Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A49461 | 35744805 | Molecules | Drugs Targeting the A3 Adenosine Receptor: Human Clinical Study Data. | 2022 | Details |
| A49486 | 35740032 | Antioxidants (Basel) | NADPH Oxidases Connecting Fatty Liver Disease, Insulin Resistance and Type 2 Diabetes: Current Knowledge and Therapeutic Outlook. | 2022 | Details |
| A49520 | 35728768 | Free Radic Biol Med | Nonalcoholic steatohepatitis and mechanisms by which it is ameliorated by activation of the CNC-bZIP transcription factor Nrf2. | 2022 | Details |
| A49526 | 35726536 | Eur J Histochem | Ferroptosis resistance cooperates with cellular senescence in the overt stage of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis. | 2022 | Details |
| A49538 | 35721478 | Front Cell Dev Biol | Mouse Models of Liver Parenchyma Injuries and Regeneration. | 2022 | Details |
| A49549 | 35718233 | Life Sci | Physical exercise and the functions of microRNAs. | 2022 | Details |
| A49579 | 35708049 | Crit Rev Food Sci Nutr | Health benefits of astaxanthin against age-related diseases of multiple organs: A comprehensive review. | 2022 | Details |
| A49638 | 35683987 | Nutrients | The Role of Phytosterols in Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A49647 | 35681014 | Cell Death Differ | Ptpn1 deletion protects oval cells against lipoapoptosis by favoring lipid droplet formation and dynamics. | 2022 | Details |
| A49651 | 35678878 | Cell Mol Life Sci | The protective effect of selenoprotein M on non-alcoholic fatty liver disease: the role of the AMPKα1-MFN2 pathway and Parkin mitophagy. | 2022 | Details |
| A49716 | 35660097 | J Nutr Biochem | Plant sterol ester of α-linolenic acid improved non-alcoholic fatty liver disease by attenuating endoplasmic reticulum stress-triggered apoptosis via activation of the AMPK. | 2022 | Details |
| A49830 | 35625696 | Biomedicines | Fatty Hepatocytes Induce Skeletal Muscle Atrophy In Vitro: A New 3D Platform to Study the Protective Effect of Albumin in Non-Alcoholic Fatty Liver. | 2022 | Details |
| A49841 | 35624731 | Antioxidants (Basel) | Administration of Glutaredoxin-1 Attenuates Liver Fibrosis Caused by Aging and Non-Alcoholic Steatohepatitis. | 2022 | Details |
| A49847 | 35622622 | Toxics | Bisphenol A Coupled with a High-Fat Diet Promotes Hepatosteatosis through Reactive-Oxygen-Species-Induced CD36 Overexpression. | 2022 | Details |
| A49883 | 35609854 | J Nutr Biochem | Excess fructose enhances oleatic cytotoxicity via reactive oxygen species production and causes necroptosis in hepatocytes. | 2022 | Details |
| A49922 | 35594708 | Biomed Pharmacother | Exogenous administration of unacylated ghrelin attenuates hepatic steatosis in high-fat diet-fed rats by modulating glucose homeostasis, lipogenesis, oxidative stress, and endoplasmic reticulum stress. | 2022 | Details |
| A49953 | 35584453 | Braz J Med Biol Res | The combination of berberine and evodiamine ameliorates high-fat diet-induced non-alcoholic fatty liver disease associated with modulation of gut microbiota in rats. | 2022 | Details |
| A49983 | 35572532 | Front Immunol | Reactive Oxygen Species Induce Fatty Liver and Ischemia-Reperfusion Injury by Promoting Inflammation and Cell Death. | 2022 | Details |
| A49994 | 35568228 | Life Sci | Protective effects of maslinic acid on high fat diet-induced liver injury in mice. | 2022 | Details |
| A50036 | 35551953 | Life Sci | Free fatty acid-induced miR-181a-5p stimulates apoptosis by targeting XIAP and Bcl2 in hepatic cells. | 2022 | Details |
| A50059 | 35540106 | JHEP Rep | Molecular characterization of chronic liver disease dynamics: From liver fibrosis to acute-on-chronic liver failure. | 2022 | Details |
| A50106 | 35525796 | Pathology | Prevalence and clinical significance of portal inflammation, portal plasma cells, interface hepatitis and biliary injury in liver biopsies from patients with non-alcoholic steatohepatitis. | 2022 | Details |
| A50132 | 35508444 | Eur J Intern Med | Uric acid in metabolic syndrome: Does uric acid have a definitive role? | 2022 | Details |
| A50169 | 35492028 | EMBO Rep | KLF10 promotes nonalcoholic steatohepatitis progression through transcriptional activation of zDHHC7. | 2022 | Details |
| A50177 | 35489641 | Ann Hepatol | Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease. | 2022 | Details |
| A50317 | 35434888 | Diabetes Obes Metab | Positive allosteric γ-aminobutyric acid type A receptor modulation prevents lipotoxicity-induced injury in hepatocytes in vitro. | 2022 | Details |
| A50418 | 35398611 | Biochem Biophys Res Commun | Abietic acid alleviates endoplasmic reticulum stress and lipid accumulation in human primary hepatocytes through the AMPK/ORP150 signaling. | 2022 | Details |
| A50468 | 35378329 | Mol Metab | Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function. | 2022 | Details |
| A50550 | 35344814 | Int Immunopharmacol | Mitigation of liver fibrosis via hepatic stellate cells mitochondrial apoptosis induced by metformin. | 2022 | Details |
| A50566 | 35338494 | J Food Biochem | Zingerone ameliorates non-alcoholic fatty liver disease in rats by activating AMPK. | 2022 | Details |
| A50569 | 35335339 | Molecules | Garcinia Biflavonoid 1 Improves Lipid Metabolism in HepG2 Cells via Regulating PPARα. | 2022 | Details |
| A50598 | 35328776 | Int J Mol Sci | Hepatocyte Proteome Alterations Induced by Individual and Combinations of Common Free Fatty Acids. | 2022 | Details |
| A50601 | 35328527 | Int J Mol Sci | SGLT-2 Inhibitors in NAFLD: Expanding Their Role beyond Diabetes and Cardioprotection. | 2022 | Details |
| A50625 | 35322862 | Mol Med Rep | Ginsenoside Rg1 exerts anti‑apoptotic effects on non‑alcoholic fatty liver cells by downregulating the expression of SGPL1. | 2022 | Details |
| A50668 | 35308224 | Front Pharmacol | Pharmacological Effects and Molecular Protective Mechanisms of Astragalus Polysaccharides on Nonalcoholic Fatty Liver Disease. | 2022 | Details |
| A50703 | 35294499 | PLoS One | Steatosis is involved in the progression of kidney disease in a high-fat-diet-induced non-alcoholic steatohepatitis mouse model. | 2022 | Details |
| A50760 | 35276900 | Nutrients | Baicalin Attenuates Oxidative Stress in a Tissue-Engineered Liver Model of NAFLD by Scavenging Reactive Oxygen Species. | 2022 | Details |
| A50802 | 35260312 | Nutr Metab Cardiovasc Dis | J-shaped relationship between serum zinc levels and the severity of hepatic necro-inflammation in patients with MAFLD. | 2022 | Details |
| A50943 | 35540668 | RSC Adv | Nifuroxazide ameliorates lipid and glucose metabolism in palmitate-induced HepG2 cells. | 2019 | Details |
| A50963 | 35559112 | RSC Adv | Proteomics for studying the effects of L. rhamnosus LV108 against non-alcoholic fatty liver disease in rats. | 2018 | Details |
| A51093 | 35793087 | JAMA Netw Open | Association of Prenatal Exposure to Endocrine-Disrupting Chemicals With Liver Injury in Children. | 2022 | Details |
| A51100 | 35766964 | J Med Food | Persimmon Water Extract Suppresses Hepatic Lipotoxicity by Regulating Lipid Metabolites. | 2022 | Details |
| A51137 | 35527487 | Nan Fang Yi Ke Da Xue Xue Bao | [Dihydromyricetin reduces lipid accumulation in LO2 cells via AMPK/mTOR-mediated lipophagy pathway and inhibits HepG2 cell proliferation in vitro]. | 2022 | Details |
| A51164 | 35408890 | Int J Mol Sci | The Role of Endoplasmic Reticulum Stress and NLRP3 Inflammasome in Liver Disorders. | 2022 | Details |
| A51246 | 35663960 | Front Immunol | Acute Intoxication With Alcohol Reduces Trauma-Induced Proinflammatory Response and Barrier Breakdown in the Lung via the Wnt/β-Catenin Signaling Pathway. | 2022 | Details |
| A51251 | 35280676 | Int J Biol Sci | Hepatocyte-specific deletion of cellular repressor of E1A-stimulated genes 1 exacerbates alcohol-induced liver injury by activating stress kinases. | 2022 | Details |
| A51299 | 35810782 | Metabolism | Comprehensive molecular mechanisms and clinical therapy in nonalcoholic steatohepatitis: An overview and current perspectives. | 2022 | Details |
| A51303 | 35777586 | J Hepatol | Augmenter of liver regeneration: mitochondrial function and steatohepatitis. | 2022 | Details |
| A51323 | 35624663 | Antioxidants (Basel) | Empagliflozin-Enhanced Antioxidant Defense Attenuates Lipotoxicity and Protects Hepatocytes by Promoting FoxO3a- and Nrf2-Mediated Nuclear Translocation via the CAMKK2/AMPK Pathway. | 2022 | Details |
| A51327 | 35592421 | Front Pharmacol | Scoparone Improves Nonalcoholic Steatohepatitis Through Alleviating JNK/Sab Signaling Pathway-Mediated Mitochondrial Dysfunction. | 2022 | Details |
| A51330 | 35559132 | ACS Omega | Lipidomics Revealed Alteration of the Sphingolipid Metabolism in the Liver of Nonalcoholic Steatohepatitis Mice Treated with Scoparone. | 2022 | Details |
| A51385 | 31024205 | J Clin Exp Hepatol | Hepatocellular Carcinoma: Etiology and Current and Future Drugs. | 2019 | Details |
| A51405 | 35763355 | JCI Insight | SHP2 inhibition enhances Yes-associated protein mediated liver regeneration in murine partial hepatectomy models. | 2022 | Details |
| A51423 | 35625937 | Biomedicines | Phospholipid Membrane Transport and Associated Diseases. | 2022 | Details |
| A51441 | 35352662 | Curr Top Med Chem | Probing the interaction of Selonsertib with human serum albumin: In silico and in vitro approaches. | 2022 | Details |
| A51443 | 35348137 | Lab Chip | Integration of a microfluidic multicellular coculture array with machine learning analysis to predict adverse cutaneous drug reactions. | 2022 | Details |
| A51447 | 35326188 | Antioxidants (Basel) | Cholesterol Induces Oxidative Stress, Mitochondrial Damage and Death in Hepatic Stellate Cells to Mitigate Liver Fibrosis in Mice Model of NASH. | 2022 | Details |
| A51453 | 35285180 | FEBS J | HPS protects the liver against steatosis, cell death, inflammation, and fibrosis in mice with steatohepatitis. | 2022 | Details |
| A51478 | 30556637 | IUBMB Life | Vitamin E: Regulatory Role on Signal Transduction. | 2018 | Details |
| A51613 | 35660447 | Sci Total Environ | Metabolomics-based safety evaluation of acute exposure to electronic cigarettes in mice. | 2022 | Details |
| A51664 | 35115945 | Front Pharmacol | Anti-Inflammatory and Pro-Autophagy Effects of the Cannabinoid Receptor CB2R: Possibility of Modulation in Type 1 Diabetes. | 2022 | Details |
| A51771 | 34236076 | Clin Sci (Lond) | Glycoursodeoxycholic acid ameliorates diet-induced metabolic disorders with inhibiting endoplasmic reticulum stress. | 2021 | Details |
| A51783 | 34098336 | Environ Int | Lipid metabolism disorders associated with dioxin exposure in a cohort of Chinese male workers revealed by a comprehensive lipidomics study. | 2021 | Details |
| A51788 | 34067313 | Biology (Basel) | Beneficial Effects of Betaine: A Comprehensive Review. | 2021 | Details |
| A51797 | 34030573 | Gut Microbes | Gut Akkermansia muciniphila ameliorates metabolic dysfunction-associated fatty liver disease by regulating the metabolism of L-aspartate via gut-liver axis. | 2021 | Details |
| A51804 | 33987742 | Int J Legal Med | Application of Q-TOF-MS based metabonomics techniques to analyze the plasma metabolic profile changes on rats following death due to acute intoxication of phorate. | 2021 | Details |
| A51807 | 33962586 | Cell Mol Biol Lett | Targeting programmed cell death in metabolic dysfunction-associated fatty liver disease (MAFLD): a promising new therapy. | 2021 | Details |
| A51821 | 33935806 | Front Physiol | Hepatic Oxidative Stress, Apoptosis, and Inflammation in Broiler Chickens With Wooden Breast Myopathy. | 2021 | Details |
| A51874 | 33535680 | Int J Mol Sci | Effects of Pyrroloquinoline Quinone on Lipid Metabolism and Anti-Oxidative Capacity in a High-Fat-Diet Metabolic Dysfunction-Associated Fatty Liver Disease Chick Model. | 2021 | Details |
| A51920 | 33233602 | Int J Mol Sci | Lipodystrophies-Disorders of the Fatty Tissue. | 2020 | Details |
| A51965 | 32835833 | Toxicol Lett | Comprehensive analysis of transcriptomics and metabolomics to understand triptolide-induced liver injury in mice. | 2020 | Details |
| A51969 | 32811819 | Nat Commun | Age-dependent loss of adipose Rubicon promotes metabolic disorders via excess autophagy. | 2020 | Details |
| A52019 | 32231246 | Cell Death Differ | OTULIN protects the liver against cell death, inflammation, fibrosis, and cancer. | 2020 | Details |
| A52039 | 32003501 | FASEB J | Resveratrol promotes white adipocytes browning and improves metabolic disorders in Sirt1-dependent manner in mice. | 2020 | Details |
| A52048 | 31904482 | Cancer Lett | Inhibition of fatty acid catabolism augments the efficacy of oxaliplatin-based chemotherapy in gastrointestinal cancers. | 2020 | Details |
| A52113 | 31073969 | J Endocrinol Invest | Sick fat: the good and the bad of old and new circulating markers of adipose tissue inflammation. | 2019 | Details |
| A52135 | 30858281 | EMBO J | Cideb controls sterol-regulated ER export of SREBP/SCAP by promoting cargo loading at ER exit sites. | 2019 | Details |
| A52150 | 30664268 | Hepatology | E-cigarettes and Western Diet: Important Metabolic Risk Factors for Hepatic Diseases. | 2019 | Details |
| A52159 | 30563841 | J Biol Chem | Glutamate-oxaloacetate transaminase activity promotes palmitate lipotoxicity in rat hepatocytes by enhancing anaplerosis and citric acid cycle flux. | 2018 | Details |
| A52168 | 30474622 | Med Sci Monit | The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN). | 2018 | Details |
| A52354 | 28239649 | JCI Insight | Switching harmful visceral fat to beneficial energy combustion improves metabolic dysfunctions. | 2017 | Details |
| A52385 | 27813205 | Genes Cells | Dietary fructose-induced hepatocellular carcinoma development manifested in mice lacking apoptosis inhibitor of macrophage (AIM). | 2016 | Details |
| A52415 | 29889427 | Eksp Klin Gastroenterol | EFFECT OF CARBOXYLIC ACIDS OF GUT MICROBIAL ORIGIN ON HOST CELL PROLIFERATION IN ORGANOTYPIC TISSUE CULTURES. | 2016 | Details |
| A52452 | 26993047 | J Mol Cell Biol | Adiponectin, the past two decades. | 2016 | Details |
| A52464 | 26829127 | J Agric Food Chem | Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure. | 2016 | Details |
| A52531 | 25916973 | Int J Dev Neurosci | Study of the serum levels of polyunsaturated fatty acids and the expression of related liver metabolic enzymes in a rat valproate-induced autism model. | 2015 | Details |
| A52540 | 25834313 | World J Gastroenterol | Long-chain acyl-CoA synthetase in fatty acid metabolism involved in liver and other diseases: an update. | 2015 | Details |
| A52580 | 25404244 | J Mol Med (Berl) | p53 in liver pathologies-taking the good with the bad. | 2014 | Details |
| A52582 | 25380806 | Drug Metab Dispos | Assessing steatotic liver function after ischemia-reperfusion injury by in vivo multiphoton imaging of fluorescein disposition. | 2014 | Details |
| A52700 | 23324104 | Expert Opin Ther Targets | Targeting endoplasmic reticulum stress in metabolic disease. | 2013 | Details |
| A52723 | 22825472 | Cell Death Dis | Skeletal muscle damage and impaired regeneration due to LPL-mediated lipotoxicity. | 2012 | Details |
| A52734 | 22664476 | J Clin Gastroenterol | Association of serum adipocytokines with insulin resistance and liver injury in patients with chronic hepatitis C genotype 4. | 2013 | Details |
| A52755 | 22424154 | J Transl Med | Are hepatic steatosis and carotid intima media thickness associated in obese patients with normal or slightly elevated gamma-glutamyl-transferase? | 2012 | Details |
| A52769 | 22241473 | J Biol Chem | Suppression of hepatocyte proliferation by hepatocyte nuclear factor 4α in adult mice. | 2012 | Details |
| A52772 | 22202034 | Front Biosci (Elite Ed) | Mitochondrial dysfunction in cholestatic liver diseases. | 2012 | Details |
| A52784 | 21979150 | Biochim Biophys Acta | Fatty acid transport proteins, implications in physiology and disease. | 2011 | Details |
| A52843 | 20961644 | J Hepatol | Activation of p53 enhances apoptosis and insulin resistance in a rat model of alcoholic liver disease. | 2010 | Details |
| A52848 | 20725711 | J Mol Med (Berl) | Mitochondrial biogenesis in the metabolic syndrome and cardiovascular disease. | 2010 | Details |
| A52926 | 19429849 | Exp Biol Med (Maywood) | Gene expression profiling in rat liver after VMH lesioning. | 2009 | Details |
| A52927 | 19421860 | Apoptosis | Diabetes and apoptosis: lipotoxicity. | 2009 | Details |