Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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PPAR2265 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A44059 | 30014902 | Redox Biol | Polydatin prevents fructose-induced liver inflammation and lipid deposition through increasing miR-200a to regulate Keap1/Nrf2 pathway. | 2018 | Details |
| A44073 | 29949360 | J Chem Inf Model | QSAR Modeling of ToxCast Assays Relevant to the Molecular Initiating Events of AOPs Leading to Hepatic Steatosis. | 2018 | Details |
| A44091 | 29785143 | J Exp Pharmacol | Pilot study of the antifibrotic effects of the multikinase inhibitor pacritinib in a mouse model of liver fibrosis. | 2018 | Details |
| A44106 | 29743883 | PPAR Res | Treatment of Diabetic Mice with a Combination of Ketogenic Diet and Aerobic Exercise via Modulations of PPARs Gene Programs. | 2018 | Details |
| A44185 | 29474705 | Toxicol Sci | PCB126 Inhibits the Activation of AMPK-CREB Signal Transduction Required for Energy Sensing in Liver. | 2018 | Details |
| A44223 | 29353249 | Gut | Plasma cell-free DNA methylation: a liquid biomarker of hepatic fibrosis. | 2018 | Details |
| A44225 | 29327584 | J Agric Food Chem | Gamma-aminobutyric Acid Enriched Rice Bran Diet Attenuates Insulin Resistance and Balances Energy Expenditure via Modification of Gut Microbiota and Short-Chain Fatty Acids. | 2018 | Details |
| A44261 | 29208699 | J Lipid Res | Regulation of fatty acid trafficking in liver by thioesterase superfamily member 1. | 2017 | Details |
| A44290 | 29142166 | J Toxicol Sci | Fish oil feeding reverses hepatomegaly and disrupted hepatic function due to the lack of FXR signaling. | 2017 | Details |
| A44385 | 28744408 | Am J Cancer Res | The role of thiazolidinediones in hepatocellular carcinoma risk reduction: a population-based cohort study in Taiwan. | 2017 | Details |
| A44389 | 28736228 | Biochim Biophys Acta Gen Subj | DBZ is a putative PPARγ agonist that prevents high fat diet-induced obesity, insulin resistance and gut dysbiosis. | 2017 | Details |
| A44418 | 28685102 | Neural Plast | Autism-Like Behaviours and Memory Deficits Result from a Western Diet in Mice. | 2017 | Details |
| A44420 | 28677122 | FEBS Lett | From chronic overnutrition to metaflammation and insulin resistance: adipose tissue and liver contributions. | 2017 | Details |
| A44465 | 28539218 | Bioorg Med Chem Lett | Switching subtype-selectivity: Fragment replacement strategy affords novel class of peroxisome proliferator-activated receptor α/δ (PPARα/δ) dual agonists. | 2017 | Details |
| A44517 | 28386270 | PPAR Res | Fimasartan Ameliorates Nonalcoholic Fatty Liver Disease through PPARδ Regulation in Hyperlipidemic and Hypertensive Conditions. | 2017 | Details |
| A44531 | 28331449 | Ochsner J | Cyclin D1 in the Liver: Role of Noncanonical Signaling in Liver Steatosis and Hormone Regulation. | 2017 | Details |
| A44570 | 28164071 | Ann Pediatr Endocrinol Metab | Transcriptional coordination of hepatic autophagy by nutrient-sensing nuclear receptor PPARα and FXR. | 2016 | Details |
| A44583 | 28096081 | Am J Physiol Endocrinol Metab | Mice with hyperbilirubinemia due to Gilbert's syndrome polymorphism are resistant to hepatic steatosis by decreased serine 73 phosphorylation of PPARα. | 2017 | Details |
| A44676 | 27752939 | Mol Biol Rep | Association between PNPLA3 (rs738409), LYPLAL1 (rs12137855), PPP1R3B (rs4240624), GCKR (rs780094), and elevated transaminase levels in overweight/obese Mexican adults. | 2016 | Details |
| A44714 | 27615179 | Med Sci (Paris) | [Sphingosine kinase-1: role in non alcoholic fatty liver disease]. | 2016 | Details |
| A44718 | 27594084 | Metabolism | Nonalcoholic fatty liver disease: Updates on associations with the metabolic syndrome and lipid profile and effects of treatment with PPAR-γ agonists. | 2016 | Details |
| A44818 | 27189109 | Sci Rep | Chronic administration of Angelica sinensis polysaccharide effectively improves fatty liver and glucose homeostasis in high-fat diet-fed mice. | 2016 | Details |
| A44844 | 27097220 | PLoS One | Spaceflight Activates Lipotoxic Pathways in Mouse Liver. | 2016 | Details |
| A44880 | 26992428 | Gut | Hepatic-specific PPARα-FGF21 action in NAFLD. | 2016 | Details |
| A44951 | 26637457 | J Virol | Hepatitis B Virus X Protein Induces Hepatic Steatosis by Enhancing the Expression of Liver Fatty Acid Binding Protein. | 2015 | Details |
| A44958 | 26615875 | Biochim Biophys Acta | Deletion of sphingosine kinase 1 ameliorates hepatic steatosis in diet-induced obese mice: Role of PPARγ. | 2015 | Details |
| A44977 | 26564715 | Am J Physiol Gastrointest Liver Physiol | Glial cell line-derived neurotrophic factor protects against high-fat diet-induced hepatic steatosis by suppressing hepatic PPAR-γ expression. | 2015 | Details |
| A45025 | 26396156 | Toxicol Sci | PCB126-Induced Disruption in Gluconeogenesis and Fatty Acid Oxidation Precedes Fatty Liver in Male Rats. | 2015 | Details |
| A45089 | 26108684 | Mol Nutr Food Res | Calebin-A inhibits adipogenesis and hepatic steatosis in high-fat diet-induced obesity via activation of AMPK signaling. | 2015 | Details |
| A45095 | 26092479 | Life Sci | Improvement in the expression of hepatic genes involved in fatty acid metabolism in obese rats supplemented with taurine. | 2015 | Details |
| A45099 | 26085100 | J Biol Chem | Hyperinsulinemia Enhances Hepatic Expression of the Fatty Acid Transporter Cd36 and Provokes Hepatosteatosis and Hepatic Insulin Resistance. | 2015 | Details |
| A45170 | 25838202 | Biochem Biophys Res Commun | Monoacylglycerol O-acyltransferase 1 is regulated by peroxisome proliferator-activated receptor γ in human hepatocytes and increases lipid accumulation. | 2015 | Details |
| A45210 | 25647851 | Zhonghua Gan Zang Bing Za Zhi | [Current perspectives on the roles of PPARa in nonalcoholic fatty liver disease and hepatocarcinogenesis]. | 2014 | Details |
| A45214 | 25644347 | J Nutr | Lycopene and apo-10'-lycopenoic acid have differential mechanisms of protection against hepatic steatosis in β-carotene-9',10'-oxygenase knockout male mice. | 2014 | Details |
| A45240 | 25564660 | Proc Natl Acad Sci U S A | Insulin-independent regulation of hepatic triglyceride synthesis by fatty acids. | 2015 | Details |
| A45282 | 25400456 | World J Gastroenterol | GW4064, a farnesoid X receptor agonist, upregulates adipokine expression in preadipocytes and HepG2 cells. | 2014 | Details |
| A45299 | 25295785 | Cell Metab | Periostin: a new extracellular regulator of obesity-induced hepatosteatosis. | 2014 | Details |
| A45301 | 25287814 | J Nutr Biochem | High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl branched-chain fatty acids. | 2014 | Details |
| A45361 | 24993917 | J Nutr Biochem | Reversal of high-fat diet-induced hepatic steatosis by n-3 LCPUFA: role of PPAR-α and SREBP-1c. | 2014 | Details |
| A45373 | 24927523 | Proc Natl Acad Sci U S A | TM6SF2 is a regulator of liver fat metabolism influencing triglyceride secretion and hepatic lipid droplet content. | 2014 | Details |
| A45387 | 24875102 | Am J Physiol Gastrointest Liver Physiol | Human FABP1 T94A variant impacts fatty acid metabolism and PPAR-α activation in cultured human female hepatocytes. | 2014 | Details |
| A45397 | 24814977 | J Lipid Res | Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. | 2014 | Details |
| A45436 | 24597776 | J Nat Prod | Identification of isosilybin a from milk thistle seeds as an agonist of peroxisome proliferator-activated receptor gamma. | 2014 | Details |
| A45486 | 24361124 | Gastroenterology | Gluconeogenic signals regulate iron homeostasis via hepcidin in mice. | 2013 | Details |
| A45529 | 24122898 | Hepatology | The hunt for treatment options of fatty liver continues: effects of retinoic acid on hepatic steatosis reveal novel transcriptional interactions of nuclear receptors. | 2014 | Details |
| A45539 | 24062606 | J Clin Biochem Nutr | S-Allyl cysteine improves nonalcoholic fatty liver disease in type 2 diabetes Otsuka Long-Evans Tokushima Fatty rats via regulation of hepatic lipogenesis and glucose metabolism. | 2013 | Details |
| A45582 | 23787705 | Hepatology | Nuclear control of inflammation and fibrosis in nonalcoholic steatohepatitis: therapeutic potential of dual peroxisome proliferator-activated receptor alpha/delta agonism. | 2013 | Details |
| A45592 | 23731091 | J Agric Food Chem | Mulberry anthocyanins inhibit oleic acid induced lipid accumulation by reduction of lipogenesis and promotion of hepatic lipid clearance. | 2013 | Details |
| A45597 | 23720735 | J Biol Chem | C/EBP homologous protein-induced macrophage apoptosis protects mice from steatohepatitis. | 2013 | Details |
| A45599 | 23715754 | Diabetes Care | Dual peroxisome proliferator-activated receptor α/δ agonist GFT505 improves hepatic and peripheral insulin sensitivity in abdominally obese subjects. | 2013 | Details |
| A45611 | 23680744 | Hosp Pract (1995) | Pleiotropic effects of thiazolidinediones: implications for the treatment of patients with type 2 diabetes mellitus. | 2013 | Details |
| A45615 | 23640498 | Arterioscler Thromb Vasc Biol | Sphingomyelin synthase 2 activity and liver steatosis: an effect of ceramide-mediated peroxisome proliferator-activated receptor γ2 suppression. | 2013 | Details |
| A45651 | 23448486 | Curr Pharm Des | Role of adiponectin in the metabolic syndrome: current perspectives on its modulation as a treatment strategy. | 2013 | Details |
| A45675 | 23322813 | Environ Health Perspect | Transgenerational inheritance of increased fat depot size, stem cell reprogramming, and hepatic steatosis elicited by prenatal exposure to the obesogen tributyltin in mice. | 2013 | Details |
| A45677 | 23316217 | PPAR Res | PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. | 2012 | Details |
| A45679 | 23304111 | PPAR Res | Misregulation of PPAR Functioning and Its Pathogenic Consequences Associated with Nonalcoholic Fatty Liver Disease in Human Obesity. | 2012 | Details |
| A45784 | 22763792 | Curr Gastroenterol Rep | Fighting fire with fire: is it time to use probiotics to manage pathogenic bacterial diseases? | 2012 | Details |
| A45792 | 22715101 | J Biol Chem | The ABCG5 ABCG8 sterol transporter opposes the development of fatty liver disease and loss of glycemic control independently of phytosterol accumulation. | 2012 | Details |
| A45885 | 22209682 | J Nutr Biochem | Oleic acid activates peroxisome proliferator-activated receptor δ to compensate insulin resistance in steatotic cells. | 2011 | Details |
| A46010 | 21599573 | Ann Med | Effects of moderate red wine consumption on liver fat and blood lipids: a prospective randomized study. | 2011 | Details |
| A46018 | 21536286 | Atherosclerosis | MicroPPARticle in atherosclerosis: guilty or innocent by-standers? | 2011 | Details |
| A46040 | 21454445 | Am J Physiol Gastrointest Liver Physiol | Hepatic steatosis, inflammation, and ER stress in mice maintained long term on a very low-carbohydrate ketogenic diet. | 2011 | Details |
| A46043 | 21441697 | Circ J | Prevention of atherosclerosis in overweight/obese patients. - In need of novel multi-targeted approaches-. | 2011 | Details |
| A46049 | 21423007 | Curr Opin Gastroenterol | Hepatobiliary pathology. | 2011 | Details |
| A46055 | 21384408 | Hepatology | The contribution of endoplasmic reticulum stress to liver diseases. | 2011 | Details |
| A46105 | 21084450 | Endocrinology | GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism. | 2010 | Details |
| A46120 | 20960377 | Semin Liver Dis | The role of lipid metabolism in the pathogenesis of alcoholic and nonalcoholic hepatic steatosis. | 2010 | Details |
| A46144 | 20731092 | Voen Med Zh | [Condition of the intestinal tract microbiocenosis in patients with nonalcoholic fatty liver disease and the methods of its correction]. | 2010 | Details |
| A46221 | 20211973 | Endocrinology | Spironolactone improves glucose and lipid metabolism by ameliorating hepatic steatosis and inflammation and suppressing enhanced gluconeogenesis induced by high-fat and high-fructose diet. | 2010 | Details |
| A46222 | 20211032 | Lipids Health Dis | Dietary saponins of sea cucumber alleviate orotic acid-induced fatty liver in rats via PPARalpha and SREBP-1c signaling. | 2010 | Details |
| A46231 | 20156580 | Int J Biochem Cell Biol | Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro. | 2010 | Details |
| A46276 | 19838201 | Nat Med | Foxo1 integrates insulin signaling with mitochondrial function in the liver. | 2009 | Details |
| A46321 | 19553925 | Obesity (Silver Spring) | Nonalcoholic hepatic steatosis in Zucker diabetic rats: spontaneous evolution and effects of metformin and fenofibrate. | 2009 | Details |
| A46333 | 19474719 | Curr Opin Clin Nutr Metab Care | Metabolic benefits from Sirt1 and Sirt1 activators. | 2009 | Details |
| A46364 | 19296690 | Anal Chem | In situ lipidomic analysis of nonalcoholic fatty liver by cluster TOF-SIMS imaging. | 2009 | Details |
| A46366 | 19284314 | Metab Syndr Relat Disord | Metabolic syndrome and cancer. | 2009 | Details |
| A46373 | 19232511 | Arch Biochem Biophys | Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. | 2009 | Details |
| A46376 | 19207680 | J Gastroenterol Hepatol | Differential effect of oleic and palmitic acid on lipid accumulation and apoptosis in cultured hepatocytes. | 2009 | Details |
| A46442 | 18627005 | Hepatology | Peroxisome proliferator-activated receptor-delta induces insulin-induced gene-1 and suppresses hepatic lipogenesis in obese diabetic mice. | 2008 | Details |
| A46459 | 18460980 | Am J Surg Pathol | Histologic abnormalities are common in protocol liver allograft biopsies from patients with normal liver function tests. | 2008 | Details |
| A46491 | 18301087 | Curr Opin Clin Nutr Metab Care | Nonalcoholic fatty liver disease: emerging mechanisms and consequences. | 2008 | Details |
| A46500 | 18235842 | Mol Med | Inflammatory mechanisms in the regulation of insulin resistance. | 2008 | Details |
| A46562 | 17571253 | Naunyn Schmiedebergs Arch Pharmacol | Unchanged serum levels of advanced glycation endproducts in patients with liver disease. | 2007 | Details |
| A46581 | 17482764 | Med Hypotheses | Peroxisome proliferator-activated receptor gamma: a common link for non-alcoholic fatty liver disease and colorectal cancer? | 2007 | Details |
| A46621 | 17244467 | Zhonghua Gan Zang Bing Za Zhi | [The association of Val227Ala polymorphism of the peroxisome proliferator activated receptor alpha (PPAR alpha) gene with non-alcoholic fatty liver disease]. | 2007 | Details |
| A46653 | 16844679 | Am J Physiol Gastrointest Liver Physiol | Inhibition of matrix metalloproteinases increases PPAR-alpha and IL-6 and prevents dietary-induced hepatic steatosis and injury in a murine model. | 2006 | Details |
| A46682 | 16557554 | Hepatology | COX-2 induction in mice with experimental nutritional steatohepatitis: Role as pro-inflammatory mediator. | 2006 | Details |
| A46692 | 16489319 | Panminerva Med | Insulin resistance, the insulin resistance syndrome, and cardiovascular disease. | 2005 | Details |
| A46711 | 16287793 | Ann Intern Med | The metabolic syndrome as a predictor of nonalcoholic fatty liver disease. | 2005 | Details |
| A46726 | 16175602 | Hepatology | Steatohepatitis induced by intragastric overfeeding in mice. | 2005 | Details |
| A46790 | 15519275 | Hepatol Res | Lack of peroxisome proliferator-activated receptor alpha in mice enhances methionine and choline deficient diet-induced steatohepatitis. | 2004 | Details |
| A46817 | 14749503 | Recent Prog Horm Res | Obesity, insulin resistance, and cardiovascular disease. | 2004 | Details |
| A46891 | 11296696 | Semin Liver Dis | Peroxisomal beta-oxidation and steatohepatitis. | 2001 | Details |
| A46905 | 34970275 | Front Immunol | Macrophage Polarization and Its Role in Liver Disease. | 2021 | Details |
| A46908 | 34817678 | Eur J Nutr | Betaine in ameliorating alcohol-induced hepatic steatosis. | 2021 | Details |
| A46919 | 34267188 | Cell Death Dis | Depdc5 deficiency exacerbates alcohol-induced hepatic steatosis via suppression of PPARα pathway. | 2021 | Details |
| A46920 | 34265279 | Biochem Pharmacol | PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1. | 2021 | Details |
| A46924 | 34116071 | Toxicol Appl Pharmacol | Liver-specific Nrf2 deficiency accelerates ethanol-induced lethality and hepatic injury in vivo. | 2021 | Details |
| A46941 | 33352397 | Cytokine | IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice. | 2020 | Details |
| A46943 | 33249138 | Free Radic Biol Med | The critical role of redox regulation of PTEN and peroxiredoxin III in alcoholic fatty liver. | 2020 | Details |