Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
stats1
stats2
stats3
stats4
Search for:
Caspase-3176 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A23776 | 23489555 | Basic Clin Pharmacol Toxicol | Effects of antihypertensive and triglyceride lowering agents on splenocyte apoptosis in rats with fatty liver. | 2013 | Details |
| A24080 | 23256442 | J Med Food | Dandelion leaf extract protects against liver injury induced by methionine- and choline-deficient diet in mice. | 2012 | Details |
| A24485 | 22847887 | Liver Transpl | Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. | 2012 | Details |
| A24753 | 22535755 | J Nutr | Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats. | 2012 | Details |
| A24825 | 22462240 | J Tradit Chin Med | Dangfei liganning capsules attenuate the susceptibility of rat nonalcoholic fatty liver to carbon tetrachloride toxicity. | 2011 | Details |
| A24830 | 22455888 | Zhonghua Bing Li Xue Za Zhi | [Mechanism of hepatocyte apoptosis in rats with liver fibrosis induced by lipogenic methionine-choline-deficient diet]. | 2012 | Details |
| A25043 | 22221411 | Lipids Health Dis | Palmitic and linoleic acids induce ER stress and apoptosis in hepatoma cells. | 2012 | Details |
| A25256 | 22037452 | Biochem Biophys Res Commun | 17β-Estradiol attenuates saturated fatty acid diet-induced liver injury in ovariectomized mice by up-regulating hepatic senescence marker protein-30. | 2011 | Details |
| A25322 | 21957160 | Am J Physiol Regul Integr Comp Physiol | Experimental evidence for therapeutic potential of taurine in the treatment of nonalcoholic fatty liver disease. | 2011 | Details |
| A25455 | 21814826 | J Mol Med (Berl) | Increased hepatic apoptosis in high-fat diet-induced NASH in rats may be associated with downregulation of hepatic stimulator substance. | 2011 | Details |
| A25481 | 21787405 | Lipids Health Dis | Effect of α-linolenic acid on endoplasmic reticulum stress-mediated apoptosis of palmitic acid lipotoxicity in primary rat hepatocytes. | 2011 | Details |
| A25611 | 21649732 | J Gastroenterol Hepatol | Susceptibility of rat non-alcoholic fatty liver to the acute toxic effect of acetaminophen. | 2012 | Details |
| A25619 | 21635548 | APMIS | Microvesicular fat, inter cellular adhesion molecule-1 and regulatory T-lymphocytes are of importance for the inflammatory process in livers with non-alcoholic steatohepatitis. | 2011 | Details |
| A25652 | 21592363 | Lipids Health Dis | α-Linolenic acid prevents endoplasmic reticulum stress-mediated apoptosis of stearic acid lipotoxicity on primary rat hepatocytes. | 2011 | Details |
| A25788 | 21455726 | Diabetologia | Apoptosis and insulin resistance in liver and peripheral tissues of morbidly obese patients is associated with different stages of non-alcoholic fatty liver disease. | 2011 | Details |
| A26430 | 20471811 | Exp Toxicol Pathol | Anti-apoptotic and anti-inflammatory effects of Silybum marianum in treatment of experimental steatohepatitis. | 2010 | Details |
| A26548 | 20226139 | Zhong Xi Yi Jie He Xue Bao | [Pathogenesis and treatment of non-alcoholic fatty liver disease]. | 2010 | Details |
| A26656 | 20038265 | Immunopharmacol Immunotoxicol | Metformin regulates palmitate-induced apoptosis and ER stress response in HepG2 liver cells. | 2010 | Details |
| A26824 | 19710104 | Innate Immun | Interleukin-6 is associated with liver lipid homeostasis but not with cell death in experimental hepatic steatosis. | 2009 | Details |
| A26839 | 19676126 | Hepatology | Pan-caspase inhibitor VX-166 reduces fibrosis in an animal model of nonalcoholic steatohepatitis. | 2009 | Details |
| A27040 | 19290887 | FEBS J | Full-length adiponectin protects hepatocytes from palmitate-induced apoptosis via inhibition of c-Jun NH2 terminal kinase. | 2009 | Details |
| A27267 | 18795706 | Hepatogastroenterology | Serum gamma-glutamyltranspeptidase distinguishes non-alcoholic fatty liver disease at high risk. | 2009 | Details |
| A27372 | 32038787 | Toxicol Res | Involvement of Endoplasmic Reticulum Stress in Palmitate-induced Apoptosis in HepG2 Cells. | 2008 | Details |
| A27825 | 17352011 | World J Gastroenterol | Soluble forms of extracellular cytokeratin 18 may differentiate simple steatosis from nonalcoholic steatohepatitis. | 2007 | Details |
| A27982 | 16799979 | Hepatology | In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. | 2006 | Details |
| A28852 | 34910547 | Sci Transl Med | β2-spectrin (SPTBN1) as a therapeutic target for diet-induced liver disease and preventing cancer development. | 2021 | Details |
| A29903 | 33296631 | Med Sci (Paris) | [Caspase inhibition: From cellular biology and thanatology to potential clinical agents]. | 2020 | Details |
| A30204 | 32821335 | World J Hepatol | Anti-inflammatory and anti-oxidant effects of aloe vera in rats with non-alcoholic steatohepatitis. | 2020 | Details |
| A30790 | 31777145 | Int J Exp Pathol | The effects of intravitreal H2 S application on apoptosis in the retina and cornea in experimental glaucoma model. | 2019 | Details |
| A31047 | 31321239 | Biomed Res Int | Elafibranor Inhibits Chronic Kidney Disease Progression in NASH Mice. | 2019 | Details |
| A31681 | 30050648 | Oxid Med Cell Longev | Double Knockout of Peroxiredoxin 4 (Prdx4) and Superoxide Dismutase 1 (Sod1) in Mice Results in Severe Liver Failure. | 2018 | Details |
| A33571 | 25682949 | Phytother Res | Artocarpus altilis (Parkinson) Fosberg Extracts and Geranyl Dihydrochalcone Inhibit STAT3 Activity in Prostate Cancer DU145 Cells. | 2015 | Details |
| A33839 | 25038800 | BMC Complement Altern Med | Anti-lipoapoptotic effect of Artemisia capillaris extract on free fatty acids-induced HepG2 cells. | 2014 | Details |
| A33915 | 24885871 | Lipids Health Dis | Linoleate appears to protect against palmitate-induced inflammation in Huh7 cells. | 2014 | Details |
| A34859 | 22411067 | Lab Invest | Caspase-1-mediated regulation of fibrogenesis in diet-induced steatohepatitis. | 2012 | Details |
| A35003 | 22006541 | Hepatology | A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis. | 2011 | Details |
| A35202 | 21452373 | Phytother Res | Black tea prevents high fat diet-induced non-alcoholic steatohepatitis. | 2011 | Details |
| A35338 | 21056947 | Hum Exp Toxicol | Teucrium polium reversed the MCD diet-induced liver injury in rats. | 2010 | Details |
| A35650 | 20028348 | Alcohol Clin Exp Res | Moderate alcohol consumption aggravates high-fat diet induced steatohepatitis in rats. | 2009 | Details |
| A35765 | 19748164 | Clin Nutr | Inhibition of JNK along with activation of ERK1/2 MAPK pathways improve steatohepatitis among the rats. | 2009 | Details |
| A35915 | 19422479 | Liver Int | Effects of ursodeoxycholic acid in combination with vitamin E on adipokines and apoptosis in patients with nonalcoholic steatohepatitis. | 2009 | Details |
| A36180 | 18806094 | J Nutr | Increased apoptosis in high-fat diet-induced nonalcoholic steatohepatitis in rats is associated with c-Jun NH2-terminal kinase activation and elevated proapoptotic Bax. | 2008 | Details |
| A36799 | 17244458 | Zhonghua Gan Zang Bing Za Zhi | [The role of apoptosis and the related genes in non-alcoholic steatohepatitis]. | 2007 | Details |
| A37164 | 16357615 | Eur J Gastroenterol Hepatol | Apoptosis and Bcl-2 expression in the livers of patients with steatohepatitis. | 2006 | Details |
| A37579 | 15330907 | Am J Gastroenterol | Hepatocyte apoptosis, expression of death receptors, and activation of NF-kappaB in the liver of nonalcoholic and alcoholic steatohepatitis patients. | 2004 | Details |
| A42359 | 34767670 | Biofactors | Vitamin D3 enhances the effects of omega-3 oils against metabolic dysfunction-associated fatty liver disease in rat. | 2021 | Details |
| A42473 | 34445250 | Int J Mol Sci | A Novel Oxygen Carrier (M101) Attenuates Ischemia-Reperfusion Injuries during Static Cold Storage in Steatotic Livers. | 2021 | Details |
| A43157 | 32410996 | Front Pharmacol | Paeoniflorin, a Natural Product With Multiple Targets in Liver Diseases-A Mini Review. | 2020 | Details |
| A43400 | 31823402 | J Food Biochem | Comparative effects of nanoemulsions loaded with duck oil and lard oil on palmitate-induced lipotoxicity. | 2019 | Details |
| A45821 | 22531045 | Drug Metab Dispos | In vitro hepatotoxicity and cytochrome P450 induction and inhibition characteristics of carnosic acid, a dietary supplement with antiadipogenic properties. | 2012 | Details |
| A45971 | 21772667 | Mediators Inflamm | Foxp3 expression in liver correlates with the degree but not the cause of inflammation. | 2011 | Details |
| A46117 | 20967760 | Hepatology | Disruption of the 12/15-lipoxygenase gene (Alox15) protects hyperlipidemic mice from nonalcoholic fatty liver disease. | 2010 | Details |
| A46186 | 20470896 | Biochim Biophys Acta | Lipid-induced up-regulation of human acyl-CoA synthetase 5 promotes hepatocellular apoptosis. | 2010 | Details |
| A46231 | 20156580 | Int J Biochem Cell Biol | Peroxisome proliferator-activated receptors gamma reverses hepatic nutritional fibrosis in mice and suppresses activation of hepatic stellate cells in vitro. | 2010 | Details |
| A46447 | 18566043 | Drug Metab Dispos | The pharmacokinetics of silymarin is altered in patients with hepatitis C virus and nonalcoholic Fatty liver disease and correlates with plasma caspase-3/7 activity. | 2008 | Details |
| A46551 | 17668872 | Hepatology | Alpha-1 antitrypsin Z protein (PiZ) increases hepatic fibrosis in a murine model of cholestasis. | 2007 | Details |
| A46586 | 17431009 | Endocrinology | Insulin protects liver cells from saturated fatty acid-induced apoptosis via inhibition of c-Jun NH2 terminal kinase activity. | 2007 | Details |
| A47009 | 30179264 | Hepatology | Pharmacological Inhibition of CCR2/5 Signaling Prevents and Reverses Alcohol-Induced Liver Damage, Steatosis, and Inflammation in Mice. | 2019 | Details |
| A47169 | 24392995 | Int J Food Sci Nutr | Effects of polysaccharide from fruiting bodies of Agaricus bisporus, Agaricus brasiliensis, and Phellinus linteus on alcoholic liver injury. | 2014 | Details |
| A47177 | 24146112 | Arch Toxicol | Protective effects of dioscin against alcohol-induced liver injury. | 2013 | Details |
| A47250 | 21414374 | Food Chem Toxicol | Herbal formula CGX ameliorates LPS/D-galactosamine-induced hepatitis. | 2011 | Details |
| A47830 | 31213776 | Drug Des Devel Ther | Salvianolic acid A attenuates CCl4-induced liver fibrosis by regulating the PI3K/AKT/mTOR, Bcl-2/Bax and caspase-3/cleaved caspase-3 signaling pathways. | 2019 | Details |
| A47886 | 30063802 | Hepatology | Emricasan (IDN-6556) Lowers Portal Pressure in Patients With Compensated Cirrhosis and Severe Portal Hypertension. | 2018 | Details |
| A47959 | 28108987 | Hepatology | Activation of silent mating type information regulation 2 homolog 1 by human chorionic gonadotropin exerts a therapeutic effect on hepatic injury and inflammation. | 2017 | Details |
| A48124 | 22521608 | Toxicol Appl Pharmacol | Cyclosporine A and palmitic acid treatment synergistically induce cytotoxicity in HepG2 cells. | 2012 | Details |
| A48249 | 18715620 | Hum Pathol | Apoptosis markers in liver biopsy of nonalcoholic steatohepatitis in pediatric patients. | 2008 | Details |
| A48756 | 29597210 | Pharmacology | Euodia daniellii Hemsl. (Bee-Bee Tree) Oil Attenuates Palmitate-Induced Lipid Accumulation and Apoptosis in Hepatocytes. | 2018 | Details |
| A49025 | 20979658 | Lipids Health Dis | Heme oxygenase-1 prevents non-alcoholic steatohepatitis through suppressing hepatocyte apoptosis in mice. | 2010 | Details |
| A49075 | 18947977 | Nutrition | Nutritional lipid-induced oxidative stress leads to mitochondrial dysfunction followed by necrotic death in FaO hepatocytes. | 2008 | Details |
| A49099 | 17845508 | Basic Clin Pharmacol Toxicol | Silymarin prevents palmitate-induced lipotoxicity in HepG2 cells: involvement of maintenance of Akt kinase activation. | 2007 | Details |
| A49642 | 35682887 | Int J Mol Sci | The Role of Autophagy and Pyroptosis in Liver Disorders. | 2022 | Details |
| A49922 | 35594708 | Biomed Pharmacother | Exogenous administration of unacylated ghrelin attenuates hepatic steatosis in high-fat diet-fed rats by modulating glucose homeostasis, lipogenesis, oxidative stress, and endoplasmic reticulum stress. | 2022 | Details |
| A49994 | 35568228 | Life Sci | Protective effects of maslinic acid on high fat diet-induced liver injury in mice. | 2022 | Details |
| A50566 | 35338494 | J Food Biochem | Zingerone ameliorates non-alcoholic fatty liver disease in rats by activating AMPK. | 2022 | Details |
| A51246 | 35663960 | Front Immunol | Acute Intoxication With Alcohol Reduces Trauma-Induced Proinflammatory Response and Barrier Breakdown in the Lung via the Wnt/β-Catenin Signaling Pathway. | 2022 | Details |
| A52464 | 26829127 | J Agric Food Chem | Trace Mineral Overload Induced Hepatic Oxidative Damage and Apoptosis in Pigs with Long-Term High-Level Dietary Mineral Exposure. | 2016 | Details |