech Model Mechanobiol | Anisotropic effects of the levator ani muscle during childbirth. | 2010 | Details |
| A35441 | 30743456 | Plant Dis | First Report of Fusarium redolens Causing Root Rot of Soybean in Minnesota. | 2010 | Details |
| A35456 | 20610974 | Am J Med Sci | Generalized lymphadenopathy secondary to an invasive fungal infection in an apparently healthy patient. | 2010 | Details |
| A35537 | 20413211 | J Environ Manage | Design and risk assessment tool for vegetative treatment areas receiving agricultural wastewater: preliminary results. | 2010 | Details |
| A35552 | 20376096 | Gene Ther | PPARgamma is essential for protection against nonalcoholic steatohepatitis. | 2010 | Details |
| A35556 | 20371730 | Dis Model Mech | Medaka as a model for human nonalcoholic steatohepatitis. | 2010 | Details |
| A35557 | 20368703 | Lab Invest | Blockade of interleukin-6 signaling enhances hepatic steatosis but improves liver injury in methionine choline-deficient diet-fed mice. | 2010 | Details |
| A35564 | 20355833 | ACS Appl Mater Interfaces | Janus nanostructures based on Au-TiO2 heterodimers and their photocatalytic activity in the oxidation of methanol. | 2009 | Details |
| A35613 | 20131406 | Hepatology | Short-term therapy with peroxisome proliferation-activator receptor-alpha agonist Wy-14,643 protects murine fatty liver against ischemia-reperfusion injury. | 2010 | Details |
| A35753 | 19764881 | Antioxid Redox Signal | Thioredoxin-binding protein-2 deficiency enhances methionine-choline deficient diet-induced hepatic steatosis but inhibits steatohepatitis in mice. | 2009 | Details |
| A35758 | 19751753 | Theor Popul Biol | A predator-prey refuge system: Evolutionary stability in ecological systems. | 2009 | Details |
| A35765 | 19748164 | Clin Nutr | Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. | 2009 | Details |
| A35768 | 19736547 | Lab Invest | Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1. | 2009 | Details |
| A35925 | 19394977 | Metabolism | Effects of adiponectin transgenic expression in liver of nonalcoholic steatohepatitis model mice. | 2009 | Details |