Research Articles
Research articles concerning NAFLD are extracted from PubMed. For each individual article, related therapeutic strategies, targets, drugs and associated diseases in NAFLDkb are presented with knowledge graphs.
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Fatty acid synthase594 records.
| Article ID | PMID | Source | Title | Publish Year | |
|---|---|---|---|---|---|
| A08459 | 32103741 | BMC Gastroenterol | Fructo-oligosaccharides ameliorate steatohepatitis, visceral adiposity, and associated chronic inflammation via increased production of short-chain fatty acids in a mouse model of non-alcoholic steatohepatitis. | 2020 | Details |
| A08525 | 32074961 | Nutrients | Dietary Platycodon grandiflorus Attenuates Hepatic Insulin Resistance and Oxidative Stress in High-Fat-Diet Induced Non-Alcoholic Fatty Liver Disease. | 2020 | Details |
| A08594 | 32045698 | Biochim Biophys Acta Mol Cell Biol Lipids | Imbalanced insulin substrate-1 and insulin substrate-2 signaling trigger hepatic steatosis in vitamin D deficient rats: 8-methoxypsoralen, a vitamin D receptor ligand with a promising anti-steatotic action. | 2020 | Details |
| A08596 | 32045588 | Toxicol Appl Pharmacol | Orlistat delays hepatocarcinogenesis in mice with hepatic co-activation of AKT and c-Met. | 2020 | Details |
| A08606 | 32043636 | FASEB J | REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high-fat diet. | 2020 | Details |
| A08640 | 32035613 | Biochem Biophys Res Commun | MicroRNA-103 represses hepatic de novo lipogenesis and alleviates NAFLD via targeting FASN and SCD1. | 2020 | Details |
| A08656 | 32031683 | Hepatology | Hepatic Deficiency of Augmenter of Liver Regeneration Predisposes to Nonalcoholic Steatohepatitis and Fibrosis. | 2020 | Details |
| A08764 | 31993306 | Acta Pharm Sin B | Cytochrome P450 endoplasmic reticulum-associated degradation (ERAD): therapeutic and pathophysiological implications. | 2019 | Details |
| A08822 | 31978277 | Mol Nutr Food Res | Lipoatrophy-Associated Insulin Resistance and Hepatic Steatosis are Attenuated by Intake of Diet Rich in Omega 3 Fatty Acids. | 2020 | Details |
| A08991 | 31913745 | Autophagy | SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. | 2020 | Details |
| A09021 | 31901728 | Redox Biol | Hepatocyte-specific Nrf2 deficiency mitigates high-fat diet-induced hepatic steatosis: Involvement of reduced PPARγ expression. | 2019 | Details |
| A09087 | 31881201 | Exp Mol Pathol | Alpha-syntrophin deficiency protects against non-alcoholic steatohepatitis associated increase of macrophages, CD8+ T-cells and galectin-3 in the liver. | 2019 | Details |
| A09189 | 31842467 | Int J Mol Sci | Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells. | 2019 | Details |
| A09212 | 31834842 | J Med Food | Effects of Eriobotrya japonica Water Extract on Alcoholic and Nonalcoholic Fatty Liver Impairment. | 2019 | Details |
| A09222 | 31832001 | World J Gastroenterol | LB100 ameliorates nonalcoholic fatty liver disease via the AMPK/Sirt1 pathway. | 2019 | Details |
| A09367 | 31776016 | Environ Res | Adolescent exposure to environmental level of PCBs (Aroclor 1254) induces non-alcoholic fatty liver disease in male mice. | 2019 | Details |
| A09554 | 31695954 | Food Sci Biotechnol | Dansameum regulates hepatic lipogenesis and inflammation in vitro and in vivo. | 2019 | Details |
| A09646 | 31660146 | Food Sci Nutr | Fermented black radish (Raphanus sativus L. var. niger) attenuates methionine and choline deficient diet-induced nonalcoholic fatty liver disease in mice. | 2019 | Details |
| A09701 | 31640183 | Nutrients | Water Extract of Curcuma longa L. Ameliorates Non-Alcoholic Fatty Liver Disease. | 2019 | Details |
| A09706 | 31638173 | Int J Mol Med | Role and mechanisms of action of microRNA‑21 as regards the regulation of the WNT/β‑catenin signaling pathway in the pathogenesis of non‑alcoholic fatty liver disease. | 2019 | Details |
| A09740 | 31630414 | Hepatology | Fatty Acid Synthase Inhibitor TVB-2640 Reduces Hepatic de Novo Lipogenesis in Males With Metabolic Abnormalities. | 2020 | Details |
| A09776 | 31614650 | J Clin Med | Polyphenol-Rich Extracts from Toona sinensis Bark and Fruit Ameliorate Free Fatty Acid-Induced Lipogenesis through AMPK and LC3 Pathways. | 2019 | Details |
| A09777 | 31614639 | Biomolecules | Allopurinol Prevents the Lipogenic Response Induced by an Acute Oral Fructose Challenge in Short-Term Fructose Fed Rats. | 2019 | Details |
| A09788 | 31610126 | J Agric Food Chem | Reduction of Hepatic Lipogenesis by Loliolide and Pinoresinol from Lysimachia vulgaris via Degrading Liver X Receptors. | 2019 | Details |
| A09807 | 31602953 | Zhongguo Zhong Yao Za Zhi | [Mechanism of Calculus Bovis Sativus in inhibiting hepatocyte lipid deposition based on serum pharmacology]. | 2019 | Details |
| A09808 | 31602526 | J Gastroenterol | Hepatic FATP5 expression is associated with histological progression and loss of hepatic fat in NAFLD patients. | 2019 | Details |
| A09881 | 31576092 | World J Gastroenterol | Zinc-α2-glycoprotein 1 attenuates non-alcoholic fatty liver disease by negatively regulating tumour necrosis factor-α. | 2019 | Details |
| A09941 | 31551937 | Front Endocrinol (Lausanne) | Non-alcoholic Fatty Liver Disease Induced by Perinatal Exposure to Bisphenol a Is Associated With Activated mTOR and TLR4/NF-κB Signaling Pathways in Offspring Rats. | 2019 | Details |
| A10030 | 31519174 | BMC Complement Altern Med | Diosgenin ameliorates palmitic acid-induced lipid accumulation via AMPK/ACC/CPT-1A and SREBP-1c/FAS signaling pathways in LO2 cells. | 2019 | Details |
| A10134 | 31472955 | Biochem Biophys Res Commun | Vitexin alleviates non-alcoholic fatty liver disease by activating AMPK in high fat diet fed mice. | 2019 | Details |
| A10144 | 31470288 | Nutr Res | Gnotobiotic mice inoculated with Firmicutes, but not Bacteroidetes, deteriorate nonalcoholic fatty liver disease severity by modulating hepatic lipid metabolism. | 2019 | Details |
| A10171 | 31455870 | Int J Obes (Lond) | Specific diacylglycerols generated by hepatic lipogenesis stimulate the oncogenic androgen receptor activity in male hepatocytes. | 2019 | Details |
| A10174 | 31454158 | Mol Nutr Food Res | Tomatidine Reduces Palmitate-Induced Lipid Accumulation by Activating AMPK via Vitamin D Receptor-Mediated Signaling in Human HepG2 Hepatocytes. | 2019 | Details |
| A10212 | 31430456 | Eur J Pharmacol | Pinolenic acid ameliorates oleic acid-induced lipogenesis and oxidative stress via AMPK/SIRT1 signaling pathway in HepG2 cells. | 2019 | Details |
| A10254 | 31409773 | Cell Death Dis | mTOR direct crosstalk with STAT5 promotes de novo lipid synthesis and induces hepatocellular carcinoma. | 2019 | Details |
| A10695 | 31233775 | J Control Release | The hepatic-targeted, resveratrol loaded nanoparticles for relief of high fat diet-induced nonalcoholic fatty liver disease. | 2019 | Details |
| A10699 | 31233505 | PLoS One | Adenovirus-mediated expression of SIK1 improves hepatic glucose and lipid metabolism in type 2 diabetes mellitus rats. | 2019 | Details |
| A10903 | 31132314 | J Gastroenterol Hepatol | Decrease in fat de novo synthesis and chemokine ligand expression in non-alcoholic fatty liver disease caused by inhibition of mixed lineage kinase domain-like pseudokinase. | 2019 | Details |
| A10920 | 31123744 | Food Funct | Ellagic acid ameliorates AKT-driven hepatic steatosis in mice by suppressing de novo lipogenesis via the AKT/SREBP-1/FASN pathway. | 2019 | Details |
| A10928 | 31117231 | Nutrients | Transcriptome Analysis of Dual FXR and GPBAR1 Agonism in Rodent Model of NASH Reveals Modulation of Lipid Droplets Formation. | 2019 | Details |
| A10945 | 31110049 | J Lipid Res | FTY720/fingolimod decreases hepatic steatosis and expression of fatty acid synthase in diet-induced nonalcoholic fatty liver disease in mice. | 2019 | Details |
| A11006 | 31083505 | Cells | Protective Effects of Licochalcone A Ameliorates Obesity and Non-Alcoholic Fatty Liver Disease Via Promotion of the Sirt-1/AMPK Pathway in Mice Fed a High-Fat Diet. | 2019 | Details |
| A11007 | 31083413 | Int J Mol Sci | Arazyme Suppresses Hepatic Steatosis and Steatohepatitis in Diet-Induced Non-Alcoholic Fatty Liver Disease-Like Mouse Model. | 2019 | Details |
| A11059 | 31063640 | Hepatology | Pharmacologic Inhibition of Epidermal Growth Factor Receptor Suppresses Nonalcoholic Fatty Liver Disease in a Murine Fast-Food Diet Model. | 2019 | Details |
| A11149 | 31022865 | Nutrients | Dietary Docosahexaenoic Acid (DHA) and Eicosapentaenoic Acid (EPA) Operate by Different Mechanisms to Modulate Hepatic Steatosis and Hyperinsulemia in fa/fa Zucker Rats. | 2019 | Details |
| A11190 | 31005808 | Phytomedicine | Amelioration of nonalcoholic fatty liver disease by swertiamarin in fructose-fed mice. | 2018 | Details |
| A11191 | 31004931 | Environ Toxicol Pharmacol | Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. | 2019 | Details |
| A11332 | 30935037 | Nutrients | Melatonin Improves Fatty Liver Syndrome by Inhibiting the Lipogenesis Pathway in Hamsters with High-Fat Diet-Induced Hyperlipidemia. | 2019 | Details |
| A11364 | 30921449 | PLoS One | Combined effects of ambient particulate matter exposure and a high-fat diet on oxidative stress and steatohepatitis in mice. | 2019 | Details |
| A11461 | 30887659 | Int J Exp Pathol | Vitronectin deficiency attenuates hepatic fibrosis in a non-alcoholic steatohepatitis-induced mouse model. | 2019 | Details |
| A11497 | 30871035 | Nutrients | Eicosapentaenoic Acid Improves Hepatic Metabolism and Reduces Inflammation Independent of Obesity in High-Fat-Fed Mice and in HepG2 Cells. | 2019 | Details |
| A11518 | 30861601 | J Cell Biochem | Mitigative effects of the bioactive flavonol fisetin on high-fat/high-sucrose induced nonalcoholic fatty liver disease in rats. | 2019 | Details |
| A11527 | 30856537 | Biomed Pharmacother | Ferulic acid ameliorates nonalcoholic fatty liver disease and modulates the gut microbiota composition in high-fat diet fed ApoE-/- mice. | 2019 | Details |
| A11574 | 30833801 | World J Gastroenterol | Procyanidin B2 protects against diet-induced obesity and non-alcoholic fatty liver disease via the modulation of the gut microbiota in rabbits. | 2019 | Details |
| A11625 | 30813654 | Nutrients | Lonicera caerulea Extract Attenuates Non-Alcoholic Fatty Liver Disease in Free Fatty Acid-Induced HepG2 Hepatocytes and in High Fat Diet-Fed Mice. | 2019 | Details |
| A11657 | 30802722 | Nutr Res | Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-β and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet. | 2019 | Details |
| A11816 | 30723896 | Lipids | Molecular Characterization of Microvesicular and Macrovesicular Steatosis Shows Widespread Differences in Metabolic Pathways. | 2019 | Details |
| A11894 | 30691143 | Nutrients | Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome. | 2019 | Details |
| A11932 | 30675881 | Food Funct | Coenzyme Q10 attenuates high-fat diet-induced non-alcoholic fatty liver disease through activation of the AMPK pathway. | 2019 | Details |
| A12051 | 30622377 | World J Gastroenterol | Mismatched effects of receptor interacting protein kinase-3 on hepatic steatosis and inflammation in non-alcoholic fatty liver disease. | 2018 | Details |
| A12054 | 30621686 | Lipids Health Dis | Crocin ameliorates hepatic steatosis through activation of AMPK signaling in db/db mice. | 2019 | Details |
| A12143 | 30583863 | Biochem Biophys Res Commun | Erythropoietin and long-acting erythropoiesis stimulating agent ameliorate non-alcoholic fatty liver disease by increasing lipolysis and decreasing lipogenesis via EPOR/STAT pathway. | 2018 | Details |
| A12152 | 30580553 | Crit Rev Food Sci Nutr | n-3 Polyunsaturated fatty acids for the management of alcoholic liver disease: A critical review. | 2018 | Details |
| A12165 | 30576936 | Biomed Pharmacother | Sodium tanshinone IIA sulfonate ameliorates hepatic steatosis by inhibiting lipogenesis and inflammation. | 2018 | Details |
| A12201 | 30564000 | J Clin Exp Hepatol | Genetic and Epigenetic Culprits in the Pathogenesis of Nonalcoholic Fatty Liver Disease. | 2018 | Details |
| A12206 | 30562559 | Biochim Biophys Acta Mol Basis Dis | Hepatic mTOR-AKT2-Insig2 signaling pathway contributes to the improvement of hepatic steatosis after Roux-en-Y Gastric Bypass in mice. | 2018 | Details |
| A12337 | 30509175 | BMC Genomics | Corn dried distillers grains with solubles (cDDGS) in the diet of pigs change the expression of adipose genes that are potential therapeutic targets in metabolic and cardiovascular diseases. | 2018 | Details |
| A12351 | 30489192 | J Med Food | Hovenia dulcis Extract Attenuates High-Fat Diet-Induced Hepatic Lipid Accumulation and Hypertriglyceridemia in C57BL/6 Mice. | 2018 | Details |
| A12387 | 30473486 | Mol Metab | Tannic acid, a novel histone acetyltransferase inhibitor, prevents non-alcoholic fatty liver disease both in vivo and in vitro model. | 2018 | Details |
| A12517 | 30411763 | Food Funct | Hepatoprotective mechanism of freshwater clam extract alleviates non-alcoholic fatty liver disease: elucidated in vitro and in vivo models. | 2018 | Details |
| A12523 | 30411231 | J Physiol Biochem | Lipid metabolism in adipose tissue and liver from diet-induced obese rats: a comparison between Wistar and Sprague-Dawley strains. | 2018 | Details |
| A12577 | 30381838 | J Physiol | SIRT1 overexpression attenuates offspring metabolic and liver disorders as a result of maternal high-fat feeding. | 2018 | Details |
| A12662 | 30340105 | Int Immunopharmacol | Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism. | 2018 | Details |
| A12687 | 30327559 | Nat Chem Biol | Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. | 2018 | Details |
| A12693 | 30324559 | Cell Biochem Biophys | Melatonin Modulates lipid Metabolism in HepG2 Cells Cultured in High Concentrations of Oleic Acid: AMPK Pathway Activation may Play an Important Role. | 2018 | Details |
| A12726 | 30315247 | Sci Rep | NLRP3 Inflammasome Modulates Post-Burn Lipolysis and Hepatic Fat Infiltration via Fatty Acid Synthase. | 2018 | Details |
| A12811 | 30273090 | J Med Food | Aqueous Extract of Humulus japonicus Attenuates Hyperlipidemia and Fatty Liver in Obese Mice. | 2018 | Details |
| A12854 | 30256948 | Hum Mol Genet | Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia. | 2019 | Details |
| A12863 | 30250238 | Sci Rep | Human hepatic 3D spheroids as a model for steatosis and insulin resistance. | 2018 | Details |
| A12885 | 30241944 | Biochem Biophys Res Commun | Spermidine ameliorates non-alcoholic fatty liver disease through regulating lipid metabolism via AMPK. | 2018 | Details |
| A12899 | 30235452 | Cell Physiol Biochem | Fisetin Protects Against Hepatic Steatosis Through Regulation of the Sirt1/AMPK and Fatty Acid β-Oxidation Signaling Pathway in High-Fat Diet-Induced Obese Mice. | 2018 | Details |
| A12952 | 30212593 | Acta Biochim Pol | Influence of oleic acid in different solvent media on BRL 3A cell growth and viability. | 2018 | Details |
| A12976 | 30200715 | Zhongguo Zhong Yao Za Zhi | [Effect of Fuzi Lizhong decoction in reducing liver injury of rats with non-alcoholic fatty liver via activating AMPK and suppressing NF-κBp65 pathway]. | 2018 | Details |
| A13005 | 30185127 | Biosci Biotechnol Biochem | Marginal iron deficiency enhances liver triglyceride accumulation in rats fed a high-sucrose diet. | 2018 | Details |
| A13032 | 30172252 | Lipids Health Dis | Exercise without dietary changes alleviates nonalcoholic fatty liver disease without weight loss benefits. | 2018 | Details |
| A13067 | 30154382 | Int J Mol Sci | Flavonones from Penthorum chinense Ameliorate Hepatic Steatosis by Activating the SIRT1/AMPK Pathway in HepG2 Cells. | 2018 | Details |
| A13161 | 30109054 | R Soc Open Sci | Synergistic effect of eicosapentaenoic acid-enriched phospholipids and sea cucumber saponin on orotic acid-induced non-alcoholic fatty liver disease in rats. | 2018 | Details |
| A13372 | 30013137 | Nat Commun | Insulin/Snail1 axis ameliorates fatty liver disease by epigenetically suppressing lipogenesis. | 2018 | Details |
| A13387 | 30006154 | Biochim Biophys Acta Mol Basis Dis | GCN2 deficiency protects against high fat diet induced hepatic steatosis and insulin resistance in mice. | 2018 | Details |
| A13431 | 29976400 | J Food Drug Anal | Tetrahydrocurcumin ameliorates free fatty acid-induced hepatic steatosis and improves insulin resistance in HepG2 cells. | 2018 | Details |
| A13553 | 29913436 | Cell Physiol Biochem | NEFA-Sensitive Orai1 Expression in Regulation of De Novo Lipogenesis. | 2018 | Details |
| A13591 | 29890650 | Foods | Protection by the Total Flavonoids from Rosa laevigata Michx Fruit against Lipopolysaccharide-Induced Liver Injury in Mice via Modulation of FXR Signaling. | 2018 | Details |
| A13730 | 29786745 | Int J Mol Med | Histone modifications in fatty acid synthase modulated by carbohydrate responsive element binding protein are associated with non‑alcoholic fatty liver disease. | 2018 | Details |
| A13785 | 29759071 | Lipids Health Dis | Metformin attenuates triglyceride accumulation in HepG2 cells through decreasing stearyl-coenzyme A desaturase 1 expression. | 2018 | Details |
| A13814 | 29743929 | Nutr Metab (Lond) | Neonatal overfeeding induced glucocorticoid overexposure accelerates hepatic lipogenesis in male rats. | 2018 | Details |
| A13872 | 29717275 | Int J Obes (Lond) | Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers. | 2018 | Details |
| A13885 | 29710028 | J Nutr Sci Vitaminol (Tokyo) | Vitamin D Deficiency Increases Lipogenesis and Reduces Beta-Oxidation in the Liver of Diet-Induced Obese Mice. | 2018 | Details |
| A14002 | 29644441 | Abdom Radiol (NY) | [11C]acetate PET as a tool for diagnosis of liver steatosis. | 2018 | Details |
| A14008 | 29637446 | J Physiol Biochem | Effect of high chronic intake of sucrose on liver metabolism in aging rats. Modulation by rutin and micronutrients. | 2018 | Details |
| A14020 | 29631603 | Lipids Health Dis | Heat shock protein 70 promotes lipogenesis in HepG2 cells. | 2018 | Details |